Gossypol

Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.

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Introduction

To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Gossypol?

Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Gossypol

MeSH term MeSH ID Detail
Abnormalities, Drug-Induced D000014 10 associated lipids
Adenocarcinoma D000230 166 associated lipids
Body Weight D001835 333 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Cattle Diseases D002418 24 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Edema D004487 152 associated lipids
Endometriosis D004715 29 associated lipids
Genital Neoplasms, Male D005834 3 associated lipids
Per page 10 20 50 100 | Total 52

PubChem Associated disorders and diseases

What pathways are associated with Gossypol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Gossypol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Gossypol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Gossypol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Gossypol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Gossypol?

Xenograft Model

Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).

Transgenic Model

Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Gossypol

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Per page 10 20 50 100 | Total 1511
Authors Title Published Journal PubMed Link
Ke YB and Tso WW Variations of gossypol susceptibility in rat spermatozoa during spermatogenesis. 1982 Int. J. Fertil. pmid:6122656
Wichmann K et al. Inhibiting herpes simplex virus type 2 infection in human epithelial cells by gossypol, a potent spermicidal and contraceptive agent. 1982 Am. J. Obstet. Gynecol. pmid:6277198
Shu HD et al. [Effects of gossypol acetate on neuromuscular transmission (author's transl)]. 1982 Zhongguo Yao Li Xue Bao pmid:6283787
Hoshiai H et al. Gossypol as oral contraceptive for male: trial case report. 1982 Tohoku J. Exp. Med. pmid:6818716
Tso WW and Lee CS Gossypol: an effective acrosin blocker. 1982 Arch. Androl. pmid:6803693
Kalla NR et al. Studies on the male antifertility agent--gossypol acetic acid. III. Effect of gossypol acetic acid on rat testis. 1981 May-Jun Andrologia pmid:6455943
Kalla NR and Vasudev M Studies on the male antifertility agent-gossypol acetic acid. II. Effect of gossypol acetic acid on the motility and ATPase activity of human spermatozoa. 1981 Mar-Apr Andrologia pmid:6454365
Liu GZ Clinical study of gossypol as a male contraceptive. 1981 Jul-Sep Reproduccion pmid:6793420
El'chits SV et al. [Glucoamylase immobilization on silochrome using gossypol]. 1981 Jan-Feb Ukr. Biokhim. Zh. pmid:6259793
Maugh TH Male "pill" blocks sperm enzyme. 1981 Science pmid:7193910
Lin T et al. Gossypol inhibits testicular steroidogenesis. 1981 Fertil. Steril. pmid:7194804
Jacobs HS Contraception in the future. 1981 Proc Annu Symp Eugen Soc pmid:7050975
Liu YX [The effect of gossypol acetate on the content of the sex steroid hormone in endometrium (author's transl)]. 1981 Zhonghua Fu Chan Ke Za Zhi pmid:7327032
[A preliminary study on gossypol used in gynecology and its mechanism of action (author's transl)]. 1981 Zhonghua Fu Chan Ke Za Zhi pmid:7327033
Zhou SW [Clinical use of gossypol in gynecology (author's transl)]. 1981 Zhonghua Fu Chan Ke Za Zhi pmid:7327034
El-Sebae AH et al. Gossypol as an inducer or inhibitor in Spodoptera littoralis larvae. 1981 J Environ Sci Health B pmid:6454717
Liang DC et al. [Studies on distribution of 14C-gossypol in subcellular fractions of rat testes and site of gossypol action (author's transl)]. 1981 Zhongguo Yi Xue Ke Xue Yuan Xue Bao pmid:6459173
Bi XF et al. [Preliminary study on gossypol in causing hypokalemia (author's transl)]. 1981 Zhongguo Yi Xue Ke Xue Yuan Xue Bao pmid:6459178
Shi QX et al. [Analysis on exfoliated cells in human semen after oral administrations of gossypol acetic acid (author's transl)]. 1981 Zhongguo Yao Li Xue Bao pmid:6462027
Bi XF et al. The effect of gossypol on ATPase activity of the kidney. 1981 Sci. Sin. pmid:6266011