Vomitoxin is a lipid of Prenol Lipids (PR) class. Vomitoxin is associated with abnormalities such as Infection and Gastroenteritis. The involved functions are known as mRNA Expression, Inflammation, Transcription, Genetic, Protein Biosynthesis and Adverse effects. Vomitoxin often locates in Lymphoid Tissue, Immune system, Bone Marrow and Plasma membrane. The associated genes with Vomitoxin are IMPACT gene, HIST1H1C gene and RBM39 gene. The related experimental models are Mouse Model.
To understand associated biological information of Vomitoxin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Vomitoxin is suspected in Infection, Gastroenteritis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Vomitoxin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Dietary fish oil suppresses experimental immunoglobulin a nephropathy in mice.' (Pestka JJ et al., 2002).
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Authors | Title | Published | Journal | PubMed Link |
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Burrows EP and Szafraniec LL | Hypochlorite-promoted transformations of trichothecenes, 3. Deoxynivalenol. | 1987 Nov-Dec | J. Nat. Prod. | pmid:2832543 |
Jia Q et al. | Docosahexaenoic acid attenuates mycotoxin-induced immunoglobulin a nephropathy, interleukin-6 transcription, and mitogen-activated protein kinase phosphorylation in mice. | 2004 | J. Nutr. | pmid:15570035 |
Jia Q et al. | Docosahexaenoic acid and eicosapentaenoic acid, but not alpha-linolenic acid, suppress deoxynivalenol-induced experimental IgA nephropathy in mice. | 2004 | J. Nutr. | pmid:15173396 |
Akbari P et al. | Galacto-oligosaccharides Protect the Intestinal Barrier by Maintaining the Tight Junction Network and Modulating the Inflammatory Responses after a Challenge with the Mycotoxin Deoxynivalenol in Human Caco-2 Cell Monolayers and B6C3F1 Mice. | 2015 | J. Nutr. | pmid:26019243 |
Jia Q et al. | Docosahexaenoic acid consumption inhibits deoxynivalenol-induced CREB/ATF1 activation and IL-6 gene transcription in mouse macrophages. | 2006 | J. Nutr. | pmid:16424113 |
Pinton P et al. | Deoxynivalenol impairs porcine intestinal barrier function and decreases the protein expression of claudin-4 through a mitogen-activated protein kinase-dependent mechanism. | 2010 | J. Nutr. | pmid:20861219 |
Pestka JJ et al. | Dietary fish oil suppresses experimental immunoglobulin a nephropathy in mice. | 2002 | J. Nutr. | pmid:11823588 |
Maresca M et al. | The mycotoxin deoxynivalenol affects nutrient absorption in human intestinal epithelial cells. | 2002 | J. Nutr. | pmid:12221236 |
Moon Y and Pestka JJ | Deoxynivalenol-induced mitogen-activated protein kinase phosphorylation and IL-6 expression in mice suppressed by fish oil. | 2003 | J. Nutr. Biochem. | pmid:14690764 |
Shi Y and Pestka JJ | Attenuation of mycotoxin-induced IgA nephropathy by eicosapentaenoic acid in the mouse: dose response and relation to IL-6 expression. | 2006 | J. Nutr. Biochem. | pmid:16524712 |
Shi Y and Pestka JJ | Mechanisms for suppression of interleukin-6 expression in peritoneal macrophages from docosahexaenoic acid-fed mice. | 2009 | J. Nutr. Biochem. | pmid:18602807 |
Kinser S et al. | Truncated deoxynivalenol-induced splenic immediate early gene response in mice consuming (n-3) polyunsaturated fatty acids. | 2005 | J. Nutr. Biochem. | pmid:15681167 |
Fioramonti J et al. | The mycotoxin, deoxynivalenol, delays gastric emptying through serotonin-3 receptors in rodents. | 1993 | J. Pharmacol. Exp. Ther. | pmid:8371135 |
Mudili V et al. | Mould incidence and mycotoxin contamination in freshly harvested maize kernels originated from India. | 2014 | J. Sci. Food Agric. | pmid:24609945 |
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Gilbert J et al. | A survey of the occurrence of the trichothecene mycotoxin deoxynivalenol (vomitoxin) in UK grown barley and in imported maize by combined gas chromatography-mass spectrometry. | 1983 | J. Sci. Food Agric. | pmid:6843094 |
Qiu J et al. | Effect of preceding crop on Fusarium species and mycotoxin contamination of wheat grains. | 2016 | J. Sci. Food Agric. | pmid:26867679 |
Zhang J et al. | Simultaneous detection of deoxynivalenol and zearalenone by dual-label time-resolved fluorescence immunoassay. | 2011 | J. Sci. Food Agric. | pmid:20945513 |
Ok HE et al. | Determination of deoxynivalenol in cereal-based foods and estimation of dietary exposure. | 2009 | J. Toxicol. Environ. Health Part A | pmid:20077214 |
Liu J et al. | Regulation of IL-8 promoter activity by verrucarin A in human monocytic THP-1 cells. | 2014 | J. Toxicol. Environ. Health Part A | pmid:25119735 |
Kinser S et al. | Gene expression profiling in spleens of deoxynivalenol-exposed mice: immediate early genes as primary targets. | 2004 | J. Toxicol. Environ. Health Part A | pmid:15371230 |
Drochner W et al. | Serum IgA-promoting effects induced by feed loads containing isolated deoxynivalenol (DON) in growing piglets. | 2004 | J. Toxicol. Environ. Health Part A | pmid:15205033 |
Amuzie CJ et al. | Effects of deoxynivalenol consumption on body weight and adiposity in the diet-induced obese mouse. | 2011 | J. Toxicol. Environ. Health Part A | pmid:21432715 |
Lee MG et al. | Effects of satratoxins and other macrocyclic trichothecenes on IL-2 production and viability of EL-4 thymoma cells. | 1999 | J. Toxicol. Environ. Health Part A | pmid:10494915 |
Zhou HR et al. | Amplified proinflammatory cytokine expression and toxicity in mice coexposed to lipopolysaccharide and the trichothecene vomitoxin (deoxynivalenol). | 1999 | J. Toxicol. Environ. Health Part A | pmid:10344227 |
Sugita-Konishi Y and Pestka JJ | Differential upregulation of TNF-alpha, IL-6, and IL-8 production by deoxynivalenol (vomitoxin) and other 8-ketotrichothecenes in a human macrophage model. | 2001 | J. Toxicol. Environ. Health Part A | pmid:11766169 |
Wong SS et al. | Effects of vomitoxin (deoxynivalenol) on the binding of transcription factors AP-1, NF-kappaB, and NF-IL6 in raw 264.7 macrophage cells. | 2002 | J. Toxicol. Environ. Health Part A | pmid:12167214 |
Osweiler GD et al. | Relationship of mycotoxins to swine reproductive failure. | 1990 | J. Vet. Diagn. Invest. | pmid:2151029 |
Johnson PJ et al. | Effect of feeding deoxynivalenol (vomitoxin)-contaminated barley to horses. | 1997 | J. Vet. Diagn. Invest. | pmid:9211250 |
Wada K et al. | Effects of mycotoxins on chemiluminescent response and cytokine mRNA expression of bovine neutrophils. | 2010 | J. Vet. Med. Sci. | pmid:20622479 |
Pralatnet S et al. | The fate and tissue disposition of deoxynivalenol in broiler chickens. | 2015 | J. Vet. Med. Sci. | pmid:25843039 |
Murata H et al. | Reduction of deoxynivalenol contaminating corn silage by short-term ultraviolet irradiation: a pilot study. | 2011 | J. Vet. Med. Sci. | pmid:21467760 |
Mikami O et al. | The effects of acute exposure to deoxynivalenol on some inflammatory parameters in miniature pigs. | 2011 | J. Vet. Med. Sci. | pmid:21224530 |
Takayama H et al. | Suppressive effect of deoxynivalenol, a Fusarium mycotoxin, on bovine and porcine neutrophil chemiluminescence: an in vitro study. | 2005 | J. Vet. Med. Sci. | pmid:15942140 |
Poapolathep A et al. | The effect of naringenin on the fate and disposition of deoxynivalenol in piglets. | 2010 | J. Vet. Med. Sci. | pmid:20467205 |
Mikami O et al. | Induction of apoptotic lesions in liver and lymphoid tissues and modulation of cytokine mRNA expression by acute exposure to deoxynivalenol in piglets. | 2010 | J. Vet. Sci. | pmid:20458150 |
Kim EJ et al. | Plasma haptoglobin and immunoglobulins as diagnostic indicators of deoxynivalenol intoxication. | 2008 | J. Vet. Sci. | pmid:18716445 |
Lee HM et al. | Development of a monoclonal antibody against deoxynivalenol for magnetic nanoparticle-based extraction and an enzyme-linked immunosorbent assay. | 2013 | J. Vet. Sci. | pmid:23388439 |
Chen F et al. | The combination of deoxynivalenol and zearalenone at permitted feed concentrations causes serious physiological effects in young pigs. | 2008 | J. Vet. Sci. | pmid:18296887 |
Boston S et al. | Consumption of deoxynivalenol-contaminated wheat by mallard ducks under experimental conditions. | 1996 | J. Wildl. Dis. | pmid:8627931 |
Etzel RA | Mycotoxins. | 2002 Jan 23-30 | JAMA | pmid:11798344 |
León-S FE et al. | Mycotoxins in myelopathies of man. | 1996 | Lancet | pmid:8855894 |
Hope R et al. | Comparison of environmental profiles for growth and deoxynivalenol production by Fusarium culmorum and F. graminearum on wheat grain. | 2005 | Lett. Appl. Microbiol. | pmid:15752221 |
Schnerr H et al. | Correlation between DNA of trichothecene-producing Fusarium species and deoxynivalenol concentrations in wheat-samples. | 2002 | Lett. Appl. Microbiol. | pmid:12100586 |
Hope R and Magan N | Two-dimensional environmental profiles of growth, deoxynivalenol and nivalenol production by Fusarium culmorum on a wheat-based substrate. | 2003 | Lett. Appl. Microbiol. | pmid:12803560 |
Cazzaniga D et al. | Mycotoxins inactivation by extrusion cooking of corn flour. | 2001 | Lett. Appl. Microbiol. | pmid:11472523 |
Payros D et al. | The Food Contaminant Deoxynivalenol Exacerbates the Genotoxicity of Gut Microbiota. | 2017 | MBio | pmid:28292979 |