(e,z)-farnesol

(e,z)-farnesol is a lipid of Prenol Lipids (PR) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 3613 references associated with (e,z)-farnesol in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for (e,z)-farnesol

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with (e,z)-farnesol

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Osteosarcoma D012516 50 associated lipids
Glioma D005910 112 associated lipids
Per page 10 20 50 | Total 23

PubChem Biomolecular Interactions and Pathways

All references with (e,z)-farnesol

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Per page 10 20 50 100 | Total 813
Authors Title Published Journal PubMed Link
Lin HP et al. Localization of isoprenylated antigen of hepatitis delta virus by anti-farnesyl antibodies. 1999 J. Gen. Virol. pmid:9934689
Weissmann N et al. Evidence for a role of protein kinase C in hypoxic pulmonary vasoconstriction. 1999 Am. J. Physiol. pmid:9887060
Niv H et al. Membrane interactions of a constitutively active GFP-Ki-Ras 4B and their role in signaling. Evidence from lateral mobility studies. 1999 J. Biol. Chem. pmid:9880539
Fisher JE et al. Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:9874784
Shipman CM et al. The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway. 1998 Cancer Res. pmid:9850051
Strickland CL et al. Crystal structure of farnesyl protein transferase complexed with a CaaX peptide and farnesyl diphosphate analogue. 1998 Biochemistry pmid:9843427
Laezza C et al. v-K-ras leads to preferential farnesylation of p21(ras) in FRTL-5 cells: multiple interference with the isoprenoid pathway. 1998 Proc. Natl. Acad. Sci. U.S.A. pmid:9811854
Ferdinandy P et al. Rapid pacing-induced preconditioning is recaptured by farnesol treatment in hearts of cholesterol-fed rats: role of polyprenyl derivatives and nitric oxide. 1998 Mol. Cell. Biochem. pmid:9774182
Pei ZM et al. Role of farnesyltransferase in ABA regulation of guard cell anion channels and plant water loss. 1998 Science pmid:9765153
Miquel K et al. Competitive inhibition of choline phosphotransferase by geranylgeraniol and farnesol inhibits phosphatidylcholine synthesis and induces apoptosis in human lung adenocarcinoma A549 cells. 1998 J. Biol. Chem. pmid:9748300
Aboushadi N and Krisans SK Analysis of isoprenoid biosynthesis in peroxisomal-deficient Pex2 CHO cell lines. 1998 J. Lipid Res. pmid:9741690
Machida K et al. Farnesol-induced generation of reactive oxygen species via indirect inhibition of the mitochondrial electron transport chain in the yeast Saccharomyces cerevisiae. 1998 J. Bacteriol. pmid:9721283
Szilvassy Z et al. Improvement of nitrergic relaxation by farnesol of the sphincter of Oddi from hypercholesterolaemic rabbits. 1998 Eur. J. Pharmacol. pmid:9721042
Nishio E et al. Alpha1-adrenoreceptor stimulation causes vascular smooth muscle cell hypertrophy: a possible role for isoprenoid intermediates. 1998 Eur. J. Pharmacol. pmid:9650858
Vaidya S et al. Massive production of farnesol-derived dicarboxylic acids in mice treated with the squalene synthase inhibitor zaragozic acid A. 1998 Arch. Biochem. Biophys. pmid:9647670
Bentinger M et al. Phosphorylation of farnesol in rat liver microsomes: properties of farnesol kinase and farnesyl phosphate kinase. 1998 Arch. Biochem. Biophys. pmid:9606952
Crick DC et al. Geranylgeraniol overcomes the block of cell proliferation by lovastatin in C6 glioma cells. 1998 J. Neurochem. pmid:9603204
Rubins JB et al. Lovastatin induces apoptosis in malignant mesothelioma cells. 1998 Am. J. Respir. Crit. Care Med. pmid:9603146
Pérez-Sala D et al. Analogs of farnesylcysteine induce apoptosis in HL-60 cells. 1998 FEBS Lett. pmid:9600259
Llorente-Cortés V et al. Esterified cholesterol accumulation induced by aggregated LDL uptake in human vascular smooth muscle cells is reduced by HMG-CoA reductase inhibitors. 1998 Arterioscler. Thromb. Vasc. Biol. pmid:9598832
Hampton RY Genetic analysis of hydroxymethylglutaryl-coenzyme A reductase regulated degradation. 1998 Curr. Opin. Lipidol. pmid:9559264
Aharonson Z et al. Stringent structural requirements for anti-Ras activity of S-prenyl analogues. 1998 Biochim. Biophys. Acta pmid:9545527
Desrosiers RR and Béliveau R Regulation by GTPgammaS of protein carboxylmethyltransferase activity in kidney brush border membranes. 1998 Arch. Biochem. Biophys. pmid:9514644
Ura H et al. Selective cytotoxicity of farnesylamine to pancreatic carcinoma cells and Ki-ras-transformed fibroblasts. 1998 Mol. Carcinog. pmid:9496909
Roullet JB et al. Inhibition of Ca2+ uptake into A7r5 vascular smooth muscle cells by farnesol: lack of effect on membrane fluidity and Ca2+-ATPase activities. 1997 J. Hypertens. pmid:9488229
Haklai R et al. Dislodgment and accelerated degradation of Ras. 1998 Biochemistry pmid:9477957
Roullet JB et al. Farnesol inhibits L-type Ca2+ channels in vascular smooth muscle cells. 1997 J. Biol. Chem. pmid:9405427
Ghosh PM et al. Lovastatin induces apoptosis by inhibiting mitotic and post-mitotic events in cultured mesangial cells. 1997 Biochim. Biophys. Acta pmid:9398081
Goossens A and Merckx L Allergic contact dermatitis from farnesol in a deodorant. 1997 Contact Derm. pmid:9385513
Gana-Weisz M et al. The Ras antagonist S-farnesylthiosalicylic acid induces inhibition of MAPK activation. 1997 Biochem. Biophys. Res. Commun. pmid:9367867
Andres DA et al. Expression cloning of a novel farnesylated protein, RDJ2, encoding a DnaJ protein homologue. 1997 Arch. Biochem. Biophys. pmid:9328291
Saisho Y et al. Determination of farnesyl pyrophosphate in dog and human plasma by high-performance liquid chromatography with fluorescence detection. 1997 Anal. Biochem. pmid:9324945
Nozawa Y et al. Stachybotrin C and parvisporin, novel neuritogenic compounds. II. Structure determination. 1997 J. Antibiot. pmid:9315075
Van Dessel G et al. Internalisation of short-chain isoprenyl diphosphates by chromaffin cells from bovine adrenal medulla. 1997 Biochem. Biophys. Res. Commun. pmid:9299441
Crick DC et al. Novel salvage pathway utilizing farnesol and geranylgeraniol for protein isoprenylation. 1997 Biochem. Biophys. Res. Commun. pmid:9299388
Zhang L et al. Isolation and characterization of a prenylcysteine lyase from bovine brain. 1997 J. Biol. Chem. pmid:9287348
Meigs TE and Simoni RD Farnesol as a regulator of HMG-CoA reductase degradation: characterization and role of farnesyl pyrophosphatase. 1997 Arch. Biochem. Biophys. pmid:9281305
Blazer-Yost BL et al. Protein prenylation is required for aldosterone-stimulated Na+ transport. 1997 Am. J. Physiol. pmid:9227422
Flint OP et al. Inhibition of cholesterol synthesis by squalene synthase inhibitors does not induce myotoxicity in vitro. 1997 Toxicol. Appl. Pharmacol. pmid:9221828
Leitner JW et al. Hyperinsulinemia potentiates activation of p21Ras by growth factors. 1997 Endocrinology pmid:9112423
Crick DC et al. Geranylgeraniol promotes entry of UT-2 cells into the cell cycle in the absence of mevalonate. 1997 Exp. Cell Res. pmid:9087171
Bostedor RG et al. Farnesol-derived dicarboxylic acids in the urine of animals treated with zaragozic acid A or with farnesol. 1997 J. Biol. Chem. pmid:9083051
Tamone SL et al. Identification and characterization of methyl farnesoate binding proteins from the crab, Cancer magister. 1997 Gen. Comp. Endocrinol. pmid:9038249
Tisch D et al. Activation of signaling pathways in HL60 cells and human neutrophils by farnesylthiosalicylate. 1996 Eur. J. Biochem. pmid:9022678
Westfall D et al. Metabolism of farnesol: phosphorylation of farnesol by rat liver microsomal and peroxisomal fractions. 1997 Biochem. Biophys. Res. Commun. pmid:9015362
Carel K et al. Insulin stimulates mitogen-activated protein kinase by a Ras-independent pathway in 3T3-L1 adipocytes. 1996 J. Biol. Chem. pmid:8940037
McGuire TF et al. Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation. 1996 J. Biol. Chem. pmid:8910319
Umetani N et al. Lovastatin inhibits gene expression of type-I scavenger receptor in THP-1 human macrophages. 1996 Biochim. Biophys. Acta pmid:8908154
Satoh T et al. The effects of pravastatin, an HMG-CoA reductase inhibitor, on cell viability and DNA production of rat hepatocytes. 1996 Life Sci. pmid:8831797
Miquel K et al. Farnesol and geranylgeraniol induce actin cytoskeleton disorganization and apoptosis in A549 lung adenocarcinoma cells. 1996 Biochem. Biophys. Res. Commun. pmid:8780704
Nishio E et al. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor impairs cell p4fferentiation in cultured adipogenic cells (3T3-L1). 1996 Eur. J. Pharmacol. pmid:8773465
Koyama T et al. Identification of significant residues in the substrate binding site of Bacillus stearothermophilus farnesyl diphosphate synthase. 1996 Biochemistry pmid:8755734
Tanaka H et al. MEKA/phosducin attenuates hydrophobicity of transducin beta gamma subunits without binding to farnesyl moiety. 1996 Biochem. Biophys. Res. Commun. pmid:8687440
Keller RK et al. Farnesol is not the nonsterol regulator mediating degradation of HMG-CoA reductase in rat liver. 1996 Arch. Biochem. Biophys. pmid:8645011
Roullet JB et al. Farnesyl analogues inhibit vasoconstriction in animal and human arteries. 1996 J. Clin. Invest. pmid:8636420
Boisvenue RJ et al. Haemonchus contortus: effects of compounds with juvenile hormone activity on the in vitro development of infective larvae. 1977 Exp. Parasitol. pmid:862711
Meigs TE et al. Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase degradation by the nonsterol mevalonate metabolite farnesol in vivo. 1996 J. Biol. Chem. pmid:8626470
Parmryd I et al. Identification of spinach farnesyl protein transferase. Dithiothreitol as an acceptor in vitro. 1995 Eur. J. Biochem. pmid:8575428
Tachibana A et al. Evidence for farnesol-mediated isoprenoid synthesis regulation in a halophilic archaeon, Haloferax volcanii. 1996 FEBS Lett. pmid:8566226
Gibbs JB et al. Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo. 1993 J. Biol. Chem. pmid:8463291
O'Donnell MP et al. Lovastatin inhibits proliferation of rat mesangial cells. 1993 J. Clin. Invest. pmid:8423236
Touhara K and Prestwich GD Juvenile hormone epoxide hydrolase. Photoaffinity labeling, purification, and characterization from tobacco hornworm eggs. 1993 J. Biol. Chem. pmid:8396141
Akopyan TN et al. Proteolytic processing of farnesylated peptides: assay and partial purification from pig brain membranes of an endopeptidase which has the characteristics of E.C. 3.4.24.15. 1994 Biochem. Biophys. Res. Commun. pmid:8297391
Foster JM et al. Biosynthesis of isoprenoid compounds in Schistosoma mansoni. 1993 Mol. Biochem. Parasitol. pmid:8264731
Inoue H et al. Formation of farnesal and 3-hydroxy-2,3-dihydrofarnesal from farnesol by protoplasts of Botryococcus braunii. 1993 Biochem. Biophys. Res. Commun. pmid:8250896
Voziyan PA et al. Farnesol inhibits phosphatidylcholine biosynthesis in cultured cells by decreasing cholinephosphotransferase activity. 1993 Biochem. J. pmid:8240288
Corsini A et al. Relationship between mevalonate pathway and arterial myocyte proliferation: in vitro studies with inhibitors of HMG-CoA reductase. 1993 Atherosclerosis pmid:8216498
Kothapalli R et al. Effects of long-chain fatty amines on the growth of ras-transformed NIH 3T3 cells. 1994 Biochem. Pharmacol. pmid:8204109
Inoue H et al. Phosphorylation of farnesol by a cell-free system from Botryococcus braunii. 1994 Biochem. Biophys. Res. Commun. pmid:8179579
Caldwell GA et al. Consequences of altered isoprenylation targets on a-factor export and bioactivity. 1994 Proc. Natl. Acad. Sci. U.S.A. pmid:8108401
Fukada Y et al. Effects of carboxyl methylation of photoreceptor G protein gamma-subunit in visual transduction. 1994 J. Biol. Chem. pmid:8106497
Lübben M and Morand K Novel prenylated hemes as cofactors of cytochrome oxidases. Archaea have modified hemes A and O. 1994 J. Biol. Chem. pmid:8063781
Kisselev OG et al. A farnesylated domain in the G protein gamma subunit is a specific determinant of receptor coupling. 1994 J. Biol. Chem. pmid:8063769
Haug JS et al. Directed cell killing (apoptosis) in human lymphoblastoid cells incubated in the presence of farnesol: effect of phosphatidylcholine. 1994 Biochim. Biophys. Acta pmid:8061045
Cox AD et al. The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation. 1994 J. Biol. Chem. pmid:8034681
Correll CC et al. Identification of farnesol as the non-sterol derivative of mevalonic acid required for the accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. 1994 J. Biol. Chem. pmid:8021239
Adany I et al. Differences in sensitivity to farnesol toxicity between neoplastically- and non-neoplastically-derived cells in culture. 1994 Cancer Lett. pmid:8019976
Tojo K et al. Diffusion and metabolism of prednisolone farnesylate in viable skin of the hairless mouse. 1994 Pharm. Res. pmid:8008705
Mallat A et al. Effect of simvastatin, an inhibitor of hydroxy-methylglutaryl coenzyme A reductase, on the growth of human Ito cells. 1994 Hepatology pmid:7982659
Biermann BJ et al. Novel isoprenylated proteins identified by an expression library screen. 1994 J. Biol. Chem. pmid:7929216
Aronheim A et al. Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway. 1994 Cell pmid:7923364
Søgaard M et al. A rab protein is required for the assembly of SNARE complexes in the docking of transport vesicles. 1994 Cell pmid:7923363
Munro E et al. Inhibition of human vascular smooth muscle cell proliferation by lovastatin: the role of isoprenoid intermediates of cholesterol synthesis. 1994 Eur. J. Clin. Invest. pmid:7890015
Yazlovitskaya EM and Melnykovych G Selective farnesol toxicity and translocation of protein kinase C in neoplastic HeLa-S3K and non-neoplastic CF-3 cells. 1995 Cancer Lett. pmid:7874691
Bondar OP et al. Effects of farnesol on the thermotropic behavior of dimyristoylphosphatidylcholine. 1994 Chem. Phys. Lipids pmid:7820904
Crick DC et al. Farnesol is utilized for protein isoprenylation and the biosynthesis of cholesterol in mammalian cells. 1995 Biochem. Biophys. Res. Commun. pmid:7794274
Forman BM et al. Identification of a nuclear receptor that is activated by farnesol metabolites. 1995 Cell pmid:7774010
Fliesler SJ and Keller RK Metabolism of [3H]farnesol to cholesterol and cholesterogenic intermediates in the living rat eye. 1995 Biochem. Biophys. Res. Commun. pmid:7763243
Marom M et al. Selective inhibition of Ras-dependent cell growth by farnesylthiosalisylic acid. 1995 J. Biol. Chem. pmid:7673206
Epand RM et al. Lipid-mediated a-factor interactions with artificial membranes. 1995 Meth. Enzymol. pmid:7651149
Meigs TE et al. Farnesyl acetate, a derivative of an isoprenoid of the mevalonate pathway, inhibits DNA replication in hamster and human cells. 1995 Exp. Cell Res. pmid:7641798
Voziyan PA et al. Mechanism of farnesol cytotoxicity: further evidence for the role of PKC-dependent signal transduction in farnesol-induced apoptotic cell death. 1995 Biochem. Biophys. Res. Commun. pmid:7626062
Corsini A et al. Pathogenesis of atherosclerosis and the role of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. 1995 Am. J. Cardiol. pmid:7604791
Kisselev O et al. Efficient interaction with a receptor requires a specific type of prenyl group on the G protein gamma subunit. 1995 J. Biol. Chem. pmid:7592699
Tsuchiya E and Fukui S Binding of rhodotorucine A, a lipopeptidyl mating hormone, to a cells of Rhodosporidium toruloides for induction of sexual differentiation. 1978 Biochem. Biophys. Res. Commun. pmid:743290
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