| MeSH term | MeSH ID | Detail |
|---|---|---|
| Prostatic Neoplasms, Castration-Resistant | D064129 | 3 associated lipids |
| Chemical and Drug Induced Liver Injury | D056486 | 39 associated lipids |
| Acute Lung Injury | D055371 | 33 associated lipids |
| Lung Injury | D055370 | 14 associated lipids |
| Micronuclei, Chromosome-Defective | D048629 | 33 associated lipids |
| Retinal Neoplasms | D019572 | 3 associated lipids |
| Hematologic Neoplasms | D019337 | 4 associated lipids |
| Carcinoma, Mucoepidermoid | D018277 | 3 associated lipids |
| Endometrial Neoplasms | D016889 | 30 associated lipids |
| Lymphoma, Large B-Cell, Diffuse | D016403 | 13 associated lipids |
Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zerp SF et al. | Targeting anti-apoptotic Bcl-2 by AT-101 to increase radiation efficacy: data from in vitro and clinical pharmacokinetic studies in head and neck cancer. | 2015 | Radiat Oncol | pmid:26223311 |
| Zerp SF et al. | AT-101, a small molecule inhibitor of anti-apoptotic Bcl-2 family members, activates the SAPK/JNK pathway and enhances radiation-induced apoptosis. | 2009 | Radiat Oncol | pmid:19852810 |
| Sessions RB et al. | A model of Plasmodium falciparum lactate dehydrogenase and its implications for the design of improved antimalarials and the enhanced detection of parasitaemia. | 1997 | Protein Eng. | pmid:9194154 |
| Fu YF et al. | Effects of gossypol on the activity of rabbit kidney Na,K-ATPase and the functions of human erythrocyte membrane. | 1988 | Prog. Clin. Biol. Res. | pmid:2975784 |
| Gonzalez-Garza T et al. | In vitro evaluation of gossypol as potential antiamoebic drug. | 1991 | Proc. West. Pharmacol. Soc. | pmid:1788315 |
| Rillema JA et al. | Studies on the possible role of protein kinase C in the prolactin regulation of cell replication in Nb2 node lymphoma cells. | 1989 | Proc. Soc. Exp. Biol. Med. | pmid:2813443 |
| HARMS WS and HOLLEY KT | Hypoprothrombinemia induced by gossypol. | 1951 | Proc. Soc. Exp. Biol. Med. | pmid:14854026 |
| Othman MA and Abou-Donia MB | Pharmacokinetic profile of (+/-)-gossypol in male Sprague-Dawley rats following single intravenous and oral and subchronic oral administration. | 1988 | Proc. Soc. Exp. Biol. Med. | pmid:3368474 |
| CASTILLON LE and ALTSCHUL AM | Preparation of water-soluble combination products of gossypol and their toxicity to aquarium fish. | 1950 | Proc. Soc. Exp. Biol. Med. | pmid:15440911 |
| Jennings MB and Reidenberg MM | Adaptation to nephrotoxic chemicals. | 1988 | Proc. Soc. Exp. Biol. Med. | pmid:3205883 |
| Heiser V et al. | Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: implications for Huntington's disease therapy. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10829068 |
| Sunilkumar G et al. | Engineering cottonseed for use in human nutrition by tissue-specific reduction of toxic gossypol. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:17110445 |
| Dash R et al. | Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda-7/IL-24-mediated toxicity. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21555592 |
| Le A et al. | Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20133848 |
| Damaty S and Hudson BJ | A secondary interaction between gossypol and cottonseed protein. | 1975 | Proc Nutr Soc | pmid:1187618 |
| Wu DF and Yu YW | Superoxide free radical formation stimulated by (+/-), (+), (-) gossypol in rat liver and kidney microsomes. | 1986 | Proc Chin Acad Med Sci Peking Union Med Coll | pmid:2827151 |
| Huang T et al. | Gossypol-induced alterations of aminophospholipid composition in human sperm. | 1990 | Proc Chin Acad Med Sci Peking Union Med Coll | pmid:2371261 |
| Zhang JB et al. | Effect of gossypol on fertilization capacity and chromosome formation of human sperm in vitro. | 1986 | Proc Chin Acad Med Sci Peking Union Med Coll | pmid:3432238 |
| Ye WS et al. | Cytological toxicity of gossypol on rat gametogenesis and spermatozoa. | 1986 | Proc Chin Acad Med Sci Peking Union Med Coll | pmid:3432239 |
| Lei HP | Future research priorities of gossypol in the field of fertility regulation. | 1987 | Proc Chin Acad Med Sci Peking Union Med Coll | pmid:3321051 |