Gossypol

Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.

Cross Reference

Introduction

To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Gossypol?

Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Gossypol

MeSH term MeSH ID Detail
Abnormalities, Drug-Induced D000014 10 associated lipids
Adenocarcinoma D000230 166 associated lipids
Body Weight D001835 333 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Cattle Diseases D002418 24 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Edema D004487 152 associated lipids
Endometriosis D004715 29 associated lipids
Genital Neoplasms, Male D005834 3 associated lipids
Per page 10 20 50 100 | Total 52

PubChem Associated disorders and diseases

What pathways are associated with Gossypol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Gossypol?

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Location Cross reference Weighted score Related literatures
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What functions are associated with Gossypol?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Gossypol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Gossypol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Gossypol?

Xenograft Model

Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).

Transgenic Model

Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Gossypol

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Per page 10 20 50 100 | Total 1511
Authors Title Published Journal PubMed Link
Hoffer AP Ultrastructural studies of spermatozoa and the epithelial lining of the epididymis and vas deferens in rats treated with gossypol. 1982 Arch. Androl. pmid:7114955
Liu YX Control of spermatogenesis in primate and prospect of male contraception. 2005 Mar-Apr Arch. Androl. pmid:15804862
Herrera J et al. Cottonseed flour effects on androgen testicular content and serum levels in rats. 1983 Arch. Androl. pmid:6688944
Bressani R et al. [Effect of free gossypol of different cottonseed flours on the growth of rats and levels of free lysin and free gossypol in animal organs, muscle and serum]. 1975 Arch Latinoam Nutr pmid:1174302
Mayorga H et al. [Extraction and precipitation of cottonseed protein by the wet method]. 1973 Arch Latinoam Nutr pmid:4801265
Braham JE et al. [Gossypol absorption in rats and in pigs]. 1971 Arch Latinoam Nutr pmid:5172839
Rolz C et al. [Method of wet concentration of protein of cotton seed cake processed by screw press]. 1971 Arch Latinoam Nutr pmid:5172841
Leal-Garza CH et al. [Frequency of sister chromatid exchange in mice treated with gossypol]. 1990 Jul-Sep Arch Invest Med (Mex) pmid:2131768
Ahmed AA et al. Gossypol as anti-fertility agent in female rats. 1988 Arch Exp Veterinarmed pmid:3219036
Zhou M et al. Metabolic engineering of gossypol in cotton. 2013 Appl. Microbiol. Biotechnol. pmid:23775273
Jensen EC et al. Lipoxygenase inhibitors shift the yeast/mycelium dimorphism in Ceratocystis ulmi. 1992 Appl. Environ. Microbiol. pmid:1514797
Margalith P Inhibitory effect of gossypol on microorganisms. 1967 Appl Microbiol pmid:6049314
Alarcón B et al. Screening for new compounds with antiherpes activity. 1984 Antiviral Res. pmid:6517562
An T et al. Amino acid derivatives of the (-) enantiomer of gossypol are effective fusion inhibitors of human immunodeficiency virus type 1. 2012 Antiviral Res. pmid:22426469
Lin TS et al. Selective inhibition of human immunodeficiency virus type 1 replication by the (-) but not the (+) enantiomer of gossypol. 1989 Antimicrob. Agents Chemother. pmid:2619282
Schteingart DE et al. Expression of anti-apoptosis genes determines the response of adrenal cancer to apoptosis-inducing chemotherapy. 2010 Anticancer Res. pmid:21187456
Ye W et al. Modulation of multidrug resistance gene expression in human breast cancer cells by (-)-gossypol-enriched cottonseed oil. 2007 Jan-Feb Anticancer Res. pmid:17352222
Brandes AA et al. New drugs in recurrent high grade gliomas. 2000 May-Jun Anticancer Res. pmid:10928126
Jiang J et al. The effects of gossypol on the invasiveness of MAT-LyLu cells and MAT-LyLu cells from the metastasized lungs of MAT-LyLu-bearing Copenhagen rats. 2000 Nov-Dec Anticancer Res. pmid:11205308
Jiang J et al. Effects of gossypol on O2 consumption and CO2 production in human prostate cancer cells. 2002 May-Jun Anticancer Res. pmid:12168828