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Synergistic combination of small molecule inhibitor and RNA interference against antiapoptotic Bcl-2 protein in head and neck cancer cells. |
2013 |
Mol. Pharm. |
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Efficacy of docetaxel-based chemotherapy following ketoconazole in metastatic castration-resistant prostate cancer: implications for prior therapy in clinical trials. |
2013 |
Urol. Oncol. |
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Gao W et al. |
Proteomic and virus-induced gene silencing (VIGS) Analyses reveal that gossypol, brassinosteroids, and jasmonic acid contribute to the resistance of cotton to Verticillium dahliae. |
2013 |
Mol. Cell Proteomics |
pmid:24019146
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Fonseca NB et al. |
Effectiveness of albumin-conjugated gossypol as an immunogen to prevent gossypol-associated acute hepatotoxicity in rats. |
2013 |
Food Chem. Toxicol. |
pmid:23485613
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Prakash O and Khan F |
Development of method for three-point data estimation and SVR-QSAR model to screen anti cancer leads. |
2013 |
Comb. Chem. High Throughput Screen. |
pmid:23410041
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Varadarajan S et al. |
Endoplasmic reticulum membrane reorganization is regulated by ionic homeostasis. |
2013 |
PLoS ONE |
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Mao YB et al. |
Cysteine protease enhances plant-mediated bollworm RNA interference. |
2013 |
Plant Mol. Biol. |
pmid:23460027
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El-Nassan HB |
Advances in the discovery of kinesin spindle protein (Eg5) inhibitors as antitumor agents. |
2013 |
Eur J Med Chem |
pmid:23434636
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Liu Z et al. |
Protective effect of gossypol on lipopolysaccharide-induced acute lung injury in mice. |
2013 |
Inflamm. Res. |
pmid:23435932
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Pridgeon JW et al. |
Attempt to develop live attenuated bacterial vaccines by selecting resistance to gossypol, proflavine hemisulfate, novobiocin, or ciprofloxacin. |
2013 |
Vaccine |
pmid:23499519
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Hamdy R et al. |
Synthesis and evaluation of 3-(benzylthio)-5-(1H-indol-3-yl)-1,2,4-triazol-4-amines as Bcl-2 inhibitory anticancer agents. |
2013 |
Bioorg. Med. Chem. Lett. |
pmid:23474389
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Yuan Y et al. |
Gossypol and an HMT G9a inhibitor act in synergy to induce cell death in pancreatic cancer cells. |
2013 |
Cell Death Dis |
pmid:23807219
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Deng S et al. |
Gossypol acetic acid induces apoptosis in RAW264.7 cells via a caspase-dependent mitochondrial signaling pathway. |
2013 |
J. Vet. Sci. |
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Zhan YH et al. |
Growth inhibition and apoptosis induction of human umbilical vein endothelial cells by apogossypolone. |
2013 |
Asian Pac. J. Cancer Prev. |
pmid:23679275
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Mellon JE et al. |
Effects of temperature and medium composition on inhibitory activities of gossypol-related compounds against aflatoxigenic fungi. |
2013 |
J. Appl. Microbiol. |
pmid:23594138
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Cho H et al. |
Poly(ethylene glycol)-block-poly(ε-caprolactone) micelles for combination drug delivery: evaluation of paclitaxel, cyclopamine and gossypol in intraperitoneal xenograft models of ovarian cancer. |
2013 |
J Control Release |
pmid:23246471
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Ahn JH et al. |
Defective autophagy in multidrug resistant cells may lead to growth inhibition by BH3-mimetic gossypol. |
2013 |
J. Cell. Physiol. |
pmid:23254564
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Zhang Z et al. |
Novel soluble myeloid cell leukemia sequence 1 (Mcl-1) inhibitor (E,E)-2-(benzylaminocarbonyl)-3-styrylacrylonitrile (4g) developed using a fragment-based approach. |
2013 |
Eur J Med Chem |
pmid:23220642
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Xin J et al. |
ApoG2 as the most potent gossypol derivatives inhibits cell growth and induces apoptosis on gastric cancer cells. |
2013 |
Biomed. Pharmacother. |
pmid:23201009
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Song T et al. |
3-Thiomorpholin-8-oxo-8H-acenaphtho [1,2-b] pyrrole-9-carbonitrile (S1) derivatives as pan-Bcl-2-inhibitors of Bcl-2, Bcl-xL and Mcl-1. |
2013 |
Bioorg. Med. Chem. |
pmid:23206987
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Cheng P et al. |
The novel BH-3 mimetic apogossypolone induces Beclin-1- and ROS-mediated autophagy in human hepatocellular carcinoma [corrected] cells. |
2013 |
Cell Death Dis |
pmid:23392177
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Ni Z et al. |
Natural Bcl-2 inhibitor (-)- gossypol induces protective autophagy via reactive oxygen species-high mobility group box 1 pathway in Burkitt lymphoma. |
2013 |
Leuk. Lymphoma |
pmid:23398207
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Huo M et al. |
Suppression of LPS-induced inflammatory responses by gossypol in RAW 264.7 cells and mouse models. |
2013 |
Int. Immunopharmacol. |
pmid:23352443
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A Pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition. |
2013 |
Cell Stem Cell |
pmid:23333150
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Anderson MA et al. |
BH3 mimetic therapy: an emerging and promising approach to treating chronic lymphocytic leukemia. |
2013 |
Leuk. Lymphoma |
pmid:23339446
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Kannan A et al. |
Effect of feeding of calcium hydroxide-treated or vitamin E-supplemented cottonseed meal on plasma gossypol levels, blood parameters, and performance of Bikaneri lambs. |
2013 |
Trop Anim Health Prod |
pmid:23345064
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Ansari N et al. |
Quantitative 3D cell-based assay performed with cellular spheroids and fluorescence microscopy. |
2013 |
Methods Cell Biol. |
pmid:23317907
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Palle SR et al. |
RNAi-mediated Ultra-low gossypol cottonseed trait: performance of transgenic lines under field conditions. |
2013 |
Plant Biotechnol. J. |
pmid:23078138
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Zelaya CA et al. |
Di(phenylpropylamino)gossypol: a derivative of the dimeric natural product gossypol. |
2013 |
Acta Crystallogr C |
pmid:23579723
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Wang J et al. |
Gossypol induces apoptosis in ovarian cancer cells through oxidative stress. |
2013 |
Mol Biosyst |
pmid:23532321
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Yang J et al. |
Synthesis and anti-H5N1 activity of chiral gossypol derivatives and its analogs implicated by a viral entry blocking mechanism. |
2013 |
Bioorg. Med. Chem. Lett. |
pmid:23538114
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Xin J et al. |
ApoG2 induces ER stress-dependent apoptosis in gastric cancer cells in vitro and its real-time evaluation by bioluminescence imaging in vivo. |
2013 |
Cancer Lett. |
pmid:23523614
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Tang H et al. |
Oxidative stress induces monocyte necrosis with enrichment of cell-bound albumin and overexpression of endoplasmic reticulum and mitochondrial chaperones. |
2013 |
PLoS ONE |
pmid:23555724
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Broderick GA et al. |
Effect of replacing soybean meal protein with protein from upland cottonseed, Pima cottonseed, or extruded Pima cottonseed on production of lactating dairy cows. |
2013 |
J. Dairy Sci. |
pmid:23462167
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Kapoor S |
Attenuating effect of gossypol on tumor growth in systemic malignancies. |
2013 |
Cell Biochem. Biophys. |
pmid:23743711
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Lin J et al. |
Induction of apoptosis and antitumor effects of a small molecule inhibitor of Bcl-2 and Bcl-xl, gossypol acetate, in multiple myeloma in vitro and in vivo. |
2013 |
Oncol. Rep. |
pmid:23708869
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Zhou M et al. |
Metabolic engineering of gossypol in cotton. |
2013 |
Appl. Microbiol. Biotechnol. |
pmid:23775273
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Song B et al. |
Gossypol suppresses mouse T lymphocytes via inhibition of NFκB, NFAT and AP-1 pathways. |
2013 |
Immunopharmacol Immunotoxicol |
pmid:23981004
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Billard C |
BH3 mimetics: status of the field and new developments. |
2013 |
Mol. Cancer Ther. |
pmid:23974697
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Guo JY et al. |
Effects of high-gossypol cotton on the development and reproduction of Bemisia tabaci (Hemiptera: Aleyrodidae) MEAM1 cryptic species. |
2013 |
J. Econ. Entomol. |
pmid:23865205
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Zhang Z et al. |
Design and application of a rigid quinazolone scaffold based on two-face Bim α-helix mimicking. |
2013 |
Eur J Med Chem |
pmid:24095762
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Karaca B et al. |
Combination of AT-101/cisplatin overcomes chemoresistance by inducing apoptosis and modulating epigenetics in human ovarian cancer cells. |
2013 |
Mol. Biol. Rep. |
pmid:23269627
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Soderquist R et al. |
Gossypol overcomes stroma-mediated resistance to the BCL2 inhibitor ABT-737 in chronic lymphocytic leukemia cells ex vivo. |
2013 |
Leukemia |
pmid:23640104
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Granchi C et al. |
Small-molecule inhibitors of human LDH5. |
2013 |
Future Med Chem |
pmid:24175747
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Zhang Z et al. |
Fragment-based design, synthesis, and biological evaluation of N-substituted-5-(4-isopropylthiophenol)-2-hydroxynicotinamide derivatives as novel Mcl-1 inhibitors. |
2013 |
Eur J Med Chem |
pmid:23314054
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Zhong S et al. |
(-)-Gossypol-enriched cottonseed oil inhibits proliferation and adipogenesis of human breast pre-adipocytes. |
2013 |
Anticancer Res. |
pmid:23482766
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Sokolova TM et al. |
Ridostin induces transcription of a wide spectrum of interferon genes in human cells. |
2013 |
Bull. Exp. Biol. Med. |
pmid:24319751
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Jiao X et al. |
Comparative transcriptomic analysis of developing cotton cotyledons and embryo axis. |
2013 |
PLoS ONE |
pmid:23977137
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Sorokina EV et al. |
[Influence of immunovac-VP-4 therapy on innate immunity effectors in patients with darier erythema annulare centrifugum]. |
2013 Nov-Dec |
Zh. Mikrobiol. Epidemiol. Immunobiol. |
pmid:24605681
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Gadelha IC et al. |
Gossypol toxicity from cottonseed products. |
2014 |
ScientificWorldJournal |
pmid:24895646
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