Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Kerr LA | Incidence and management of poisonings in livestock. | 1990 | Vet Hum Toxicol | pmid:2238452 |
Morgan SE | Gossypol as a toxicant in livestock. | 1989 | Vet. Clin. North Am. Food Anim. Pract. | pmid:2667706 |
Rogers GM et al. | Feeding cotton products to cattle. | 2002 | Vet. Clin. North Am. Food Anim. Pract. | pmid:12235661 |
Holmberg CA et al. | Pathological and toxicological studies of calves fed a high concentration cotton seed meal diet. | 1988 | Vet. Pathol. | pmid:3363792 |
Lin YC et al. | Gossypol pharmacokinetics in mid-lactation Brown Swiss dairy cows. | 1991 | Vet. Res. Commun. | pmid:1771762 |
Deoras DP et al. | Effect of gossypol on hepatic and serum gamma-glutamyltransferase activity in rats. | 1997 | Vet. Res. Commun. | pmid:9232775 |
Nagalakshmi D et al. | Pathological lesions in lambs fed raw or processed cottonseed meal. | 2000 | Vet. Res. Commun. | pmid:10868552 |
Pirogov AI et al. | [Postoperative bronchopleural complications in the combined treatment of lung cancer]. | 1974 | Vopr Onkol | pmid:4211564 |
VERMEL EM and KRUGLIAK SA | [ANTINEOPLASTIC ACTIVITY OF GOSSYPOL IN EXPERIMENTAL TRANSPLANTED TUMORS]. | 1963 | Vopr Onkol | pmid:14148612 |
Sakhibov AD et al. | [Mechanism of Na,K-ATPase inhibition with gossypol and megasin]. | 1986 May-Jun | Vopr. Med. Khim. | pmid:3014735 |
Posevaia TA et al. | [The role of herpetic infection in epithelial dysplasias of the cervix uteri and a trial of their treatment with antiherpetic preparations]. | 1991 Jan-Feb | Vopr. Virusol. | pmid:1650068 |
Achilova GSh et al. | [Antiviral activity of derivatives of aldehydophenols, aldehydo- naphthols and sugar derivatives]. | 1989 May-Jun | Vopr. Virusol. | pmid:2552684 |
Ershov FI et al. | [A new interferon inducer active via peroral administration]. | 1986 May-Jun | Vopr. Virusol. | pmid:2429451 |
Ershov FI et al. | [Interferonogenic activity of low-molecular compounds of plant origin]. | 1988 Nov-Dec | Vopr. Virusol. | pmid:2470203 |
Karpovich LG et al. | [Indices of lymphocyte functional activity in patients with recurrent cutaneous-genital herpes during treatment with a herpes vaccine]. | 1986 Mar-Apr | Vopr. Virusol. | pmid:3014750 |
BelokrinitskiÄ DV et al. | [Indices of the immune status of recurrent herpes patients being treated with a herpes polyvaccine]. | 1987 Mar-Apr | Vopr. Virusol. | pmid:3037800 |
Labzo SS et al. | [Stimulation of interferon formation by natural and synthetic inducers in cultures of human tonsil cells]. | 1980 Jan-Feb | Vopr. Virusol. | pmid:6158181 |
SaÄitkulov AM et al. | [Biological characteristics of new interferon inducers created on a gossypol base]. | 1984 Nov-Dec | Vopr. Virusol. | pmid:6084903 |
Vagabov RM et al. | [Comparative study of the effectiveness of the interferon inducers, poly(I) : poly(C) and GSS (gossypol-beta-aminoethylsodium sulfate), in combination with a specific vaccine in experimental infection with the human acute encephalomyelitis virus]. | 1980 May-Jun | Vopr. Virusol. | pmid:7434726 |
Galegov GA et al. | [The effect of Kagocel on herpes virus reproduction]. | 2002 Jul-Aug | Vopr. Virusol. | pmid:12271726 |