| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
| Leukemia, Experimental | D007942 | 42 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Mol. Cancer Ther. (4)
- Proc. Natl. Acad. Sci. U.S.A. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (2)
- Others (13)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zhong CQ | [The morphology and formation of micronuclei of blood lymphocytes in man after cessation of gossypol administration]. | 1986 | Shengzhi Yu Biyun | pmid:12314624 |
| Cheng CC | A common structural pattern among many biologically active compounds of natural and synthetic origin. | 1986 | Med. Hypotheses | pmid:3090407 |
| Vongsorasak L and Svasti J | Gossypol prevents activation of purified proenzyme of human seminal plasma acidic proteinase. | 1986 | Biochim. Biophys. Acta | pmid:3091079 |
| Sun TS | [Long-term follow-up studies on patients poisoned by cottonseed oil]. | 1986 | Zhonghua Yi Xue Za Zhi | pmid:3091216 |
| Sheriff DS et al. | Gossypol and lipid peroxidation. | 1986 | Am. J. Obstet. Gynecol. | pmid:3740171 |
| Sein GM | The embryotoxic and immunodepressive effects of gossypol. | 1986 | Am. J. Chin. Med. | pmid:3799526 |
| Burgos C et al. | In vitro inhibition by gossypol of oxidoreductases from human tissues. | 1986 | Biochem. Pharmacol. | pmid:3754138 |
| Joseph AE et al. | Cytotoxicity of enantiomers of gossypol. | 1986 | Br. J. Cancer | pmid:3756086 |
| Wichmann K et al. | Studies on structure-activity relationship of gossypol, gossypol ethers and three naphthaldehydes in the inhibition of spermatozoal metabolism. | 1986 | Contraception | pmid:3757514 |
| Jiang DH et al. | [The comparison of some properties of gossypol recrystallized from different solvents]. | 1986 | Yao Xue Xue Bao | pmid:3811948 |
| Förstermann U et al. | Inhibitors of acyl-coenzyme A:lysolecithin acyltransferase activate the production of endothelium-derived vascular relaxing factor. | 1986 | J. Pharmacol. Exp. Ther. | pmid:3487639 |
| Kalla NR et al. | Involvement of prostaglandin in the antifertility effects of gossypol. | 1986 | Contraception | pmid:3465506 |
| Chongthammakun S et al. | Effects of gossypol on human and monkey sperm motility in vitro. | 1986 | Contraception | pmid:3791997 |
| Zhao DP et al. | [Effect of gossypol formic acid on the fluidity of the spermatocyte plasma membrane of the rat]. | 1986 | Zhongguo Yao Li Xue Bao | pmid:2945391 |
| Xu Y et al. | [Analysis of the effect of gossypol on the activity of purified LDH-X]. | 1986 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:2952308 |
| Fody EP and Walker EM | Effects of drugs on the male and female reproductive systems. | 1985 Nov-Dec | Ann. Clin. Lab. Sci. | pmid:4062226 |
| Kim IC et al. | Inhibition of LDH-X by gossypol optical isomers. | 1985 Nov-Dec | J. Androl. | pmid:4077725 |
| Sadykov AS et al. | [Effect of gossypol on spermatogenesis and fertility in man and mammals]. | 1985 Jul-Aug | Ontogenez | pmid:3900844 |
| Shi QX and Friend DS | Effect of gossypol acetate on guinea pig epididymal spermatozoa in vivo and their susceptibility to capacitation in vitro. | 1985 Jan-Feb | J. Androl. | pmid:3972719 |
| Kim SH et al. | Gossypol, a hyperthermic sensitizer of HeLa cells. | 1985 | Cancer Res. | pmid:4063984 |
| Haspel HC et al. | Effect of gossypol on erythrocyte membrane function: specific inhibition of inorganic anion exchange and interaction with band 3. | 1985 | J. Pharmacol. Exp. Ther. | pmid:4032282 |
| Kimura K et al. | Inhibition by gossypol of phospholipid-sensitive Ca2+-dependent protein kinase from pig testis. | 1985 | Biochim. Biophys. Acta | pmid:3157405 |
| Berry CN et al. | Gossypol is a potent inhibitor of the NAD+-dependent dehydrogenase responsible for the inactivation of prostaglandins. | 1985 | Zhongguo Yao Li Xue Bao | pmid:3158161 |
| Li FY et al. | [The antiandrogen effect of gossypol and its influence on androgen receptor]. | 1985 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:3158419 |
| Wang YF | [Late effect of gossypol treatment in gynecological diseases--a clinical study of 72 cases]. | 1985 | Zhong Xi Yi Jie He Za Zhi | pmid:3158438 |
| [The clinical study of gossypol in 8,806 men]. | 1985 | Shengzhi Yu Biyun | pmid:12267797 | |
| Wang MZ et al. | [Determination of gossypol with high performance liquid chromatography]. | 1985 | Yao Xue Xue Bao | pmid:3834747 |
| Vongsorasak L and Svasti J | Inhibition of liquefaction and protein degradation in human semen by gossypol. | 1985 | Int. J. Androl. | pmid:3835162 |
| Tone JN and Jensen DR | Radioiron utilization and gossypol acetic acid in male rats. | 1985 | Drug Chem Toxicol | pmid:4017900 |
| Rikihisa Y et al. | Histopathologic changes of uterus following gossypol treatment during early pregnancy in rats. | 1985 | Anat. Rec. | pmid:4073564 |
| Krasil'nikov OV et al. | [Dependence of the protonophore and channel-forming capacity of gossypol on the pH]. | 1985 | Dokl. Akad. Nauk SSSR | pmid:2408838 |
| Kainz P et al. | The in vivo effect of gossypol on macromolecular synthesis in rat testis. | 1985 | Contraception | pmid:2419026 |
| McClarty GA et al. | Ribonucleotide reductase: an intracellular target for the male antifertility agent, gossypol. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3907637 |
| Qian SZ | Gossypol-hypokalaemia interrelationships. | 1985 | Int. J. Androl. | pmid:3908325 |
| Wang C and Yeung RT | Gossypol and hypokalaemia. | 1985 | Contraception | pmid:3910352 |
| Liu GZ | [Clinical trial of gossypol as a male contraceptive: a randomized controlled study]. | 1985 | Zhonghua Yi Xue Za Zhi | pmid:3921206 |
| Zhang LS | [Effect of gossypol on serum gonadotropin and testosterone levels: long-term follow-up study]. | 1985 | Zhonghua Yi Xue Za Zhi | pmid:3931874 |
| Zhang GY et al. | Dynamic study of serum gonadotrophin and testosterone levels in gossypol-treated men. Long term follow-up study of 60 cases. | 1985 | Int. J. Androl. | pmid:3932223 |
| Hawkins GE et al. | Physiological effects of whole cottonseed in the diet of lactating dairy cows. | 1985 | J. Dairy Sci. | pmid:3934243 |
| Wang WC et al. | [Changes of serum concentrations of testosterone, LH and FSH in men taking gossypol]. | 1985 | Yao Xue Xue Bao | pmid:3938917 |
| Hamasaki Y and Tai HH | Gossypol, a potent inhibitor of arachidonate 5- and 12-lipoxygenases. | 1985 | Biochim. Biophys. Acta | pmid:3919771 |
| Matlin SA et al. | (-)-Gossypol: an active male antifertility agent. | 1985 | Contraception | pmid:3987276 |
| Wang Y et al. | Antifertility effect of polyvinylpyrrolidone-gossypol and gossypol in male rats. | 1985 | Contraception | pmid:4092462 |
| Lagerlöf RK and Tone JN | The effect of gossypol acetic acid on female reproduction. | 1985 | Drug Chem Toxicol | pmid:4092619 |
| Gao H et al. | [Primary observations on distal renal tubule acidosis in 177 cases caused by gossypol intoxication]. | 1985 | Zhonghua Nei Ke Za Zhi | pmid:4053804 |
| Wang MZ et al. | High-performance liquid chromatography with electrochemical detection of gossypol in human plasma. | 1985 | J. Chromatogr. | pmid:4066879 |
| Wang WH et al. | [Influence of salicylaldehyde and its analogs on the antispermatogenic effect of gossypol]. | 1985 | Yao Xue Xue Bao | pmid:4083027 |
| Pearce S et al. | The viability of mouse Leydig cells in vitro following incubation with gossypol. | 1985 | Contraception | pmid:4085245 |
| Gu Y and Anderson NO | Effects of gossypol on the estrous cycle and ovarian weight in the rat. | 1985 | Contraception | pmid:4085249 |
| Patton CS et al. | Heart failure caused by gossypol poisoning in two dogs. | 1985 | J. Am. Vet. Med. Assoc. | pmid:4086371 |