Vomitoxin

Vomitoxin is a lipid of Prenol Lipids (PR) class. Vomitoxin is associated with abnormalities such as Infection and Gastroenteritis. The involved functions are known as mRNA Expression, Inflammation, Transcription, Genetic, Protein Biosynthesis and Adverse effects. Vomitoxin often locates in Lymphoid Tissue, Immune system, Bone Marrow and Plasma membrane. The associated genes with Vomitoxin are IMPACT gene, HIST1H1C gene and RBM39 gene. The related experimental models are Mouse Model.

Cross Reference

Introduction

To understand associated biological information of Vomitoxin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Vomitoxin?

Vomitoxin is suspected in Infection, Gastroenteritis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Vomitoxin

MeSH term MeSH ID Detail
Kashin-Beck Disease D057767 2 associated lipids
Fetal Weight D020567 12 associated lipids
Coronavirus Infections D018352 4 associated lipids
Adrenocortical Carcinoma D018268 4 associated lipids
Mycotoxicosis D015651 5 associated lipids
Weight Loss D015431 56 associated lipids
Weight Gain D015430 101 associated lipids
Thymus Neoplasms D013953 15 associated lipids
Swine Diseases D013553 16 associated lipids
Stomach Neoplasms D013274 24 associated lipids
Splenic Diseases D013158 5 associated lipids
Precancerous Conditions D011230 48 associated lipids
Poultry Diseases D011201 21 associated lipids
Obesity D009765 29 associated lipids
Mycoses D009181 18 associated lipids
Inflammation D007249 119 associated lipids
Immune Complex Diseases D007105 9 associated lipids
Hyperplasia D006965 34 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hemolysis D006461 131 associated lipids
Per page 10 20 50 | Total 29

PubChem Associated disorders and diseases

What pathways are associated with Vomitoxin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Vomitoxin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Vomitoxin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Vomitoxin?

There are no associated biomedical information in the current reference collection.

What genes are associated with Vomitoxin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Vomitoxin?

Mouse Model

Mouse Model are used in the study 'Dietary fish oil suppresses experimental immunoglobulin a nephropathy in mice.' (Pestka JJ et al., 2002).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with Vomitoxin

Download all related citations
Per page 10 20 50 100 | Total 1588
Authors Title Published Journal PubMed Link
Brera C et al. Exposure assessment for Italian population groups to deoxynivalenol deriving from pasta consumption. 2013 Toxins (Basel) pmid:24287568
Basso K et al. Deoxynivanelol and fumonisin, alone or in combination, induce changes on intestinal junction complexes and in E-cadherin expression. 2013 Toxins (Basel) pmid:24287571
Drakulic J et al. Contrasting Roles of Deoxynivalenol and Nivalenol in Host-Mediated Interactions between Fusarium graminearum and Sitobion avenae. 2016 Toxins (Basel) pmid:27916862
Alizadeh A et al. Deoxynivalenol and Its Modified Forms: Are There Major Differences? 2016 Toxins (Basel) pmid:27854268
Tian Y et al. Detoxification of Deoxynivalenol via Glycosylation Represents Novel Insights on Antagonistic Activities of Trichoderma when Confronted with Fusarium graminearum. 2016 Toxins (Basel) pmid:27854265
Uhlig S et al. Glutathione-Conjugates of Deoxynivalenol in Naturally Contaminated Grain Are Primarily Linked via the Epoxide Group. 2016 Toxins (Basel) pmid:27845722
Audenaert K et al. Deoxynivalenol: a major player in the multifaceted response of Fusarium to its environment. 2014 Toxins (Basel) pmid:24451843
Giménez I et al. Effects of bread making and wheat germ addition on the natural deoxynivalenol content in bread. 2014 Toxins (Basel) pmid:24451845
Fruhmann P et al. Stereoselective Luche reduction of deoxynivalenol and three of its acetylated derivatives at C8. 2014 Toxins (Basel) pmid:24434906
Wiwart M et al. The Response of Selected Triticum spp. Genotypes with Different Ploidy Levels to Head Blight Caused by Fusarium culmorum (W.G.Smith) Sacc. 2016 Toxins (Basel) pmid:27092526
Sanders M et al. Comparison of Enzyme-Linked Immunosorbent Assay, Surface Plasmon Resonance and Biolayer Interferometry for Screening of Deoxynivalenol in Wheat and Wheat Dust. 2016 Toxins (Basel) pmid:27077883
Suzuki T and Iwahashi Y Acetylated Deoxynivalenol Generates Differences of Gene Expression that Discriminate Trichothecene Toxicity. 2016 Toxins (Basel) pmid:26861396
Goossens J et al. Influence of mycotoxins and a mycotoxin adsorbing agent on the oral bioavailability of commonly used antibiotics in pigs. 2012 Toxins (Basel) pmid:22606377
Generotti S et al. Deoxynivalenol & Deoxynivalenol-3-Glucoside Mitigation through Bakery Production Strategies: Effective Experimental Design within Industrial Rusk-Making Technology. 2015 Toxins (Basel) pmid:26213969
Michlmayr H et al. Biochemical Characterization of a Recombinant UDP-glucosyltransferase from Rice and Enzymatic Production of Deoxynivalenol-3-O-β-D-glucoside. 2015 Toxins (Basel) pmid:26197338
Alizadeh A et al. Deoxynivalenol Impairs Weight Gain and Affects Markers of Gut Health after Low-Dose, Short-Term Exposure of Growing Pigs. 2015 Toxins (Basel) pmid:26067367
Hassan YI et al. A novel Peptide-binding motifs inference approach to understand deoxynivalenol molecular toxicity. 2015 Toxins (Basel) pmid:26043274
Zhou HR et al. Direct activation of ribosome-associated double-stranded RNA-dependent protein kinase (PKR) by deoxynivalenol, anisomycin and ricin: a new model for ribotoxic stress response induction. 2014 Toxins (Basel) pmid:25521494
Pietsch C et al. Occurrence of deoxynivalenol and zearalenone in commercial fish feed: an initial study. 2013 Toxins (Basel) pmid:23325300
Mesterházy A et al. Role of fungicides, application of nozzle types, and the resistance level of wheat varieties in the control of Fusarium head blight and deoxynivalenol. 2011 Toxins (Basel) pmid:22174980
Streit E et al. Current situation of mycotoxin contamination and co-occurrence in animal feed--focus on Europe. 2012 Toxins (Basel) pmid:23162698
Njobeh PB et al. Estimation of multi-mycotoxin contamination in South African compound feeds. 2012 Toxins (Basel) pmid:23162700
Gajęcka M et al. The expression of type-1 and type-2 nitric oxide synthase in selected tissues of the gastrointestinal tract during mixed mycotoxicosis. 2013 Toxins (Basel) pmid:24284830
Awad W et al. The toxicological impacts of the Fusarium mycotoxin, deoxynivalenol, in poultry flocks with special reference to immunotoxicity. 2013 Toxins (Basel) pmid:23628787
Maresca M From the gut to the brain: journey and pathophysiological effects of the food-associated trichothecene mycotoxin deoxynivalenol. 2013 Toxins (Basel) pmid:23612752
Subramaniam R and Rampitsch C Towards systems biology of mycotoxin regulation. 2013 Toxins (Basel) pmid:23598563
Weaver AC et al. Protective effect of two yeast based feed additives on pigs chronically exposed to deoxynivalenol and zearalenone. 2014 Toxins (Basel) pmid:25533517
Kim DH et al. Incidence and levels of deoxynivalenol, fumonisins and zearalenone contaminants in animal feeds used in Korea in 2012. 2014 Toxins (Basel) pmid:24366207
Ivanova L et al. Cytotoxicity of enniatins A, A1, B, B1, B2 and B3 from Fusarium avenaceum. 2006 Toxicon pmid:16730043
Abbas HK et al. Cytotoxicity and phytotoxicity of trichothecene mycotoxins produced by Fusarium spp. 2013 Toxicon pmid:23933195
Luongo D et al. Effects of four Fusarium toxins (fumonisin B(1), alpha-zearalenol, nivalenol and deoxynivalenol) on porcine whole-blood cellular proliferation. 2008 Toxicon pmid:18620720
Ruiz MJ et al. Toxicological interactions between the mycotoxins beauvericin, deoxynivalenol and T-2 toxin in CHO-K1 cells in vitro. 2011 Toxicon pmid:21821061
Ficheux AS et al. Co-exposure of Fusarium mycotoxins: in vitro myelotoxicity assessment on human hematopoietic progenitors. 2012 Toxicon pmid:22921581
Gajęcka M et al. Changes in the metabolic profile and body weight of pre-pubertal gilts during prolonged monotonic exposure to low doses of zearalenone and deoxynivalenol. 2017 Toxicon pmid:27840141
Ji J et al. GC-TOF/MS-based metabolomic strategy for combined toxicity effects of deoxynivalenol and zearalenone on murine macrophage ANA-1 cells. 2016 Toxicon pmid:27530666
Albonico M et al. Toxicological effects of fumonisin B1 alone and in combination with other fusariotoxins on bovine granulosa cells. 2016 Toxicon pmid:27108238
Pizzo F et al. In vitro effects of deoxynivalenol and zearalenone major metabolites alone and combined, on cell proliferation, steroid production and gene expression in bovine small-follicle granulosa cells. 2016 Toxicon pmid:26657070
Ueno Y et al. Examination of Chinese and U.S.S.R. cereals for the Fusarium mycotoxins, nivalenol, deoxynivalenol and zearalenone. 1986 Toxicon pmid:2944249
Dinu D et al. Adapted response of the antioxidant defense system to oxidative stress induced by deoxynivalenol in Hek-293 cells. 2011 Toxicon pmid:21549142
Lucioli J et al. The food contaminant deoxynivalenol activates the mitogen activated protein kinases in the intestine: interest of ex vivo models as an alternative to in vivo experiments. 2013 Toxicon pmid:23403092
Caloni F et al. Effects of a trichothecene, T-2 toxin, on proliferation and steroid production by porcine granulosa cells. 2009 Toxicon pmid:19463844
Sun LH et al. Individual and combined cytotoxic effects of aflatoxin B1, zearalenone, deoxynivalenol and fumonisin B1 on BRL 3A rat liver cells. 2015 Toxicon pmid:25549941
Zhang X et al. The role of oxidative stress in deoxynivalenol-induced DNA damage in HepG2 cells. 2009 Toxicon pmid:19486909
Luongo D et al. Trichothecenes NIV and DON modulate the maturation of murine dendritic cells. 2010 Toxicon pmid:19635492
Kouadio JH et al. Effects of combinations of Fusarium mycotoxins on the inhibition of macromolecular synthesis, malondialdehyde levels, DNA methylation and fragmentation, and viability in Caco-2 cells. 2007 Toxicon pmid:17109910
Zielonka Ł et al. The effect of environmental mycotoxins on selected ovarian tissue fragments of multiparous female wild boars at the beginning of astronomical winter. 2014 Toxicon pmid:25016169
Bensassi F et al. In vitro investigation of toxicological interactions between the fusariotoxins deoxynivalenol and zearalenone. 2014 Toxicon pmid:24680766
Chung YJ et al. Up-regulation of macrophage inflammatory protein-2 and complement 3A receptor by the trichothecenes deoxynivalenol and satratoxin G. 2003 Toxicology pmid:12604170
Greene DM et al. Vomitoxin (deoxynivalenol)-induced IgA nephropathy in the B6C3F1 mouse: dose response and male predilection. 1994 Toxicology pmid:7940564
Savard C et al. Prevention of deoxynivalenol- and zearalenone-associated oxidative stress does not restore MA-10 Leydig cell functions. 2016 Toxicology pmid:26783879
Yang GH and Pestka JJ Vomitoxin (deoxynivalenol)-mediated inhibition of nuclear protein binding to NRE-A, an IL-2 promoter negative regulatory element, in EL-4 cells. 2002 Toxicology pmid:11893416
Ouyang YL et al. Effects of trichothecene structure on cytokine secretion and gene expression in murine CD4+ T-cells. 1995 Toxicology pmid:8560498
Instanes C and Hetland G Deoxynivalenol (DON) is toxic to human colonic, lung and monocytic cell lines, but does not increase the IgE response in a mouse model for allergy. 2004 Toxicology pmid:15369845
Yang H et al. Ribotoxic mycotoxin deoxynivalenol induces G2/M cell cycle arrest via p21Cip/WAF1 mRNA stabilization in human epithelial cells. 2008 Toxicology pmid:18006205
Königs M et al. Cytotoxicity, metabolism and cellular uptake of the mycotoxin deoxynivalenol in human proximal tubule cells and lung fibroblasts in primary culture. 2007 Toxicology pmid:17825972
Yan D et al. Potential role for IL-5 and IL-6 in enhanced IgA secretion by Peyer's patch cells isolated from mice acutely exposed to vomitoxin. 1997 Toxicology pmid:9274810
Amuzie CJ et al. Tissue distribution and proinflammatory cytokine induction by the trichothecene deoxynivalenol in the mouse: comparison of nasal vs. oral exposure. 2008 Toxicology pmid:18433975
Ji GE et al. Modulation of nitric oxide, hydrogen peroxide and cytokine production in a clonal macrophage model by the trichothecene vomitoxin (deoxynivalenol). 1998 Toxicology pmid:9570333
Pestka JJ et al. Induction of apoptosis and cytokine production in the Jurkat human T cells by deoxynivalenol: role of mitogen-activated protein kinases and comparison to other 8-ketotrichothecenes. 2005 Toxicology pmid:15588914
Kouadio JH et al. Comparative study of cytotoxicity and oxidative stress induced by deoxynivalenol, zearalenone or fumonisin B1 in human intestinal cell line Caco-2. 2005 Toxicology pmid:16019124
Mikami O et al. Porcine hepatocyte apoptosis and reduction of albumin secretion induced by deoxynivalenol. 2004 Toxicology pmid:15388250
Flannery BM et al. Evaluation of insulin-like growth factor acid-labile subunit as a potential biomarker of effect for deoxynivalenol-induced proinflammatory cytokine expression. 2013 Toxicology pmid:23298694
Wong S et al. Superinduction of TNF-alpha and IL-6 in macrophages by vomitoxin (deoxynivalenol) modulated by mRNA stabilization. 2001 Toxicology pmid:11295263
Waché YJ et al. The mycotoxin deoxynivalenol inhibits the cell surface expression of activation markers in human macrophages. 2009 Toxicology pmid:19549553
Schultze N et al. Mitochondrial functions of THP-1 monocytes following the exposure to selected natural compounds. 2017 Toxicology pmid:28013001
Bensassi F et al. Pathway of deoxynivalenol-induced apoptosis in human colon carcinoma cells. 2009 Toxicology pmid:19664677
Robbana-Barnat S et al. Immunosuppressive properties of deoxynivalenol. 1988 Toxicology pmid:3257592
Zhou HR et al. Rapid, sequential activation of mitogen-activated protein kinases and transcription factors precedes proinflammatory cytokine mRNA expression in spleens of mice exposed to the trichothecene vomitoxin. 2003 Toxicol. Sci. pmid:12604842
Moon Y and Pestka JJ Vomitoxin-induced cyclooxygenase-2 gene expression in macrophages mediated by activation of ERK and p38 but not JNK mitogen-activated protein kinases. 2002 Toxicol. Sci. pmid:12377986
Bae H et al. Hematopoietic cell kinase associates with the 40S ribosomal subunit and mediates the ribotoxic stress response to deoxynivalenol in mononuclear phagocytes. 2010 Toxicol. Sci. pmid:20181660
Bae HK and Pestka JJ Deoxynivalenol induces p38 interaction with the ribosome in monocytes and macrophages. 2008 Toxicol. Sci. pmid:18502741
Gray JS et al. Double-stranded RNA-activated protein kinase mediates induction of interleukin-8 expression by deoxynivalenol, Shiga toxin 1, and ricin in monocytes. 2008 Toxicol. Sci. pmid:18599499
Pan X et al. Dynamic changes in ribosome-associated proteome and phosphoproteome during deoxynivalenol-induced translation inhibition and ribotoxic stress. 2014 Toxicol. Sci. pmid:24284785
Zhou HR et al. Lipopolysaccharide and the trichothecene vomitoxin (deoxynivalenol) synergistically induce apoptosis in murine lymphoid organs. 2000 Toxicol. Sci. pmid:10696773
Girardet C et al. Central inflammation and sickness-like behavior induced by the food contaminant deoxynivalenol: a PGE2-independent mechanism. 2011 Toxicol. Sci. pmid:21873375
Wu W et al. Role of cholecystokinin in anorexia induction following oral exposure to the 8-ketotrichothecenes deoxynivalenol, 15-acetyldeoxynivalenol, 3-acetyldeoxynivalenol, fusarenon X, and nivalenol. 2014 Toxicol. Sci. pmid:24385417
Park SH et al. Chronic Nod2 stimulation potentiates activating transcription factor 3 and paradoxical superinduction of epithelial proinflammatory chemokines by mucoactive ribotoxic stressors via RNA-binding protein human antigen R. 2012 Toxicol. Sci. pmid:22003189
Wu W et al. Comparison of emetic potencies of the 8-ketotrichothecenes deoxynivalenol, 15-acetyldeoxynivalenol, 3-acetyldeoxynivalenol, fusarenon X, and nivalenol. 2013 Toxicol. Sci. pmid:22997060
Flannery BM et al. Anorexia induction by the trichothecene deoxynivalenol (vomitoxin) is mediated by the release of the gut satiety hormone peptide YY. 2012 Toxicol. Sci. pmid:22903826
Gray JS and Pestka JJ Transcriptional regulation of deoxynivalenol-induced IL-8 expression in human monocytes. 2007 Toxicol. Sci. pmid:17636245
Zhou HR and Pestka JJ Deoxynivalenol (Vomitoxin)-Induced Cholecystokinin and Glucagon-Like Peptide-1 Release in the STC-1 Enteroendocrine Cell Model Is Mediated by Calcium-Sensing Receptor and Transient Receptor Potential Ankyrin-1 Channel. 2015 Toxicol. Sci. pmid:25787141
Wang X et al. JAK/STAT pathway plays a critical role in the proinflammatory gene expression and apoptosis of RAW264.7 cells induced by trichothecenes as DON and T-2 toxin. 2012 Toxicol. Sci. pmid:22454431
He K et al. Targets and intracellular signaling mechanisms for deoxynivalenol-induced ribosomal RNA cleavage. 2012 Toxicol. Sci. pmid:22491426
Wu W et al. Comparison of anorectic and emetic potencies of deoxynivalenol (vomitoxin) to the plant metabolite deoxynivalenol-3-glucoside and synthetic deoxynivalenol derivatives EN139528 and EN139544. 2014 Toxicol. Sci. pmid:25173790
Zhou HR et al. Ribotoxic stress response to the trichothecene deoxynivalenol in the macrophage involves the SRC family kinase Hck. 2005 Toxicol. Sci. pmid:15772366
Pinton P et al. Toxicity of deoxynivalenol and its acetylated derivatives on the intestine: differential effects on morphology, barrier function, tight junction proteins, and mitogen-activated protein kinases. 2012 Toxicol. Sci. pmid:22859312
Wu W et al. Peptide YY3-36 and 5-hydroxytryptamine mediate emesis induction by trichothecene deoxynivalenol (vomitoxin). 2013 Toxicol. Sci. pmid:23457120
Pan X et al. Early phosphoproteomic changes in the mouse spleen during deoxynivalenol-induced ribotoxic stress. 2013 Toxicol. Sci. pmid:23811945
Shi Y et al. Role of GRP78/BiP degradation and ER stress in deoxynivalenol-induced interleukin-6 upregulation in the macrophage. 2009 Toxicol. Sci. pmid:19336499
Zhou HR et al. Induction of competing apoptotic and survival signaling pathways in the macrophage by the ribotoxic trichothecene deoxynivalenol. 2005 Toxicol. Sci. pmid:15976193
Li M et al. Modulation of murine host response to enteric reovirus infection by the trichothecene deoxynivalenol. 2005 Toxicol. Sci. pmid:15958657
Burger HM et al. Development and evaluation of a sensitive mycotoxin risk assessment model (MYCORAM). 2014 Toxicol. Sci. pmid:24980263
Amuzie CJ et al. Induction of suppressors of cytokine signaling by the trichothecene deoxynivalenol in the mouse. 2009 Toxicol. Sci. pmid:19625342
Li M et al. Deoxynivalenol exacerbates viral bronchopneumonia induced by respiratory reovirus infection. 2007 Toxicol. Sci. pmid:17090620
Zhou HR et al. Role of double-stranded RNA-activated protein kinase R (PKR) in deoxynivalenol-induced ribotoxic stress response. 2003 Toxicol. Sci. pmid:12773753
Islam Z and Pestka JJ Role of IL-1(beta) in endotoxin potentiation of deoxynivalenol-induced corticosterone response and leukocyte apoptosis in mice. 2003 Toxicol. Sci. pmid:12773775
Voss KA A new perspective on deoxynivalenol and growth suppression. 2010 Toxicol. Sci. pmid:19933702
Pestka J and Zhou HR Toll-like receptor priming sensitizes macrophages to proinflammatory cytokine gene induction by deoxynivalenol and other toxicants. 2006 Toxicol. Sci. pmid:16687389
Amuzie CJ and Pestka JJ Suppression of insulin-like growth factor acid-labile subunit expression--a novel mechanism for deoxynivalenol-induced growth retardation. 2010 Toxicol. Sci. pmid:19805407
He K et al. Modulation of inflammatory gene expression by the ribotoxin deoxynivalenol involves coordinate regulation of the transcriptome and translatome. 2013 Toxicol. Sci. pmid:22968694