| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Esophageal Neoplasms | D004938 | 20 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Stomach Neoplasms | D013274 | 24 associated lipids |
| Hematuria | D006417 | 13 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Obesity | D009765 | 29 associated lipids |
Vomitoxin
Vomitoxin is a lipid of Prenol Lipids (PR) class. Vomitoxin is associated with abnormalities such as Infection and Gastroenteritis. The involved functions are known as mRNA Expression, Inflammation, Transcription, Genetic, Protein Biosynthesis and Adverse effects. Vomitoxin often locates in Lymphoid Tissue, Immune system, Bone Marrow and Plasma membrane. The associated genes with Vomitoxin are IMPACT gene, HIST1H1C gene and RBM39 gene. The related experimental models are Mouse Model.
Cross Reference
Introduction
To understand associated biological information of Vomitoxin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Vomitoxin?
Vomitoxin is suspected in Infection, Gastroenteritis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Vomitoxin
PubChem Associated disorders and diseases
What pathways are associated with Vomitoxin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Vomitoxin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Vomitoxin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Vomitoxin?
There are no associated biomedical information in the current reference collection.
What genes are associated with Vomitoxin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Vomitoxin?
Mouse Model
Mouse Model are used in the study 'Dietary fish oil suppresses experimental immunoglobulin a nephropathy in mice.' (Pestka JJ et al., 2002).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Vomitoxin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zhou HR et al. | Rapid, sequential activation of mitogen-activated protein kinases and transcription factors precedes proinflammatory cytokine mRNA expression in spleens of mice exposed to the trichothecene vomitoxin. | 2003 | Toxicol. Sci. | pmid:12604842 |
| Bae H et al. | Hematopoietic cell kinase associates with the 40S ribosomal subunit and mediates the ribotoxic stress response to deoxynivalenol in mononuclear phagocytes. | 2010 | Toxicol. Sci. | pmid:20181660 |
| Bae HK and Pestka JJ | Deoxynivalenol induces p38 interaction with the ribosome in monocytes and macrophages. | 2008 | Toxicol. Sci. | pmid:18502741 |
| Pan X et al. | Dynamic changes in ribosome-associated proteome and phosphoproteome during deoxynivalenol-induced translation inhibition and ribotoxic stress. | 2014 | Toxicol. Sci. | pmid:24284785 |
| Zhou HR et al. | Lipopolysaccharide and the trichothecene vomitoxin (deoxynivalenol) synergistically induce apoptosis in murine lymphoid organs. | 2000 | Toxicol. Sci. | pmid:10696773 |
| Girardet C et al. | Central inflammation and sickness-like behavior induced by the food contaminant deoxynivalenol: a PGE2-independent mechanism. | 2011 | Toxicol. Sci. | pmid:21873375 |
| Wu W et al. | Role of cholecystokinin in anorexia induction following oral exposure to the 8-ketotrichothecenes deoxynivalenol, 15-acetyldeoxynivalenol, 3-acetyldeoxynivalenol, fusarenon X, and nivalenol. | 2014 | Toxicol. Sci. | pmid:24385417 |
| Flannery BM et al. | Anorexia induction by the trichothecene deoxynivalenol (vomitoxin) is mediated by the release of the gut satiety hormone peptide YY. | 2012 | Toxicol. Sci. | pmid:22903826 |
| Gray JS and Pestka JJ | Transcriptional regulation of deoxynivalenol-induced IL-8 expression in human monocytes. | 2007 | Toxicol. Sci. | pmid:17636245 |
| Zhou HR and Pestka JJ | Deoxynivalenol (Vomitoxin)-Induced Cholecystokinin and Glucagon-Like Peptide-1 Release in the STC-1 Enteroendocrine Cell Model Is Mediated by Calcium-Sensing Receptor and Transient Receptor Potential Ankyrin-1 Channel. | 2015 | Toxicol. Sci. | pmid:25787141 |
| He K et al. | Targets and intracellular signaling mechanisms for deoxynivalenol-induced ribosomal RNA cleavage. | 2012 | Toxicol. Sci. | pmid:22491426 |
| Zhou HR et al. | Ribotoxic stress response to the trichothecene deoxynivalenol in the macrophage involves the SRC family kinase Hck. | 2005 | Toxicol. Sci. | pmid:15772366 |
| Wu W et al. | Peptide YY3-36 and 5-hydroxytryptamine mediate emesis induction by trichothecene deoxynivalenol (vomitoxin). | 2013 | Toxicol. Sci. | pmid:23457120 |
| Pan X et al. | Early phosphoproteomic changes in the mouse spleen during deoxynivalenol-induced ribotoxic stress. | 2013 | Toxicol. Sci. | pmid:23811945 |
| Shi Y et al. | Role of GRP78/BiP degradation and ER stress in deoxynivalenol-induced interleukin-6 upregulation in the macrophage. | 2009 | Toxicol. Sci. | pmid:19336499 |
| Burger HM et al. | Development and evaluation of a sensitive mycotoxin risk assessment model (MYCORAM). | 2014 | Toxicol. Sci. | pmid:24980263 |
| Amuzie CJ et al. | Induction of suppressors of cytokine signaling by the trichothecene deoxynivalenol in the mouse. | 2009 | Toxicol. Sci. | pmid:19625342 |
| Li M et al. | Deoxynivalenol exacerbates viral bronchopneumonia induced by respiratory reovirus infection. | 2007 | Toxicol. Sci. | pmid:17090620 |
| Islam Z and Pestka JJ | Role of IL-1(beta) in endotoxin potentiation of deoxynivalenol-induced corticosterone response and leukocyte apoptosis in mice. | 2003 | Toxicol. Sci. | pmid:12773775 |
| Pestka J and Zhou HR | Toll-like receptor priming sensitizes macrophages to proinflammatory cytokine gene induction by deoxynivalenol and other toxicants. | 2006 | Toxicol. Sci. | pmid:16687389 |
| He K et al. | Modulation of inflammatory gene expression by the ribotoxin deoxynivalenol involves coordinate regulation of the transcriptome and translatome. | 2013 | Toxicol. Sci. | pmid:22968694 |
| Chung YJ et al. | Up-regulation of macrophage inflammatory protein-2 and complement 3A receptor by the trichothecenes deoxynivalenol and satratoxin G. | 2003 | Toxicology | pmid:12604170 |
| Greene DM et al. | Vomitoxin (deoxynivalenol)-induced IgA nephropathy in the B6C3F1 mouse: dose response and male predilection. | 1994 | Toxicology | pmid:7940564 |
| Savard C et al. | Prevention of deoxynivalenol- and zearalenone-associated oxidative stress does not restore MA-10 Leydig cell functions. | 2016 | Toxicology | pmid:26783879 |
| Yang GH and Pestka JJ | Vomitoxin (deoxynivalenol)-mediated inhibition of nuclear protein binding to NRE-A, an IL-2 promoter negative regulatory element, in EL-4 cells. | 2002 | Toxicology | pmid:11893416 |
| Ouyang YL et al. | Effects of trichothecene structure on cytokine secretion and gene expression in murine CD4+ T-cells. | 1995 | Toxicology | pmid:8560498 |
| Instanes C and Hetland G | Deoxynivalenol (DON) is toxic to human colonic, lung and monocytic cell lines, but does not increase the IgE response in a mouse model for allergy. | 2004 | Toxicology | pmid:15369845 |
| Yang H et al. | Ribotoxic mycotoxin deoxynivalenol induces G2/M cell cycle arrest via p21Cip/WAF1 mRNA stabilization in human epithelial cells. | 2008 | Toxicology | pmid:18006205 |
| Königs M et al. | Cytotoxicity, metabolism and cellular uptake of the mycotoxin deoxynivalenol in human proximal tubule cells and lung fibroblasts in primary culture. | 2007 | Toxicology | pmid:17825972 |
| Yan D et al. | Potential role for IL-5 and IL-6 in enhanced IgA secretion by Peyer's patch cells isolated from mice acutely exposed to vomitoxin. | 1997 | Toxicology | pmid:9274810 |
| Amuzie CJ et al. | Tissue distribution and proinflammatory cytokine induction by the trichothecene deoxynivalenol in the mouse: comparison of nasal vs. oral exposure. | 2008 | Toxicology | pmid:18433975 |
| Ji GE et al. | Modulation of nitric oxide, hydrogen peroxide and cytokine production in a clonal macrophage model by the trichothecene vomitoxin (deoxynivalenol). | 1998 | Toxicology | pmid:9570333 |
| Pestka JJ et al. | Induction of apoptosis and cytokine production in the Jurkat human T cells by deoxynivalenol: role of mitogen-activated protein kinases and comparison to other 8-ketotrichothecenes. | 2005 | Toxicology | pmid:15588914 |
| Kouadio JH et al. | Comparative study of cytotoxicity and oxidative stress induced by deoxynivalenol, zearalenone or fumonisin B1 in human intestinal cell line Caco-2. | 2005 | Toxicology | pmid:16019124 |
| Mikami O et al. | Porcine hepatocyte apoptosis and reduction of albumin secretion induced by deoxynivalenol. | 2004 | Toxicology | pmid:15388250 |
| Flannery BM et al. | Evaluation of insulin-like growth factor acid-labile subunit as a potential biomarker of effect for deoxynivalenol-induced proinflammatory cytokine expression. | 2013 | Toxicology | pmid:23298694 |
| Wong S et al. | Superinduction of TNF-alpha and IL-6 in macrophages by vomitoxin (deoxynivalenol) modulated by mRNA stabilization. | 2001 | Toxicology | pmid:11295263 |
| Waché YJ et al. | The mycotoxin deoxynivalenol inhibits the cell surface expression of activation markers in human macrophages. | 2009 | Toxicology | pmid:19549553 |
| Schultze N et al. | Mitochondrial functions of THP-1 monocytes following the exposure to selected natural compounds. | 2017 | Toxicology | pmid:28013001 |
| Bensassi F et al. | Pathway of deoxynivalenol-induced apoptosis in human colon carcinoma cells. | 2009 | Toxicology | pmid:19664677 |
| Robbana-Barnat S et al. | Immunosuppressive properties of deoxynivalenol. | 1988 | Toxicology | pmid:3257592 |
| Ruiz MJ et al. | Toxicological interactions between the mycotoxins beauvericin, deoxynivalenol and T-2 toxin in CHO-K1 cells in vitro. | 2011 | Toxicon | pmid:21821061 |
| Ficheux AS et al. | Co-exposure of Fusarium mycotoxins: in vitro myelotoxicity assessment on human hematopoietic progenitors. | 2012 | Toxicon | pmid:22921581 |
| Ji J et al. | GC-TOF/MS-based metabolomic strategy for combined toxicity effects of deoxynivalenol and zearalenone on murine macrophage ANA-1 cells. | 2016 | Toxicon | pmid:27530666 |
| Ueno Y et al. | Examination of Chinese and U.S.S.R. cereals for the Fusarium mycotoxins, nivalenol, deoxynivalenol and zearalenone. | 1986 | Toxicon | pmid:2944249 |
| Dinu D et al. | Adapted response of the antioxidant defense system to oxidative stress induced by deoxynivalenol in Hek-293 cells. | 2011 | Toxicon | pmid:21549142 |
| Sun LH et al. | Individual and combined cytotoxic effects of aflatoxin B1, zearalenone, deoxynivalenol and fumonisin B1 on BRL 3A rat liver cells. | 2015 | Toxicon | pmid:25549941 |
| Luongo D et al. | Trichothecenes NIV and DON modulate the maturation of murine dendritic cells. | 2010 | Toxicon | pmid:19635492 |
| Zielonka Å et al. | The effect of environmental mycotoxins on selected ovarian tissue fragments of multiparous female wild boars at the beginning of astronomical winter. | 2014 | Toxicon | pmid:25016169 |
| Bensassi F et al. | In vitro investigation of toxicological interactions between the fusariotoxins deoxynivalenol and zearalenone. | 2014 | Toxicon | pmid:24680766 |