Vomitoxin is a lipid of Prenol Lipids (PR) class. Vomitoxin is associated with abnormalities such as Infection and Gastroenteritis. The involved functions are known as mRNA Expression, Inflammation, Transcription, Genetic, Protein Biosynthesis and Adverse effects. Vomitoxin often locates in Lymphoid Tissue, Immune system, Bone Marrow and Plasma membrane. The associated genes with Vomitoxin are IMPACT gene, HIST1H1C gene and RBM39 gene. The related experimental models are Mouse Model.
To understand associated biological information of Vomitoxin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Vomitoxin is suspected in Infection, Gastroenteritis and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Vomitoxin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Dietary fish oil suppresses experimental immunoglobulin a nephropathy in mice.' (Pestka JJ et al., 2002).
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Authors | Title | Published | Journal | PubMed Link |
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Kasuga F et al. | In vitro effect of deoxynivalenol on the differentiation of human colonic cell lines Caco-2 and T84. | 1998 | Mycopathologia | pmid:10052164 |
Charoenpornsook K et al. | The effects of four mycotoxins on the mitogen stimulated proliferation of bovine peripheral blood mononuclear cells in vitro. | 1998 | Mycopathologia | pmid:10205890 |
Hughes DM et al. | Overt signs of toxicity to dogs and cats of dietary deoxynivalenol. | 1999 | J. Anim. Sci. | pmid:10229366 |
Zhou HR et al. | Amplified proinflammatory cytokine expression and toxicity in mice coexposed to lipopolysaccharide and the trichothecene vomitoxin (deoxynivalenol). | 1999 | J. Toxicol. Environ. Health Part A | pmid:10344227 |
Groves FD et al. | Fusarium mycotoxins in corn and corn products in a high-risk area for gastric cancer in Shandong Province, China. | 1999 May-Jun | J AOAC Int | pmid:10367384 |
Banotai C et al. | Effects of intermittent vomitoxin exposure on body weight, immunoglobulin levels and haematuria in the B6C3F1 mouse. | 1999 | Food Chem. Toxicol. | pmid:10418952 |
Yuan Q et al. | Identification of mimotope peptides which bind to the mycotoxin deoxynivalenol-specific monoclonal antibody. | 1999 | Appl. Environ. Microbiol. | pmid:10427007 |
Banotai C et al. | Effects of vomitoxin ingestion on murine models for systemic lupus erythematosus. | 1999 | Food Chem. Toxicol. | pmid:10456682 |
Wolf-Hall CE et al. | Stability of deoxynivalenol in heat-treated foods. | 1999 | J. Food Prot. | pmid:10456755 |
Thuvander A et al. | In vitro exposure of human lymphocytes to trichothecenes: individual variation in sensitivity and effects of combined exposure on lymphocyte function. | 1999 | Food Chem. Toxicol. | pmid:10478832 |
González HH et al. | Relationship between Fusarium graminearum and Alternaria alternata contamination and deoxynivalenol occurrence on Argentinian durum wheat. | 1998-1999 | Mycopathologia | pmid:10481289 |
Langseth W et al. | Mycotoxin production and cytotoxicity of Fusarium strains isolated from Norwegian cereals. | 1998-1999 | Mycopathologia | pmid:10481290 |
Wetter MT et al. | Occurrence and distribution of Fusarium graminearum and deoxynivalenol in sweet corn ears. | 1999 | Food Addit Contam | pmid:10492704 |
Lee MG et al. | Effects of satratoxins and other macrocyclic trichothecenes on IL-2 production and viability of EL-4 thymoma cells. | 1999 | J. Toxicol. Environ. Health Part A | pmid:10494915 |
Razzazi-Fazeli E et al. | Determination of nivalenol and deoxynivalenol in wheat using liquid chromatography-mass spectrometry with negative ion atmospheric pressure chemical ionisation. | 1999 | J Chromatogr A | pmid:10497927 |
Hsueh CC et al. | Indirect electrochemical detection of type-B trichothecene mycotoxins. | 1999 | Anal. Chem. | pmid:10500491 |
Janardhana GR et al. | Mycotoxin contamination of maize grains grown in Karnataka (India). | 1999 | Food Chem. Toxicol. | pmid:10506010 |
Cahill LM et al. | Quantification of deoxynivalenol in wheat using an immunoaffinity column and liquid chromatography. | 1999 | J Chromatogr A | pmid:10563412 |
Sprando RL et al. | The effect of vomitoxin (Deoxnivalenol) on testicular morphology, testicular spermatid counts and epididymal sperm counts in IL-6KO [B6129-IL6 [TmlKopf] (IL-6 gene deficient)] and WT [B6129F2 (wild type to B6129-IL6 with an intact IL-6 gene)] mice. | 1999 | Food Chem. Toxicol. | pmid:10566878 |
Accerbi M et al. | Utilization of highly deoxynivalenol-contaminated wheat via extrusion processing. | 1999 | J. Food Prot. | pmid:10606158 |
Yang GH et al. | Down-regulation of the endoplasmic reticulum chaperone GRP78/BiP by vomitoxin (Deoxynivalenol). | 2000 | Toxicol. Appl. Pharmacol. | pmid:10652249 |
Li S et al. | Modulation of transcription factor AP-1 activity in murine EL-4 thymoma cells by vomitoxin (deoxynivalenol). | 2000 | Toxicol. Appl. Pharmacol. | pmid:10662601 |
Zhou HR et al. | Lipopolysaccharide and the trichothecene vomitoxin (deoxynivalenol) synergistically induce apoptosis in murine lymphoid organs. | 2000 | Toxicol. Sci. | pmid:10696773 |
Johannisson A et al. | Effects of four trichothecene mycotoxins on activation marker expression and cell proliferation of human lymphocytes in culture. | 1999 | Cell Biol. Toxicol. | pmid:10696820 |
Desjardins AE et al. | Fusarium species from nepalese rice and production of mycotoxins and gibberellic acid by selected species. | 2000 | Appl. Environ. Microbiol. | pmid:10698766 |
Rimando AM and Porter JK | Effects of Fusarium mycotoxins on levels of serotonin, melatonin, and 5-hydroxytryptophan in pineal cell cultures. | 1999 | Adv. Exp. Med. Biol. | pmid:10721085 |
Boeira LS et al. | The effect of combinations of Fusarium mycotoxins (deoxynivalenol, zearalenone and fumonisin B1) on growth of brewing yeasts. | 2000 | J. Appl. Microbiol. | pmid:10747219 |
Yang GH et al. | Apoptosis induction by the satratoxins and other trichothecene mycotoxins: relationship to ERK, p38 MAPK, and SAPK/JNK activation. | 2000 | Toxicol. Appl. Pharmacol. | pmid:10764628 |
Wuchiyama J et al. | A trichothecene efflux pump encoded by Tri102 in the biosynthesis gene cluster of Fusarium graminearum. | 2000 | J. Antibiot. | pmid:10805582 |
Schollenberger M et al. | A survey of Fusarium toxins in cereal-based foods marketed in an area of southwest Germany. | 1999 | Mycopathologia | pmid:10872516 |
May HD et al. | Effects of the Fusarium spp. mycotoxins fusaric acid and deoxynivalenol on the growth of Ruminococcus albus and Methanobrevibacter ruminantium. | 2000 | Can. J. Microbiol. | pmid:10941514 |
Pestka JJ and Zhou HR | Interleukin-6-deficient mice refractory to IgA dysregulation but not anorexia induction by vomitoxin (deoxynivalenol) ingestion. | 2000 | Food Chem. Toxicol. | pmid:10942317 |
Reid LM et al. | Pre-harvest accumulation of deoxynivalenol in sweet corn ears inoculated with Fusarium graminearum. | 2000 | Food Addit Contam | pmid:11027030 |
Widestrand J et al. | Cytotoxicity of four trichothecenes evaluated by three colorimetric bioassays. | 1999 | Mycopathologia | pmid:11040865 |
Langseth W and Rundberget T | The occurrence of HT-2 toxin and other trichothecenes in Norwegian cereals. | 1999 | Mycopathologia | pmid:11040866 |
Moreno Contreras MC et al. | [Determination of deoxynivalenol (DON) in wheat, barley and corn and its relationship with the levels of total molds, Fusarium spp., colonization percentage and water activity]. | 2000 | Arch Latinoam Nutr | pmid:11048592 |
Freese L et al. | Variability of deoxynivalenol measurements in barley. | 2000 Sep-Oct | J AOAC Int | pmid:11048870 |
Whitaker TB et al. | Sampling, sample preparation, and analytical variability associated with testing wheat for deoxynivalenol. | 2000 Sep-Oct | J AOAC Int | pmid:11048874 |
Malone B | Solution fluorometric method for deoxynivalenol in grains. | 2001 | Methods Mol. Biol. | pmid:11050997 |
Yoshizawa T | Chromatographic methods for trichothecenes. | 2001 | Methods Mol. Biol. | pmid:11050998 |
Rafai P et al. | Evaluation of mycotoxin-contaminated cereals for their use in animal feeds in Hungary. | 2000 | Food Addit Contam | pmid:11091794 |
Plattner RD | HPLC/MS analysis of fusarium mycotoxins, fumonisins and deoxynivalenol. | 1999 | Nat. Toxins | pmid:11122531 |
Cooney JM et al. | Impact of competitive fungi on Trichothecene production by Fusarium graminearum. | 2001 | J. Agric. Food Chem. | pmid:11170621 |
Schneider L et al. | An enzyme linked immunoassay for the determination of deoxynivalenol in wheat based on chicken egg yolk antibodies. | 2000 | Fresenius J Anal Chem | pmid:11227446 |
Grabarkiewicz-Szczesna J et al. | Fusariotoxins in kernels of winter wheat cultivars field samples collected during 1993 in Poland. | 2001 | Nahrung | pmid:11253636 |
Machado LC and Kemmelmeier C | Identification of deoxynivalenol, 3-acetyldeoxynivalenol and zearalenone in the galactose oxidase-producing fungus Dactylium dendroides. | 2001 | Mycopathologia | pmid:11265166 |
Birzele B et al. | Deoxynivalenol and ochratoxin A in German wheat and changes of level in relation to storage parameters. | 2000 | Food Addit Contam | pmid:11271837 |
Edwards SG et al. | Quantification of trichothecene-producing Fusarium species in harvested grain by competitive PCR to determine efficacies of fungicides against Fusarium head blight of winter wheat. | 2001 | Appl. Environ. Microbiol. | pmid:11282607 |
Fink-Gremmels J | [An alternative view. Mycotoxins and mycoses]. | 2001 | Tijdschr Diergeneeskd | pmid:11285646 |
Wong S et al. | Superinduction of TNF-alpha and IL-6 in macrophages by vomitoxin (deoxynivalenol) modulated by mRNA stabilization. | 2001 | Toxicology | pmid:11295263 |
Froquet R et al. | Trichothecene toxicity on human megakaryocyte progenitors (CFU-MK). | 2001 | Hum Exp Toxicol | pmid:11327514 |
Brown DW et al. | A genetic and biochemical approach to study trichothecene diversity in Fusarium sporotrichioides and Fusarium graminearum. | 2001 | Fungal Genet. Biol. | pmid:11352533 |
Fazekas B et al. | Natural deoxynivalenol (DON) contamination of wheat samples grown in 1998 as determined by high-performance liquid chromatography. | 2000 | Acta Vet. Hung. | pmid:11402697 |
Mateo JJ et al. | Critical study of and improvements in chromatographic methods for the analysis of type B trichothecenes. | 2001 | J Chromatogr A | pmid:11403460 |
Lee T et al. | Identification of deoxynivalenol- and nivalenol-producing chemotypes of Gibberella zeae by using PCR. | 2001 | Appl. Environ. Microbiol. | pmid:11425709 |
Meky FA et al. | Deoxynivalenol-induced immunomodulation of human lymphocyte proliferation and cytokine production. | 2001 | Food Chem. Toxicol. | pmid:11434990 |
Cazzaniga D et al. | Mycotoxins inactivation by extrusion cooking of corn flour. | 2001 | Lett. Appl. Microbiol. | pmid:11472523 |
Debouck C et al. | Skeletal deformities induced by the intraperitoneal administration of deoxynivalenol (vomitoxin) in mice. | 2001 | Int Orthop | pmid:11482540 |
Samar MM et al. | Effect of fermentation on naturally occurring deoxynivalenol (DON) in Argentinean bread processing technology. | 2001 | Food Addit Contam | pmid:11665728 |
Widestrand J and Pettersson H | Effect of time, temperature and solvent on the stability of T-2 toxin, HT-2 toxin, deoxynivalenol and nivalenol calibrants. | 2001 | Food Addit Contam | pmid:11665740 |
Langseth W et al. | Production of culmorin compounds and other secondary metabolites by Fusarium culmorum and F. graminearum strains isolated from Norwegian cereals. | 2001 | Mycopathologia | pmid:11694092 |
Froquet R et al. | Improvement of megakaryocytic progenitor culture for toxicological investigations. | 2001 | Toxicol In Vitro | pmid:11698171 |
Martins ML and Martins HM | Determination of deoxynivalenol in wheat-based breakfast cereals marketed in Portugal. | 2001 | J. Food Prot. | pmid:11726173 |
Krysińska-Traczyk E et al. | Levels of fungi and mycotoxins in samples of grain and grain dust collected on farms in Eastern Poland. | 2001 | Ann Agric Environ Med | pmid:11748887 |
Ghebremeskel M and Langseth W | The occurrence of culmorin and hydroxy-culmorins in cereals. | 2001 | Mycopathologia | pmid:11761144 |
Sugita-Konishi Y and Pestka JJ | Differential upregulation of TNF-alpha, IL-6, and IL-8 production by deoxynivalenol (vomitoxin) and other 8-ketotrichothecenes in a human macrophage model. | 2001 | J. Toxicol. Environ. Health Part A | pmid:11766169 |
Etzel RA | Mycotoxins. | 2002 Jan 23-30 | JAMA | pmid:11798344 |
Pestka JJ et al. | Dietary fish oil suppresses experimental immunoglobulin a nephropathy in mice. | 2002 | J. Nutr. | pmid:11823588 |
Schollenberger M et al. | Fusarium toxins in wheat flour collected in an area in southwest Germany. | 2002 | Int. J. Food Microbiol. | pmid:11843417 |
Olsson J et al. | Detection and quantification of ochratoxin A and deoxynivalenol in barley grains by GC-MS and electronic nose. | 2002 | Int. J. Food Microbiol. | pmid:11845819 |
Yang GH and Pestka JJ | Vomitoxin (deoxynivalenol)-mediated inhibition of nuclear protein binding to NRE-A, an IL-2 promoter negative regulatory element, in EL-4 cells. | 2002 | Toxicology | pmid:11893416 |
Maragos CM and Plattner RD | Rapid fluorescence polarization immunoassay for the mycotoxin deoxynivalenol in wheat. | 2002 | J. Agric. Food Chem. | pmid:11902919 |
Lombaert GA | Methods for the determination of deoxynivalenol and other trichothecenes in foods. | 2002 | Adv. Exp. Med. Biol. | pmid:11922082 |
Trigo-Stockli DM | Effect of processing on deoxynivalenol and other trichothecenes. | 2002 | Adv. Exp. Med. Biol. | pmid:11922085 |
Schaafsma AW | Economic changes imposed by mycotoxins in food grains: case study of deoxynivalenol in winter wheat. | 2002 | Adv. Exp. Med. Biol. | pmid:11922094 |
Schisler DA et al. | Biological control of Fusarium head blight of wheat and deoxynivalenol levels in grain via use of microbial antagonists. | 2002 | Adv. Exp. Med. Biol. | pmid:11922099 |
Whitaker TB et al. | Sampling wheat for deoxynivalenol. | 2002 | Adv. Exp. Med. Biol. | pmid:11922100 |
Islam Z et al. | Endotoxin potentiation of trichothecene-induced lymphocyte apoptosis is mediated by up-regulation of glucocorticoids. | 2002 | Toxicol. Appl. Pharmacol. | pmid:11922776 |
Pieters MN et al. | Risk assessment of deoxynivalenol in food: concentration limits, exposure and effects. | 2002 | Adv. Exp. Med. Biol. | pmid:11924598 |
Wang H et al. | [Effect of deoxynivalenol and aflatoxin G1 on apoptosis of human blood lymphocytes in vitro]. | 1999 | Wei Sheng Yan Jiu | pmid:11938994 |
Maragos CM et al. | Fluorescence polarization as a tool for the determination of deoxynivalenol in wheat. | 2002 | Food Addit Contam | pmid:11962698 |
Lee T et al. | Tri13 and Tri7 determine deoxynivalenol- and nivalenol-producing chemotypes of Gibberella zeae. | 2002 | Appl. Environ. Microbiol. | pmid:11976083 |
Bai GH et al. | Deoxynivalenol-nonproducing fusarium graminearum causes initial infection, but does not cause disease spread in wheat spikes. | 2002 | Mycopathologia | pmid:12000132 |
Berek L et al. | The immunosuppressive effect of Fusarium mycotoxin as a function of HLA antigens. | 2002 | Acta Microbiol Immunol Hung | pmid:12073830 |
Schnerr H et al. | Correlation between DNA of trichothecene-producing Fusarium species and deoxynivalenol concentrations in wheat-samples. | 2002 | Lett. Appl. Microbiol. | pmid:12100586 |
Swamy HV et al. | Effects of feeding blends of grains naturally contaminated with Fusarium mycotoxins on production and metabolism in broilers. | 2002 | Poult. Sci. | pmid:12162357 |
Wong SS et al. | Effects of vomitoxin (deoxynivalenol) on the binding of transcription factors AP-1, NF-kappaB, and NF-IL6 in raw 264.7 macrophage cells. | 2002 | J. Toxicol. Environ. Health Part A | pmid:12167214 |
Pestka JJ and Zhou HR | Effects of tumor necrosis factor type 1 and 2 receptor deficiencies on anorexia, growth and IgA dysregulation in mice exposed to the trichothecene vomitoxin. | 2002 | Food Chem. Toxicol. | pmid:12176089 |
Maresca M et al. | The mycotoxin deoxynivalenol affects nutrient absorption in human intestinal epithelial cells. | 2002 | J. Nutr. | pmid:12221236 |
Rodrigues-Fo E et al. | Electron ionization mass spectral fragmentation of deoxynivalenol and related tricothecenes. | 2002 | Rapid Commun. Mass Spectrom. | pmid:12271447 |
Szkudelska K et al. | Short-time deoxynivalenol treatment induces metabolic disturbances in the rat. | 2002 | Toxicol. Lett. | pmid:12368054 |
Moon Y and Pestka JJ | Vomitoxin-induced cyclooxygenase-2 gene expression in macrophages mediated by activation of ERK and p38 but not JNK mitogen-activated protein kinases. | 2002 | Toxicol. Sci. | pmid:12377986 |
Bakan B et al. | Identification by PCR of Fusarium culmorum strains producing large and small amounts of deoxynivalenol. | 2002 | Appl. Environ. Microbiol. | pmid:12406740 |
Alm H et al. | The influence of the mycotoxins deoxynivalenol and zearalenol on in vitro maturation of pig oocytes and in vitro culture of pig zygotes. | 2002 | Toxicol In Vitro | pmid:12423645 |
Dänicke S et al. | Effect of addition of a detoxifying agent to laying hen diets containing uncontaminated or Fusarium toxin-contaminated maize on performance of hens and on carryover of zearalenone. | 2002 | Poult. Sci. | pmid:12455595 |
Leblanc JC et al. | Simulation of the exposure to deoxynivalenol of French consumers of organic and conventional foodstuffs. | 2002 | Regul. Toxicol. Pharmacol. | pmid:12460749 |
Eriksen GS et al. | Transformation of trichothecenes in ileal digesta and faeces from pigs. | 2002 | Arch Tierernahr | pmid:12462911 |
Rupp HS | Determination of deoxynivalenol in whole wheat flour and wheat bran. | 2002 Nov-Dec | J AOAC Int | pmid:12477199 |
Meky FA et al. | Development of a urinary biomarker of human exposure to deoxynivalenol. | 2003 | Food Chem. Toxicol. | pmid:12480302 |