Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Teng CS | Biological activity in the repopulating rat spermatocyte after the withdrawal of gossypol treatment: III. The activity for the transcription of messenger RNA. | 1992 | Contraception | pmid:1559338 |
Smith C et al. | Protection by albumin against the pro-oxidant actions of phenolic dietary components. | 1992 | Food Chem. Toxicol. | pmid:1379971 |
Udoh P and Patil DR | Effects of gossypol acetate on pituitary-adrenal axis in male albino rats. | 1992 | Contraception | pmid:1324828 |
Sagach VF et al. | Functional hyperemia of skeletal muscle: role of endothelium. | 1992 | J. Cardiovasc. Pharmacol. | pmid:1282960 |
Tkachenko MN et al. | Involvement of endothelium in vasodilating effects of vintoperol. | 1992 | J. Cardiovasc. Pharmacol. | pmid:1282997 |
Zaidi R and Hadi SM | Complexes involving gossypol, DNA and Cu(II). | 1992 | Biochem. Int. | pmid:1290468 |
Zaidi R and Hadi SM | Strand scission in DNA by gossypol and Cu(II): role of Cu(I) and oxygen-free radicals. | 1992 | J. Biochem. Toxicol. | pmid:1293310 |
González-Garza MT et al. | Further studies on the in vitro activity of gossypol as antiamebic agent. | 1992 | Arch. Med. Res. | pmid:1340324 |
Lan ZJ et al. | Effects of multiglycosides of Tripterygium wilfordii (GTW) on rat fertility and Leydig and Sertoli cells. | 1992 | Contraception | pmid:1511610 |
Jensen EC et al. | Lipoxygenase inhibitors shift the yeast/mycelium dimorphism in Ceratocystis ulmi. | 1992 | Appl. Environ. Microbiol. | pmid:1514797 |
Stein RC et al. | A preliminary clinical study of gossypol in advanced human cancer. | 1992 | Cancer Chemother. Pharmacol. | pmid:1394805 |
Risco CA et al. | Effect of graded concentrations of gossypol on calf performance: toxicological and pathological considerations. | 1992 | J. Dairy Sci. | pmid:1430484 |
Lin YC et al. | Transfer of 3H-gossypol to neonatal rats via milk of nursing dams. | 1992 | Life Sci. | pmid:1435075 |
Bialy G and Alexander NJ | Developments in male contraception. | 1992 | Health Sex | pmid:12286189 |
Rao AG | A stoichiometric analysis of bovine serum albumin-gossypol interactions: a fluorescence quenching study. | 1992 | Indian J. Biochem. Biophys. | pmid:1398710 |
MartÃnez F | The antifertility agent, gossypol, changes several mitochondrial functions in the presence of Mg2+. | 1992 | Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. | pmid:1360378 |
Sheriff DS | Effect of gossypol on tissue levels of glutathione and thiobarbituric acid reactive products in rats. | 1992 | Indian J. Exp. Biol. | pmid:1459652 |
Franklin RB et al. | Prolactin stimulates transcription of aspartate aminotransferase in prostate cells. | 1992 | Mol. Cell. Endocrinol. | pmid:1301396 |
Chang SM et al. | [Effect of gossypol on the proliferation of rat prostate cells studies in vivo and in vitro]. | 1992 | Shi Yan Sheng Wu Xue Bao | pmid:1303003 |
Herndon N | Looking for the "male pill". | 1992 | Netw Res Triangle Park N C | pmid:12317724 |
Lin YC et al. | Binding of 3H-gossypol in organelles of cultured bovine luteal cells. | 1992 | Life Sci. | pmid:1734162 |
Terry BJ et al. | Inhibition of herpes simplex virus type 1 DNA polymerase by the natural product oosporein. | 1992 | J. Antibiot. | pmid:1556024 |
Knych ET | Endothelium-dependent tolerance to ethanol-induced contraction of rat aorta: effect of inhibition of EDRF action and nitric oxide synthesis. | 1992 | Alcohol. Clin. Exp. Res. | pmid:1558303 |
Wang JM et al. | Differential binding of (+) and (-) gossypol to plasma protein and their entry into rat testis. | 1992 | J. Reprod. Fertil. | pmid:1625243 |
Moh PP et al. | Characteristics of covalent gossypol binding to microsomal proteins. | 1992 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:1636054 |
Randel RD et al. | Effects of gossypol and cottonseed products on reproduction of mammals. | 1992 | J. Anim. Sci. | pmid:1526930 |
Tres LL et al. | Permeable collagen-glycosaminoglycan cross-linked copolymers for the study of biological responses of cocultured Sertoli and spermatogenic cells. | 1992 Jul-Sep | Cell Biol. Toxicol. | pmid:1446259 |
Andrade AT | [Information on advances in sciences and technology. Advances in contraceptive technology]. | 1993 | Bol Cent Biol Reprod | pmid:12345521 |
Sullivan JL et al. | Performance of dairy cows fed short staple, Pima, and cracked Pima cottonseed and feed characteristics. | 1993 | J. Dairy Sci. | pmid:8270698 |
Prusoff W et al. | Empirical and rational approaches for development of inhibitors of the human immunodeficiency virus--HIV-1. | 1993 | Pharmacol. Ther. | pmid:8022862 |
Li H and He X | [The effects of optical isomers of gossypol on Sertoli cells in vitro]. | 1993 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:8242829 |
Fornés MW et al. | Sperm motility loss induced by gossypol: relation with OH. scavengers, motile stimulators and malondialdehyde production. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8216260 |
Moh PP et al. | Effect of gossypol on 5 alpha-reductase and 3 alpha-hydroxysteroid dehydrogenase activities in adult rat testes. | 1993 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:8272571 |
Ye W et al. | Effect of intra-vas deferens injection of gossypol-polylactic acid on fertility and spermatogenesis in rats. | 1993 | Chin. Med. Sci. J. | pmid:8274715 |
González-Garza MT et al. | Entamoeba histolytica: inhibition of malic enzyme and alcohol dehydrogenase by (+/- )-, (+)-, and (-)- gossypol. | 1993 | Arch. Med. Res. | pmid:8274846 |
Wu D and Reidenberg MM | Effect of potassium deficiency and gossypol on urinary N-acetyl-beta-glucosaminidase excretion in the rat. | 1993 | Contraception | pmid:8275698 |
Hu YF et al. | Gossypol inhibits basal and estrogen-stimulated DNA synthesis in human breast carcinoma cells. | 1993 | Life Sci. | pmid:8255144 |
Xiao DM et al. | [Comparison between the effects of (-)- and (+)-gossypol on protein kinase C and protein kinase A]. | 1993 | Yao Xue Xue Bao | pmid:8285048 |
Zhang SC et al. | [The adverse effects of the preparations of the active principles of Chinese herbal drugs]. | 1993 | Zhongguo Zhong Yao Za Zhi | pmid:8267848 |
Aletor VA | Allelochemicals in plant foods and feedingstuffs: 1. Nutritional, biochemical and physiopathological aspects in animal production. | 1993 | Vet Hum Toxicol | pmid:8434459 |
Gray ML et al. | Effects of dietary gossypol consumption on metabolic homeostasis and reproductive endocrine function in beef heifers and cows. | 1993 | J. Anim. Sci. | pmid:8270527 |
Teng CS | Biological activity in the repopulating rat spermatocyte after the withdrawal of gossypol treatment. IV. The activity for the modification of core histones. | 1993 | Contraception | pmid:8403913 |
Kulp SK et al. | In vitro uptake and autoradiographic localization of tritiated gossypol in Taenia taeniaeformis metacestodes. | 1993 | Parasitol. Res. | pmid:8327450 |
Lei HQ and Xu YX | [Effects of gossypol acetic acid on the motility of rat oviduct smooth muscle]. | 1993 | Yao Xue Xue Bao | pmid:8328273 |
Lin TS et al. | Anti-HIV-1 activity and cellular pharmacology of various analogs of gossypol. | 1993 | Biochem. Pharmacol. | pmid:8347147 |
Miranda FJ et al. | Endothelial modulation of 5-hydroxytryptamine-induced contraction in goat cerebral arteries. | 1993 | Gen. Pharmacol. | pmid:8365646 |
Hasegawa K et al. | Angiotensin II-induced endothelium-dependent relaxation of fowl aorta. | 1993 | Am. J. Physiol. | pmid:8498599 |
Flack MR et al. | Oral gossypol in the treatment of metastatic adrenal cancer. | 1993 | J. Clin. Endocrinol. Metab. | pmid:8473376 |
Chang CJ et al. | Antiproliferative and antimetastatic effects of gossypol on Dunning prostate cell-bearing Copenhagen rats. | 1993 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:8480076 |
Xu Y et al. | [Intratesticular subcapsular assay, a simple method for the preliminary screening of male contraceptives]. | 1993 | Yao Xue Xue Bao | pmid:8010008 |