Vomitoxin is a lipid of Prenol Lipids (PR) class. Vomitoxin is associated with abnormalities such as Infection and Gastroenteritis. The involved functions are known as mRNA Expression, Inflammation, Transcription, Genetic, Protein Biosynthesis and Adverse effects. Vomitoxin often locates in Lymphoid Tissue, Immune system, Bone Marrow and Plasma membrane. The associated genes with Vomitoxin are IMPACT gene, HIST1H1C gene and RBM39 gene. The related experimental models are Mouse Model.
To understand associated biological information of Vomitoxin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Vomitoxin is suspected in Infection, Gastroenteritis and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Vomitoxin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Mouse Model are used in the study 'Dietary fish oil suppresses experimental immunoglobulin a nephropathy in mice.' (Pestka JJ et al., 2002).
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Authors | Title | Published | Journal | PubMed Link |
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Magan N et al. | Environmental factors and interactions with mycobiota of grain and grapes: effects on growth, deoxynivalenol and ochratoxin production by Fusarium culmorum and Aspergillus carbonarius. | 2010 | Toxins (Basel) | pmid:22069589 |
Pestka JJ | Deoxynivalenol-induced proinflammatory gene expression: mechanisms and pathological sequelae. | 2010 | Toxins (Basel) | pmid:22069639 |
Ji F et al. | Enzyme-linked immunosorbent-assay for Deoxynivalenol (DON). | 2011 | Toxins (Basel) | pmid:22069751 |
Zhang ZQ et al. | Phosphoproteome Analysis Reveals the Molecular Mechanisms Underlying Deoxynivalenol-Induced Intestinal Toxicity in IPEC-J2 Cells. | 2016 | Toxins (Basel) | pmid:27669298 |
Hassan YI et al. | Beyond Ribosomal Binding: The Increased Polarity and Aberrant Molecular Interactions of 3-epi-deoxynivalenol. | 2016 | Toxins (Basel) | pmid:27618101 |
Springler A et al. | Early Activation of MAPK p44/42 Is Partially Involved in DON-Induced Disruption of the Intestinal Barrier Function and Tight Junction Network. | 2016 | Toxins (Basel) | pmid:27618100 |
Ajandouz el H et al. | Hydrolytic Fate of 3/15-Acetyldeoxynivalenol in Humans: Specific Deacetylation by the Small Intestine and Liver Revealed Using in Vitro and ex Vivo Approaches. | 2016 | Toxins (Basel) | pmid:27483321 |
Grenier B et al. | Susceptibility of Broiler Chickens to Coccidiosis When Fed Subclinical Doses of Deoxynivalenol and Fumonisins-Special Emphasis on the Immunological Response and the Mycotoxin Interaction. | 2016 | Toxins (Basel) | pmid:27472362 |
Ansari KI et al. | Light influences how the fungal toxin deoxynivalenol affects plant cell death and defense responses. | 2014 | Toxins (Basel) | pmid:24561479 |
Pietsch C et al. | Organ damage and hepatic lipid accumulation in carp (Cyprinus carpio L.) after feed-borne exposure to the mycotoxin, deoxynivalenol (DON). | 2014 | Toxins (Basel) | pmid:24566729 |
Forrer HR et al. | Fusarium head blight control and prevention of mycotoxin contamination in wheat with botanicals and tannic acid. | 2014 | Toxins (Basel) | pmid:24577585 |
Ji J et al. | The Antagonistic Effect of Mycotoxins Deoxynivalenol and Zearalenone on Metabolic Profiling in Serum and Liver of Mice. | 2017 | Toxins (Basel) | pmid:28075412 |
Waśkiewicz A et al. | Deoxynivalenol in the gastrointestinal tract of immature gilts under per os toxin application. | 2014 | Toxins (Basel) | pmid:24603665 |
Cirlini M et al. | Are Treated Celiac Patients at Risk for Mycotoxins? An Italian Case-Study. | 2016 | Toxins (Basel) | pmid:28036017 |
Saint-Cyr MJ et al. | Risk Assessment of Deoxynivalenol by Revisiting Its Bioavailability in Pig and Rat Models to Establish Which Is More Suitable. | 2015 | Toxins (Basel) | pmid:26633505 |
Bannert E et al. | Metabolic and hematological consequences of dietary deoxynivalenol interacting with systemic Escherichia coli lipopolysaccharide. | 2015 | Toxins (Basel) | pmid:26580654 |
Schwartz-Zimmermann HE et al. | Metabolism of deoxynivalenol and deepoxy-deoxynivalenol in broiler chickens, pullets, roosters and turkeys. | 2015 | Toxins (Basel) | pmid:26569307 |
Paulick M et al. | Studies on the bioavailability of deoxynivalenol (DON) and DON sulfonate (DONS) 1, 2, and 3 in pigs fed with sodium sulfite-treated DON-contaminated maize. | 2015 | Toxins (Basel) | pmid:26556376 |
Clark ES et al. | High Sensitivity of Aged Mice to Deoxynivalenol (Vomitoxin)-Induced Anorexia Corresponds to Elevated Proinflammatory Cytokine and Satiety Hormone Responses. | 2015 | Toxins (Basel) | pmid:26492270 |
Wu L et al. | Dietary L-arginine supplementation protects weanling pigs from deoxynivalenol-induced toxicity. | 2015 | Toxins (Basel) | pmid:25884909 |
Paulick M et al. | Effects of increasing concentrations of sodium sulfite on deoxynivalenol and deoxynivalenol sulfonate concentrations of maize kernels and maize meal preserved at various moisture content. | 2015 | Toxins (Basel) | pmid:25760079 |
Przybylska-Gornowicz B et al. | The effects of low doses of two Fusarium toxins, zearalenone and deoxynivalenol, on the pig jejunum. A light and electron microscopic study. | 2015 | Toxins (Basel) | pmid:26569306 |
Bonnet MS et al. | Advances in deoxynivalenol toxicity mechanisms: the brain as a target. | 2012 | Toxins (Basel) | pmid:23202308 |
Wegulo SN | Factors influencing deoxynivalenol accumulation in small grain cereals. | 2012 | Toxins (Basel) | pmid:23202310 |
Qiu J and Shi J | Genetic relationships, carbendazim sensitivity and mycotoxin production of the Fusarium graminearum populations from maize, wheat and rice in eastern China. | 2014 | Toxins (Basel) | pmid:25093387 |
Piotrowska M et al. | The effect of experimental fusarium mycotoxicosis on microbiota diversity in porcine ascending colon contents. | 2014 | Toxins (Basel) | pmid:25025709 |
Schollenberger M et al. | Occurrence and distribution of 13 trichothecene toxins in naturally contaminated maize plants in Germany. | 2012 | Toxins (Basel) | pmid:23162697 |
Sliková S et al. | Occurrence of deoxynivalenol in wheat in Slovakia during 2010 and 2011. | 2013 | Toxins (Basel) | pmid:23917334 |
Ivanova L et al. | Cytotoxicity of enniatins A, A1, B, B1, B2 and B3 from Fusarium avenaceum. | 2006 | Toxicon | pmid:16730043 |
Abbas HK et al. | Cytotoxicity and phytotoxicity of trichothecene mycotoxins produced by Fusarium spp. | 2013 | Toxicon | pmid:23933195 |
Luongo D et al. | Effects of four Fusarium toxins (fumonisin B(1), alpha-zearalenol, nivalenol and deoxynivalenol) on porcine whole-blood cellular proliferation. | 2008 | Toxicon | pmid:18620720 |
Ruiz MJ et al. | Toxicological interactions between the mycotoxins beauvericin, deoxynivalenol and T-2 toxin in CHO-K1 cells in vitro. | 2011 | Toxicon | pmid:21821061 |
Ficheux AS et al. | Co-exposure of Fusarium mycotoxins: in vitro myelotoxicity assessment on human hematopoietic progenitors. | 2012 | Toxicon | pmid:22921581 |
Gajęcka M et al. | Changes in the metabolic profile and body weight of pre-pubertal gilts during prolonged monotonic exposure to low doses of zearalenone and deoxynivalenol. | 2017 | Toxicon | pmid:27840141 |
Ji J et al. | GC-TOF/MS-based metabolomic strategy for combined toxicity effects of deoxynivalenol and zearalenone on murine macrophage ANA-1 cells. | 2016 | Toxicon | pmid:27530666 |
Albonico M et al. | Toxicological effects of fumonisin B1 alone and in combination with other fusariotoxins on bovine granulosa cells. | 2016 | Toxicon | pmid:27108238 |
Pizzo F et al. | In vitro effects of deoxynivalenol and zearalenone major metabolites alone and combined, on cell proliferation, steroid production and gene expression in bovine small-follicle granulosa cells. | 2016 | Toxicon | pmid:26657070 |
Ueno Y et al. | Examination of Chinese and U.S.S.R. cereals for the Fusarium mycotoxins, nivalenol, deoxynivalenol and zearalenone. | 1986 | Toxicon | pmid:2944249 |
Dinu D et al. | Adapted response of the antioxidant defense system to oxidative stress induced by deoxynivalenol in Hek-293 cells. | 2011 | Toxicon | pmid:21549142 |
Lucioli J et al. | The food contaminant deoxynivalenol activates the mitogen activated protein kinases in the intestine: interest of ex vivo models as an alternative to in vivo experiments. | 2013 | Toxicon | pmid:23403092 |
Caloni F et al. | Effects of a trichothecene, T-2 toxin, on proliferation and steroid production by porcine granulosa cells. | 2009 | Toxicon | pmid:19463844 |
Sun LH et al. | Individual and combined cytotoxic effects of aflatoxin B1, zearalenone, deoxynivalenol and fumonisin B1 on BRL 3A rat liver cells. | 2015 | Toxicon | pmid:25549941 |
Zhang X et al. | The role of oxidative stress in deoxynivalenol-induced DNA damage in HepG2 cells. | 2009 | Toxicon | pmid:19486909 |
Luongo D et al. | Trichothecenes NIV and DON modulate the maturation of murine dendritic cells. | 2010 | Toxicon | pmid:19635492 |
Kouadio JH et al. | Effects of combinations of Fusarium mycotoxins on the inhibition of macromolecular synthesis, malondialdehyde levels, DNA methylation and fragmentation, and viability in Caco-2 cells. | 2007 | Toxicon | pmid:17109910 |
Zielonka Å et al. | The effect of environmental mycotoxins on selected ovarian tissue fragments of multiparous female wild boars at the beginning of astronomical winter. | 2014 | Toxicon | pmid:25016169 |
Bensassi F et al. | In vitro investigation of toxicological interactions between the fusariotoxins deoxynivalenol and zearalenone. | 2014 | Toxicon | pmid:24680766 |
Chung YJ et al. | Up-regulation of macrophage inflammatory protein-2 and complement 3A receptor by the trichothecenes deoxynivalenol and satratoxin G. | 2003 | Toxicology | pmid:12604170 |
Greene DM et al. | Vomitoxin (deoxynivalenol)-induced IgA nephropathy in the B6C3F1 mouse: dose response and male predilection. | 1994 | Toxicology | pmid:7940564 |
Savard C et al. | Prevention of deoxynivalenol- and zearalenone-associated oxidative stress does not restore MA-10 Leydig cell functions. | 2016 | Toxicology | pmid:26783879 |
Yang GH and Pestka JJ | Vomitoxin (deoxynivalenol)-mediated inhibition of nuclear protein binding to NRE-A, an IL-2 promoter negative regulatory element, in EL-4 cells. | 2002 | Toxicology | pmid:11893416 |
Ouyang YL et al. | Effects of trichothecene structure on cytokine secretion and gene expression in murine CD4+ T-cells. | 1995 | Toxicology | pmid:8560498 |
Instanes C and Hetland G | Deoxynivalenol (DON) is toxic to human colonic, lung and monocytic cell lines, but does not increase the IgE response in a mouse model for allergy. | 2004 | Toxicology | pmid:15369845 |
Yang H et al. | Ribotoxic mycotoxin deoxynivalenol induces G2/M cell cycle arrest via p21Cip/WAF1 mRNA stabilization in human epithelial cells. | 2008 | Toxicology | pmid:18006205 |
Königs M et al. | Cytotoxicity, metabolism and cellular uptake of the mycotoxin deoxynivalenol in human proximal tubule cells and lung fibroblasts in primary culture. | 2007 | Toxicology | pmid:17825972 |
Yan D et al. | Potential role for IL-5 and IL-6 in enhanced IgA secretion by Peyer's patch cells isolated from mice acutely exposed to vomitoxin. | 1997 | Toxicology | pmid:9274810 |
Amuzie CJ et al. | Tissue distribution and proinflammatory cytokine induction by the trichothecene deoxynivalenol in the mouse: comparison of nasal vs. oral exposure. | 2008 | Toxicology | pmid:18433975 |
Ji GE et al. | Modulation of nitric oxide, hydrogen peroxide and cytokine production in a clonal macrophage model by the trichothecene vomitoxin (deoxynivalenol). | 1998 | Toxicology | pmid:9570333 |
Pestka JJ et al. | Induction of apoptosis and cytokine production in the Jurkat human T cells by deoxynivalenol: role of mitogen-activated protein kinases and comparison to other 8-ketotrichothecenes. | 2005 | Toxicology | pmid:15588914 |
Kouadio JH et al. | Comparative study of cytotoxicity and oxidative stress induced by deoxynivalenol, zearalenone or fumonisin B1 in human intestinal cell line Caco-2. | 2005 | Toxicology | pmid:16019124 |
Mikami O et al. | Porcine hepatocyte apoptosis and reduction of albumin secretion induced by deoxynivalenol. | 2004 | Toxicology | pmid:15388250 |
Flannery BM et al. | Evaluation of insulin-like growth factor acid-labile subunit as a potential biomarker of effect for deoxynivalenol-induced proinflammatory cytokine expression. | 2013 | Toxicology | pmid:23298694 |
Wong S et al. | Superinduction of TNF-alpha and IL-6 in macrophages by vomitoxin (deoxynivalenol) modulated by mRNA stabilization. | 2001 | Toxicology | pmid:11295263 |
Waché YJ et al. | The mycotoxin deoxynivalenol inhibits the cell surface expression of activation markers in human macrophages. | 2009 | Toxicology | pmid:19549553 |
Schultze N et al. | Mitochondrial functions of THP-1 monocytes following the exposure to selected natural compounds. | 2017 | Toxicology | pmid:28013001 |
Bensassi F et al. | Pathway of deoxynivalenol-induced apoptosis in human colon carcinoma cells. | 2009 | Toxicology | pmid:19664677 |
Robbana-Barnat S et al. | Immunosuppressive properties of deoxynivalenol. | 1988 | Toxicology | pmid:3257592 |
Zhou HR et al. | Rapid, sequential activation of mitogen-activated protein kinases and transcription factors precedes proinflammatory cytokine mRNA expression in spleens of mice exposed to the trichothecene vomitoxin. | 2003 | Toxicol. Sci. | pmid:12604842 |
Moon Y and Pestka JJ | Vomitoxin-induced cyclooxygenase-2 gene expression in macrophages mediated by activation of ERK and p38 but not JNK mitogen-activated protein kinases. | 2002 | Toxicol. Sci. | pmid:12377986 |
Bae H et al. | Hematopoietic cell kinase associates with the 40S ribosomal subunit and mediates the ribotoxic stress response to deoxynivalenol in mononuclear phagocytes. | 2010 | Toxicol. Sci. | pmid:20181660 |
Bae HK and Pestka JJ | Deoxynivalenol induces p38 interaction with the ribosome in monocytes and macrophages. | 2008 | Toxicol. Sci. | pmid:18502741 |
Li M and Pestka JJ | Comparative induction of 28S ribosomal RNA cleavage by ricin and the trichothecenes deoxynivalenol and T-2 toxin in the macrophage. | 2008 | Toxicol. Sci. | pmid:18535001 |
Gray JS et al. | Double-stranded RNA-activated protein kinase mediates induction of interleukin-8 expression by deoxynivalenol, Shiga toxin 1, and ricin in monocytes. | 2008 | Toxicol. Sci. | pmid:18599499 |
Pan X et al. | Dynamic changes in ribosome-associated proteome and phosphoproteome during deoxynivalenol-induced translation inhibition and ribotoxic stress. | 2014 | Toxicol. Sci. | pmid:24284785 |
Zhou HR et al. | Lipopolysaccharide and the trichothecene vomitoxin (deoxynivalenol) synergistically induce apoptosis in murine lymphoid organs. | 2000 | Toxicol. Sci. | pmid:10696773 |
Girardet C et al. | Central inflammation and sickness-like behavior induced by the food contaminant deoxynivalenol: a PGE2-independent mechanism. | 2011 | Toxicol. Sci. | pmid:21873375 |
Wu W et al. | Role of cholecystokinin in anorexia induction following oral exposure to the 8-ketotrichothecenes deoxynivalenol, 15-acetyldeoxynivalenol, 3-acetyldeoxynivalenol, fusarenon X, and nivalenol. | 2014 | Toxicol. Sci. | pmid:24385417 |
Park SH et al. | Chronic Nod2 stimulation potentiates activating transcription factor 3 and paradoxical superinduction of epithelial proinflammatory chemokines by mucoactive ribotoxic stressors via RNA-binding protein human antigen R. | 2012 | Toxicol. Sci. | pmid:22003189 |
Wu W et al. | Comparison of emetic potencies of the 8-ketotrichothecenes deoxynivalenol, 15-acetyldeoxynivalenol, 3-acetyldeoxynivalenol, fusarenon X, and nivalenol. | 2013 | Toxicol. Sci. | pmid:22997060 |
Flannery BM et al. | Anorexia induction by the trichothecene deoxynivalenol (vomitoxin) is mediated by the release of the gut satiety hormone peptide YY. | 2012 | Toxicol. Sci. | pmid:22903826 |
Gray JS and Pestka JJ | Transcriptional regulation of deoxynivalenol-induced IL-8 expression in human monocytes. | 2007 | Toxicol. Sci. | pmid:17636245 |
Zhou HR and Pestka JJ | Deoxynivalenol (Vomitoxin)-Induced Cholecystokinin and Glucagon-Like Peptide-1 Release in the STC-1 Enteroendocrine Cell Model Is Mediated by Calcium-Sensing Receptor and Transient Receptor Potential Ankyrin-1 Channel. | 2015 | Toxicol. Sci. | pmid:25787141 |
Wang X et al. | JAK/STAT pathway plays a critical role in the proinflammatory gene expression and apoptosis of RAW264.7 cells induced by trichothecenes as DON and T-2 toxin. | 2012 | Toxicol. Sci. | pmid:22454431 |
He K et al. | Targets and intracellular signaling mechanisms for deoxynivalenol-induced ribosomal RNA cleavage. | 2012 | Toxicol. Sci. | pmid:22491426 |
Wu W et al. | Comparison of anorectic and emetic potencies of deoxynivalenol (vomitoxin) to the plant metabolite deoxynivalenol-3-glucoside and synthetic deoxynivalenol derivatives EN139528 and EN139544. | 2014 | Toxicol. Sci. | pmid:25173790 |
Zhou HR et al. | Ribotoxic stress response to the trichothecene deoxynivalenol in the macrophage involves the SRC family kinase Hck. | 2005 | Toxicol. Sci. | pmid:15772366 |
Pinton P et al. | Toxicity of deoxynivalenol and its acetylated derivatives on the intestine: differential effects on morphology, barrier function, tight junction proteins, and mitogen-activated protein kinases. | 2012 | Toxicol. Sci. | pmid:22859312 |
Wu W et al. | Peptide YY3-36 and 5-hydroxytryptamine mediate emesis induction by trichothecene deoxynivalenol (vomitoxin). | 2013 | Toxicol. Sci. | pmid:23457120 |
Pan X et al. | Early phosphoproteomic changes in the mouse spleen during deoxynivalenol-induced ribotoxic stress. | 2013 | Toxicol. Sci. | pmid:23811945 |
Shi Y et al. | Role of GRP78/BiP degradation and ER stress in deoxynivalenol-induced interleukin-6 upregulation in the macrophage. | 2009 | Toxicol. Sci. | pmid:19336499 |
Zhou HR et al. | Induction of competing apoptotic and survival signaling pathways in the macrophage by the ribotoxic trichothecene deoxynivalenol. | 2005 | Toxicol. Sci. | pmid:15976193 |
Li M et al. | Modulation of murine host response to enteric reovirus infection by the trichothecene deoxynivalenol. | 2005 | Toxicol. Sci. | pmid:15958657 |
Burger HM et al. | Development and evaluation of a sensitive mycotoxin risk assessment model (MYCORAM). | 2014 | Toxicol. Sci. | pmid:24980263 |
Li M et al. | Deoxynivalenol exacerbates viral bronchopneumonia induced by respiratory reovirus infection. | 2007 | Toxicol. Sci. | pmid:17090620 |
Zhou HR et al. | Role of double-stranded RNA-activated protein kinase R (PKR) in deoxynivalenol-induced ribotoxic stress response. | 2003 | Toxicol. Sci. | pmid:12773753 |
Islam Z and Pestka JJ | Role of IL-1(beta) in endotoxin potentiation of deoxynivalenol-induced corticosterone response and leukocyte apoptosis in mice. | 2003 | Toxicol. Sci. | pmid:12773775 |
Voss KA | A new perspective on deoxynivalenol and growth suppression. | 2010 | Toxicol. Sci. | pmid:19933702 |
Pestka J and Zhou HR | Toll-like receptor priming sensitizes macrophages to proinflammatory cytokine gene induction by deoxynivalenol and other toxicants. | 2006 | Toxicol. Sci. | pmid:16687389 |
Amuzie CJ and Pestka JJ | Suppression of insulin-like growth factor acid-labile subunit expression--a novel mechanism for deoxynivalenol-induced growth retardation. | 2010 | Toxicol. Sci. | pmid:19805407 |
He K et al. | Modulation of inflammatory gene expression by the ribotoxin deoxynivalenol involves coordinate regulation of the transcriptome and translatome. | 2013 | Toxicol. Sci. | pmid:22968694 |