Vomitoxin
Vomitoxin is a lipid of Prenol Lipids (PR) class. Vomitoxin is associated with abnormalities such as Infection and Gastroenteritis. The involved functions are known as mRNA Expression, Inflammation, Transcription, Genetic, Protein Biosynthesis and Adverse effects. Vomitoxin often locates in Lymphoid Tissue, Immune system, Bone Marrow and Plasma membrane. The associated genes with Vomitoxin are IMPACT gene, HIST1H1C gene and RBM39 gene. The related experimental models are Mouse Model.
Cross Reference
Introduction
To understand associated biological information of Vomitoxin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Vomitoxin?
Vomitoxin is suspected in Infection, Gastroenteritis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Vomitoxin
PubChem Associated disorders and diseases
What pathways are associated with Vomitoxin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Vomitoxin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Vomitoxin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Vomitoxin?
There are no associated biomedical information in the current reference collection.
What genes are associated with Vomitoxin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Vomitoxin?
Mouse Model
Mouse Model are used in the study 'Dietary fish oil suppresses experimental immunoglobulin a nephropathy in mice.' (Pestka JJ et al., 2002).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with Vomitoxin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zhou HR et al. | Rapid, sequential activation of mitogen-activated protein kinases and transcription factors precedes proinflammatory cytokine mRNA expression in spleens of mice exposed to the trichothecene vomitoxin. | 2003 | Toxicol. Sci. | pmid:12604842 |
| Pan X et al. | Dynamic changes in ribosome-associated proteome and phosphoproteome during deoxynivalenol-induced translation inhibition and ribotoxic stress. | 2014 | Toxicol. Sci. | pmid:24284785 |
| Wu W et al. | Role of cholecystokinin in anorexia induction following oral exposure to the 8-ketotrichothecenes deoxynivalenol, 15-acetyldeoxynivalenol, 3-acetyldeoxynivalenol, fusarenon X, and nivalenol. | 2014 | Toxicol. Sci. | pmid:24385417 |
| Wu W et al. | Comparison of emetic potencies of the 8-ketotrichothecenes deoxynivalenol, 15-acetyldeoxynivalenol, 3-acetyldeoxynivalenol, fusarenon X, and nivalenol. | 2013 | Toxicol. Sci. | pmid:22997060 |
| Flannery BM et al. | Anorexia induction by the trichothecene deoxynivalenol (vomitoxin) is mediated by the release of the gut satiety hormone peptide YY. | 2012 | Toxicol. Sci. | pmid:22903826 |
| Gray JS and Pestka JJ | Transcriptional regulation of deoxynivalenol-induced IL-8 expression in human monocytes. | 2007 | Toxicol. Sci. | pmid:17636245 |
| Zhou HR and Pestka JJ | Deoxynivalenol (Vomitoxin)-Induced Cholecystokinin and Glucagon-Like Peptide-1 Release in the STC-1 Enteroendocrine Cell Model Is Mediated by Calcium-Sensing Receptor and Transient Receptor Potential Ankyrin-1 Channel. | 2015 | Toxicol. Sci. | pmid:25787141 |
| Wang X et al. | JAK/STAT pathway plays a critical role in the proinflammatory gene expression and apoptosis of RAW264.7 cells induced by trichothecenes as DON and T-2 toxin. | 2012 | Toxicol. Sci. | pmid:22454431 |
| He K et al. | Targets and intracellular signaling mechanisms for deoxynivalenol-induced ribosomal RNA cleavage. | 2012 | Toxicol. Sci. | pmid:22491426 |
| Wu W et al. | Comparison of anorectic and emetic potencies of deoxynivalenol (vomitoxin) to the plant metabolite deoxynivalenol-3-glucoside and synthetic deoxynivalenol derivatives EN139528 and EN139544. | 2014 | Toxicol. Sci. | pmid:25173790 |
| Zhou HR et al. | Ribotoxic stress response to the trichothecene deoxynivalenol in the macrophage involves the SRC family kinase Hck. | 2005 | Toxicol. Sci. | pmid:15772366 |
| Wu W et al. | Peptide YY3-36 and 5-hydroxytryptamine mediate emesis induction by trichothecene deoxynivalenol (vomitoxin). | 2013 | Toxicol. Sci. | pmid:23457120 |
| Pan X et al. | Early phosphoproteomic changes in the mouse spleen during deoxynivalenol-induced ribotoxic stress. | 2013 | Toxicol. Sci. | pmid:23811945 |
| Shi Y et al. | Role of GRP78/BiP degradation and ER stress in deoxynivalenol-induced interleukin-6 upregulation in the macrophage. | 2009 | Toxicol. Sci. | pmid:19336499 |
| Burger HM et al. | Development and evaluation of a sensitive mycotoxin risk assessment model (MYCORAM). | 2014 | Toxicol. Sci. | pmid:24980263 |
| Amuzie CJ et al. | Induction of suppressors of cytokine signaling by the trichothecene deoxynivalenol in the mouse. | 2009 | Toxicol. Sci. | pmid:19625342 |
| Zhou HR et al. | Role of double-stranded RNA-activated protein kinase R (PKR) in deoxynivalenol-induced ribotoxic stress response. | 2003 | Toxicol. Sci. | pmid:12773753 |
| Islam Z and Pestka JJ | Role of IL-1(beta) in endotoxin potentiation of deoxynivalenol-induced corticosterone response and leukocyte apoptosis in mice. | 2003 | Toxicol. Sci. | pmid:12773775 |
| Pestka J and Zhou HR | Toll-like receptor priming sensitizes macrophages to proinflammatory cytokine gene induction by deoxynivalenol and other toxicants. | 2006 | Toxicol. Sci. | pmid:16687389 |
| Amuzie CJ and Pestka JJ | Suppression of insulin-like growth factor acid-labile subunit expression--a novel mechanism for deoxynivalenol-induced growth retardation. | 2010 | Toxicol. Sci. | pmid:19805407 |
| He K et al. | Modulation of inflammatory gene expression by the ribotoxin deoxynivalenol involves coordinate regulation of the transcriptome and translatome. | 2013 | Toxicol. Sci. | pmid:22968694 |
| Chung YJ et al. | Up-regulation of macrophage inflammatory protein-2 and complement 3A receptor by the trichothecenes deoxynivalenol and satratoxin G. | 2003 | Toxicology | pmid:12604170 |
| Greene DM et al. | Vomitoxin (deoxynivalenol)-induced IgA nephropathy in the B6C3F1 mouse: dose response and male predilection. | 1994 | Toxicology | pmid:7940564 |
| Savard C et al. | Prevention of deoxynivalenol- and zearalenone-associated oxidative stress does not restore MA-10 Leydig cell functions. | 2016 | Toxicology | pmid:26783879 |
| Yang GH and Pestka JJ | Vomitoxin (deoxynivalenol)-mediated inhibition of nuclear protein binding to NRE-A, an IL-2 promoter negative regulatory element, in EL-4 cells. | 2002 | Toxicology | pmid:11893416 |
| Ouyang YL et al. | Effects of trichothecene structure on cytokine secretion and gene expression in murine CD4+ T-cells. | 1995 | Toxicology | pmid:8560498 |
| Instanes C and Hetland G | Deoxynivalenol (DON) is toxic to human colonic, lung and monocytic cell lines, but does not increase the IgE response in a mouse model for allergy. | 2004 | Toxicology | pmid:15369845 |
| Yang H et al. | Ribotoxic mycotoxin deoxynivalenol induces G2/M cell cycle arrest via p21Cip/WAF1 mRNA stabilization in human epithelial cells. | 2008 | Toxicology | pmid:18006205 |
| Königs M et al. | Cytotoxicity, metabolism and cellular uptake of the mycotoxin deoxynivalenol in human proximal tubule cells and lung fibroblasts in primary culture. | 2007 | Toxicology | pmid:17825972 |
| Yan D et al. | Potential role for IL-5 and IL-6 in enhanced IgA secretion by Peyer's patch cells isolated from mice acutely exposed to vomitoxin. | 1997 | Toxicology | pmid:9274810 |
| Amuzie CJ et al. | Tissue distribution and proinflammatory cytokine induction by the trichothecene deoxynivalenol in the mouse: comparison of nasal vs. oral exposure. | 2008 | Toxicology | pmid:18433975 |
| Ji GE et al. | Modulation of nitric oxide, hydrogen peroxide and cytokine production in a clonal macrophage model by the trichothecene vomitoxin (deoxynivalenol). | 1998 | Toxicology | pmid:9570333 |
| Pestka JJ et al. | Induction of apoptosis and cytokine production in the Jurkat human T cells by deoxynivalenol: role of mitogen-activated protein kinases and comparison to other 8-ketotrichothecenes. | 2005 | Toxicology | pmid:15588914 |
| Kouadio JH et al. | Comparative study of cytotoxicity and oxidative stress induced by deoxynivalenol, zearalenone or fumonisin B1 in human intestinal cell line Caco-2. | 2005 | Toxicology | pmid:16019124 |
| Mikami O et al. | Porcine hepatocyte apoptosis and reduction of albumin secretion induced by deoxynivalenol. | 2004 | Toxicology | pmid:15388250 |
| Flannery BM et al. | Evaluation of insulin-like growth factor acid-labile subunit as a potential biomarker of effect for deoxynivalenol-induced proinflammatory cytokine expression. | 2013 | Toxicology | pmid:23298694 |
| Wong S et al. | Superinduction of TNF-alpha and IL-6 in macrophages by vomitoxin (deoxynivalenol) modulated by mRNA stabilization. | 2001 | Toxicology | pmid:11295263 |
| Waché YJ et al. | The mycotoxin deoxynivalenol inhibits the cell surface expression of activation markers in human macrophages. | 2009 | Toxicology | pmid:19549553 |
| Schultze N et al. | Mitochondrial functions of THP-1 monocytes following the exposure to selected natural compounds. | 2017 | Toxicology | pmid:28013001 |
| Bensassi F et al. | Pathway of deoxynivalenol-induced apoptosis in human colon carcinoma cells. | 2009 | Toxicology | pmid:19664677 |
| Robbana-Barnat S et al. | Immunosuppressive properties of deoxynivalenol. | 1988 | Toxicology | pmid:3257592 |
| Ivanova L et al. | Cytotoxicity of enniatins A, A1, B, B1, B2 and B3 from Fusarium avenaceum. | 2006 | Toxicon | pmid:16730043 |
| Abbas HK et al. | Cytotoxicity and phytotoxicity of trichothecene mycotoxins produced by Fusarium spp. | 2013 | Toxicon | pmid:23933195 |
| Luongo D et al. | Effects of four Fusarium toxins (fumonisin B(1), alpha-zearalenol, nivalenol and deoxynivalenol) on porcine whole-blood cellular proliferation. | 2008 | Toxicon | pmid:18620720 |
| Ruiz MJ et al. | Toxicological interactions between the mycotoxins beauvericin, deoxynivalenol and T-2 toxin in CHO-K1 cells in vitro. | 2011 | Toxicon | pmid:21821061 |
| Ficheux AS et al. | Co-exposure of Fusarium mycotoxins: in vitro myelotoxicity assessment on human hematopoietic progenitors. | 2012 | Toxicon | pmid:22921581 |
| Gajęcka M et al. | Changes in the metabolic profile and body weight of pre-pubertal gilts during prolonged monotonic exposure to low doses of zearalenone and deoxynivalenol. | 2017 | Toxicon | pmid:27840141 |
| Ji J et al. | GC-TOF/MS-based metabolomic strategy for combined toxicity effects of deoxynivalenol and zearalenone on murine macrophage ANA-1 cells. | 2016 | Toxicon | pmid:27530666 |
| Albonico M et al. | Toxicological effects of fumonisin B1 alone and in combination with other fusariotoxins on bovine granulosa cells. | 2016 | Toxicon | pmid:27108238 |
| Pizzo F et al. | In vitro effects of deoxynivalenol and zearalenone major metabolites alone and combined, on cell proliferation, steroid production and gene expression in bovine small-follicle granulosa cells. | 2016 | Toxicon | pmid:26657070 |
| Ueno Y et al. | Examination of Chinese and U.S.S.R. cereals for the Fusarium mycotoxins, nivalenol, deoxynivalenol and zearalenone. | 1986 | Toxicon | pmid:2944249 |
| Dinu D et al. | Adapted response of the antioxidant defense system to oxidative stress induced by deoxynivalenol in Hek-293 cells. | 2011 | Toxicon | pmid:21549142 |
| Lucioli J et al. | The food contaminant deoxynivalenol activates the mitogen activated protein kinases in the intestine: interest of ex vivo models as an alternative to in vivo experiments. | 2013 | Toxicon | pmid:23403092 |
| Caloni F et al. | Effects of a trichothecene, T-2 toxin, on proliferation and steroid production by porcine granulosa cells. | 2009 | Toxicon | pmid:19463844 |
| Sun LH et al. | Individual and combined cytotoxic effects of aflatoxin B1, zearalenone, deoxynivalenol and fumonisin B1 on BRL 3A rat liver cells. | 2015 | Toxicon | pmid:25549941 |
| Zhang X et al. | The role of oxidative stress in deoxynivalenol-induced DNA damage in HepG2 cells. | 2009 | Toxicon | pmid:19486909 |
| Luongo D et al. | Trichothecenes NIV and DON modulate the maturation of murine dendritic cells. | 2010 | Toxicon | pmid:19635492 |
| Kouadio JH et al. | Effects of combinations of Fusarium mycotoxins on the inhibition of macromolecular synthesis, malondialdehyde levels, DNA methylation and fragmentation, and viability in Caco-2 cells. | 2007 | Toxicon | pmid:17109910 |
| Zielonka Å et al. | The effect of environmental mycotoxins on selected ovarian tissue fragments of multiparous female wild boars at the beginning of astronomical winter. | 2014 | Toxicon | pmid:25016169 |
| Bensassi F et al. | In vitro investigation of toxicological interactions between the fusariotoxins deoxynivalenol and zearalenone. | 2014 | Toxicon | pmid:24680766 |
| Weaver AC et al. | The use of feed additives to reduce the effects of aflatoxin and deoxynivalenol on pig growth, organ health and immune status during chronic exposure. | 2013 | Toxins (Basel) | pmid:23867763 |
| Drakulic J et al. | Contrasting Roles of Deoxynivalenol and Nivalenol in Host-Mediated Interactions between Fusarium graminearum and Sitobion avenae. | 2016 | Toxins (Basel) | pmid:27916862 |
| Alizadeh A et al. | Deoxynivalenol and Its Modified Forms: Are There Major Differences? | 2016 | Toxins (Basel) | pmid:27854268 |
| Tian Y et al. | Detoxification of Deoxynivalenol via Glycosylation Represents Novel Insights on Antagonistic Activities of Trichoderma when Confronted with Fusarium graminearum. | 2016 | Toxins (Basel) | pmid:27854265 |
| Uhlig S et al. | Glutathione-Conjugates of Deoxynivalenol in Naturally Contaminated Grain Are Primarily Linked via the Epoxide Group. | 2016 | Toxins (Basel) | pmid:27845722 |
| Eckard S et al. | Incidence of Fusarium species and mycotoxins in silage maize. | 2011 | Toxins (Basel) | pmid:22069750 |
| Wells L et al. | Determination of Deoxynivalenol in the Urine of Pregnant Women in the UK. | 2016 | Toxins (Basel) | pmid:27792137 |
| He WJ et al. | Aerobic De-Epoxydation of Trichothecene Mycotoxins by a Soil Bacterial Consortium Isolated Using In Situ Soil Enrichment. | 2016 | Toxins (Basel) | pmid:27669304 |
| Zhang ZQ et al. | Phosphoproteome Analysis Reveals the Molecular Mechanisms Underlying Deoxynivalenol-Induced Intestinal Toxicity in IPEC-J2 Cells. | 2016 | Toxins (Basel) | pmid:27669298 |
| Hassan YI et al. | Beyond Ribosomal Binding: The Increased Polarity and Aberrant Molecular Interactions of 3-epi-deoxynivalenol. | 2016 | Toxins (Basel) | pmid:27618101 |
| Audenaert K et al. | Deoxynivalenol: a major player in the multifaceted response of Fusarium to its environment. | 2014 | Toxins (Basel) | pmid:24451843 |
| Giménez I et al. | Effects of bread making and wheat germ addition on the natural deoxynivalenol content in bread. | 2014 | Toxins (Basel) | pmid:24451845 |
| Fruhmann P et al. | Stereoselective Luche reduction of deoxynivalenol and three of its acetylated derivatives at C8. | 2014 | Toxins (Basel) | pmid:24434906 |
| Ansari KI et al. | Light influences how the fungal toxin deoxynivalenol affects plant cell death and defense responses. | 2014 | Toxins (Basel) | pmid:24561479 |
| Pietsch C et al. | Organ damage and hepatic lipid accumulation in carp (Cyprinus carpio L.) after feed-borne exposure to the mycotoxin, deoxynivalenol (DON). | 2014 | Toxins (Basel) | pmid:24566729 |
| Wu L et al. | Optimization for the Production of Deoxynivalenoland Zearalenone by Fusarium graminearum UsingResponse Surface Methodology. | 2017 | Toxins (Basel) | pmid:28208576 |
| Suzuki T and Iwahashi Y | Acetylated Deoxynivalenol Generates Differences of Gene Expression that Discriminate Trichothecene Toxicity. | 2016 | Toxins (Basel) | pmid:26861396 |
| Goossens J et al. | Influence of mycotoxins and a mycotoxin adsorbing agent on the oral bioavailability of commonly used antibiotics in pigs. | 2012 | Toxins (Basel) | pmid:22606377 |
| Tesch T et al. | Does Dietary Deoxynivalenol Modulate the Acute Phase Reaction in Endotoxaemic Pigs?--Lessons from Clinical Signs, White Blood Cell Counts, and TNF-Alpha. | 2015 | Toxins (Basel) | pmid:26703732 |
| Saint-Cyr MJ et al. | Risk Assessment of Deoxynivalenol by Revisiting Its Bioavailability in Pig and Rat Models to Establish Which Is More Suitable. | 2015 | Toxins (Basel) | pmid:26633505 |
| Bannert E et al. | Metabolic and hematological consequences of dietary deoxynivalenol interacting with systemic Escherichia coli lipopolysaccharide. | 2015 | Toxins (Basel) | pmid:26580654 |
| Schwartz-Zimmermann HE et al. | Metabolism of deoxynivalenol and deepoxy-deoxynivalenol in broiler chickens, pullets, roosters and turkeys. | 2015 | Toxins (Basel) | pmid:26569307 |
| Michlmayr H et al. | Biochemical Characterization of a Recombinant UDP-glucosyltransferase from Rice and Enzymatic Production of Deoxynivalenol-3-O-β-D-glucoside. | 2015 | Toxins (Basel) | pmid:26197338 |
| Alizadeh A et al. | Deoxynivalenol Impairs Weight Gain and Affects Markers of Gut Health after Low-Dose, Short-Term Exposure of Growing Pigs. | 2015 | Toxins (Basel) | pmid:26067367 |
| Hassan YI et al. | A novel Peptide-binding motifs inference approach to understand deoxynivalenol molecular toxicity. | 2015 | Toxins (Basel) | pmid:26043274 |
| Cheat S et al. | Nivalenol has a greater impact than deoxynivalenol on pig jejunum mucosa in vitro on explants and in vivo on intestinal loops. | 2015 | Toxins (Basel) | pmid:26035490 |
| Tola S et al. | Effects of Wheat Naturally Contaminated with Fusarium Mycotoxins on Growth Performance and Selected Health Indices of Red Tilapia (Oreochromis niloticus × O. mossambicus). | 2015 | Toxins (Basel) | pmid:26035489 |
| Zhou HR et al. | Direct activation of ribosome-associated double-stranded RNA-dependent protein kinase (PKR) by deoxynivalenol, anisomycin and ricin: a new model for ribotoxic stress response induction. | 2014 | Toxins (Basel) | pmid:25521494 |
| De Girolamo A et al. | Rapid analysis of deoxynivalenol in durum wheat by FT-NIR spectroscopy. | 2014 | Toxins (Basel) | pmid:25384107 |
| Devreese M et al. | Efficacy of active carbon towards the absorption of deoxynivalenol in pigs. | 2014 | Toxins (Basel) | pmid:25337799 |
| Pietsch C et al. | Occurrence of deoxynivalenol and zearalenone in commercial fish feed: an initial study. | 2013 | Toxins (Basel) | pmid:23325300 |
| Mesterházy A et al. | Role of fungicides, application of nozzle types, and the resistance level of wheat varieties in the control of Fusarium head blight and deoxynivalenol. | 2011 | Toxins (Basel) | pmid:22174980 |
| Streit E et al. | Current situation of mycotoxin contamination and co-occurrence in animal feed--focus on Europe. | 2012 | Toxins (Basel) | pmid:23162698 |
| Njobeh PB et al. | Estimation of multi-mycotoxin contamination in South African compound feeds. | 2012 | Toxins (Basel) | pmid:23162700 |
| Awad W et al. | The toxicological impacts of the Fusarium mycotoxin, deoxynivalenol, in poultry flocks with special reference to immunotoxicity. | 2013 | Toxins (Basel) | pmid:23628787 |
| Maresca M | From the gut to the brain: journey and pathophysiological effects of the food-associated trichothecene mycotoxin deoxynivalenol. | 2013 | Toxins (Basel) | pmid:23612752 |
| Subramaniam R and Rampitsch C | Towards systems biology of mycotoxin regulation. | 2013 | Toxins (Basel) | pmid:23598563 |
| Bonnet MS et al. | Advances in deoxynivalenol toxicity mechanisms: the brain as a target. | 2012 | Toxins (Basel) | pmid:23202308 |
| Wegulo SN | Factors influencing deoxynivalenol accumulation in small grain cereals. | 2012 | Toxins (Basel) | pmid:23202310 |
| Qiu J and Shi J | Genetic relationships, carbendazim sensitivity and mycotoxin production of the Fusarium graminearum populations from maize, wheat and rice in eastern China. | 2014 | Toxins (Basel) | pmid:25093387 |