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Reversibility of the reproductive toxicity of gossypol in peripubertal bulls. |
2004 |
Theriogenology |
pmid:15037004
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Wang X and Plhak LC |
Monoclonal antibodies for the analysis of gossypol in cottonseed products. |
2004 |
J. Agric. Food Chem. |
pmid:14969520
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Ergun MA et al. |
Apoptosis and nitric oxide release induced by thalidomide, gossypol and dexamethasone in cultured human chronic myelogenous leukemic K-562 cells. |
2004 |
Cell Biol. Int. |
pmid:14984751
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Aneja R et al. |
Effect of gossypol in association with chromium protoporphyrin on heme metabolic enzymes. |
2004 |
Artif Cells Blood Substit Immobil Biotechnol |
pmid:15027808
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Bork S et al. |
Identification of Babesia bovis L-lactate dehydrogenase as a potential chemotherapeutical target against bovine babesiosis. |
2004 |
Mol. Biochem. Parasitol. |
pmid:15478796
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Przybylski P et al. |
The schiff base of gossypol with 3,6,9,12,15,18,21,24-octaoxa-pentacosylamine complexes and monovalent cations studied by electrospray ionization-mass spectrometry, (1)H nuclear magnetic resonance, Fourier transform infrared, as well as PM5 semiempirical methods. |
2004 |
Biopolymers |
pmid:15211497
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Dao VT et al. |
Cytotoxicity of enantiomers of gossypol Schiff's bases and optical stability of gossypolone. |
2004 |
Eur J Med Chem |
pmid:15236842
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Fombad RB and Bryant MJ |
Effects of cottonseed cake-based diets supplemented with blood meal, alone or with lysine, on the growth of pigs. |
2004 |
Trop Anim Health Prod |
pmid:15241972
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Fombad RB and Bryant MJ |
An evaluation of the use of cottonseed cake in the diet of growing pigs. |
2004 |
Trop Anim Health Prod |
pmid:15080544
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Fiorini C et al. |
Sertoli cell junctional proteins as early targets for different classes of reproductive toxicants. |
2004 |
Reprod. Toxicol. |
pmid:15082077
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Hockenbery D |
Breaking down tumor defenses. |
2004 |
Chem. Biol. |
pmid:15123233
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Becattini B et al. |
Rational design and real time, in-cell detection of the proapoptotic activity of a novel compound targeting Bcl-X(L). |
2004 |
Chem. Biol. |
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Abe F et al. |
Trypanocidal constituents in plants 3. Leaves of Garcinia intermedia and heartwood of Calophyllum brasiliense. |
2004 |
Biol. Pharm. Bull. |
pmid:14709920
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Jiang J et al. |
The inhibitory effects of gossypol on human prostate cancer cells-PC3 are associated with transforming growth factor beta1 (TGFbeta1) signal transduction pathway. |
2004 Jan-Feb |
Anticancer Res. |
pmid:15015581
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Sabirova FM et al. |
[Immunomodulating effect of the novel water-soluble gossypol derivative Mebavin in adjuvant arthritis]. |
2004 Mar-Apr |
Eksp Klin Farmakol |
pmid:15188763
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Hernández-Cerón J et al. |
Timing of inhibitory actions of gossypol on cultured bovine embryos. |
2005 |
J. Dairy Sci. |
pmid:15738226
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Shen YL et al. |
Study on structure and characterization of inclusion complex of gossypol/beta cyclodextrin. |
2005 |
Spectrochim Acta A Mol Biomol Spectrosc |
pmid:15741097
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Nutrient content of whole cottonseed. |
2005 |
J. Dairy Sci. |
pmid:15778316
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Konac E et al. |
An in vitro study of cytotoxic effects of gossypol on human epidermoid larynx carcinoma cell line (HEp-2). |
2005 |
Exp. Oncol. |
pmid:15812364
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The calcineurin inhibitor gossypol impairs growth, cell signalling and development in Dictyostelium discoideum. |
2005 |
FEMS Microbiol. Lett. |
pmid:15621416
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Wang J et al. |
Reversal of a full-length mutant huntingtin neuronal cell phenotype by chemical inhibitors of polyglutamine-mediated aggregation. |
2005 |
BMC Neurosci |
pmid:15649316
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Lopez LM et al. |
Nonhormonal drugs for contraception in men: a systematic review. |
2005 |
Obstet Gynecol Surv |
pmid:16250923
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Dodou K et al. |
Investigations on gossypol: past and present developments. |
2005 |
Expert Opin Investig Drugs |
pmid:16255680
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Mohammad RM et al. |
Nonpeptidic small-molecule inhibitor of Bcl-2 and Bcl-XL, (-)-Gossypol, enhances biological effect of genistein against BxPC-3 human pancreatic cancer cell line. |
2005 |
Pancreas |
pmid:16258364
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Stipanovic RD et al. |
Occurrence of (+)- and (-)-gossypol in wild species of cotton and in Gossypium hirsutum Var. marie-galante (Watt) Hutchinson. |
2005 |
J. Agric. Food Chem. |
pmid:16076104
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Bauer JA et al. |
Reversal of cisplatin resistance with a BH3 mimetic, (-)-gossypol, in head and neck cancer cells: role of wild-type p53 and Bcl-xL. |
2005 |
Mol. Cancer Ther. |
pmid:16020667
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Mohammad RM et al. |
Preclinical studies of a nonpeptidic small-molecule inhibitor of Bcl-2 and Bcl-X(L) [(-)-gossypol] against diffuse large cell lymphoma. |
2005 |
Mol. Cancer Ther. |
pmid:15657349
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Oliver CL et al. |
(-)-Gossypol acts directly on the mitochondria to overcome Bcl-2- and Bcl-X(L)-mediated apoptosis resistance. |
2005 |
Mol. Cancer Ther. |
pmid:15657350
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(-)-Gossypol enhances response to radiation therapy and results in tumor regression of human prostate cancer. |
2005 |
Mol. Cancer Ther. |
pmid:15713891
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Schiff bases of gossypol: an NMR and DFT study. |
2005 |
Magn Reson Chem |
pmid:15678567
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Synthesis of gossypol atropisomers and derivatives and evaluation of their anti-proliferative and anti-oxidant activity. |
2005 |
Bioorg. Med. Chem. |
pmid:15878283
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Antisense suppression of a (+)-delta-cadinene synthase gene in cotton prevents the induction of this defense response gene during bacterial blight infection but not its constitutive expression. |
2005 |
Plant Physiol. |
pmid:15849309
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Wang J et al. |
Development of competitive direct ELISA for gossypol analysis. |
2005 |
J. Agric. Food Chem. |
pmid:15998107
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Mapping the binding site for gossypol-like inhibitors of Plasmodium falciparum lactate dehydrogenase. |
2005 |
Mol. Biochem. Parasitol. |
pmid:15978953
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Protective effect of ginkgo biloba against gossypol-induced apoptosis in human lymphocytes. |
2005 |
Cell Biol. Int. |
pmid:15949956
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Gossypol toxicosis in a dog consequent to ingestion of cottonseed bedding. |
2005 |
J. Vet. Diagn. Invest. |
pmid:16475530
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Effects of source of gossypol and supplemental iron on plasma gossypol in Holstein steers. |
2005 |
J. Dairy Sci. |
pmid:16162530
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Relative toxicity of gossypol enantiomers in broilers. |
2005 |
Poult. Sci. |
pmid:16206558
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Liu YX |
Control of spermatogenesis in primate and prospect of male contraception. |
2005 Mar-Apr |
Arch. Androl. |
pmid:15804862
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Ojha P et al. |
Effect of antispermatogenic agents on cell marker enzymes of rat Sertoli cells in vitro. |
2006 |
Contraception |
pmid:16371305
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Benedict CR et al. |
The peroxidative coupling of hemigossypol to (+)- and (-)-gossypol in cottonseed extracts. |
2006 |
Phytochemistry |
pmid:16403543
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Dale GL and Friese P |
Bax activators potentiate coated-platelet formation. |
2006 |
J. Thromb. Haemost. |
pmid:16970802
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Coward L et al. |
Quantitative determination of apogossypol, a pro-apoptotic analog of gossypol, in mouse plasma using LC/MS/MS. |
2006 |
J Pharm Biomed Anal |
pmid:16859853
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Cranston JJ et al. |
Effects of feeding whole cottonseed and cottonseed products on performance and carcass characteristics of finishing beef cattle. |
2006 |
J. Anim. Sci. |
pmid:16864881
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Zhang WJ et al. |
Effect of selected fungi on the reduction of gossypol levels and nutritional value during solid substrate fermentation of cottonseed meal. |
2006 |
J Zhejiang Univ Sci B |
pmid:16909468
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Zhang WJ et al. |
Optimization of process parameters for reduction of gossypol levels in cottonseed meal by Candida tropicalis ZD-3 during solid substrate fermentation. |
2006 |
Toxicon |
pmid:16846625
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Lei X et al. |
Gossypol induces Bax/Bak-independent activation of apoptosis and cytochrome c release via a conformational change in Bcl-2. |
2006 |
FASEB J. |
pmid:16935937
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Stipanovic RD et al. |
Ratios of (+)- and (-)-gossypol in leaves, stems, and roots of selected accessions of Gossypium hirsutum var. marie galante (Watt) Hutchinson. |
2006 |
J. Agric. Food Chem. |
pmid:16506812
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Yang G et al. |
Molecular cloning and characterization of a novel lactate dehydrogenase gene from Clonorchis sinensis. |
2006 |
Parasitol. Res. |
pmid:16479375
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Price CP et al. |
Dissecting the behavior of a promiscuous solvate former. |
2006 |
Angew. Chem. Int. Ed. Engl. |
pmid:16493716
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Wang G et al. |
Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins. |
2006 |
J. Med. Chem. |
pmid:17034116
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Cleverley J |
American Society of Clinical Oncology--42nd annual meeting. Poster presentations on leukemia and cytotoxic chemotherapy. 2-6 June 2006, Atlanta, GA, USA. |
2006 |
IDrugs |
pmid:16871453
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Shen YL et al. |
Determinations of the inclusion complex between gossypol and beta-cyclodextrin. |
2006 |
Spectrochim Acta A Mol Biomol Spectrosc |
pmid:16877036
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Yeow WS et al. |
Gossypol, a phytochemical with BH3-mimetic property, sensitizes cultured thoracic cancer cells to Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand. |
2006 |
J. Thorac. Cardiovasc. Surg. |
pmid:17140955
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de Andrade SF et al. |
Epididymis-specific pathologic disorders in rats exposed to gossypol from weaning through puberty. |
2006 |
Toxicol Pathol |
pmid:17162530
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Sunilkumar G et al. |
Engineering cottonseed for use in human nutrition by tissue-specific reduction of toxic gossypol. |
2006 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:17110445
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Przybylski P et al. |
1H- and 13C-NMR, FTIR, UV-VIS, ESI-MS, and PM5 studies as well as emission properties of a new Schiff base of gossypol with 5-methoxytryptamine and a new hydrazone of gossypol with dansylhydrazine. |
2006 |
Biopolymers |
pmid:16538663
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Przybylski P et al. |
Multinuclear magnetic resonance, electrospray ionization-mass spectroscopy, and parametric method 5 studies of a new derivative of gossypol with 2-thiophenecarbohydrazide as well as its complexes with LI+, Na+, K+, RB+, and Cs+ cations. |
2006 |
Biopolymers |
pmid:16741985
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Galvão KN et al. |
Embryo survival from gossypol-fed heifers after transfer to lactating cows treated with human chorionic gonadotropin. |
2006 |
J. Dairy Sci. |
pmid:16702269
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Stipanovic RD et al. |
Effect of racemic and (+)- and (-)-gossypol on the survival and development of Helicoverpa zea larvae. |
2006 |
J. Chem. Ecol. |
pmid:16739016
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Wolter KG et al. |
(-)-gossypol inhibits growth and promotes apoptosis of human head and neck squamous cell carcinoma in vivo. |
2006 |
Neoplasia |
pmid:16611409
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Akinola OB et al. |
Proteinaceous diet inhibits gossypol-induced spermatotoxicity. |
2006 Jul-Sep |
Eur J Histochem |
pmid:16920644
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Huang YW et al. |
Molecular mechanisms of (-)-gossypol-induced apoptosis in human prostate cancer cells. |
2006 May-Jun |
Anticancer Res. |
pmid:16827126
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Huang YW et al. |
Effects of serum on (-)-gossypol-suppressed growth in human prostate cancer cells. |
2006 Sep-Oct |
Anticancer Res. |
pmid:17094491
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Meng Y et al. |
(-)Gossypol and its combination with imatinib induce apoptosis in human chronic myeloid leukemic cells. |
2007 |
Leuk. Lymphoma |
pmid:17926190
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Mao YB et al. |
Silencing a cotton bollworm P450 monooxygenase gene by plant-mediated RNAi impairs larval tolerance of gossypol. |
2007 |
Nat. Biotechnol. |
pmid:17982444
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Lordelo MM et al. |
Relative toxicity of gossypol enantiomers in laying and broiler breeder hens. |
2007 |
Poult. Sci. |
pmid:17297172
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Zhang M et al. |
Differential growth inhibition and induction of apoptosis by gossypol between HCT116 and HCT116/Bax(-/-) colorectal cancer cells. |
2007 |
Clin. Exp. Pharmacol. Physiol. |
pmid:17250644
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Leyman A et al. |
The absence of expression of the three isoenzymes of the inositol 1,4,5-trisphosphate 3-kinase does not prevent the formation of inositol pentakisphosphate and hexakisphosphate in mouse embryonic fibroblasts. |
2007 |
Cell. Signal. |
pmid:17355905
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Costantino A et al. |
Current status and future perspectives in male contraception. |
2007 |
Minerva Ginecol |
pmid:17576406
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Tang G et al. |
Structure-based design of flavonoid compounds as a new class of small-molecule inhibitors of the anti-apoptotic Bcl-2 proteins. |
2007 |
J. Med. Chem. |
pmid:17552510
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Ko CH et al. |
Gossypol reduction of tumor growth through ROS-dependent mitochondria pathway in human colorectal carcinoma cells. |
2007 |
Int. J. Cancer |
pmid:17597109
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Wolter KG et al. |
Therapeutic window for melanoma treatment provided by selective effects of the proteasome on Bcl-2 proteins. |
2007 |
Cell Death Differ. |
pmid:17541428
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Kasten-Pisula U et al. |
Radiosensitization of tumour cell lines by the polyphenol Gossypol results from depressed double-strand break repair and not from enhanced apoptosis. |
2007 |
Radiother Oncol |
pmid:17521756
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Feng BY et al. |
A high-throughput screen for aggregation-based inhibition in a large compound library. |
2007 |
J. Med. Chem. |
pmid:17447748
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Badawy SZ et al. |
Gossypol inhibits proliferation of endometrioma cells in culture. |
2007 |
Asian J. Androl. |
pmid:17486280
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Orth RG et al. |
Determining larval host plant use by a polyphagous lepidopteran through analysis of adult moths for plant secondary metabolites. |
2007 |
J. Chem. Ecol. |
pmid:17492366
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Choi SR et al. |
Design, synthesis, and biological evaluation of Plasmodium falciparum lactate dehydrogenase inhibitors. |
2007 |
J. Med. Chem. |
pmid:17636950
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Loberg RD et al. |
In vivo evaluation of AT-101 (R-(-)-gossypol acetic acid) in androgen-independent growth of VCaP prostate cancer cells in combination with surgical castration. |
2007 |
Neoplasia |
pmid:18084610
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Turco E et al. |
The in vitro effect of gossypol and its interaction with salts on conidial germination and viability of Fusarium oxysporum sp. vasinfectum isolates. |
2007 |
J. Appl. Microbiol. |
pmid:18045422
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Akinola OB et al. |
Spermatoprotective activity of the leaf extract of Psidium guajava Linn. |
2007 |
Niger Postgrad Med J |
pmid:18163132
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Gerasimidis K et al. |
Preparation of an edible cottonseed protein concentrate and evaluation of its functional properties. |
2007 |
Int J Food Sci Nutr |
pmid:17710592
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Carruthers NJ et al. |
Gossypol inhibits calcineurin phosphatase activity at multiple sites. |
2007 |
Eur. J. Pharmacol. |
pmid:17141216
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Liu F et al. |
Pharmacophore identification of KSP inhibitors. |
2007 |
Bioorg. Med. Chem. Lett. |
pmid:17095225
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Zhang M et al. |
Gossypol induces apoptosis in human PC-3 prostate cancer cells by modulating caspase-dependent and caspase-independent cell death pathways. |
2007 |
Life Sci. |
pmid:17156797
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Song JJ et al. |
Evidence for two modes of development of acquired tumor necrosis factor-related apoptosis-inducing ligand resistance. Involvement of Bcl-xL. |
2007 |
J. Biol. Chem. |
pmid:17110373
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Xing C et al. |
Development of selective inhibitors for anti-apoptotic Bcl-2 proteins from BHI-1. |
2007 |
Bioorg. Med. Chem. |
pmid:17227711
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Lv G et al. |
[The effect of gossypol, praziquantel and artemether on recombinant lactate dehydrogenase from Schistosoma japonicum]. |
2007 |
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi |
pmid:18441994
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Denisov AY et al. |
Heat-induced dimerization of BCL-xL through alpha-helix swapping. |
2007 |
Biochemistry |
pmid:17223694
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Makkar HP et al. |
Plant secondary metabolites. |
2007 |
Methods Mol. Biol. |
pmid:19238775
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Ye W et al. |
Modulation of multidrug resistance gene expression in human breast cancer cells by (-)-gossypol-enriched cottonseed oil. |
2007 Jan-Feb |
Anticancer Res. |
pmid:17352222
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Cui G et al. |
Gossypol with methyltestosterone and ethinylestradiol male does not affect rat spermatogonial stem cell differentiation. |
2007 Mar-Apr |
Arch. Androl. |
pmid:17453689
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Politzer WM |
Long-term clinical remission of a patient with chronic lymphocytic leukemia using alternative treatment option: cottonseed oil (gossypol). |
2008 |
Phytomedicine |
pmid:18573644
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Shaaban WF et al. |
Reproductive toxicologic effects of gossypol on male rabbits: biochemical, enzymatic, and electrolytic properties of seminal plasma. |
2008 |
Fertil. Steril. |
pmid:17953964
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Paoluzzi L et al. |
Targeting Bcl-2 family members with the BH3 mimetic AT-101 markedly enhances the therapeutic effects of chemotherapeutic agents in in vitro and in vivo models of B-cell lymphoma. |
2008 |
Blood |
pmid:18292288
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Przybylski P et al. |
CP/MAS spectroscopy in the determination of the tautomeric forms of gossypol, its Schiff bases and hydrazones in the solid state. |
2008 |
Magn Reson Chem |
pmid:18338327
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Zha SW et al. |
[Male antifertility drugs and cell apoptosis]. |
2008 |
Zhonghua Nan Ke Xue |
pmid:18297819
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Boonsri S et al. |
Cytotoxic and antibacterial sesquiterpenes from Thespesia populnea. |
2008 |
J. Nat. Prod. |
pmid:18553924
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Zhou DR et al. |
Gossypol repressed the gap junctional intercellular communication between Sertoli cells by decreasing the expression of Connexin43. |
2008 |
Toxicol In Vitro |
pmid:18706992
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Etxebarria A et al. |
Regulation of antiapoptotic MCL-1 function by gossypol: mechanistic insights from in vitro reconstituted systems. |
2008 |
Biochem. Pharmacol. |
pmid:18762177
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