Vomitoxin is a lipid of Prenol Lipids (PR) class. Vomitoxin is associated with abnormalities such as Infection and Gastroenteritis. The involved functions are known as mRNA Expression, Inflammation, Transcription, Genetic, Protein Biosynthesis and Adverse effects. Vomitoxin often locates in Lymphoid Tissue, Immune system, Bone Marrow and Plasma membrane. The associated genes with Vomitoxin are IMPACT gene, HIST1H1C gene and RBM39 gene. The related experimental models are Mouse Model.
To understand associated biological information of Vomitoxin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Vomitoxin is suspected in Infection, Gastroenteritis and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Vomitoxin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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There are no associated biomedical information in the current reference collection.
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Mouse Model are used in the study 'Dietary fish oil suppresses experimental immunoglobulin a nephropathy in mice.' (Pestka JJ et al., 2002).
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Authors | Title | Published | Journal | PubMed Link |
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Ma Y et al. | A mitochondria-mediated apoptotic pathway induced by deoxynivalenol in human colon cancer cells. | 2012 | Toxicol In Vitro | pmid:22269384 |
Cano-Sancho G et al. | Cytotoxicity of the mycotoxins deoxynivalenol and ochratoxin A on Caco-2 cell line in presence of resveratrol. | 2015 | Toxicol In Vitro | pmid:26100224 |
Seeling K et al. | On the effects of Fusarium toxin contaminated wheat and wheat chaff on nutrient utilisation and turnover of deoxynivalenol and zearalenone in vitro (Rusitec). | 2006 | Toxicol In Vitro | pmid:16321500 |
Devreese M et al. | An in vitro model using the IPEC-J2 cell line for efficacy and drug interaction testing of mycotoxin detoxifying agents. | 2013 | Toxicol In Vitro | pmid:23078954 |
Minervini F et al. | Toxicity and apoptosis induced by the mycotoxins nivalenol, deoxynivalenol and fumonisin B1 in a human erythroleukemia cell line. | 2004 | Toxicol In Vitro | pmid:14630058 |
Froquet R et al. | Improvement of megakaryocytic progenitor culture for toxicological investigations. | 2001 | Toxicol In Vitro | pmid:11698171 |
Le Dréan G et al. | Myelotoxicity of trichothecenes and apoptosis: an in vitro study on human cord blood CD34+ hematopoietic progenitor. | 2005 | Toxicol In Vitro | pmid:15908172 |
Hymery N et al. | In vitro effects of trichothecenes on human dendritic cells. | 2006 | Toxicol In Vitro | pmid:16517116 |
Alm H et al. | The influence of the mycotoxins deoxynivalenol and zearalenol on in vitro maturation of pig oocytes and in vitro culture of pig zygotes. | 2002 | Toxicol In Vitro | pmid:12423645 |
Li S et al. | Modulation of transcription factor AP-1 activity in murine EL-4 thymoma cells by vomitoxin (deoxynivalenol). | 2000 | Toxicol. Appl. Pharmacol. | pmid:10662601 |
Yang GH et al. | Down-regulation of the endoplasmic reticulum chaperone GRP78/BiP by vomitoxin (Deoxynivalenol). | 2000 | Toxicol. Appl. Pharmacol. | pmid:10652249 |
Wu W et al. | Effects of oral exposure to naturally-occurring and synthetic deoxynivalenol congeners on proinflammatory cytokine and chemokine mRNA expression in the mouse. | 2014 | Toxicol. Appl. Pharmacol. | pmid:24793808 |
Yang GH et al. | Apoptosis induction by the satratoxins and other trichothecene mycotoxins: relationship to ERK, p38 MAPK, and SAPK/JNK activation. | 2000 | Toxicol. Appl. Pharmacol. | pmid:10764628 |
Mishra S et al. | Deoxynivalenol induced mouse skin cell proliferation and inflammation via MAPK pathway. | 2014 | Toxicol. Appl. Pharmacol. | pmid:24937323 |
Pietsch C et al. | Frequent biphasic cellular responses of permanent fish cell cultures to deoxynivalenol (DON). | 2011 | Toxicol. Appl. Pharmacol. | pmid:21791220 |
Chung YJ et al. | Transcriptional and posttranscriptional roles for p38 mitogen-activated protein kinase in upregulation of TNF-alpha expression by deoxynivalenol (vomitoxin). | 2003 | Toxicol. Appl. Pharmacol. | pmid:14644621 |
Ouyang YL et al. | Vomitoxin-mediated IL-2, IL-4, and IL-5 superinduction in murine CD4+ T cells stimulated with phorbol ester calcium ionophore: relation to kinetics of proliferation. | 1996 | Toxicol. Appl. Pharmacol. | pmid:8658534 |
Dong W et al. | Elevated gene expression and production of interleukins 2, 4, 5, and 6 during exposure to vomitoxin (deoxynivalenol) and cycloheximide in the EL-4 thymoma. | 1994 | Toxicol. Appl. Pharmacol. | pmid:8048072 |
Khera KS et al. | Vomitoxin (4-deoxynivalenol): effects on reproduction of mice and rats. | 1984 | Toxicol. Appl. Pharmacol. | pmid:6740683 |
Moon Y et al. | Hypo-responsiveness of interleukin-8 production in human embryonic epithelial intestine 407 cells independent of NF-kappaB pathway: new lessons from endotoxin and ribotoxic deoxynivalenol. | 2008 | Toxicol. Appl. Pharmacol. | pmid:18485432 |
Azcona-Olivera JI et al. | Induction of cytokine mRNAs in mice after oral exposure to the trichothecene vomitoxin (deoxynivalenol): relationship to toxin distribution and protein synthesis inhibition. | 1995 | Toxicol. Appl. Pharmacol. | pmid:7597700 |
van Kol SW et al. | The effects of deoxynivalenol on gene expression in the murine thymus. | 2011 | Toxicol. Appl. Pharmacol. | pmid:21074547 |
Li S et al. | Superinduction of IL-2 gene expression by vomitoxin (deoxynivalenol) involves increased mRNA stability. | 1997 | Toxicol. Appl. Pharmacol. | pmid:9439728 |
Ouyang YL et al. | Effects of vomitoxin (deoxynivalenol) on transcription factor NF-kappa B/Rel binding activity in murine EL-4 thymoma and primary CD4+ T cells. | 1996 | Toxicol. Appl. Pharmacol. | pmid:8887449 |
Maresca M et al. | Both direct and indirect effects account for the pro-inflammatory activity of enteropathogenic mycotoxins on the human intestinal epithelium: stimulation of interleukin-8 secretion, potentiation of interleukin-1beta effect and increase in the transepithelial passage of commensal bacteria. | 2008 | Toxicol. Appl. Pharmacol. | pmid:18308354 |
Zhou HR et al. | Differential cytokine mRNA expression in mice after oral exposure to the trichothecene vomitoxin (deoxynivalenol): dose response and time course. | 1997 | Toxicol. Appl. Pharmacol. | pmid:9194413 |
Yan D et al. | Role of macrophages in elevated IgA and IL-6 production by Peyer's patch cultures following acute oral vomitoxin exposure. | 1998 | Toxicol. Appl. Pharmacol. | pmid:9473534 |
Bondy GS and Pestka JJ | Dietary exposure to the trichothecene vomitoxin (deoxynivalenol) stimulates terminal differentiation of Peyer's patch B cells to IgA secreting plasma cells. | 1991 | Toxicol. Appl. Pharmacol. | pmid:2020973 |
Katika MR et al. | Transcriptome analysis of the human T lymphocyte cell line Jurkat and human peripheral blood mononuclear cells exposed to deoxynivalenol (DON): New mechanistic insights. | 2012 | Toxicol. Appl. Pharmacol. | pmid:22846391 |
Islam Z et al. | p38 Mitogen-activated protein kinase mediates IL-8 induction by the ribotoxin deoxynivalenol in human monocytes. | 2006 | Toxicol. Appl. Pharmacol. | pmid:16364386 |
Zhou HR et al. | Induction of cytokine gene expression in mice after repeated and subchronic oral exposure to vomitoxin (Deoxynivalenol): differential toxin-induced hyporesponsiveness and recovery. | 1998 | Toxicol. Appl. Pharmacol. | pmid:9707511 |
Pinton P et al. | The food contaminant deoxynivalenol, decreases intestinal barrier permeability and reduces claudin expression. | 2009 | Toxicol. Appl. Pharmacol. | pmid:19289138 |
Islam Z et al. | Endotoxin potentiation of trichothecene-induced lymphocyte apoptosis is mediated by up-regulation of glucocorticoids. | 2002 | Toxicol. Appl. Pharmacol. | pmid:11922776 |
Islam Z and Pestka JJ | LPS priming potentiates and prolongs proinflammatory cytokine response to the trichothecene deoxynivalenol in the mouse. | 2006 | Toxicol. Appl. Pharmacol. | pmid:16009389 |
Pan X et al. | Global protein phosphorylation dynamics during deoxynivalenol-induced ribotoxic stress response in the macrophage. | 2013 | Toxicol. Appl. Pharmacol. | pmid:23352502 |
Choi HJ et al. | HuR/ELAVL1 RNA binding protein modulates interleukin-8 induction by muco-active ribotoxin deoxynivalenol. | 2009 | Toxicol. Appl. Pharmacol. | pmid:19591856 |
He K et al. | Mechanisms for ribotoxin-induced ribosomal RNA cleavage. | 2012 | Toxicol. Appl. Pharmacol. | pmid:23022514 |
Islam Z et al. | Differential induction of glucocorticoid-dependent apoptosis in murine lymphoid subpopulations in vivo following coexposure to lipopolysaccharide and vomitoxin (deoxynivalenol). | 2003 | Toxicol. Appl. Pharmacol. | pmid:12649039 |
Moon Y and Pestka JJ | Cyclooxygenase-2 mediates interleukin-6 upregulation by vomitoxin (deoxynivalenol) in vitro and in vivo. | 2003 | Toxicol. Appl. Pharmacol. | pmid:12649040 |
De Walle JV et al. | Deoxynivalenol affects in vitro intestinal epithelial cell barrier integrity through inhibition of protein synthesis. | 2010 | Toxicol. Appl. Pharmacol. | pmid:20362602 |
Alassane-Kpembi I et al. | New insights into mycotoxin mixtures: the toxicity of low doses of Type B trichothecenes on intestinal epithelial cells is synergistic. | 2013 | Toxicol. Appl. Pharmacol. | pmid:23735874 |
Larsen JC et al. | Workshop on trichothecenes with a focus on DON: summary report. | 2004 | Toxicol. Lett. | pmid:15342076 |
Edwards SG | Influence of agricultural practices on fusarium infection of cereals and subsequent contamination of grain by trichothecene mycotoxins. | 2004 | Toxicol. Lett. | pmid:15342078 |
Ndossi DG et al. | An in vitro investigation of endocrine disrupting effects of trichothecenes deoxynivalenol (DON), T-2 and HT-2 toxins. | 2012 | Toxicol. Lett. | pmid:22982764 |
Casteel M et al. | Impact of DUSP1 on the apoptotic potential of deoxynivalenol in the epithelial cell line HepG2. | 2010 | Toxicol. Lett. | pmid:20708668 |
Warth B et al. | Assessment of human deoxynivalenol exposure using an LC-MS/MS based biomarker method. | 2012 | Toxicol. Lett. | pmid:22429874 |
Pestka JJ et al. | Altered serum immunoglobulin response to model intestinal antigens during dietary exposure to vomitoxin (deoxynivalenol). | 1990 | Toxicol. Lett. | pmid:2296780 |
Van De Walle J et al. | Influence of deoxynivalenol on NF-kappaB activation and IL-8 secretion in human intestinal Caco-2 cells. | 2008 | Toxicol. Lett. | pmid:18343055 |
Trichothecenes with a special focus on DON. Proceedings of a workshop. September 10-12, 2003. Dublin Ireland. | 2004 | Toxicol. Lett. | pmid:15510395 | |
Döll S et al. | Interactions of deoxynivalenol and lipopolysaccharides on cytokine excretion and mRNA expression in porcine hepatocytes and Kupffer cell enriched hepatocyte cultures. | 2009 | Toxicol. Lett. | pmid:19607891 |