| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Cattle Diseases | D002418 | 24 associated lipids |
| Infertility, Male | D007248 | 11 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Testicular Diseases | D013733 | 15 associated lipids |
| Lymphoma, Large B-Cell, Diffuse | D016403 | 13 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Abnormalities, Drug-Induced | D000014 | 10 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Mol. Cancer Ther. (4)
- Proc. Natl. Acad. Sci. U.S.A. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (2)
- Others (13)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zheng DK et al. | Resolution of racemic gossypol. | 1985 | J. Chem. Soc. Chem. Commun. | pmid:12340526 |
| Gonzales-garza MT et al. | Cytotoxic effects of gossypol and vitamin E on human and rat lymphocytes and spermatozoa. | 1985 | Nutr Rep Int | pmid:12340733 |
| Kainz P et al. | Effect of gossypol on macromolecular synthesis in rat testis. An in vitro study. | 1985 | Contraception | pmid:2580663 |
| Haider SG et al. | Reversible changes in rat spermatogenesis induced by an antifertility substance (Gossypol). A histochemical report. | 1985 | Acta Histochem. | pmid:2420139 |
| Kainz P et al. | The in vivo effect of gossypol on macromolecular synthesis in rat testis. | 1985 | Contraception | pmid:2419026 |
| Matlin SA et al. | (-)-Gossypol: an active male antifertility agent. | 1985 | Contraception | pmid:3987276 |
| Sufi SB et al. | Inhibition by (+) and (-) isomers of gossypol of testosterone release from mouse Leydig cells in vitro. | 1985 | Contraception | pmid:3987277 |
| Donaldson A et al. | Inhibition by gossypol of testosterone production by mouse Leydig cells in vitro. | 1985 | Contraception | pmid:3987278 |
| Rao PN et al. | Antitumor effects of gossypol on murine tumors. | 1985 | Cancer Chemother. Pharmacol. | pmid:4006045 |
| Lin YC et al. | Gossypol in female fertility control: ovum implantation and early pregnancy inhibited in rats. | 1985 | Life Sci. | pmid:4010468 |
| Wu YW et al. | Effect of gossypol on the potential difference of rat seminiferous tubules. | 1985 | Sci. Sin., Ser. B, Chem. Biol. Agric. Med. Earth Sci. | pmid:4012264 |
| Maliwal BP et al. | Spectroscopic study of the interaction of gossypol with bovine serum albumin. | 1985 | Int. J. Pept. Protein Res. | pmid:4019021 |
| Liang JC and Ye WS | Clastogenicity of a male contraceptive, gossypol, in mammalian cell cultures with and without the metabolic activation by S9 mix. | 1985 | Environ. Res. | pmid:3967635 |
| Vainio P et al. | Hydrolysis of phospholipid monolayers by human spermatozoa. Inhibition by male contraceptive gossypol. | 1985 | Biochim. Biophys. Acta | pmid:3978108 |
| Beaudoin AR | The embryotoxicity of gossypol. | 1985 | Teratology | pmid:4049283 |
| Hoffer AP and Lisser SP | Recovery of normal testicular ultrastructure and sperm motility after cessation of gossypol treatment in rats. | 1984 Nov-Dec | J. Androl. | pmid:6511655 |
| Kim I and Waller DP | Specific inhibition of the testicular mitochondrial respiratory chain in vitro by gossypol. | 1984 Nov-Dec | J. Androl. | pmid:6511656 |
| SaÄitkulov AM et al. | [Biological characteristics of new interferon inducers created on a gossypol base]. | 1984 Nov-Dec | Vopr. Virusol. | pmid:6084903 |
| Kalla NR et al. | Studies on the male antifertility agent gossypol acetic acid. VI. Effect of gossypol acetic acid on the fertility of bonnet monkey. Macaca radiata. | 1984 May-Jun | Andrologia | pmid:6465549 |
| Qian SZ and Wang ZG | Gossypol: a potential antifertility agent for males. | 1984 | Annu. Rev. Pharmacol. Toxicol. | pmid:6375548 |
| de Peyster A et al. | Oxygen radical formation induced by gossypol in rat liver microsomes and human sperm. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6322752 |
| Pathak HK et al. | Gossypol, ouabain and vanadate on the isolated perfused rat kidney and Na, K-ATPase. | 1984 | Zhongguo Yao Li Xue Bao | pmid:6326465 |
| Zhang ZS et al. | [Use of technique of culturing cells in diffusion chamber in host-mediate for testing chromosomal effects of gossypol acetate on human lymphocytes]. | 1984 | Shengzhi Yu Biyun | pmid:12267337 |
| Hamasaki Y et al. | [Rat basophilic leukemia-1 cell possesses 12-lipoxygenase and 5-lipoxygenase activities which are specifically inhibited by gossypol acetic acid]. | 1984 | Arerugi | pmid:6442854 |
| Gu ZW et al. | Studies on fertility control-the formation and antifertility effect of polyvinyl-pyrolidone-gossypol complex. | 1984 | Biomater Med Devices Artif Organs | pmid:6532483 |
| Engler SJ et al. | Absence of histopathology in somatic tissues of rats made infertile with gossypol. | 1984 | Arch. Androl. | pmid:6534283 |
| Zhu PD | [Electron microscopic observations on the effect of gossypol on the human endometrium]. | 1984 | Zhonghua Fu Chan Ke Za Zhi | pmid:6536444 |
| Bhargava SK | Semen characteristics of gossypol-treated langurs (Presbytis entellus entellus Dufresne). | 1984 | Arch. Androl. | pmid:6537746 |
| Zhang ZR et al. | [High performance liquid chromatography of gossypol]. | 1984 | Yao Xue Xue Bao | pmid:6544029 |
| Wang NG et al. | [Effect of gossypol acetic acid on early pregnancy in rats]. | 1984 | Yao Xue Xue Bao | pmid:6544547 |
| Wang NG et al. | [Effects of (-) and (+) gossypol on the fertility of male rats]. | 1984 | Yao Xue Xue Bao | pmid:6544566 |
| Paz GF and Homonnai ZT | Effect of the antifertility agent, gossypol acetic acid, on the metabolism and testosterone secretion of isolated rat interstitial cells in vitro. | 1984 | Contraception | pmid:6467943 |
| Coutinho EM et al. | Antispermatogenic action of gossypol in men. | 1984 | Fertil. Steril. | pmid:6468676 |
| Reddy RM et al. | Pattern of ovarian and uterine carbohydrate metabolism during induced antiimplantation by (+)gossypol. | 1984 | Indian J. Exp. Biol. | pmid:6510968 |
| Tanphaichitr N et al. | Direct effect of gossypol on TR-ST cells: perturbation of rhodamine 123 accumulation in mitochondria. | 1984 | Biol. Reprod. | pmid:6518226 |
| Baker ME | Gossypol inhibits estrogen binding to rat alpha-fetoprotein. | 1984 | FEBS Lett. | pmid:6207049 |
| Gossypol prospects. | 1984 | Lancet | pmid:6144835 | |
| Soufir JC et al. | Epididymal effects of gossypol. | 1984 | Lancet | pmid:6145995 |
| Olgiati KL et al. | Gossypol modulation of nucleotide metabolizing enzymes in the reproductive tract of male rats. | 1984 | Biol. Reprod. | pmid:6095938 |
| Madzhidov UV | [T-suppressors in experimental adjuvant arthritis and immunosuppression]. | 1984 | Zh. Mikrobiol. Epidemiol. Immunobiol. | pmid:6230839 |
| Herrera J et al. | Modifications in the testis steroidogenic pathways in rats fed with cottonseed flour. | 1984 | Arch. Androl. | pmid:6236762 |
| Wang RL et al. | [Effect of gossypol acetic acid on the induction of sister chromatid exchange of spermatogonial cell in mice]. | 1984 | Zhongguo Yao Li Xue Bao | pmid:6240903 |
| Steiner M et al. | In vivo study of LDH isoenzyme activities in heart, liver and testis cytosols of gossypol-treated rats. | 1984 | Int. J. Androl. | pmid:6526516 |
| Breitbart H et al. | Effect of gossypol-acetic acid on calcium transport and ATPase activity in plasma membranes from ram and bull spermatozoa. | 1984 | Int. J. Androl. | pmid:6151940 |
| Hoffer AP and Hinton BT | Morphological evidence for a blood-epididymis barrier and the effects of gossypol on its integrity. | 1984 | Biol. Reprod. | pmid:6733204 |
| Oko R and Hrudka F | Comparison of the effects of gossypol, estradiol-17 beta and testosterone compensation on male rat reproductive organs. | 1984 | Biol. Reprod. | pmid:6733210 |
| Whaley KJ et al. | A circular dichroism study of (+) gossypol binding to proteins. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6743322 |
| Wong PY et al. | Gossypol does not affect testicular fluid secretion in rats. | 1984 | Contraception | pmid:6744863 |
| Reyes J et al. | Molecular mechanisms of gossypol action on lipid membranes. | 1984 | J. Biol. Chem. | pmid:6746663 |
| Marcelle GB et al. | Analysis of gossypol and gossypol-acetic acid by high-performance liquid chromatography. | 1984 | J Pharm Sci | pmid:6716251 |