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Bax and Bak are required for apogossypolone, a BH3-mimetic, induced apoptosis in chronic lymphocytic leukemia cells. |
2013 |
Leuk. Lymphoma |
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ApoG2 as the most potent gossypol derivatives inhibits cell growth and induces apoptosis on gastric cancer cells. |
2013 |
Biomed. Pharmacother. |
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3-Thiomorpholin-8-oxo-8H-acenaphtho [1,2-b] pyrrole-9-carbonitrile (S1) derivatives as pan-Bcl-2-inhibitors of Bcl-2, Bcl-xL and Mcl-1. |
2013 |
Bioorg. Med. Chem. |
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Cheng P et al. |
The novel BH-3 mimetic apogossypolone induces Beclin-1- and ROS-mediated autophagy in human hepatocellular carcinoma [corrected] cells. |
2013 |
Cell Death Dis |
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Ni Z et al. |
Natural Bcl-2 inhibitor (-)- gossypol induces protective autophagy via reactive oxygen species-high mobility group box 1 pathway in Burkitt lymphoma. |
2013 |
Leuk. Lymphoma |
pmid:23398207
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Huo M et al. |
Suppression of LPS-induced inflammatory responses by gossypol in RAW 264.7 cells and mouse models. |
2013 |
Int. Immunopharmacol. |
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A Pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition. |
2013 |
Cell Stem Cell |
pmid:23333150
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Anderson MA et al. |
BH3 mimetic therapy: an emerging and promising approach to treating chronic lymphocytic leukemia. |
2013 |
Leuk. Lymphoma |
pmid:23339446
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Kannan A et al. |
Effect of feeding of calcium hydroxide-treated or vitamin E-supplemented cottonseed meal on plasma gossypol levels, blood parameters, and performance of Bikaneri lambs. |
2013 |
Trop Anim Health Prod |
pmid:23345064
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Ansari N et al. |
Quantitative 3D cell-based assay performed with cellular spheroids and fluorescence microscopy. |
2013 |
Methods Cell Biol. |
pmid:23317907
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Senarisoy M et al. |
Gossypol interferes with both type I and type II topoisomerase activities without generating strand breaks. |
2013 |
Cell Biochem. Biophys. |
pmid:23161103
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Bcl-2 family of proteins as therapeutic targets in genitourinary neoplasms. |
2013 |
Clin Genitourin Cancer |
pmid:23083798
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RNAi-mediated Ultra-low gossypol cottonseed trait: performance of transgenic lines under field conditions. |
2013 |
Plant Biotechnol. J. |
pmid:23078138
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Zelaya CA et al. |
Di(phenylpropylamino)gossypol: a derivative of the dimeric natural product gossypol. |
2013 |
Acta Crystallogr C |
pmid:23579723
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Karaca B et al. |
Combination of AT-101/cisplatin overcomes chemoresistance by inducing apoptosis and modulating epigenetics in human ovarian cancer cells. |
2013 |
Mol. Biol. Rep. |
pmid:23269627
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Soderquist R et al. |
Gossypol overcomes stroma-mediated resistance to the BCL2 inhibitor ABT-737 in chronic lymphocytic leukemia cells ex vivo. |
2013 |
Leukemia |
pmid:23640104
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Granchi C et al. |
Small-molecule inhibitors of human LDH5. |
2013 |
Future Med Chem |
pmid:24175747
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Zhang Z et al. |
Fragment-based design, synthesis, and biological evaluation of N-substituted-5-(4-isopropylthiophenol)-2-hydroxynicotinamide derivatives as novel Mcl-1 inhibitors. |
2013 |
Eur J Med Chem |
pmid:23314054
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Zhong S et al. |
(-)-Gossypol-enriched cottonseed oil inhibits proliferation and adipogenesis of human breast pre-adipocytes. |
2013 |
Anticancer Res. |
pmid:23482766
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Varadarajan S et al. |
Sabutoclax (BI97C1) and BI112D1, putative inhibitors of MCL-1, induce mitochondrial fragmentation either upstream of or independent of apoptosis. |
2013 |
Neoplasia |
pmid:23633928
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