Vomitoxin

Vomitoxin is a lipid of Prenol Lipids (PR) class. Vomitoxin is associated with abnormalities such as Infection and Gastroenteritis. The involved functions are known as mRNA Expression, Inflammation, Transcription, Genetic, Protein Biosynthesis and Adverse effects. Vomitoxin often locates in Lymphoid Tissue, Immune system, Bone Marrow and Plasma membrane. The associated genes with Vomitoxin are IMPACT gene, HIST1H1C gene and RBM39 gene. The related experimental models are Mouse Model.

Cross Reference

Introduction

To understand associated biological information of Vomitoxin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Vomitoxin?

Vomitoxin is suspected in Infection, Gastroenteritis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Vomitoxin

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Inflammation D007249 119 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Esophageal Neoplasms D004938 20 associated lipids
Precancerous Conditions D011230 48 associated lipids
Stomach Neoplasms D013274 24 associated lipids
Hematuria D006417 13 associated lipids
Weight Gain D015430 101 associated lipids
Obesity D009765 29 associated lipids
Hyperplasia D006965 34 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Fetal Weight D020567 12 associated lipids
Immune Complex Diseases D007105 9 associated lipids
Glomerulonephritis, IGA D005922 7 associated lipids
Swine Diseases D013553 16 associated lipids
Poultry Diseases D011201 21 associated lipids
Thymus Neoplasms D013953 15 associated lipids
Bronchopneumonia D001996 7 associated lipids
Fetal Resorption D005327 15 associated lipids
Weight Loss D015431 56 associated lipids
Anorexia D000855 8 associated lipids
Mycoses D009181 18 associated lipids
Coronavirus Infections D018352 4 associated lipids
Mycotoxicosis D015651 5 associated lipids
Adrenocortical Carcinoma D018268 4 associated lipids
Splenic Diseases D013158 5 associated lipids
Kashin-Beck Disease D057767 2 associated lipids
Ascaridiasis D001198 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Vomitoxin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Vomitoxin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Vomitoxin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Vomitoxin?

There are no associated biomedical information in the current reference collection.

What genes are associated with Vomitoxin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Vomitoxin?

Mouse Model

Mouse Model are used in the study 'Dietary fish oil suppresses experimental immunoglobulin a nephropathy in mice.' (Pestka JJ et al., 2002).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Vomitoxin

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Per page 10 20 50 100 | Total 1588
Authors Title Published Journal PubMed Link
Ma Y et al. A mitochondria-mediated apoptotic pathway induced by deoxynivalenol in human colon cancer cells. 2012 Toxicol In Vitro pmid:22269384
Cano-Sancho G et al. Cytotoxicity of the mycotoxins deoxynivalenol and ochratoxin A on Caco-2 cell line in presence of resveratrol. 2015 Toxicol In Vitro pmid:26100224
Seeling K et al. On the effects of Fusarium toxin contaminated wheat and wheat chaff on nutrient utilisation and turnover of deoxynivalenol and zearalenone in vitro (Rusitec). 2006 Toxicol In Vitro pmid:16321500
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Yang GH et al. Down-regulation of the endoplasmic reticulum chaperone GRP78/BiP by vomitoxin (Deoxynivalenol). 2000 Toxicol. Appl. Pharmacol. pmid:10652249
Wu W et al. Effects of oral exposure to naturally-occurring and synthetic deoxynivalenol congeners on proinflammatory cytokine and chemokine mRNA expression in the mouse. 2014 Toxicol. Appl. Pharmacol. pmid:24793808
Yang GH et al. Apoptosis induction by the satratoxins and other trichothecene mycotoxins: relationship to ERK, p38 MAPK, and SAPK/JNK activation. 2000 Toxicol. Appl. Pharmacol. pmid:10764628
Mishra S et al. Deoxynivalenol induced mouse skin cell proliferation and inflammation via MAPK pathway. 2014 Toxicol. Appl. Pharmacol. pmid:24937323
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Chung YJ et al. Transcriptional and posttranscriptional roles for p38 mitogen-activated protein kinase in upregulation of TNF-alpha expression by deoxynivalenol (vomitoxin). 2003 Toxicol. Appl. Pharmacol. pmid:14644621
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Khera KS et al. Vomitoxin (4-deoxynivalenol): effects on reproduction of mice and rats. 1984 Toxicol. Appl. Pharmacol. pmid:6740683
Moon Y et al. Hypo-responsiveness of interleukin-8 production in human embryonic epithelial intestine 407 cells independent of NF-kappaB pathway: new lessons from endotoxin and ribotoxic deoxynivalenol. 2008 Toxicol. Appl. Pharmacol. pmid:18485432
Azcona-Olivera JI et al. Induction of cytokine mRNAs in mice after oral exposure to the trichothecene vomitoxin (deoxynivalenol): relationship to toxin distribution and protein synthesis inhibition. 1995 Toxicol. Appl. Pharmacol. pmid:7597700
van Kol SW et al. The effects of deoxynivalenol on gene expression in the murine thymus. 2011 Toxicol. Appl. Pharmacol. pmid:21074547
Li S et al. Superinduction of IL-2 gene expression by vomitoxin (deoxynivalenol) involves increased mRNA stability. 1997 Toxicol. Appl. Pharmacol. pmid:9439728
Ouyang YL et al. Effects of vomitoxin (deoxynivalenol) on transcription factor NF-kappa B/Rel binding activity in murine EL-4 thymoma and primary CD4+ T cells. 1996 Toxicol. Appl. Pharmacol. pmid:8887449
Maresca M et al. Both direct and indirect effects account for the pro-inflammatory activity of enteropathogenic mycotoxins on the human intestinal epithelium: stimulation of interleukin-8 secretion, potentiation of interleukin-1beta effect and increase in the transepithelial passage of commensal bacteria. 2008 Toxicol. Appl. Pharmacol. pmid:18308354
Zhou HR et al. Differential cytokine mRNA expression in mice after oral exposure to the trichothecene vomitoxin (deoxynivalenol): dose response and time course. 1997 Toxicol. Appl. Pharmacol. pmid:9194413
Yan D et al. Role of macrophages in elevated IgA and IL-6 production by Peyer's patch cultures following acute oral vomitoxin exposure. 1998 Toxicol. Appl. Pharmacol. pmid:9473534
Bondy GS and Pestka JJ Dietary exposure to the trichothecene vomitoxin (deoxynivalenol) stimulates terminal differentiation of Peyer's patch B cells to IgA secreting plasma cells. 1991 Toxicol. Appl. Pharmacol. pmid:2020973
Katika MR et al. Transcriptome analysis of the human T lymphocyte cell line Jurkat and human peripheral blood mononuclear cells exposed to deoxynivalenol (DON): New mechanistic insights. 2012 Toxicol. Appl. Pharmacol. pmid:22846391
Islam Z et al. p38 Mitogen-activated protein kinase mediates IL-8 induction by the ribotoxin deoxynivalenol in human monocytes. 2006 Toxicol. Appl. Pharmacol. pmid:16364386
Zhou HR et al. Induction of cytokine gene expression in mice after repeated and subchronic oral exposure to vomitoxin (Deoxynivalenol): differential toxin-induced hyporesponsiveness and recovery. 1998 Toxicol. Appl. Pharmacol. pmid:9707511
Pinton P et al. The food contaminant deoxynivalenol, decreases intestinal barrier permeability and reduces claudin expression. 2009 Toxicol. Appl. Pharmacol. pmid:19289138
Islam Z et al. Endotoxin potentiation of trichothecene-induced lymphocyte apoptosis is mediated by up-regulation of glucocorticoids. 2002 Toxicol. Appl. Pharmacol. pmid:11922776
Islam Z and Pestka JJ LPS priming potentiates and prolongs proinflammatory cytokine response to the trichothecene deoxynivalenol in the mouse. 2006 Toxicol. Appl. Pharmacol. pmid:16009389
Pan X et al. Global protein phosphorylation dynamics during deoxynivalenol-induced ribotoxic stress response in the macrophage. 2013 Toxicol. Appl. Pharmacol. pmid:23352502
Choi HJ et al. HuR/ELAVL1 RNA binding protein modulates interleukin-8 induction by muco-active ribotoxin deoxynivalenol. 2009 Toxicol. Appl. Pharmacol. pmid:19591856
He K et al. Mechanisms for ribotoxin-induced ribosomal RNA cleavage. 2012 Toxicol. Appl. Pharmacol. pmid:23022514
Islam Z et al. Differential induction of glucocorticoid-dependent apoptosis in murine lymphoid subpopulations in vivo following coexposure to lipopolysaccharide and vomitoxin (deoxynivalenol). 2003 Toxicol. Appl. Pharmacol. pmid:12649039
Moon Y and Pestka JJ Cyclooxygenase-2 mediates interleukin-6 upregulation by vomitoxin (deoxynivalenol) in vitro and in vivo. 2003 Toxicol. Appl. Pharmacol. pmid:12649040
De Walle JV et al. Deoxynivalenol affects in vitro intestinal epithelial cell barrier integrity through inhibition of protein synthesis. 2010 Toxicol. Appl. Pharmacol. pmid:20362602
Alassane-Kpembi I et al. New insights into mycotoxin mixtures: the toxicity of low doses of Type B trichothecenes on intestinal epithelial cells is synergistic. 2013 Toxicol. Appl. Pharmacol. pmid:23735874
Larsen JC et al. Workshop on trichothecenes with a focus on DON: summary report. 2004 Toxicol. Lett. pmid:15342076
Edwards SG Influence of agricultural practices on fusarium infection of cereals and subsequent contamination of grain by trichothecene mycotoxins. 2004 Toxicol. Lett. pmid:15342078
Ndossi DG et al. An in vitro investigation of endocrine disrupting effects of trichothecenes deoxynivalenol (DON), T-2 and HT-2 toxins. 2012 Toxicol. Lett. pmid:22982764
Casteel M et al. Impact of DUSP1 on the apoptotic potential of deoxynivalenol in the epithelial cell line HepG2. 2010 Toxicol. Lett. pmid:20708668
Warth B et al. Assessment of human deoxynivalenol exposure using an LC-MS/MS based biomarker method. 2012 Toxicol. Lett. pmid:22429874
Pestka JJ et al. Altered serum immunoglobulin response to model intestinal antigens during dietary exposure to vomitoxin (deoxynivalenol). 1990 Toxicol. Lett. pmid:2296780
Van De Walle J et al. Influence of deoxynivalenol on NF-kappaB activation and IL-8 secretion in human intestinal Caco-2 cells. 2008 Toxicol. Lett. pmid:18343055
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Döll S et al. Interactions of deoxynivalenol and lipopolysaccharides on cytokine excretion and mRNA expression in porcine hepatocytes and Kupffer cell enriched hepatocyte cultures. 2009 Toxicol. Lett. pmid:19607891