Gossypol

Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.

Cross Reference

Introduction

To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Gossypol?

Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Gossypol

MeSH term MeSH ID Detail
Abnormalities, Drug-Induced D000014 10 associated lipids
Adenocarcinoma D000230 166 associated lipids
Body Weight D001835 333 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Cattle Diseases D002418 24 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Edema D004487 152 associated lipids
Endometriosis D004715 29 associated lipids
Genital Neoplasms, Male D005834 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Gossypol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Gossypol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Gossypol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Gossypol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Gossypol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Gossypol?

Xenograft Model

Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).

Transgenic Model

Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Gossypol

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Per page 10 20 50 100 | Total 1511
Authors Title Published Journal PubMed Link
Posevaia TA et al. [The role of herpetic infection in epithelial dysplasias of the cervix uteri and a trial of their treatment with antiherpetic preparations]. 1991 Jan-Feb Vopr. Virusol. pmid:1650068
BelokrinitskiÄ­ DV et al. [Indices of the immune status of recurrent herpes patients being treated with a herpes polyvaccine]. 1987 Mar-Apr Vopr. Virusol. pmid:3037800
SaÄ­itkulov AM et al. [Biological characteristics of new interferon inducers created on a gossypol base]. 1984 Nov-Dec Vopr. Virusol. pmid:6084903
Shi A et al. [Screening and breeding of highly-effected degrading cotton-phenol strains and study on defoxication technology and conditions]. 1998 Wei Sheng Wu Xue Bao pmid:12549423
Han J et al. [Determination of anti-nutrients in genetically modified crops]. 2004 Wei Sheng Yan Jiu pmid:15727185
Zhan WH et al. [Studies on the killing effect of gamma ray irradiated peripheral blood mononuclear cells combined with (-)-gossypol on human prostate cancer LNCaP cells]. 2010 Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi pmid:21319440
Zheng YH et al. [Effect of gossypol acetic acid on hCG-stimulated progesterone production of dissociated rat luteal cells]. 1991 Yao Xue Xue Bao pmid:1668561
Zheng DK et al. [Studies on the resolution of racemic gossypol. II. By chiral alpha-methylphenethylamine and alpha-methylbenzylamine]. 1990 Yao Xue Xue Bao pmid:2284966
Si YK et al. [Studies on the resolution of racemic gossypol. III. Study on the chemical and physical properties of the amino condensates of gossypol]. 1990 Yao Xue Xue Bao pmid:2284967
Han SD et al. [Study on quality of gossypol recrystalized from chloroform]. 1989 Yao Xue Xue Bao pmid:2609986
Deng HL et al. [The subcellular distribution and covalent binding of 3H-(+) and 3H-(-) gossypol in the main tissues of rats]. 1989 Yao Xue Xue Bao pmid:2618689
Wu GP et al. [Synthesis and antifertility actions of gossypol derivatives and phenol aldehydes]. 1989 Yao Xue Xue Bao pmid:2618691
Jiang DH et al. [The comparison of some properties of gossypol recrystallized from different solvents]. 1986 Yao Xue Xue Bao pmid:3811948
Guo ZM et al. [Synthesis of mono-aldehyde gossypol and its analogues]. 1987 Yao Xue Xue Bao pmid:3450164
Zhou RH and Lin XD [Isolation of (-)-gossypol from natural plant]. 1987 Yao Xue Xue Bao pmid:3450165
Wu DF et al. [Determination of (+)- and (-)-gossypol in human plasma using high performance liquid chromatography with pre-column chemical derivatization]. 1988 Yao Xue Xue Bao pmid:3256191
Xu Y et al. [Intratesticular subcapsular assay, a simple method for the preliminary screening of male contraceptives]. 1993 Yao Xue Xue Bao pmid:8010008
Ma XN et al. [Effect of gossypol acetic acid on testosterone, LH and FSH levels of male rats]. 1983 Yao Xue Xue Bao pmid:6433647
Ye WS et al. [The antifertility effect of gossypol plus testosterone and estrogen]. 1996 Yao Xue Xue Bao pmid:9208651
Tang Y et al. [Progress in small-molecule inhibitors of Bcl-2 family proteins]. 2008 Yao Xue Xue Bao pmid:18819468