Vomitoxin is a lipid of Prenol Lipids (PR) class. Vomitoxin is associated with abnormalities such as Infection and Gastroenteritis. The involved functions are known as mRNA Expression, Inflammation, Transcription, Genetic, Protein Biosynthesis and Adverse effects. Vomitoxin often locates in Lymphoid Tissue, Immune system, Bone Marrow and Plasma membrane. The associated genes with Vomitoxin are IMPACT gene, HIST1H1C gene and RBM39 gene. The related experimental models are Mouse Model.
To understand associated biological information of Vomitoxin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Vomitoxin is suspected in Infection, Gastroenteritis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Vomitoxin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
---|
Mouse Model are used in the study 'Dietary fish oil suppresses experimental immunoglobulin a nephropathy in mice.' (Pestka JJ et al., 2002).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Shephard GS et al. | Multiple mycotoxin exposure determined by urinary biomarkers in rural subsistence farmers in the former Transkei, South Africa. | 2013 | Food Chem. Toxicol. | pmid:23985452 |
Yang W et al. | Deoxynivalenol induced oxidative stress and genotoxicity in human peripheral blood lymphocytes. | 2014 | Food Chem. Toxicol. | pmid:24355168 |
Ruiz MJ et al. | Cytotoxic effects of mycotoxin combinations in mammalian kidney cells. | 2011 | Food Chem. Toxicol. | pmid:21798303 |
Savard C et al. | In vitro effect of deoxynivalenol (DON) mycotoxin on porcine reproductive and respiratory syndrome virus replication. | 2014 | Food Chem. Toxicol. | pmid:24394488 |
Videmann B et al. | Epithelial transport of deoxynivalenol: involvement of human P-glycoprotein (ABCB1) and multidrug resistance-associated protein 2 (ABCC2). | 2007 | Food Chem. Toxicol. | pmid:17543436 |
Wu X et al. | Synthesis and characterization of deoxynivalenol glucuronide: its comparative immunotoxicity with deoxynivalenol. | 2007 | Food Chem. Toxicol. | pmid:17507135 |
Sanden M et al. | Zebrafish (Danio rerio) as a model for investigating dietary toxic effects of deoxynivalenol contamination in aquaculture feeds. | 2012 | Food Chem. Toxicol. | pmid:22975143 |
Morrissey RE | Teratological study of Fischer rats fed diet containing added vomitoxin. | 1984 | Food Chem. Toxicol. | pmid:6539735 |
Dänicke S et al. | Systemic and local effects of the Fusarium toxin deoxynivalenol (DON) are not alleviated by dietary supplementation of humic substances (HS). | 2012 | Food Chem. Toxicol. | pmid:22222930 |
Cunha SC and Fernandes JO | Development and validation of a gas chromatography-mass spectrometry method for determination of deoxynivalenol and its metabolites in human urine. | 2012 | Food Chem. Toxicol. | pmid:22227217 |
Hunder G et al. | Influence of subchronic exposure to low dietary deoxynivalenol, a trichothecene mycotoxin, on intestinal absorption of nutrients in mice. | 1991 | Food Chem. Toxicol. | pmid:1765325 |
Nielsen JK et al. | Deoxynivalenol transport across the human placental barrier. | 2011 | Food Chem. Toxicol. | pmid:21620924 |
Jia Q and Pestka JJ | Role of cyclooxygenase-2 in deoxynivalenol-induced immunoglobulin a nephropathy. | 2005 | Food Chem. Toxicol. | pmid:15778012 |
Turner PC et al. | Assessment of deoxynivalenol metabolite profiles in UK adults. | 2011 | Food Chem. Toxicol. | pmid:20934480 |
Wan LY et al. | Individual and combined cytotoxic effects of Fusarium toxins (deoxynivalenol, nivalenol, zearalenone and fumonisins B1) on swine jejunal epithelial cells. | 2013 | Food Chem. Toxicol. | pmid:23562706 |
Banotai C et al. | Effects of vomitoxin ingestion on murine models for systemic lupus erythematosus. | 1999 | Food Chem. Toxicol. | pmid:10456682 |
Dänicke S and Brezina U | Kinetics and metabolism of the Fusarium toxin deoxynivalenol in farm animals: consequences for diagnosis of exposure and intoxication and carry over. | 2013 | Food Chem. Toxicol. | pmid:23872131 |
Yan D et al. | Experimental murine IgA nephropathy following passive administration of vomitoxin-induced IgA monoclonal antibodies. | 1998 | Food Chem. Toxicol. | pmid:9862652 |
Arnold DL et al. | The toxicity of orally administered deoxynivalenol (vomitoxin) in rats and mice. | 1986 | Food Chem. Toxicol. | pmid:3781440 |
Pestka JJ et al. | Emetic activity of the trichothecene 15-acetyldeoxynivalenol in swine. | 1987 | Food Chem. Toxicol. | pmid:3692388 |
Muri SD et al. | Comparison of human health risks resulting from exposure to fungicides and mycotoxins via food. | 2009 | Food Chem. Toxicol. | pmid:19345717 |
Meky FA et al. | Deoxynivalenol-induced immunomodulation of human lymphocyte proliferation and cytokine production. | 2001 | Food Chem. Toxicol. | pmid:11434990 |
Côté LM et al. | Lack of hepatic microsomal metabolism of deoxynivalenol and its metabolite, DOM-1. | 1987 | Food Chem. Toxicol. | pmid:3583156 |
Pestka JJ and Zhou HR | Effects of tumor necrosis factor type 1 and 2 receptor deficiencies on anorexia, growth and IgA dysregulation in mice exposed to the trichothecene vomitoxin. | 2002 | Food Chem. Toxicol. | pmid:12176089 |
Forsell JH et al. | Comparison of acute toxicities of deoxynivalenol (vomitoxin) and 15-acetyldeoxynivalenol in the B6C3F1 mouse. | 1987 | Food Chem. Toxicol. | pmid:3557238 |
Janardhana GR et al. | Mycotoxin contamination of maize grains grown in Karnataka (India). | 1999 | Food Chem. Toxicol. | pmid:10506010 |
Raiola A et al. | Bioaccessibility of deoxynivalenol and its natural co-occurrence with ochratoxin A and aflatoxin B1 in Italian commercial pasta. | 2012 | Food Chem. Toxicol. | pmid:22005256 |
Frankic T et al. | The role of dietary nucleotides in reduction of DNA damage induced by T-2 toxin and deoxynivalenol in chicken leukocytes. | 2006 | Food Chem. Toxicol. | pmid:16875771 |
Sirot V et al. | Dietary exposure to mycotoxins and health risk assessment in the second French total diet study. | 2013 | Food Chem. Toxicol. | pmid:23137957 |
Goyarts T et al. | Effects of the Fusarium toxin deoxynivalenol from naturally contaminated wheat given subchronically or as one single dose on the in vivo protein synthesis of peripheral blood lymphocytes and plasma proteins in the pig. | 2006 | Food Chem. Toxicol. | pmid:16950553 |
Tiemann U et al. | Influence of diets with cereal grains contaminated by graded levels of two Fusarium toxins on selected enzymatic and histological parameters of liver in gilts. | 2006 | Food Chem. Toxicol. | pmid:16580769 |
Bradlaw JA et al. | Evaluation of purified 4-deoxynivalenol (vomitoxin) for unscheduled DNA synthesis in the primary rat hepatocyte-DNA repair assay. | 1985 | Food Chem. Toxicol. | pmid:4076935 |
Rasooly L and Pestka JJ | Vomitoxin-induced dysregulation of serum IgA, IgM and IgG reactive with gut bacterial and self antigens. | 1992 | Food Chem. Toxicol. | pmid:1500035 |
Grove JF | The trichothecenes and their biosynthesis. | 2007 | Fortschr Chem Org Naturst | pmid:17302179 |
Krishnaswamy R et al. | Lutein protects HT-29 cells against Deoxynivalenol-induced oxidative stress and apoptosis: prevention of NF-kappaB nuclear localization and down regulation of NF-kappaB and Cyclo-Oxygenase-2 expression. | 2010 | Free Radic. Biol. Med. | pmid:20347963 |
Schneider L et al. | An enzyme linked immunoassay for the determination of deoxynivalenol in wheat based on chicken egg yolk antibodies. | 2000 | Fresenius J Anal Chem | pmid:11227446 |
Walter S et al. | Components of the gene network associated with genotype-dependent response of wheat to the Fusarium mycotoxin deoxynivalenol. | 2008 | Funct. Integr. Genomics | pmid:18592282 |
Jia H et al. | Quantitative trait loci conferring resistance to Fusarium head blight in barley respond differentially to Fusarium graminearum infection. | 2011 | Funct. Integr. Genomics | pmid:20865292 |
Dong W and Pestka JJ | Persistent dysregulation of IgA production and IgA nephropathy in the B6C3F1 mouse following withdrawal of dietary vomitoxin (deoxynivalenol). | 1993 | Fundam Appl Toxicol | pmid:8432427 |
Greene DM et al. | Effects of dihydrotestosterone and estradiol on experimental IgA nephropathy induced by vomitoxin. | 1995 | Fundam Appl Toxicol | pmid:7657054 |
Pestka JJ and Dong W | Progressive serum IgE elevation in the B6C3F1 mouse following withdrawal of dietary vomitoxin (deoxynivalenol). | 1994 | Fundam Appl Toxicol | pmid:8005381 |
Rotter BA et al. | Influence of low-level exposure to Fusarium mycotoxins on selected immunological and hematological parameters in young swine. | 1994 | Fundam Appl Toxicol | pmid:7958555 |
Dong W et al. | Quantitative assessment of mesangial immunoglobulin A (IgA) accumulation, elevated circulating IgA immune complexes, and hematuria during vomitoxin-induced IgA nephropathy. | 1991 | Fundam Appl Toxicol | pmid:1833256 |
Prelusky DB et al. | Excretion profiles of the mycotoxin deoxynivalenol, following oral and intravenous administration to sheep. | 1986 | Fundam Appl Toxicol | pmid:3699325 |
Prelusky DB et al. | Tissue distribution and excretion of radioactivity following administration of 14C-labeled deoxynivalenol to White Leghorn hens. | 1986 | Fundam Appl Toxicol | pmid:3803758 |
Arnold DL et al. | A short-term feeding study with deoxynivalenol (vomitoxin) using rats. | 1986 | Fundam Appl Toxicol | pmid:3710037 |
Prelusky DB et al. | Pharmacokinetic fate of 14C-labeled deoxynivalenol in swine. | 1988 | Fundam Appl Toxicol | pmid:3356314 |
Droce A et al. | PTR2 peptide transporters in Fusarium graminearum influence secondary metabolite production and sexual development. | 2017 | Fungal Biol | pmid:28390508 |
Qi PF et al. | Effect of salicylic acid on Fusarium graminearum, the major causal agent of fusarium head blight in wheat. | 2012 | Fungal Biol | pmid:22385623 |
Fu J et al. | Cystathionine gamma-synthase is essential for methionine biosynthesis in Fusarium graminearum. | 2013 | Fungal Biol | pmid:23332829 |
Liu N et al. | The transcription cofactor FgSwi6 plays a role in growth and development, carbendazim sensitivity, cellulose utilization, lithium tolerance, deoxynivalenol production and virulence in the filamentous fungus Fusarium graminearum. | 2013 Sep-Oct | Fungal Genet. Biol. | pmid:23994322 |
Jiang J et al. | FgVELB is associated with vegetative differentiation, secondary metabolism and virulence in Fusarium graminearum. | 2012 | Fungal Genet. Biol. | pmid:22713714 |
Nguyen LN et al. | Autophagy-related lipase FgATG15 of Fusarium graminearum is important for lipid turnover and plant infection. | 2011 | Fungal Genet. Biol. | pmid:21094265 |
Brown DW et al. | Functional demarcation of the Fusarium core trichothecene gene cluster. | 2004 | Fungal Genet. Biol. | pmid:14998528 |
Brown DW et al. | A genetic and biochemical approach to study trichothecene diversity in Fusarium sporotrichioides and Fusarium graminearum. | 2001 | Fungal Genet. Biol. | pmid:11352533 |
Nussbaumer T et al. | Joint Transcriptomic and Metabolomic Analyses Reveal Changes in the Primary Metabolism and Imbalances in the Subgenome Orchestration in the Bread Wheat Molecular Response to Fusarium graminearum. | 2015 | G3 (Bethesda) | pmid:26438291 |
Fomenko VN et al. | [Changes in the hemostatic system after administration of the mycotoxin deoxynivalenol (vomitoxin) to rhesus monkeys]. | 1991 | Gematol Transfuziol | pmid:1769503 |
Somers DJ et al. | Molecular mapping of novel genes controlling Fusarium head blight resistance and deoxynivalenol accumulation in spring wheat. | 2003 | Genome | pmid:12897863 |
Tutel'ian VA et al. | [Embryotoxic effects of deoxynivalenol mycotoxin (vomitoxin) in rats]. | 1991 | Gig Sanit | pmid:1806423 |
Razafimanjato H et al. | The ribotoxin deoxynivalenol affects the viability and functions of glial cells. | 2011 | Glia | pmid:21748807 |
Zhou WC et al. | Effect of individual Sumai 3 chromosomes on resistance to scab spread within spikes and deoxynivalenol accumulation within kernels in wheat. | 2002 | Hereditas | pmid:12627831 |
Rio B et al. | In vitro toxicity of trichothecenes on human erythroblastic progenitors. | 1997 | Hum Exp Toxicol | pmid:9426370 |
Froquet R et al. | Trichothecene toxicity on human megakaryocyte progenitors (CFU-MK). | 2001 | Hum Exp Toxicol | pmid:11327514 |
Bimczok D et al. | The Fusarium toxin deoxynivalenol disrupts phenotype and function of monocyte-derived dendritic cells in vivo and in vitro. | 2007 | Immunobiology | pmid:17869643 |
Kidd MT et al. | Trichothecene mycotoxins depress the mononuclear-phagocytic system of young turkeys. | 1995 | Immunopharmacol Immunotoxicol | pmid:7650297 |
Fornelli F et al. | Cytotoxicity induced by nivalenol, deoxynivalenol, and fumonisin B1 in the SF-9 insect cell line. | 2004 May-Jun | In Vitro Cell. Dev. Biol. Anim. | pmid:15479121 |
Hubert J et al. | The effect of Tyrophagus putrescentiae on Fusarium poae transmission and fungal community in stored barley in a laboratory experiment. | 2014 | Insect Sci. | pmid:23955921 |
Shi C et al. | Biocontrol of Fusarium graminearum growth and deoxynivalenol production in wheat kernels with bacterial antagonists. | 2014 | Int J Environ Res Public Health | pmid:24441510 |
Skóra J et al. | Evaluation of Microbiological and Chemical Contaminants in Poultry Farms. | 2016 | Int J Environ Res Public Health | pmid:26861361 |
Skládanka J et al. | Forage as a primary source of mycotoxins in animal diets. | 2011 | Int J Environ Res Public Health | pmid:21318013 |
Ragab WS et al. | Fate of deoxynivalenol in contaminated wheat grain during preparation of Egyptian 'balila'. | 2007 | Int J Food Sci Nutr | pmid:17514535 |
Rai M et al. | Emerging nanotechnology for detection of mycotoxins in food and feed. | 2015 | Int J Food Sci Nutr | pmid:26001087 |
Gauthier L et al. | Metabolomics to Decipher the Chemical Defense of Cereals against Fusarium graminearum and Deoxynivalenol Accumulation. | 2015 | Int J Mol Sci | pmid:26492237 |
He CH et al. | The individual and combined effects of deoxynivalenol and aflatoxin Bâ‚on primary hepatocytes of Cyprinus carpio. | 2010 | Int J Mol Sci | pmid:21152299 |
Waché YJ et al. | Impact of deoxynivalenol on the intestinal microflora of pigs. | 2009 | Int J Mol Sci | pmid:19333431 |
Awad WA et al. | The impact of the Fusarium mycotoxin deoxynivalenol on the health and performance of broiler chickens. | 2011 | Int J Mol Sci | pmid:22174646 |
Vasatkova A et al. | Changes in metallothionein level in rat hepatic tissue after administration of natural mouldy wheat. | 2009 | Int J Mol Sci | pmid:19399242 |
Debouck C et al. | Skeletal deformities induced by the intraperitoneal administration of deoxynivalenol (vomitoxin) in mice. | 2001 | Int Orthop | pmid:11482540 |
Verheijden KA et al. | Inflammation-induced expression of the alarmin interleukin 33 can be suppressed by galacto-oligosaccharides. | 2015 | Int. Arch. Allergy Immunol. | pmid:26304032 |
Mishra S et al. | Deoxynivalenol induced mouse skin tumor initiation: Elucidation of molecular mechanisms in human HaCaT keratinocytes. | 2016 | Int. J. Cancer | pmid:27389473 |
Kottapalli B and Wolf-Hall CE | Effect of hot water treatments on the safety and quality of Fusarium-infected malting barley. | 2008 | Int. J. Food Microbiol. | pmid:18472174 |
Denschlag C et al. | Real-time loop-mediated isothermal amplification (LAMP) assay for group specific detection of important trichothecene producing Fusarium species in wheat. | 2014 | Int. J. Food Microbiol. | pmid:24631635 |
Abramson D et al. | Relationships among deoxynivalenol, ergosterol and Fusarium exoantigens in Canadian hard and soft wheat. | 1998 | Int. J. Food Microbiol. | pmid:9926999 |
Vegi A et al. | Quantification of Tri5 gene, expression, and deoxynivalenol production during the malting of barley. | 2011 | Int. J. Food Microbiol. | pmid:21871683 |
Tanaka K et al. | Mycotoxins in rice. | 2007 | Int. J. Food Microbiol. | pmid:17913273 |
Schaafsma AW and Hooker DC | Climatic models to predict occurrence of Fusarium toxins in wheat and maize. | 2007 | Int. J. Food Microbiol. | pmid:17900733 |
Llorens A et al. | Influence of environmental factors on the biosynthesis of type B trichothecenes by isolates of Fusarium spp. from Spanish crops. | 2004 | Int. J. Food Microbiol. | pmid:15172484 |
Connolly P and Corry JE | Effect of polymyxin B nonapeptide and polymyxin B sulphate on trichothecene mycotoxin sensitivity of yeasts using a conductimetric instrument. | 1990 | Int. J. Food Microbiol. | pmid:2168726 |
Beyer M et al. | Estimating mycotoxin contents of Fusarium-damaged winter wheat kernels. | 2007 | Int. J. Food Microbiol. | pmid:17706313 |
Yuen GY and Schoneweis SD | Strategies for managing Fusarium head blight and deoxynivalenol accumulation in wheat. | 2007 | Int. J. Food Microbiol. | pmid:17716767 |
Oliveira PM et al. | Fundamental study on the influence of Fusarium infection on quality and ultrastructure of barley malt. | 2012 | Int. J. Food Microbiol. | pmid:22424933 |
Reynoso MM et al. | Trichothecene genotypes and chemotypes in Fusarium graminearum strains isolated from wheat in Argentina. | 2011 | Int. J. Food Microbiol. | pmid:21320729 |
Armando MR et al. | In vitro study on the effect of Saccharomyces cerevisiae strains on growth and mycotoxin production by Aspergillus carbonarius and Fusarium graminearum. | 2013 | Int. J. Food Microbiol. | pmid:23334096 |
Baturo-Ciesniewska A and Suchorzynska M | Verification of the effectiveness of SCAR (sequence characterized amplified region) primers for the identification of Polish strains of Fusarium culmorum and their potential ability to produce B-trichothecenes and zearalenone. | 2011 | Int. J. Food Microbiol. | pmid:21664712 |
Ramirez ML et al. | Temperature and water activity effects on growth and temporal deoxynivalenol production by two Argentinean strains of Fusarium graminearum on irradiated wheat grain. | 2006 | Int. J. Food Microbiol. | pmid:16236377 |
Beyer M et al. | Effect of relative humidity on germination of ascospores and macroconidia of Gibberella zeae and deoxynivalenol production. | 2005 | Int. J. Food Microbiol. | pmid:15698684 |
Olsson J et al. | Detection and quantification of ochratoxin A and deoxynivalenol in barley grains by GC-MS and electronic nose. | 2002 | Int. J. Food Microbiol. | pmid:11845819 |
Schollenberger M et al. | Fusarium toxins in wheat flour collected in an area in southwest Germany. | 2002 | Int. J. Food Microbiol. | pmid:11843417 |
Kottapalli B et al. | Effect of electron-beam irradiation on the safety and quality of Fusarium-infected malting barley. | 2006 | Int. J. Food Microbiol. | pmid:16780979 |
Demeke T et al. | Development of a specific TaqMan real-time PCR assay for quantification of Fusarium graminearum clade 7 and comparison of fungal biomass determined by PCR with deoxynivalenol content in wheat and barley. | 2010 | Int. J. Food Microbiol. | pmid:20483187 |