Fulda S |
Modulation of apoptosis by natural products for cancer therapy. |
2010 |
Planta Med. |
pmid:20486070
|
Williams JL et al. |
Fitness cost of resistance to Bt cotton linked with increased gossypol content in pink bollworm larvae. |
2011 |
PLoS ONE |
pmid:21738799
|
Varadarajan S et al. |
Endoplasmic reticulum membrane reorganization is regulated by ionic homeostasis. |
2013 |
PLoS ONE |
pmid:23457590
|
Zhang P et al. |
Suppression of jasmonic acid-dependent defense in cotton plant by the mealybug Phenacoccus solenopsis. |
2011 |
PLoS ONE |
pmid:21818315
|
Mishra PJ et al. |
Integrated Genomics Identifies miR-32/MCL-1 Pathway as a Critical Driver of Melanomagenesis: Implications for miR-Replacement and Combination Therapy. |
2016 |
PLoS ONE |
pmid:27846237
|
Zhang J et al. |
Breeding Potential of Introgression Lines Developed from Interspecific Crossing between Upland Cotton (Gossypium hirsutum) and Gossypium barbadense: Heterosis, Combining Ability and Genetic Effects. |
2016 |
PLoS ONE |
pmid:26730964
|
Wong FY et al. |
Combination therapy with gossypol reveals synergism against gemcitabine resistance in cancer cells with high BCL-2 expression. |
2012 |
PLoS ONE |
pmid:23226540
|
Câmara AC et al. |
Toxicity of Gossypol from Cottonseed Cake to Sheep Ovarian Follicles. |
2015 |
PLoS ONE |
pmid:26600470
|
He Z et al. |
Chemical Composition of Defatted Cottonseed and Soy Meal Products. |
2015 |
PLoS ONE |
pmid:26079931
|
Wang Q et al. |
Salt Stress Effects on Secondary Metabolites of Cotton in Relation to Gene Expression Responsible for Aphid Development. |
2015 |
PLoS ONE |
pmid:26061875
|
Tang H et al. |
Oxidative stress induces monocyte necrosis with enrichment of cell-bound albumin and overexpression of endoplasmic reticulum and mitochondrial chaperones. |
2013 |
PLoS ONE |
pmid:23555724
|
Thakur A et al. |
Pan-Bcl-2 inhibitor AT-101 enhances tumor cell killing by EGFR targeted T cells. |
2012 |
PLoS ONE |
pmid:23185240
|
Kaza N et al. |
BNIP3 regulates AT101 [(-)-gossypol] induced death in malignant peripheral nerve sheath tumor cells. |
2014 |
PLoS ONE |
pmid:24824755
|
Cho H et al. |
Polymeric micelles for apoptosis-targeted optical imaging of cancer and intraoperative surgical guidance. |
2014 |
PLoS ONE |
pmid:24587157
|
Jiao X et al. |
Comparative transcriptomic analysis of developing cotton cotyledons and embryo axis. |
2013 |
PLoS ONE |
pmid:23977137
|
Lordelo MM et al. |
Relative toxicity of gossypol enantiomers in laying and broiler breeder hens. |
2007 |
Poult. Sci. |
pmid:17297172
|
Berg LR and Lawrence WW |
Cottonseed meal, dehydrated grass and ascorbic acid as dietary factors preventing toxicity of vanadium for the chick. |
1971 |
Poult. Sci. |
pmid:5109894
|
Lordelo MM et al. |
Relative toxicity of gossypol enantiomers in broilers. |
2005 |
Poult. Sci. |
pmid:16206558
|
Blevins S et al. |
Effects of silymarin on gossypol toxicosis in divergent lines of chickens. |
2010 |
Poult. Sci. |
pmid:20709972
|
Rikihisa Y and Lin YC |
Ultrastructure of the testis and epididymis of Japanese quail (Coturnix coturnix japonica) administered gossypol. |
1988 |
Poult. Sci. |
pmid:3413024
|
Zeng QF et al. |
The response of meat ducks from 15 to 35 d of age to gossypol from cottonseed meal. |
2015 |
Poult. Sci. |
pmid:25834247
|
Gamboa DA et al. |
Tissue distribution of gossypol enantiomers in broilers fed various cottonseed meals. |
2001 |
Poult. Sci. |
pmid:11469655
|
Zeng QF et al. |
Effects of dietary gossypol concentration on growth performance, blood profiles, and hepatic histopathology in meat ducks. |
2014 |
Poult. Sci. |
pmid:24902707
|
Henry MH et al. |
The performance of broiler chicks fed diets containing extruded cottonseed meal supplemented with lysine. |
2001 |
Poult. Sci. |
pmid:11441843
|
Gamboa DA et al. |
Use of expander cottonseed meal in broiler diets formulated on a digestible amino acid basis. |
2001 |
Poult. Sci. |
pmid:11441847
|
Aitken RJ |
New techniques in contraception: gossypol, vaccines and GnRH analogues. |
1983 |
Proc Annu Symp Eugen Soc |
pmid:6366784
|
Jacobs HS |
Contraception in the future. |
1981 |
Proc Annu Symp Eugen Soc |
pmid:7050975
|
Wu DF and Yu YW |
Superoxide free radical formation stimulated by (+/-), (+), (-) gossypol in rat liver and kidney microsomes. |
1986 |
Proc Chin Acad Med Sci Peking Union Med Coll |
pmid:2827151
|
Su SY and Liu Y |
Electron microscopic observation of gossypol effects on gastrocnemius muscles in laboratory animals. |
1987 |
Proc Chin Acad Med Sci Peking Union Med Coll |
pmid:2827153
|
Zhao Y et al. |
Studies on frequencies of sister chromatid exchange in peripheral blood lymphocytes before and after gossypol treatment. |
1986 |
Proc Chin Acad Med Sci Peking Union Med Coll |
pmid:3422992
|
Liu GZ et al. |
Effect of K salt and K sparing agent in preventing gossypol-induced hypokalemia. |
1987 |
Proc Chin Acad Med Sci Peking Union Med Coll |
pmid:3423005
|
Cheng JX et al. |
Effect of gossypol(+/-, +, -) on Leydig cells of rat in vitro. |
1987 |
Proc Chin Acad Med Sci Peking Union Med Coll |
pmid:3423013
|
Huang T et al. |
Gossypol-induced alterations of aminophospholipid composition in human sperm. |
1990 |
Proc Chin Acad Med Sci Peking Union Med Coll |
pmid:2371261
|
Zhang JB et al. |
Effect of gossypol on fertilization capacity and chromosome formation of human sperm in vitro. |
1986 |
Proc Chin Acad Med Sci Peking Union Med Coll |
pmid:3432238
|
Ye WS et al. |
Cytological toxicity of gossypol on rat gametogenesis and spermatozoa. |
1986 |
Proc Chin Acad Med Sci Peking Union Med Coll |
pmid:3432239
|
Lei HP |
Future research priorities of gossypol in the field of fertility regulation. |
1987 |
Proc Chin Acad Med Sci Peking Union Med Coll |
pmid:3321051
|
Damaty S and Hudson BJ |
A secondary interaction between gossypol and cottonseed protein. |
1975 |
Proc Nutr Soc |
pmid:1187618
|
Heiser V et al. |
Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: implications for Huntington's disease therapy. |
2000 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:10829068
|
Sunilkumar G et al. |
Engineering cottonseed for use in human nutrition by tissue-specific reduction of toxic gossypol. |
2006 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:17110445
|
Dash R et al. |
Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda-7/IL-24-mediated toxicity. |
2011 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:21555592
|
Le A et al. |
Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression. |
2010 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:20133848
|
Rillema JA et al. |
Studies on the possible role of protein kinase C in the prolactin regulation of cell replication in Nb2 node lymphoma cells. |
1989 |
Proc. Soc. Exp. Biol. Med. |
pmid:2813443
|
HARMS WS and HOLLEY KT |
Hypoprothrombinemia induced by gossypol. |
1951 |
Proc. Soc. Exp. Biol. Med. |
pmid:14854026
|
Othman MA and Abou-Donia MB |
Pharmacokinetic profile of (+/-)-gossypol in male Sprague-Dawley rats following single intravenous and oral and subchronic oral administration. |
1988 |
Proc. Soc. Exp. Biol. Med. |
pmid:3368474
|
CASTILLON LE and ALTSCHUL AM |
Preparation of water-soluble combination products of gossypol and their toxicity to aquarium fish. |
1950 |
Proc. Soc. Exp. Biol. Med. |
pmid:15440911
|
Jennings MB and Reidenberg MM |
Adaptation to nephrotoxic chemicals. |
1988 |
Proc. Soc. Exp. Biol. Med. |
pmid:3205883
|
Gonzalez-Garza T et al. |
In vitro evaluation of gossypol as potential antiamoebic drug. |
1991 |
Proc. West. Pharmacol. Soc. |
pmid:1788315
|
Fu YF et al. |
Effects of gossypol on the activity of rabbit kidney Na,K-ATPase and the functions of human erythrocyte membrane. |
1988 |
Prog. Clin. Biol. Res. |
pmid:2975784
|
Sessions RB et al. |
A model of Plasmodium falciparum lactate dehydrogenase and its implications for the design of improved antimalarials and the enhanced detection of parasitaemia. |
1997 |
Protein Eng. |
pmid:9194154
|
Zerp SF et al. |
Targeting anti-apoptotic Bcl-2 by AT-101 to increase radiation efficacy: data from in vitro and clinical pharmacokinetic studies in head and neck cancer. |
2015 |
Radiat Oncol |
pmid:26223311
|
Zerp SF et al. |
AT-101, a small molecule inhibitor of anti-apoptotic Bcl-2 family members, activates the SAPK/JNK pathway and enhances radiation-induced apoptosis. |
2009 |
Radiat Oncol |
pmid:19852810
|
Ivanov AA et al. |
[Immunopharmacological analysis of secondary postradiation immunodeficiency]. |
1994 Jul-Oct |
Radiats Biol Radioecol |
pmid:7951873
|
Lebedev VG et al. |
[Effect of kagocel on the postradiation recovery of the hematopoiesis and immune status in mice exposed to ionizing radiation in sublethal dosage]. |
1994 Jul-Oct |
Radiats Biol Radioecol |
pmid:7951886
|
Kasten-Pisula U et al. |
Radiosensitization of tumour cell lines by the polyphenol Gossypol results from depressed double-strand break repair and not from enhanced apoptosis. |
2007 |
Radiother Oncol |
pmid:17521756
|
Radigue C et al. |
Early effects of gossypol on the testis and epididymis in the rat. |
1988 |
Reprod Nutr Dev |
pmid:3253903
|
Fiorini C et al. |
Sertoli cell junctional proteins as early targets for different classes of reproductive toxicants. |
2004 |
Reprod. Toxicol. |
pmid:15082077
|
Akingbemi BT et al. |
The influence of protein malnutrition on the antifertility action of gossypol in the Trypanosoma brucei-infected rat: some ultrastructural observations from the testis. |
1997 Jul-Aug |
Reprod. Toxicol. |
pmid:9241673
|
Liu GZ |
Clinical study of gossypol as a male contraceptive. |
1981 Jul-Sep |
Reproduccion |
pmid:6793420
|
Gu Y and Lin YC |
Suppression of adrenocorticotropic hormone (ACTH)-induced corticosterone secretion in cultured rat adrenocortical cells by gossypol and gossypolone. |
1991 |
Res. Commun. Chem. Pathol. Pharmacol. |
pmid:1647048
|
Moh PP et al. |
Characteristics of covalent gossypol binding to microsomal proteins. |
1992 |
Res. Commun. Chem. Pathol. Pharmacol. |
pmid:1636054
|
Messiha FS |
Gossypol modulation of mouse heart and liver lactate dehydrogenase isoenzymes as a function of gender. |
1990 |
Res. Commun. Chem. Pathol. Pharmacol. |
pmid:2396051
|
Moh PP et al. |
Effect of gossypol on 5 alpha-reductase and 3 alpha-hydroxysteroid dehydrogenase activities in adult rat testes. |
1993 |
Res. Commun. Chem. Pathol. Pharmacol. |
pmid:8272571
|
Chang CJ et al. |
Antiproliferative and antimetastatic effects of gossypol on Dunning prostate cell-bearing Copenhagen rats. |
1993 |
Res. Commun. Chem. Pathol. Pharmacol. |
pmid:8480076
|
Chang WY et al. |
Experimentally-induced prostatic hyperplasia in young beagles: a model to evaluate the chemotherapeutic effects of gossypol. |
1996 |
Res. Commun. Mol. Pathol. Pharmacol. |
pmid:8827831
|
Mushtaq M et al. |
Gossypol inhibits human chorionic gonadotropin-stimulated testosterone production by cultured canine testicular interstitial cells. |
1996 |
Res. Commun. Mol. Pathol. Pharmacol. |
pmid:8829766
|
Abou-Donia MB |
Physiological effects and metabolism of gossypol. |
1976 |
Residue Rev |
pmid:778955
|
Demoulin A |
[Male contraception]. |
1984 |
Rev Med Liege |
pmid:6729295
|
Jackson H and Schnieden H |
Aspects of male reproductive pharmacology and toxicology. |
1982 Jan-Mar |
Rev Pure Appl Pharmacol Sci |
pmid:6291102
|
Nogueda-Torres B et al. |
Trypanocidal activity of 4 isopropyl salicylaldehyde and 4-isopropyl salicylic acid on Trypanosoma cruzi. |
2001 Jan-Mar |
Rev. Latinoam. Microbiol. |
pmid:17061565
|
Vershinina MY et al. |
Regulation of cytokine mRNAs by interferon and interferon inducers. |
2002 |
Russ. J. Immunol. |
pmid:12687259
|
Räsänen TL et al. |
Gossypol activates pancreatic polyamine catabolism in normal rats and induces acute pancreatitis in transgenic rats over-expressing spermidine/spermine N1-acetyltransferase. |
2003 |
Scand. J. Gastroenterol. |
pmid:12889567
|
Wu G et al. |
Temporal allocation of metabolic tolerance in the body of beet armyworm in response to three gossypol-cotton cultivars. |
2009 |
Sci. China, C, Life Sci. |
pmid:20016971
|
Shepu X et al. |
Antispermatogenic effect of gossypol on the germinal epithelium of the rat testes. A cytological, autoradiographical and ultrastructural observation. |
1980 |
Sci. Sin. |
pmid:7403840
|
Bi XF et al. |
The effect of gossypol on ATPase activity of the kidney. |
1981 |
Sci. Sin. |
pmid:6266011
|
Xue SP et al. |
Subcellular site of antispermatogenic effect of gossypol and its possible molecular mechanism of action. |
1983 |
Sci. Sin., Ser. B, Chem. Biol. Agric. Med. Earth Sci. |
pmid:6623054
|
Wu YW et al. |
Effect of gossypol on the potential difference of rat seminiferous tubules. |
1985 |
Sci. Sin., Ser. B, Chem. Biol. Agric. Med. Earth Sci. |
pmid:4012264
|
Fishbein L |
Natural non-nutrient substances in the food chain. |
1972 |
Sci. Total Environ. |
pmid:4121147
|
Baugher WL and Campbell TC |
Gossypol detoxication by fungi. |
1969 |
Science |
pmid:5786644
|
Maugh TH |
Male "pill" blocks sperm enzyme. |
1981 |
Science |
pmid:7193910
|
Eagle E |
Chronic Toxicity of Gossypol. |
1949 |
Science |
pmid:17742136
|
Montamat EE et al. |
Inhibitory action of gossypol on enzymes and growth of Trypanosoma cruzi. |
1982 |
Science |
pmid:6750791
|
Gadelha IC et al. |
Gossypol promotes degeneration of ovarian follicles in rats. |
2014 |
ScientificWorldJournal |
pmid:25540815
|
Gadelha IC et al. |
Gossypol toxicity from cottonseed products. |
2014 |
ScientificWorldJournal |
pmid:24895646
|
Cui X et al. |
[Determination of free gossypol in meat by reversed-phased high performance liquid chromatography]. |
2004 |
Se Pu |
pmid:15706952
|
Anderson MA et al. |
Targeting BCL2 for the treatment of lymphoid malignancies. |
2014 |
Semin. Hematol. |
pmid:25048785
|
Guo Z et al. |
[Gossypol acetic acid induces DNA double-strand breaks in human mucoepidermoid carcinoma cell MEC-1]. |
2011 |
Sheng Li Xue Bao |
pmid:21505732
|
Yuan JR |
[Methods of extraction and purification of gossypol]. |
1984 |
Shengzhi Yu Biyun |
pmid:12339570
|
Wang R |
[Sister chromatid exchanges in gossypol formic acid users after its discontinuation]. |
1986 |
Shengzhi Yu Biyun |
pmid:12341303
|
Wu GP |
[Gossypol and its related compounds as contraceptive drugs and drugs for gynecological diseases]. |
1988 |
Shengzhi Yu Biyun |
pmid:12282152
|
Zhong CQ |
[The morphology and formation of micronuclei of blood lymphocytes in man after cessation of gossypol administration]. |
1986 |
Shengzhi Yu Biyun |
pmid:12314624
|
Zhong CQ |
[Studies on sperm function in man long after cessation of gossypol administration]. |
1988 |
Shengzhi Yu Biyun |
pmid:12315492
|
Zhang ZS et al. |
[Use of technique of culturing cells in diffusion chamber in host-mediate for testing chromosomal effects of gossypol acetate on human lymphocytes]. |
1984 |
Shengzhi Yu Biyun |
pmid:12267337
|
|
[The clinical study of gossypol in 8,806 men]. |
1985 |
Shengzhi Yu Biyun |
pmid:12267797
|
Huang JX et al. |
[Studies on the synthesis of gossypol derivatives and their antifertility action]. |
1986 |
Shengzhi Yu Biyun |
pmid:12267916
|
Tan FQ |
[Gossypol acetate users]. |
1986 |
Shengzhi Yu Biyun |
pmid:12267917
|
Wang YX and Chen ZX |
[A possible mechanism of gossypol-induced hypokalemia and its relation to gossypol dose]. |
1991 |
Shengzhi Yu Biyun |
pmid:12317367
|
Chang SM et al. |
[Effect of gossypol on the proliferation of rat prostate cells studies in vivo and in vitro]. |
1992 |
Shi Yan Sheng Wu Xue Bao |
pmid:1303003
|
Wu YW et al. |
[Electrophysiological and ultrastructural studies of the blood-epididymis barrier of the rat]. |
1986 |
Shi Yan Sheng Wu Xue Bao |
pmid:3577546
|
Wu YW et al. |
[Ultrastructural studies on sodium and potassium ion active transport in the rat epididymis]. |
1988 |
Shi Yan Sheng Wu Xue Bao |
pmid:2849267
|
Aoyama K |
[Determination of gossypol in feeds by HPLC]. |
2008 |
Shokuhin Eiseigaku Zasshi |
pmid:18787315
|