Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Lin YC et al. | Inhibition of in vitro fertilization and early embryonic development in hamsters by gossypol. | 1994 | Life Sci. | pmid:8090055 |
González-Garza MT et al. | Differential effects of the (+)- and (-)-gossypol enantiomers upon Entamoeba histolytica axenic cultures. | 1993 | J. Pharm. Pharmacol. | pmid:8095532 |
MartÃnez F et al. | The antifertility agent, gossypol, releases calcium from rat liver mitochondria. | 1993 | Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. | pmid:8097449 |
Chase CC et al. | Growth and reproductive development in Brahman bulls fed diets containing gossypol. | 1994 | J. Anim. Sci. | pmid:8157529 |
East NE et al. | Apparent gossypol-induced toxicosis in adult dairy goats. | 1994 | J. Am. Vet. Med. Assoc. | pmid:8163423 |
Cowart CL et al. | The effects of cyclic adenosine monophosphate, forskolin, and theophylline on motility parameters in gossypol-treated human sperm. | 1994 | Fertil. Steril. | pmid:8174733 |
Fornés MW et al. | Sperm motility loss induced by gossypol: relation with OH. scavengers, motile stimulators and malondialdehyde production. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8216260 |
Li H and He X | [The effects of optical isomers of gossypol on Sertoli cells in vitro]. | 1993 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:8242829 |
Hu YF et al. | Gossypol inhibits basal and estrogen-stimulated DNA synthesis in human breast carcinoma cells. | 1993 | Life Sci. | pmid:8255144 |
Zhang SC et al. | [The adverse effects of the preparations of the active principles of Chinese herbal drugs]. | 1993 | Zhongguo Zhong Yao Za Zhi | pmid:8267848 |
Gray ML et al. | Effects of dietary gossypol consumption on metabolic homeostasis and reproductive endocrine function in beef heifers and cows. | 1993 | J. Anim. Sci. | pmid:8270527 |
Sullivan JL et al. | Performance of dairy cows fed short staple, Pima, and cracked Pima cottonseed and feed characteristics. | 1993 | J. Dairy Sci. | pmid:8270698 |
Moh PP et al. | Effect of gossypol on 5 alpha-reductase and 3 alpha-hydroxysteroid dehydrogenase activities in adult rat testes. | 1993 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:8272571 |
Ye W et al. | Effect of intra-vas deferens injection of gossypol-polylactic acid on fertility and spermatogenesis in rats. | 1993 | Chin. Med. Sci. J. | pmid:8274715 |
González-Garza MT et al. | Entamoeba histolytica: inhibition of malic enzyme and alcohol dehydrogenase by (+/- )-, (+)-, and (-)- gossypol. | 1993 | Arch. Med. Res. | pmid:8274846 |
Wu D and Reidenberg MM | Effect of potassium deficiency and gossypol on urinary N-acetyl-beta-glucosaminidase excretion in the rat. | 1993 | Contraception | pmid:8275698 |
Xiao DM et al. | [Comparison between the effects of (-)- and (+)-gossypol on protein kinase C and protein kinase A]. | 1993 | Yao Xue Xue Bao | pmid:8285048 |
Kulp SK et al. | In vitro uptake and autoradiographic localization of tritiated gossypol in Taenia taeniaeformis metacestodes. | 1993 | Parasitol. Res. | pmid:8327450 |
Lei HQ and Xu YX | [Effects of gossypol acetic acid on the motility of rat oviduct smooth muscle]. | 1993 | Yao Xue Xue Bao | pmid:8328273 |
Lin TS et al. | Anti-HIV-1 activity and cellular pharmacology of various analogs of gossypol. | 1993 | Biochem. Pharmacol. | pmid:8347147 |
Miranda FJ et al. | Endothelial modulation of 5-hydroxytryptamine-induced contraction in goat cerebral arteries. | 1993 | Gen. Pharmacol. | pmid:8365646 |
Srivastava S et al. | Maturation, capacitation, and metabolism of goat spermatozoa using magnetic resonance methods. | 1993 Jul-Aug | Andrologia | pmid:8394662 |
Teng CS | Biological activity in the repopulating rat spermatocyte after the withdrawal of gossypol treatment. IV. The activity for the modification of core histones. | 1993 | Contraception | pmid:8403913 |
Cuéllar A and RamÃrez J | Further studies on the mechanism of action of gossypol on mitochondrial membrane. | 1993 | Int. J. Biochem. | pmid:8405656 |
Price WD et al. | Naturally occurring toxins in feedstuffs: Center for Veterinary Medicine Perspective. | 1993 | J. Anim. Sci. | pmid:8407668 |
Aletor VA | Allelochemicals in plant foods and feedingstuffs: 1. Nutritional, biochemical and physiopathological aspects in animal production. | 1993 | Vet Hum Toxicol | pmid:8434459 |
Flack MR et al. | Oral gossypol in the treatment of metastatic adrenal cancer. | 1993 | J. Clin. Endocrinol. Metab. | pmid:8473376 |
Chang CJ et al. | Antiproliferative and antimetastatic effects of gossypol on Dunning prostate cell-bearing Copenhagen rats. | 1993 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:8480076 |
Hasegawa K et al. | Angiotensin II-induced endothelium-dependent relaxation of fowl aorta. | 1993 | Am. J. Physiol. | pmid:8498599 |
Orhan G et al. | The effect of the male contraceptive agent gossypol acetic acid on mouse bone marrow cells in vivo: micronuclei and mitotic index. | 1993 | Contraception | pmid:8508667 |
Teng CS et al. | Biological activity in the repopulating rat spermatocyte after the withdrawal of gossypol treatment. VI. Alteration in nuclear factors for interaction with histone gene promoter. | 1995 | Contraception | pmid:8536450 |
Zelski RZ et al. | Gossypol toxicity in preruminant calves. | 1995 | Aust. Vet. J. | pmid:8599575 |
Nwoha PU | The blood constituents of gossypol-treated, protein-malnourished Wistar rats. | 1995 | Contraception | pmid:8605784 |
Nwoha PU and Aire TA | The effects of gossypol and chloroquine interaction on serum electrolytes of protein-malnourished rats. | 1995 | Contraception | pmid:8605785 |
Nwoha PU and Aire TA | Reduced level of serum cholesterol in low protein-fed Wistar rats administered gossypol and chloroquine. | 1995 | Contraception | pmid:8605786 |
Kim HL et al. | Accumulation of gossypol enantiomers in ovine tissues. | 1996 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:8653593 |
Javed MH and Waqar MA | Protective effect of histidine by inhibition of gossypol on rat's liver LDH-5. | 1995 | Biochem. Soc. Trans. | pmid:8654811 |
Ohmura H | [Suppressive effect of Gossypol, Gossypolone and serum from Gossypol treated rats on steroidogenesis in cultured porcine granulosa cells]. | 1996 | Nippon Ika Daigaku Zasshi | pmid:8707919 |
Fan LP et al. | [Emergency treatment and care of hypokalemia paralysis due to gossypol poisoning]. | 1995 | Zhonghua Hu Li Za Zhi | pmid:8716068 |
Liang XS et al. | Developing gossypol derivatives with enhanced antitumor activity. | 1995 | Invest New Drugs | pmid:8729944 |
Gschwentner M et al. | Blockade of swelling-induced chloride channels by phenol derivatives. | 1996 | Br. J. Pharmacol. | pmid:8733574 |
González-Garza MT et al. | Orally administered gossypol has no effect on eight hamster erythrocytic enzymes. | 1995 | Contraception | pmid:8749602 |
Teng CS | Gossypol-induced apoptotic DNA fragmentation correlates with inhibited protein kinase C activity in spermatocytes. | 1995 | Contraception | pmid:8749604 |
Guan MZ and Wang NG | [Effect of (+), (-) and (+/-) gossypol on early pregnancy in rats]. | 1996 | Yao Xue Xue Bao | pmid:8762457 |
Szücs G et al. | Characterization of volume-activated chloride currents in endothelial cells from bovine pulmonary artery. | 1996 | J. Membr. Biol. | pmid:8801351 |
Wu Y et al. | Changes in membrane properties during energy depletion-induced cell injury studied with fluorescence microscopy. | 1996 | Biophys. J. | pmid:8804592 |
Barhoumi R and Burghardt RC | Kinetic analysis of the chronology of patulin- and gossypol-induced cytotoxicity in vitro. | 1996 | Fundam Appl Toxicol | pmid:8812278 |
Cusack PM and Perry V | The effect of feeding whole cottonseed on the fertility of bulls. | 1995 | Aust. Vet. J. | pmid:8825312 |
Graier WF et al. | High D-glucose-induced changes in endothelial Ca2+/EDRF signaling are due to generation of superoxide anions. | 1996 | Diabetes | pmid:8826976 |
Chang WY et al. | Experimentally-induced prostatic hyperplasia in young beagles: a model to evaluate the chemotherapeutic effects of gossypol. | 1996 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:8827831 |
Mushtaq M et al. | Gossypol inhibits human chorionic gonadotropin-stimulated testosterone production by cultured canine testicular interstitial cells. | 1996 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:8829766 |
Akingbemi BT et al. | Infection with Trypanosoma brucei potentiates the antifertility effect of gossypol, especially in the protein-malnourished male rat. | 1996 | Int. J. Androl. | pmid:8876268 |
Akingbemi BT et al. | Gossypol toxicosis in the rat associated with protein malnutrition and experimental infection with Trypanosoma brucei. | 1996 | J. Comp. Pathol. | pmid:8878748 |
Hansen LL and Jaroszewski JW | Effect of gossypol on cultured TM3 Leydig and TM4 Sertoli cells: 31P and 23Na NMR study. | 1996 | NMR Biomed | pmid:8887371 |
Zavos PM and Zarmakoupis-Zavos PN | The inhibitory effects of gossypol on human sperm motility characteristics: possible modes of reversibility of those effects. | 1996 | Tohoku J. Exp. Med. | pmid:8888505 |
Akingbemi BT et al. | Ethanol intake may modify gossypol toxicosis in the rat. | 1996 Sep-Oct | J Appl Toxicol | pmid:8889787 |
Achudume AC and Eno TL | Characterization of ion interference in gossypol consumption. | 1996 | Adv Contracept | pmid:8910664 |
Hervé JC et al. | Contraceptive gossypol blocks cell-to-cell communication in human and rat cells. | 1996 | Eur. J. Pharmacol. | pmid:8911921 |
Shidaifat F et al. | Inhibition of human prostate cancer cells growth by gossypol is associated with stimulation of transforming growth factor-beta. | 1996 | Cancer Lett. | pmid:8913264 |
Barhoumi R et al. | Alteration of oxytocin-induced calcium oscillations in clone 9 cells by toxin exposure. | 1996 | Fundam Appl Toxicol | pmid:8921340 |
Colin-Negrete J et al. | Effect of whole cottonseed on serum constituents, fragility of erythrocyte cells, and reproduction of growing Holstein heifers. | 1996 | J. Dairy Sci. | pmid:8961108 |
Soubeyrand S et al. | Purification of a novel phospholipase A2 from bovine seminal plasma. | 1997 | J. Biol. Chem. | pmid:8995251 |
Teng CS | Reversible changes in the content of cellular and microtubular tubulin in spermatogenic cells after gossypol treatment. | 1997 | Contraception | pmid:9013060 |
González-Garza MT et al. | Gossypol anti-amebic effect in vivo. | 1997 | Arch. Med. Res. | pmid:9033108 |
Cruz-Vega DE et al. | Determination of the antiamebic effect of a metronidazole/gossypol blend. | 1997 | Arch. Med. Res. | pmid:9033109 |
Rekha GK and Sladek NE | Inhibition of human class 3 aldehyde dehydrogenase, and sensitization of tumor cells that express significant amounts of this enzyme to oxazaphosphorines, by the naturally occurring compound gossypol. | 1997 | Adv. Exp. Med. Biol. | pmid:9059615 |
Broderick GA | Effect of processing on protein utilization by ruminants. | 1977 | Adv. Exp. Med. Biol. | pmid:906927 |
Chang WY et al. | Gossypol induces spermidine/spermine N1-acetyltransferase in canine prostate epithelial cells. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9070284 |
Teng CS | Reversible changes in the content of cellular and microtubular tubulin in spermatogenic cells after gossypol treatment. | 1997 | Contraception | pmid:9115008 |
Shidaifat F et al. | Gossypol arrests human benign prostatic hyperplastic cell growth at G0/G1 phase of the cell cycle. | 1997 Mar-Apr | Anticancer Res. | pmid:9137441 |
Sessions RB et al. | A model of Plasmodium falciparum lactate dehydrogenase and its implications for the design of improved antimalarials and the enhanced detection of parasitaemia. | 1997 | Protein Eng. | pmid:9194154 |
Ye WS et al. | [The antifertility effect of gossypol plus testosterone and estrogen]. | 1996 | Yao Xue Xue Bao | pmid:9208651 |
Ligueros M et al. | Gossypol inhibition of mitosis, cyclin D1 and Rb protein in human mammary cancer cells and cyclin-D1 transfected human fibrosarcoma cells. | 1997 | Br. J. Cancer | pmid:9218727 |
Deoras DP et al. | Effect of gossypol on hepatic and serum gamma-glutamyltransferase activity in rats. | 1997 | Vet. Res. Commun. | pmid:9232775 |
Blauwiekel R et al. | Effect of whole cottonseed, gossypol, and ruminally protected lysine supplementation on milk yield and composition. | 1997 | J. Dairy Sci. | pmid:9241597 |
Akingbemi BT et al. | The influence of protein malnutrition on the antifertility action of gossypol in the Trypanosoma brucei-infected rat: some ultrastructural observations from the testis. | 1997 Jul-Aug | Reprod. Toxicol. | pmid:9241673 |
Akingbemi BT et al. | Chronic ethanol intake may delay the onset of gossypol-induced infertility in the male rat. | 1997 Jul-Aug | Andrologia | pmid:9263570 |
Zhang Y et al. | Estrogen and progestin cytosol receptor concentrations in patients with endometriosis and their changes after gossypol therapy. | 1996 | Chin. Med. J. | pmid:9275362 |
Kalla NR et al. | alpha-Glucosidase activity in the rat epididymis under different physiological conditions. | 1997 | Int. J. Androl. | pmid:9292319 |
Bernard JK and Calhoun MC | Response of lactating dairy cows to mechanically processed whole cottonseed. | 1997 | J. Dairy Sci. | pmid:9313148 |
Brocas C et al. | Deleterious actions of gossypol on bovine spermatozoa, oocytes, and embryos. | 1997 | Biol. Reprod. | pmid:9314596 |
Roberts R | Protein products and hulls for animal foods. | 1976 | J Am Oil Chem Soc | pmid:932385 |
Yu BZ et al. | Gossypol modification of Ala-1 of secreted phospholipase A2: a probe for the kinetic effects of sulfate glycoconjugates. | 1997 | Biochemistry | pmid:9376343 |
Wu T et al. | [Effects of gossypol acetic acid on human ejaculated sperm Ca2+ influx and rat vas deferens contraction action]. | 1996 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:9388965 |
Tran PT et al. | Effect of gossypol on Spisula sperm observed with real-time confocal microscopy, polarized light microscopy, and video microscopy. | 1997 | Biol. Bull. | pmid:9390392 |
Kumar M et al. | Gossypol-induced hypokalemia and role of exogenous potassium salt supplementation when used as an antispermatogenic agent in male langur monkey. | 1997 | Contraception | pmid:9408707 |
Blackstaffe L et al. | Cytotoxicity of gossypol enantiomers and its quinone metabolite gossypolone in melanoma cell lines. | 1997 | Melanoma Res. | pmid:9429219 |
Gupta GS and Kang BP | Quenching of intrinsic fluorescence of sperm specific LDH by optical isomers of gossypol. | 1997 | Gen. Physiol. Biophys. | pmid:9452944 |
Gomez MS et al. | Substrate and cofactor specificity and selective inhibition of lactate dehydrogenase from the malarial parasite P. falciparum. | 1997 | Mol. Biochem. Parasitol. | pmid:9497046 |
Teng CS and Vilagrasa X | Biphasic c-Myc protein expression during gossypol-induced apoptosis in rat spermatocytes. | 1998 | Contraception | pmid:9589839 |
Chan WK et al. | Effects of alpha-tocopherol on metmyoglobin formation and reduction in beef from cattle fed soybean or cottonseed meal diets. | 1998 | J. Anim. Sci. | pmid:9621948 |
Yu ZH and Chan HC | Gossypol as a male antifertility agent--why studies should have been continued. | 1998 | Int. J. Androl. | pmid:9639145 |
Waites GM et al. | Gossypol: reasons for its failure to be accepted as a safe, reversible male antifertility drug. | 1998 | Int. J. Androl. | pmid:9639146 |
Teng CS | c-fos protein expression in apoptotic rat spermatocytes induced by gossypol. | 1998 | Contraception | pmid:9649921 |
Monsees TK et al. | Influence of gossypol on the secretory function of cultured rat sertoli cells. | 1998 | Toxicon | pmid:9655644 |
Frick J et al. | [A pill for the man? Current status of fertility control in the man]. | 1998 | Gynakol Geburtshilfliche Rundsch | pmid:9658718 |
Guo J and Reidenberg MM | Inhibition of 11beta-hydroxysteroid dehydrogenase by bioflavonoids and their interaction with furosemide and gossypol. | 1998 | J. Lab. Clin. Med. | pmid:9665369 |
Hutchinson RW et al. | Attenuation of gossypol cytotoxicity by cyclic AMP in a rat liver cell line. | 1998 | Toxicol. Appl. Pharmacol. | pmid:9707507 |
Velasquez-Pereira J et al. | Long-term effects of gossypol and vitamin E in the diets of dairy bulls. | 1998 | J. Dairy Sci. | pmid:9785239 |
Michael AE | 11 beta HSD and the mechanism of gossypol-induced hypokalemia. | 1998 | Int. J. Androl. | pmid:9805249 |