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Ultra-low gossypol cottonseed: generational stability of the seed-specific, RNAi-mediated phenotype and resumption of terpenoid profile following seed germination. |
2012 |
Plant Biotechnol. J. |
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An T et al. |
Amino acid derivatives of the (-) enantiomer of gossypol are effective fusion inhibitors of human immunodeficiency virus type 1. |
2012 |
Antiviral Res. |
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Tao XY et al. |
Gossypol-enhanced P450 gene pool contributes to cotton bollworm tolerance to a pyrethroid insecticide. |
2012 |
Mol. Ecol. |
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Hemigossypol, a constituent in developing glanded cottonseed (Gossypium hirsutum). |
2012 |
J. Agric. Food Chem. |
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Pretreatment with AT-101 enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis of breast cancer cells by inducing death receptors 4 and 5 protein levels. |
2012 |
J. Cancer Res. Clin. Oncol. |
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Bodur C and Basaga H |
Bcl-2 inhibitors: emerging drugs in cancer therapy. |
2012 |
Curr. Med. Chem. |
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Hsiao WT et al. |
Involvement of Smac, p53, and caspase pathways in induction of apoptosis by gossypol in human retinoblastoma cells. |
2012 |
Mol. Vis. |
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Impact of antinutritional factors in food proteins on the digestibility of protein and the bioavailability of amino acids and on protein quality. |
2012 |
Br. J. Nutr. |
pmid:23107545
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Vshivkov S et al. |
Capillary electrophoresis to quantitate gossypol enantiomers in cotton flower petals and seed. |
2012 |
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. |
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Zbidah M et al. |
Gossypol-induced suicidal erythrocyte death. |
2012 |
Toxicology |
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Small molecule inhibition of the steroid receptor coactivators, SRC-3 and SRC-1. |
2011 |
Mol. Endocrinol. |
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Double-blind, placebo-controlled, randomized phase 2 study of the proapoptotic agent AT-101 plus docetaxel, in second-line non-small cell lung cancer. |
2011 |
J Thorac Oncol |
pmid:21289522
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[Gossypol decreases the expression of connexin 43 in Sertoli cells]. |
2011 |
Zhonghua Nan Ke Xue |
pmid:22141269
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Fitness cost of resistance to Bt cotton linked with increased gossypol content in pink bollworm larvae. |
2011 |
PLoS ONE |
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Chang Q et al. |
Drug synergistic antifertility effect of combined administration of low-dose gossypol with steroid hormones in rats. |
2011 |
Chin. Med. J. |
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Gunassekaran GR et al. |
In vitro and in vivo studies on antitumor effects of gossypol on human stomach adenocarcinoma (AGS) cell line and MNNG induced experimental gastric cancer. |
2011 |
Biochem. Biophys. Res. Commun. |
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Novel O-glycosidic gossypol isomers and their bioactivities. |
2011 |
Carbohydr. Res. |
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Ouyang DY et al. |
Valproic acid synergistically enhances the cytotoxicity of gossypol in DU145 prostate cancer cells: an iTRTAQ-based quantitative proteomic analysis. |
2011 |
J Proteomics |
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Liposomes containing (-)-gossypol-enriched cottonseed oil suppress Bcl-2 and Bcl-xL expression in breast cancer cells. |
2011 |
Pharm. Res. |
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Dash R et al. |
Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda-7/IL-24-mediated toxicity. |
2011 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:21555592
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Pang X et al. |
(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis. |
2011 |
Mol. Cancer Ther. |
pmid:21372225
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Guo Z et al. |
[Gossypol acetic acid induces DNA double-strand breaks in human mucoepidermoid carcinoma cell MEC-1]. |
2011 |
Sheng Li Xue Bao |
pmid:21505732
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Ma X et al. |
Environmental inhibitors of 11β-hydroxysteroid dehydrogenase type 2. |
2011 |
Toxicology |
pmid:21515335
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Mao YB et al. |
Cotton plants expressing CYP6AE14 double-stranded RNA show enhanced resistance to bollworms. |
2011 |
Transgenic Res. |
pmid:20953975
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Moon DO et al. |
Gossypol decreases tumor necrosis factor-α-induced intercellular adhesion molecule-1 expression via suppression of NF-κB activity. |
2011 |
Food Chem. Toxicol. |
pmid:21223991
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Inhibitory effects of gossypol-related compounds on growth of Aspergillus flavus. |
2011 |
Lett. Appl. Microbiol. |
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Evidence for a trianion intermediate in the metalation of 4-hydroxy-6,7-dimethoxy-8-methyl-2-naphthoic acid. Methodology and application to racemic 5,5'-didesisopropyl-5,5'-dialkylapogossypol derivatives. |
2011 |
J. Org. Chem. |
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Apogossypolone targets mitochondria and light enhances its anticancer activity by stimulating generation of singlet oxygen and reactive oxygen species. |
2011 |
Chin J Cancer |
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Baggstrom MQ et al. |
A phase II study of AT-101 (Gossypol) in chemotherapy-sensitive recurrent extensive-stage small cell lung cancer. |
2011 |
J Thorac Oncol |
pmid:21918390
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Mirabamides E-H, HIV-inhibitory depsipeptides from the sponge Stelletta clavosa. |
2011 |
J. Nat. Prod. |
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Suppression of jasmonic acid-dependent defense in cotton plant by the mealybug Phenacoccus solenopsis. |
2011 |
PLoS ONE |
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Lian J et al. |
A natural BH3 mimetic induces autophagy in apoptosis-resistant prostate cancer via modulating Bcl-2-Beclin1 interaction at endoplasmic reticulum. |
2011 |
Cell Death Differ. |
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Quercetin downregulates Mcl-1 by acting on mRNA stability and protein degradation. |
2011 |
Br. J. Cancer |
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Mechanisms of drug sensitization to TRA-8, an agonistic death receptor 5 antibody, involve modulation of the intrinsic apoptotic pathway in human breast cancer cells. |
2011 |
Mol. Cancer Res. |
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Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells. |
2011 |
J. Med. Chem. |
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Transcriptional responses underlying the hormetic and detrimental effects of the plant secondary metabolite gossypol on the generalist herbivore Helicoverpa armigera. |
2011 |
BMC Genomics |
pmid:22111916
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Akagunduz O et al. |
Radiosensitization of hormone-refractory prostate cancer cells by gossypol treatment. |
2010 Oct-Dec |
J BUON |
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[Synthesis, structures, and acute toxicity of gossypol nonsymmetrical aldehyde derivatives]. |
2010 May-Jun |
Bioorg. Khim. |
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A novel water-soluble gossypol derivative increases chemotherapeutic sensitivity and promotes growth inhibition in colon cancer. |
2010 |
J. Med. Chem. |
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Responses of three successive generations of beet armyworm, Spodoptera exigua, fed exclusively on different levels of gossypol in cotton leaves. |
2010 |
J. Insect Sci. |
pmid:21067414
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Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. |
2010 |
J. Med. Chem. |
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Involvement of Bcl-2, Src, and ERα in gossypol-mediated growth inhibition and apoptosis in human uterine leiomyoma and myometrial cells. |
2010 |
Acta Pharmacol. Sin. |
pmid:21102482
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Zhan WH et al. |
[Studies on the killing effect of gamma ray irradiated peripheral blood mononuclear cells combined with (-)-gossypol on human prostate cancer LNCaP cells]. |
2010 |
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi |
pmid:21319440
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AT-101, a pan-Bcl-2 inhibitor, leads to radiosensitization of non-small cell lung cancer. |
2010 |
J Thorac Oncol |
pmid:20354451
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Priyadarshi A et al. |
Structural insights into mouse anti-apoptotic Bcl-xl reveal affinity for Beclin 1 and gossypol. |
2010 |
Biochem. Biophys. Res. Commun. |
pmid:20206602
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Reddish JM et al. |
(-)-Gossypol containing hen sera and a myosin (-)-gossypol conjugate reduces the proliferation of MCF-7 cells. |
2010 |
Anticancer Res. |
pmid:20332451
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Banerjee S et al. |
Preclinical studies of apogossypolone, a novel pan inhibitor of bcl-2 and mcl-1, synergistically potentiates cytotoxic effect of gemcitabine in pancreatic cancer cells. |
2010 |
Pancreas |
pmid:19823097
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Zhang XQ et al. |
Inhibition of proliferation of prostate cancer cell line, PC-3, in vitro and in vivo using (-)-gossypol. |
2010 |
Asian J. Androl. |
pmid:20081872
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Liu YX |
Temperature control of spermatogenesis and prospect of male contraception. |
2010 |
Front Biosci (Schol Ed) |
pmid:20036980
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El-Sharaky AS et al. |
Spermatotoxicity, biochemical changes and histological alteration induced by gossypol in testicular and hepatic tissues of male rats. |
2010 |
Food Chem. Toxicol. |
pmid:20832445
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