Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Wu Y et al. | Changes in membrane properties during energy depletion-induced cell injury studied with fluorescence microscopy. | 1996 | Biophys. J. | pmid:8804592 |
Wu T et al. | [Effects of gossypol acetic acid on human ejaculated sperm Ca2+ influx and rat vas deferens contraction action]. | 1996 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:9388965 |
Colin-Negrete J et al. | Effect of whole cottonseed on serum constituents, fragility of erythrocyte cells, and reproduction of growing Holstein heifers. | 1996 | J. Dairy Sci. | pmid:8961108 |
Barhoumi R et al. | Alteration of oxytocin-induced calcium oscillations in clone 9 cells by toxin exposure. | 1996 | Fundam Appl Toxicol | pmid:8921340 |
Akingbemi BT et al. | Gossypol toxicosis in the rat associated with protein malnutrition and experimental infection with Trypanosoma brucei. | 1996 | J. Comp. Pathol. | pmid:8878748 |
Hansen LL and Jaroszewski JW | Effect of gossypol on cultured TM3 Leydig and TM4 Sertoli cells: 31P and 23Na NMR study. | 1996 | NMR Biomed | pmid:8887371 |
Zavos PM and Zarmakoupis-Zavos PN | The inhibitory effects of gossypol on human sperm motility characteristics: possible modes of reversibility of those effects. | 1996 | Tohoku J. Exp. Med. | pmid:8888505 |
Akingbemi BT et al. | Infection with Trypanosoma brucei potentiates the antifertility effect of gossypol, especially in the protein-malnourished male rat. | 1996 | Int. J. Androl. | pmid:8876268 |
Zhang Y et al. | Estrogen and progestin cytosol receptor concentrations in patients with endometriosis and their changes after gossypol therapy. | 1996 | Chin. Med. J. | pmid:9275362 |
Ye WS et al. | [The antifertility effect of gossypol plus testosterone and estrogen]. | 1996 | Yao Xue Xue Bao | pmid:9208651 |
Achudume AC and Eno TL | Characterization of ion interference in gossypol consumption. | 1996 | Adv Contracept | pmid:8910664 |
Hervé JC et al. | Contraceptive gossypol blocks cell-to-cell communication in human and rat cells. | 1996 | Eur. J. Pharmacol. | pmid:8911921 |
Shidaifat F et al. | Inhibition of human prostate cancer cells growth by gossypol is associated with stimulation of transforming growth factor-beta. | 1996 | Cancer Lett. | pmid:8913264 |
Szücs G et al. | Characterization of volume-activated chloride currents in endothelial cells from bovine pulmonary artery. | 1996 | J. Membr. Biol. | pmid:8801351 |
Guan MZ and Wang NG | [Effect of (+), (-) and (+/-) gossypol on early pregnancy in rats]. | 1996 | Yao Xue Xue Bao | pmid:8762457 |
Chang WY et al. | Experimentally-induced prostatic hyperplasia in young beagles: a model to evaluate the chemotherapeutic effects of gossypol. | 1996 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:8827831 |
Mushtaq M et al. | Gossypol inhibits human chorionic gonadotropin-stimulated testosterone production by cultured canine testicular interstitial cells. | 1996 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:8829766 |
Barhoumi R and Burghardt RC | Kinetic analysis of the chronology of patulin- and gossypol-induced cytotoxicity in vitro. | 1996 | Fundam Appl Toxicol | pmid:8812278 |
Kim HL et al. | Accumulation of gossypol enantiomers in ovine tissues. | 1996 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:8653593 |
Gschwentner M et al. | Blockade of swelling-induced chloride channels by phenol derivatives. | 1996 | Br. J. Pharmacol. | pmid:8733574 |
Ohmura H | [Suppressive effect of Gossypol, Gossypolone and serum from Gossypol treated rats on steroidogenesis in cultured porcine granulosa cells]. | 1996 | Nippon Ika Daigaku Zasshi | pmid:8707919 |
Graier WF et al. | High D-glucose-induced changes in endothelial Ca2+/EDRF signaling are due to generation of superoxide anions. | 1996 | Diabetes | pmid:8826976 |
Akingbemi BT et al. | Ethanol intake may modify gossypol toxicosis in the rat. | 1996 Sep-Oct | J Appl Toxicol | pmid:8889787 |
Gupta GS and Kang BP | Quenching of intrinsic fluorescence of sperm specific LDH by optical isomers of gossypol. | 1997 | Gen. Physiol. Biophys. | pmid:9452944 |
Kumar M et al. | Gossypol-induced hypokalemia and role of exogenous potassium salt supplementation when used as an antispermatogenic agent in male langur monkey. | 1997 | Contraception | pmid:9408707 |
Bernard JK and Calhoun MC | Response of lactating dairy cows to mechanically processed whole cottonseed. | 1997 | J. Dairy Sci. | pmid:9313148 |
Brocas C et al. | Deleterious actions of gossypol on bovine spermatozoa, oocytes, and embryos. | 1997 | Biol. Reprod. | pmid:9314596 |
Blackstaffe L et al. | Cytotoxicity of gossypol enantiomers and its quinone metabolite gossypolone in melanoma cell lines. | 1997 | Melanoma Res. | pmid:9429219 |
Tran PT et al. | Effect of gossypol on Spisula sperm observed with real-time confocal microscopy, polarized light microscopy, and video microscopy. | 1997 | Biol. Bull. | pmid:9390392 |
Ligueros M et al. | Gossypol inhibition of mitosis, cyclin D1 and Rb protein in human mammary cancer cells and cyclin-D1 transfected human fibrosarcoma cells. | 1997 | Br. J. Cancer | pmid:9218727 |
Kalla NR et al. | alpha-Glucosidase activity in the rat epididymis under different physiological conditions. | 1997 | Int. J. Androl. | pmid:9292319 |
Deoras DP et al. | Effect of gossypol on hepatic and serum gamma-glutamyltransferase activity in rats. | 1997 | Vet. Res. Commun. | pmid:9232775 |
Sessions RB et al. | A model of Plasmodium falciparum lactate dehydrogenase and its implications for the design of improved antimalarials and the enhanced detection of parasitaemia. | 1997 | Protein Eng. | pmid:9194154 |
Chang WY et al. | Gossypol induces spermidine/spermine N1-acetyltransferase in canine prostate epithelial cells. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9070284 |
Teng CS | Reversible changes in the content of cellular and microtubular tubulin in spermatogenic cells after gossypol treatment. | 1997 | Contraception | pmid:9115008 |
González-Garza MT et al. | Gossypol anti-amebic effect in vivo. | 1997 | Arch. Med. Res. | pmid:9033108 |
Cruz-Vega DE et al. | Determination of the antiamebic effect of a metronidazole/gossypol blend. | 1997 | Arch. Med. Res. | pmid:9033109 |
Soubeyrand S et al. | Purification of a novel phospholipase A2 from bovine seminal plasma. | 1997 | J. Biol. Chem. | pmid:8995251 |
Teng CS | Reversible changes in the content of cellular and microtubular tubulin in spermatogenic cells after gossypol treatment. | 1997 | Contraception | pmid:9013060 |
Rekha GK and Sladek NE | Inhibition of human class 3 aldehyde dehydrogenase, and sensitization of tumor cells that express significant amounts of this enzyme to oxazaphosphorines, by the naturally occurring compound gossypol. | 1997 | Adv. Exp. Med. Biol. | pmid:9059615 |
Gomez MS et al. | Substrate and cofactor specificity and selective inhibition of lactate dehydrogenase from the malarial parasite P. falciparum. | 1997 | Mol. Biochem. Parasitol. | pmid:9497046 |
Yu BZ et al. | Gossypol modification of Ala-1 of secreted phospholipase A2: a probe for the kinetic effects of sulfate glycoconjugates. | 1997 | Biochemistry | pmid:9376343 |
Blauwiekel R et al. | Effect of whole cottonseed, gossypol, and ruminally protected lysine supplementation on milk yield and composition. | 1997 | J. Dairy Sci. | pmid:9241597 |
Wang MS et al. | NAD- and NADP-dependent 11 beta-hydroxysteroid dehydrogenase isoforms in guinea pig kidney with gossypol inhibition. | 1997 | Zhongguo Yao Li Xue Bao | pmid:10322899 |
Chen Y et al. | [Effect of gossypol in combination with misoprostol on termination of early pregnancy in rats and mice]. | 1997 | Yao Xue Xue Bao | pmid:11596197 |
Yang B et al. | [The effects of gossypol on rat luteal cells, human decidual cells and cytotrophoblasts]. | 1997 | Yao Xue Xue Bao | pmid:11596304 |
Akingbemi BT et al. | Chronic ethanol intake may delay the onset of gossypol-induced infertility in the male rat. | 1997 Jul-Aug | Andrologia | pmid:9263570 |
Akingbemi BT et al. | The influence of protein malnutrition on the antifertility action of gossypol in the Trypanosoma brucei-infected rat: some ultrastructural observations from the testis. | 1997 Jul-Aug | Reprod. Toxicol. | pmid:9241673 |
Shidaifat F et al. | Gossypol arrests human benign prostatic hyperplastic cell growth at G0/G1 phase of the cell cycle. | 1997 Mar-Apr | Anticancer Res. | pmid:9137441 |
Hutchinson RW et al. | Induction of c-fos, and cytochrome c oxidase subunits I and II by gossypol acetic acid in rat liver cells. | 1998 | Cell Biol. Toxicol. | pmid:9879931 |