Vomitoxin
Vomitoxin is a lipid of Prenol Lipids (PR) class. Vomitoxin is associated with abnormalities such as Infection and Gastroenteritis. The involved functions are known as mRNA Expression, Inflammation, Transcription, Genetic, Protein Biosynthesis and Adverse effects. Vomitoxin often locates in Lymphoid Tissue, Immune system, Bone Marrow and Plasma membrane. The associated genes with Vomitoxin are IMPACT gene, HIST1H1C gene and RBM39 gene. The related experimental models are Mouse Model.
Cross Reference
Introduction
To understand associated biological information of Vomitoxin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Vomitoxin?
Vomitoxin is suspected in Infection, Gastroenteritis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Vomitoxin
PubChem Associated disorders and diseases
What pathways are associated with Vomitoxin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Vomitoxin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Vomitoxin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Vomitoxin?
There are no associated biomedical information in the current reference collection.
What genes are associated with Vomitoxin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Vomitoxin?
Mouse Model
Mouse Model are used in the study 'Dietary fish oil suppresses experimental immunoglobulin a nephropathy in mice.' (Pestka JJ et al., 2002).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with Vomitoxin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Girardet C et al. | Central inflammation and sickness-like behavior induced by the food contaminant deoxynivalenol: a PGE2-independent mechanism. | 2011 | Toxicol. Sci. | pmid:21873375 |
| Wang K et al. | A novel and sensitive method for the detection of deoxynivalenol in food by time-resolved fluoroimmunoassay. | 2009 | Toxicol. Mech. Methods | pmid:19874133 |
| Dänicke S et al. | Effects of the Fusarium toxin deoxynivalenol on tissue protein synthesis in pigs. | 2006 | Toxicol. Lett. | pmid:16814494 |
| Tiemann U et al. | The effect of feeding a diet naturally contaminated with deoxynivalenol (DON) and zearalenone (ZON) on the spleen and liver of sow and fetus from day 35 to 70 of gestation. | 2008 | Toxicol. Lett. | pmid:18550300 |
| Atkinson HA and Miller K | Inhibitory effect of deoxynivalenol, 3-acetyldeoxynivalenol and zearalenone on induction of rat and human lymphocyte proliferation. | 1984 | Toxicol. Lett. | pmid:6239410 |
| Smith MC et al. | Individual and combined toxicological effects of deoxynivalenol and zearalenone on human hepatocytes in in vitro chronic exposure conditions. | 2017 | Toxicol. Lett. | pmid:28865950 |
| Schmeits PC et al. | DON shares a similar mode of action as the ribotoxic stress inducer anisomycin while TBTO shares ER stress patterns with the ER stress inducer thapsigargin based on comparative gene expression profiling in Jurkat T cells. | 2014 | Toxicol. Lett. | pmid:24247028 |
| Pestka JJ | Deoxynivalenol-induced IgA production and IgA nephropathy-aberrant mucosal immune response with systemic repercussions. | 2003 | Toxicol. Lett. | pmid:12676476 |
| Larsen JC et al. | Workshop on trichothecenes with a focus on DON: summary report. | 2004 | Toxicol. Lett. | pmid:15342076 |
| Edwards SG | Influence of agricultural practices on fusarium infection of cereals and subsequent contamination of grain by trichothecene mycotoxins. | 2004 | Toxicol. Lett. | pmid:15342078 |
| Snijders CH | Resistance in wheat to Fusarium infection and trichothecene formation. | 2004 | Toxicol. Lett. | pmid:15342079 |
| Hazel CM and Patel S | Influence of processing on trichothecene levels. | 2004 | Toxicol. Lett. | pmid:15342081 |
| Pestka JJ et al. | Cellular and molecular mechanisms for immune modulation by deoxynivalenol and other trichothecenes: unraveling a paradox. | 2004 | Toxicol. Lett. | pmid:15342082 |
| Schlatter J | Toxicity data relevant for hazard characterization. | 2004 | Toxicol. Lett. | pmid:15342084 |
| Koch P | State of the art of trichothecenes analysis. | 2004 | Toxicol. Lett. | pmid:15342087 |
| Schneider E et al. | Rapid methods for deoxynivalenol and other trichothecenes. | 2004 | Toxicol. Lett. | pmid:15342088 |
| Pieters MN et al. | Reduced intake of deoxynivalenol in The Netherlands: a risk assessment update. | 2004 | Toxicol. Lett. | pmid:15342091 |
| Visconti A et al. | Reduction of deoxynivalenol during durum wheat processing and spaghetti cooking. | 2004 | Toxicol. Lett. | pmid:15342095 |
| Goyarts T et al. | On the transfer of the Fusarium toxins deoxynivalenol (DON) and zearalenone (ZON) from sows to their fetuses during days 35-70 of gestation. | 2007 | Toxicol. Lett. | pmid:17544604 |
| Ndossi DG et al. | An in vitro investigation of endocrine disrupting effects of trichothecenes deoxynivalenol (DON), T-2 and HT-2 toxins. | 2012 | Toxicol. Lett. | pmid:22982764 |
| Tryphonas H et al. | Effect of deoxynivalenol (vomitoxin) on the humoral immunity of mice. | 1984 | Toxicol. Lett. | pmid:6485014 |
| Casteel M et al. | Impact of DUSP1 on the apoptotic potential of deoxynivalenol in the epithelial cell line HepG2. | 2010 | Toxicol. Lett. | pmid:20708668 |
| Tutelyan VA | Deoxynivalenol in cereals in Russia. | 2004 | Toxicol. Lett. | pmid:15342094 |
| Warth B et al. | New insights into the human metabolism of the Fusarium mycotoxins deoxynivalenol and zearalenone. | 2013 | Toxicol. Lett. | pmid:23623764 |
| Pinton P et al. | Ingestion of deoxynivalenol (DON) contaminated feed alters the pig vaccinal immune responses. | 2008 | Toxicol. Lett. | pmid:18329193 |
| Warth B et al. | Assessment of human deoxynivalenol exposure using an LC-MS/MS based biomarker method. | 2012 | Toxicol. Lett. | pmid:22429874 |
| Pestka JJ et al. | Altered serum immunoglobulin response to model intestinal antigens during dietary exposure to vomitoxin (deoxynivalenol). | 1990 | Toxicol. Lett. | pmid:2296780 |
| Van De Walle J et al. | Influence of deoxynivalenol on NF-kappaB activation and IL-8 secretion in human intestinal Caco-2 cells. | 2008 | Toxicol. Lett. | pmid:18343055 |
| Pestka JJ et al. | Immunochemical assessment of deoxynivalenol tissue distribution following oral exposure in the mouse. | 2008 | Toxicol. Lett. | pmid:18395371 |
| Diesing AK et al. | Mycotoxin deoxynivalenol (DON) mediates biphasic cellular response in intestinal porcine epithelial cell lines IPEC-1 and IPEC-J2. | 2011 | Toxicol. Lett. | pmid:20937367 |
| Nagl V et al. | Metabolism of the masked mycotoxin deoxynivalenol-3-glucoside in rats. | 2012 | Toxicol. Lett. | pmid:22884771 |
| Goyarts T and Dänicke S | Bioavailability of the Fusarium toxin deoxynivalenol (DON) from naturally contaminated wheat for the pig. | 2006 | Toxicol. Lett. | pmid:16326049 |
| Trichothecenes with a special focus on DON. Proceedings of a workshop. September 10-12, 2003. Dublin Ireland. | 2004 | Toxicol. Lett. | pmid:15510395 | |
| Dänicke S et al. | The Fusarium toxin deoxynivalenol (DON) modulates the LPS induced acute phase reaction in pigs. | 2013 | Toxicol. Lett. | pmid:23603058 |
| Döll S et al. | Deoxynivalenol-induced cytotoxicity, cytokines and related genes in unstimulated or lipopolysaccharide stimulated primary porcine macrophages. | 2009 | Toxicol. Lett. | pmid:19027837 |
| Schmeits PC et al. | Assessment of the usefulness of the murine cytotoxic T cell line CTLL-2 for immunotoxicity screening by transcriptomics. | 2013 | Toxicol. Lett. | pmid:23253260 |
| Döll S et al. | Interactions of deoxynivalenol and lipopolysaccharides on cytotoxicity protein synthesis and metabolism of DON in porcine hepatocytes and Kupffer cell enriched hepatocyte cultures. | 2009 | Toxicol. Lett. | pmid:19477247 |
| Fitzpatrick DW et al. | Comparison of the trichothecenes deoxynivalenol and T-2 toxin for their effects on brain biogenic monoamines in the rat. | 1988 | Toxicol. Lett. | pmid:3354008 |
| Tryphonas H et al. | Effects of deoxynivalenol (vomitoxin) on the humoral and cellular immunity of mice. | 1986 | Toxicol. Lett. | pmid:3518157 |
| Sergent T et al. | Deoxynivalenol transport across human intestinal Caco-2 cells and its effects on cellular metabolism at realistic intestinal concentrations. | 2006 | Toxicol. Lett. | pmid:16442754 |
| Stanek C et al. | A chronic oral exposure of pigs with deoxynivalenol partially prevents the acute effects of lipopolysaccharides on hepatic histopathology and blood clinical chemistry. | 2012 | Toxicol. Lett. | pmid:23123154 |
| Döll S et al. | Interactions of deoxynivalenol and lipopolysaccharides on cytokine excretion and mRNA expression in porcine hepatocytes and Kupffer cell enriched hepatocyte cultures. | 2009 | Toxicol. Lett. | pmid:19607891 |
| Szkudelska K et al. | Short-time deoxynivalenol treatment induces metabolic disturbances in the rat. | 2002 | Toxicol. Lett. | pmid:12368054 |
| Marzocco S et al. | Pro-apoptotic effects of nivalenol and deoxynivalenol trichothecenes in J774A.1 murine macrophages. | 2009 | Toxicol. Lett. | pmid:19410639 |
| Flannery BM et al. | Deoxynivalenol-induced weight loss in the diet-induced obese mouse is reversible and PKR-independent. | 2013 | Toxicol. Lett. | pmid:23707852 |
| Sugiyama K et al. | Deoxynivalenol and nivalenol inhibit lipopolysaccharide-induced nitric oxide production by mouse macrophage cells. | 2010 | Toxicol. Lett. | pmid:19857559 |
| Bony S et al. | Genotoxicity assessment of deoxynivalenol in the Caco-2 cell line model using the Comet assay. | 2006 | Toxicol. Lett. | pmid:16828243 |
| Li S et al. | Modulation of transcription factor AP-1 activity in murine EL-4 thymoma cells by vomitoxin (deoxynivalenol). | 2000 | Toxicol. Appl. Pharmacol. | pmid:10662601 |
| Yang GH et al. | Down-regulation of the endoplasmic reticulum chaperone GRP78/BiP by vomitoxin (Deoxynivalenol). | 2000 | Toxicol. Appl. Pharmacol. | pmid:10652249 |
| Wu W et al. | Effects of oral exposure to naturally-occurring and synthetic deoxynivalenol congeners on proinflammatory cytokine and chemokine mRNA expression in the mouse. | 2014 | Toxicol. Appl. Pharmacol. | pmid:24793808 |
| Yang GH et al. | Apoptosis induction by the satratoxins and other trichothecene mycotoxins: relationship to ERK, p38 MAPK, and SAPK/JNK activation. | 2000 | Toxicol. Appl. Pharmacol. | pmid:10764628 |
| Mishra S et al. | Deoxynivalenol induced mouse skin cell proliferation and inflammation via MAPK pathway. | 2014 | Toxicol. Appl. Pharmacol. | pmid:24937323 |
| Pietsch C et al. | Frequent biphasic cellular responses of permanent fish cell cultures to deoxynivalenol (DON). | 2011 | Toxicol. Appl. Pharmacol. | pmid:21791220 |
| Chung YJ et al. | Transcriptional and posttranscriptional roles for p38 mitogen-activated protein kinase in upregulation of TNF-alpha expression by deoxynivalenol (vomitoxin). | 2003 | Toxicol. Appl. Pharmacol. | pmid:14644621 |
| Ouyang YL et al. | Vomitoxin-mediated IL-2, IL-4, and IL-5 superinduction in murine CD4+ T cells stimulated with phorbol ester calcium ionophore: relation to kinetics of proliferation. | 1996 | Toxicol. Appl. Pharmacol. | pmid:8658534 |
| Dong W et al. | Elevated gene expression and production of interleukins 2, 4, 5, and 6 during exposure to vomitoxin (deoxynivalenol) and cycloheximide in the EL-4 thymoma. | 1994 | Toxicol. Appl. Pharmacol. | pmid:8048072 |
| Khera KS et al. | Vomitoxin (4-deoxynivalenol): effects on reproduction of mice and rats. | 1984 | Toxicol. Appl. Pharmacol. | pmid:6740683 |
| Moon Y et al. | Hypo-responsiveness of interleukin-8 production in human embryonic epithelial intestine 407 cells independent of NF-kappaB pathway: new lessons from endotoxin and ribotoxic deoxynivalenol. | 2008 | Toxicol. Appl. Pharmacol. | pmid:18485432 |
| Azcona-Olivera JI et al. | Induction of cytokine mRNAs in mice after oral exposure to the trichothecene vomitoxin (deoxynivalenol): relationship to toxin distribution and protein synthesis inhibition. | 1995 | Toxicol. Appl. Pharmacol. | pmid:7597700 |
| van Kol SW et al. | The effects of deoxynivalenol on gene expression in the murine thymus. | 2011 | Toxicol. Appl. Pharmacol. | pmid:21074547 |
| Li S et al. | Superinduction of IL-2 gene expression by vomitoxin (deoxynivalenol) involves increased mRNA stability. | 1997 | Toxicol. Appl. Pharmacol. | pmid:9439728 |
| Ouyang YL et al. | Effects of vomitoxin (deoxynivalenol) on transcription factor NF-kappa B/Rel binding activity in murine EL-4 thymoma and primary CD4+ T cells. | 1996 | Toxicol. Appl. Pharmacol. | pmid:8887449 |
| Maresca M et al. | Both direct and indirect effects account for the pro-inflammatory activity of enteropathogenic mycotoxins on the human intestinal epithelium: stimulation of interleukin-8 secretion, potentiation of interleukin-1beta effect and increase in the transepithelial passage of commensal bacteria. | 2008 | Toxicol. Appl. Pharmacol. | pmid:18308354 |
| Zhou HR et al. | Differential cytokine mRNA expression in mice after oral exposure to the trichothecene vomitoxin (deoxynivalenol): dose response and time course. | 1997 | Toxicol. Appl. Pharmacol. | pmid:9194413 |
| Yan D et al. | Role of macrophages in elevated IgA and IL-6 production by Peyer's patch cultures following acute oral vomitoxin exposure. | 1998 | Toxicol. Appl. Pharmacol. | pmid:9473534 |
| Bondy GS and Pestka JJ | Dietary exposure to the trichothecene vomitoxin (deoxynivalenol) stimulates terminal differentiation of Peyer's patch B cells to IgA secreting plasma cells. | 1991 | Toxicol. Appl. Pharmacol. | pmid:2020973 |
| Katika MR et al. | Transcriptome analysis of the human T lymphocyte cell line Jurkat and human peripheral blood mononuclear cells exposed to deoxynivalenol (DON): New mechanistic insights. | 2012 | Toxicol. Appl. Pharmacol. | pmid:22846391 |
| Islam Z et al. | p38 Mitogen-activated protein kinase mediates IL-8 induction by the ribotoxin deoxynivalenol in human monocytes. | 2006 | Toxicol. Appl. Pharmacol. | pmid:16364386 |
| Zhou HR et al. | Induction of cytokine gene expression in mice after repeated and subchronic oral exposure to vomitoxin (Deoxynivalenol): differential toxin-induced hyporesponsiveness and recovery. | 1998 | Toxicol. Appl. Pharmacol. | pmid:9707511 |
| Pinton P et al. | The food contaminant deoxynivalenol, decreases intestinal barrier permeability and reduces claudin expression. | 2009 | Toxicol. Appl. Pharmacol. | pmid:19289138 |
| Islam Z et al. | Endotoxin potentiation of trichothecene-induced lymphocyte apoptosis is mediated by up-regulation of glucocorticoids. | 2002 | Toxicol. Appl. Pharmacol. | pmid:11922776 |
| Islam Z and Pestka JJ | LPS priming potentiates and prolongs proinflammatory cytokine response to the trichothecene deoxynivalenol in the mouse. | 2006 | Toxicol. Appl. Pharmacol. | pmid:16009389 |
| Pan X et al. | Global protein phosphorylation dynamics during deoxynivalenol-induced ribotoxic stress response in the macrophage. | 2013 | Toxicol. Appl. Pharmacol. | pmid:23352502 |
| Choi HJ et al. | HuR/ELAVL1 RNA binding protein modulates interleukin-8 induction by muco-active ribotoxin deoxynivalenol. | 2009 | Toxicol. Appl. Pharmacol. | pmid:19591856 |
| He K et al. | Mechanisms for ribotoxin-induced ribosomal RNA cleavage. | 2012 | Toxicol. Appl. Pharmacol. | pmid:23022514 |
| Islam Z et al. | Differential induction of glucocorticoid-dependent apoptosis in murine lymphoid subpopulations in vivo following coexposure to lipopolysaccharide and vomitoxin (deoxynivalenol). | 2003 | Toxicol. Appl. Pharmacol. | pmid:12649039 |
| Moon Y and Pestka JJ | Cyclooxygenase-2 mediates interleukin-6 upregulation by vomitoxin (deoxynivalenol) in vitro and in vivo. | 2003 | Toxicol. Appl. Pharmacol. | pmid:12649040 |
| De Walle JV et al. | Deoxynivalenol affects in vitro intestinal epithelial cell barrier integrity through inhibition of protein synthesis. | 2010 | Toxicol. Appl. Pharmacol. | pmid:20362602 |
| Alassane-Kpembi I et al. | New insights into mycotoxin mixtures: the toxicity of low doses of Type B trichothecenes on intestinal epithelial cells is synergistic. | 2013 | Toxicol. Appl. Pharmacol. | pmid:23735874 |
| Van De Walle J et al. | Physio-pathological parameters affect the activation of inflammatory pathways by deoxynivalenol in Caco-2 cells. | 2010 | Toxicol In Vitro | pmid:20633634 |
| Ma Y et al. | A mitochondria-mediated apoptotic pathway induced by deoxynivalenol in human colon cancer cells. | 2012 | Toxicol In Vitro | pmid:22269384 |
| Cano-Sancho G et al. | Cytotoxicity of the mycotoxins deoxynivalenol and ochratoxin A on Caco-2 cell line in presence of resveratrol. | 2015 | Toxicol In Vitro | pmid:26100224 |
| Seeling K et al. | On the effects of Fusarium toxin contaminated wheat and wheat chaff on nutrient utilisation and turnover of deoxynivalenol and zearalenone in vitro (Rusitec). | 2006 | Toxicol In Vitro | pmid:16321500 |
| Devreese M et al. | An in vitro model using the IPEC-J2 cell line for efficacy and drug interaction testing of mycotoxin detoxifying agents. | 2013 | Toxicol In Vitro | pmid:23078954 |
| Minervini F et al. | Toxicity and apoptosis induced by the mycotoxins nivalenol, deoxynivalenol and fumonisin B1 in a human erythroleukemia cell line. | 2004 | Toxicol In Vitro | pmid:14630058 |
| Kadota T et al. | Comparative study of deoxynivalenol, 3-acetyldeoxynivalenol, and 15-acetyldeoxynivalenol on intestinal transport and IL-8 secretion in the human cell line Caco-2. | 2013 | Toxicol In Vitro | pmid:23792671 |
| Froquet R et al. | Improvement of megakaryocytic progenitor culture for toxicological investigations. | 2001 | Toxicol In Vitro | pmid:11698171 |
| Le Dréan G et al. | Myelotoxicity of trichothecenes and apoptosis: an in vitro study on human cord blood CD34+ hematopoietic progenitor. | 2005 | Toxicol In Vitro | pmid:15908172 |
| Goyarts T et al. | Effect of the Fusarium toxin deoxynivalenol (DON) on IgA, IgM and IgG concentrations and proliferation of porcine blood lymphocytes. | 2006 | Toxicol In Vitro | pmid:16480848 |
| Nasri T et al. | Differential induction of apoptosis by type A and B trichothecenes in Jurkat T-lymphocytes. | 2006 | Toxicol In Vitro | pmid:16472964 |
| Hymery N et al. | In vitro effects of trichothecenes on human dendritic cells. | 2006 | Toxicol In Vitro | pmid:16517116 |
| Kolf-Clauw M et al. | Development of a pig jejunal explant culture for studying the gastrointestinal toxicity of the mycotoxin deoxynivalenol: histopathological analysis. | 2009 | Toxicol In Vitro | pmid:19607908 |
| Alm H et al. | The influence of the mycotoxins deoxynivalenol and zearalenol on in vitro maturation of pig oocytes and in vitro culture of pig zygotes. | 2002 | Toxicol In Vitro | pmid:12423645 |
| Fink-Gremmels J | [An alternative view. Mycotoxins and mycoses]. | 2001 | Tijdschr Diergeneeskd | pmid:11285646 |
| Cortinovis C et al. | Effects of fumonisin B1 alone and combined with deoxynivalenol or zearalenone on porcine granulosa cell proliferation and steroid production. | 2014 | Theriogenology | pmid:24576714 |
| Schoevers EJ et al. | Porcine oocytes are most vulnerable to the mycotoxin deoxynivalenol during formation of the meiotic spindle. | 2010 | Theriogenology | pmid:20570324 |
| Navara S and Smith KP | Using near-isogenic barley lines to validate deoxynivalenol (DON) QTL previously identified through association analysis. | 2014 | Theor. Appl. Genet. | pmid:24343199 |
| Ansari KI et al. | Retrotransposon and gene activation in wheat in response to mycotoxigenic and non-mycotoxigenic-associated Fusarium stress. | 2007 | Theor. Appl. Genet. | pmid:17256175 |
| Burt C et al. | Mapping a Type 1 FHB resistance on chromosome 4AS of Triticum macha and deployment in combination with two Type 2 resistances. | 2015 | Theor. Appl. Genet. | pmid:26040404 |
| Jiang GL et al. | QTL analysis of resistance to Fusarium head blight in the novel wheat germplasm CJ 9306. II. Resistance to deoxynivalenol accumulation and grain yield loss. | 2007 | Theor. Appl. Genet. | pmid:17726598 |