| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Cattle Diseases | D002418 | 24 associated lipids |
| Infertility, Male | D007248 | 11 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Mol. Cancer Ther. (4)
- Proc. Natl. Acad. Sci. U.S.A. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (2)
- Others (13)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Teng CS | Biological activity in the repopulating rat spermatocyte after the withdrawal of gossypol treatment: III. The activity for the transcription of messenger RNA. | 1992 | Contraception | pmid:1559338 |
| Srivastava A et al. | Studies on mechanism(s) of antifertility action of gossypol in rat and hamster. | 1989 | Contraception | pmid:2469550 |
| Lan ZJ et al. | Effects of multiglycosides of Tripterygium wilfordii (GTW) on rat fertility and Leydig and Sertoli cells. | 1992 | Contraception | pmid:1511610 |
| Fu YF et al. | Effects of gossypol on the activity of kidney (Na+ + K+)-ATPase and the functions of erythrocyte membrane. | 1988 | Contraception | pmid:2836126 |
| White IG et al. | Studies of the mechanism of action of gossypol as a male antifertility agent. | 1988 | Contraception | pmid:2836127 |
| Pearce S et al. | Inhibition by gossypol of cyclic AMP production in mouse Leydig cells. | 1986 | Contraception | pmid:3030630 |
| Tang F et al. | Inhibition of catechol-O-methyltransferase by gossypol: the effect of plasma proteins. | 1982 | Contraception | pmid:7160182 |
| Giridharan N et al. | Inhibition of rat testis LDH-X activity by gossypol. | 1982 | Contraception | pmid:7168954 |
| Meng GD et al. | Follow-up of men in the recovery period immediately after the cessation of gossypol treatment. | 1988 | Contraception | pmid:3131064 |
| Hahn DW et al. | Antifertility and endocrine activities of gossypol in rodents. | 1981 | Contraception | pmid:7273769 |
| Waller DP et al. | Antifertility effects of gossypol and its impurities on male hamsters. | 1981 | Contraception | pmid:7285581 |
| Chang MC et al. | Effects of Gossypol on the fertility of male rats, hamsters and rabbits. | 1980 | Contraception | pmid:7428357 |
| Sakesena SK et al. | Gossypol: its toxicological and endocrinological effects in male rabbits. | 1981 | Contraception | pmid:7297071 |
| Tanphaichitr N and Fitzgerald LM | Adverse effects of gossypol analogs on TM4 cell mitochondrial function. | 1989 | Contraception | pmid:2752754 |
| Tanphaichitr N et al. | Inhibitory effects of gossypol analogs on human sperm motility. | 1989 | Contraception | pmid:2752755 |
| Whaley KJ et al. | Monkey lactate dehydrogenase-C4 as a model for the interaction of enzymes with gossypol. | 1986 | Contraception | pmid:3769483 |
| Teng CS | Biological activity in the repopulating rat spermatocyte after the withdrawal of gossypol treatment. V. Inhibition and recovery of microtubular dynein. | 1995 | Contraception | pmid:7628207 |
| Paz GF and Homonnai ZT | Effect of the antifertility agent, gossypol acetic acid, on the metabolism and testosterone secretion of isolated rat interstitial cells in vitro. | 1984 | Contraception | pmid:6467943 |
| Benz C et al. | Selective toxicity of gossypol against epithelial tumors and its detection by magnetic resonance spectroscopy. | 1988 | Contraception | pmid:3370994 |
| Matlin SA et al. | Large-scale resolution of gossypol enantiomers for biological evaluation. | 1988 | Contraception | pmid:3370995 |
| Zhou RH and Lin XD | Isolation of (-)-gossypol from natural plant. | 1988 | Contraception | pmid:3370996 |
| Sonenberg M et al. | Anti-fertility and other actions of gossypol analogues. | 1988 | Contraception | pmid:3370997 |
| Stumpf WE et al. | Sites of action of gossypol studied by autoradiography and enzyme histochemistry. | 1988 | Contraception | pmid:3370998 |
| Fei RR and Teng CS | The effects of gossypol on nuclear protein in rat testes. I. Reduction in the content of basic proteins in the spermiogenic cells. | 1988 | Contraception | pmid:3370999 |
| Teng CS and Fei RR | The effects of gossypol on nuclear protein in rat testes. II. The synthesis of histones and testis-specific proteins after gossypol treatment. | 1988 | Contraception | pmid:3371000 |
| Hoffer AP et al. | Antifertility, spermicidal and ultrastructural effects of gossypol and derivatives administered orally and by intratesticular injections. | 1988 | Contraception | pmid:3371001 |
| Tso WW and Lee CS | Gossypol uncoupling of respiratory chain and oxidative phosphorylation in ejaculated boar spermatozoa. | 1982 | Contraception | pmid:6889482 |
| Kalla NR et al. | Involvement of prostaglandin in the antifertility effects of gossypol. | 1986 | Contraception | pmid:3465506 |
| Lin YC et al. | Effect of gossypol on thyroid hormones in young female rats. | 1990 | Contraception | pmid:2335106 |
| Kanwar U et al. | Gossypol-induced inhibition of glucose uptake in human ejaculated spermatozoa may be mediated by lipid peroxidation. | 1990 | Contraception | pmid:2272185 |
| Achedume AC et al. | Biochemical studies of the effect of gossypol consumption on cholesterol and residual glucose in fed and protein-energy deficient rats. | 1994 | Contraception | pmid:7813227 |
| Teng CS | Reversible changes in the content of cellular and microtubular tubulin in spermatogenic cells after gossypol treatment. | 1997 | Contraception | pmid:9115008 |
| Chongthammakun S et al. | Effects of gossypol on human and monkey sperm motility in vitro. | 1986 | Contraception | pmid:3791997 |
| Teng CS | Reversible changes in the content of cellular and microtubular tubulin in spermatogenic cells after gossypol treatment. | 1997 | Contraception | pmid:9013060 |
| Teng CS | Biological activity in the repopulating rat spermatocyte after the withdrawal of gossypol treatment. IV. The activity for the modification of core histones. | 1993 | Contraception | pmid:8403913 |
| Polsky B et al. | Inactivation of human immunodeficiency virus in vitro by gossypol. | 1989 | Contraception | pmid:2473865 |
| Bender HS et al. | A histopathologic study of the effects of gossypol on the female rat. | 1988 | Contraception | pmid:3197423 |
| Nwoha PU | The blood constituents of gossypol-treated, protein-malnourished Wistar rats. | 1995 | Contraception | pmid:8605784 |
| Nwoha PU and Aire TA | The effects of gossypol and chloroquine interaction on serum electrolytes of protein-malnourished rats. | 1995 | Contraception | pmid:8605785 |
| Nwoha PU and Aire TA | Reduced level of serum cholesterol in low protein-fed Wistar rats administered gossypol and chloroquine. | 1995 | Contraception | pmid:8605786 |
| Orhan G et al. | The effect of the male contraceptive agent gossypol acetic acid on mouse bone marrow cells in vivo: micronuclei and mitotic index. | 1993 | Contraception | pmid:8508667 |
| Teng CS and Vilagrasa X | Biphasic c-Myc protein expression during gossypol-induced apoptosis in rat spermatocytes. | 1998 | Contraception | pmid:9589839 |
| Teng CS | c-fos protein expression in apoptotic rat spermatocytes induced by gossypol. | 1998 | Contraception | pmid:9649921 |
| Matlin SA et al. | (-)-Gossypol: an active male antifertility agent. | 1985 | Contraception | pmid:3987276 |
| Sufi SB et al. | Inhibition by (+) and (-) isomers of gossypol of testosterone release from mouse Leydig cells in vitro. | 1985 | Contraception | pmid:3987277 |
| Donaldson A et al. | Inhibition by gossypol of testosterone production by mouse Leydig cells in vitro. | 1985 | Contraception | pmid:3987278 |
| Wong PY et al. | Gossypol does not affect testicular fluid secretion in rats. | 1984 | Contraception | pmid:6744863 |
| Wang Y et al. | Antifertility effect of polyvinylpyrrolidone-gossypol and gossypol in male rats. | 1985 | Contraception | pmid:4092462 |
| Wu YM et al. | Effects of gossypol on pituitary-ovarian endocrine function, ovulation and fertility in female hamsters. | 1981 | Contraception | pmid:6796329 |
| Anuja MN et al. | Spermatotoxicity of a protein isolated from the root of Achyranthes aspera: a comparative study with gossypol. | 2010 | Contraception | pmid:20851234 |