| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Cattle Diseases | D002418 | 24 associated lipids |
| Infertility, Male | D007248 | 11 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Testicular Diseases | D013733 | 15 associated lipids |
| Lymphoma, Large B-Cell, Diffuse | D016403 | 13 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Abnormalities, Drug-Induced | D000014 | 10 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Braham JE and Bressani R | Effect of different levels of gossypol on transaminase activity, on nonessential to essential amino acid ratio, and on iron and nitrogen retention in rats. | 1975 | J. Nutr. | pmid:1117346 |
| Damaty S and Hudson BJ | A secondary interaction between gossypol and cottonseed protein. | 1975 | Proc Nutr Soc | pmid:1187618 |
| Jolad SD et al. | Tumor-inhibitory agent from Montezuma speciosissima (Malvaceae). | 1975 | J Pharm Sci | pmid:1195125 |
| Abou-Donia MB and Dieckert JW | Metabolic fate of gossypol: the metabolism of [14-C]gossypol in swine. | 1975 | Toxicol. Appl. Pharmacol. | pmid:1129787 |
| Dorsett PH et al. | Letter: Antiviral activity of gossypol and apogossypol. | 1975 | J Pharm Sci | pmid:1133739 |
| Aripov UA et al. | [Immunodepressive properties of the drug "Batriden" in experiments on parabionts]. | 1975 | Dokl. Akad. Nauk SSSR | pmid:1140070 |
| Pandey SN and Thejappa N | Study on relationship between oil, protein, and gossypol in cottonseed kernels. | 1975 | J Am Oil Chem Soc | pmid:1242138 |
| Krylov VF | [Treatment of patients with influenza]. | 1975 | Ter. Arkh. | pmid:52894 |
| Tone JN and Jensen DR | Hematological effects of injected gossypol and iron in rats. | 1974 Jan-Feb | J. Agric. Food Chem. | pmid:4811630 |
| Abou-Donia MB and Dieckert JW | Gossypol: uncoupling of respiratory chain and oxidative phosphorylation. | 1974 | Life Sci. | pmid:4277086 |
| Pirogov AI et al. | [Postoperative bronchopleural complications in the combined treatment of lung cancer]. | 1974 | Vopr Onkol | pmid:4211564 |
| Abou-Donia MB and Dieckert JW | Urinary and biliary excretion of 14C-gossypol in swine. | 1974 | J. Nutr. | pmid:4830281 |
| Skutches CL et al. | Effect of dietary free gossypol on blood components and tissue iron in swine and rats. | 1974 | J. Nutr. | pmid:4816926 |
| Kilburn KH et al. | Two patterns for bronchial damage from inhaled materials. | 1974 | Chest | pmid:4819236 |
| Smith FH | Preparation of 14C-gossypol by incorporation of acetate-1-14C and acetate-2-14C by biosynthesis. | 1974 | J Am Oil Chem Soc | pmid:4415176 |
| Skutches CL and Smith FH | Effect of phenobarbital on the level of gossypol in the liver and the effect of gossypol and phenobarbital on liver microsomal O-demethylation and lipid peroxidation activities in the rat. | 1974 | J. Nutr. | pmid:4430931 |
| Abou-Donia MB et al. | Gossypol: antagonistic effect on toxicity of insecticides to Spodoptera littoralis. | 1974 | Experientia | pmid:4435119 |
| Skutches CL and Smith FH | Metabolism of gossypol, biosynthesized from methyl-14C-and carboxyl-14 C-labeled sodium acetate, in rat. | 1974 | J Am Oil Chem Soc | pmid:4479245 |
| el-Nockrashy AS et al. | Biochemical changes in cottonseed during germination. | 1974 | Nahrung | pmid:4365683 |
| Mayorga H et al. | [Extraction and precipitation of cottonseed protein by the wet method]. | 1973 | Arch Latinoam Nutr | pmid:4801265 |