Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Mol. Cancer Ther. (4)
- Proc. Natl. Acad. Sci. U.S.A. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (2)
- Others (13)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
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What functions are associated with Gossypol?
Related references are published most in these journals:
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What lipids are associated with Gossypol?
Related references are published most in these journals:
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What genes are associated with Gossypol?
Related references are published most in these journals:
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Fu YF et al. | Effects of gossypol on the activity of kidney (Na+ + K+)-ATPase and the functions of erythrocyte membrane. | 1988 | Contraception | pmid:2836126 |
| White IG et al. | Studies of the mechanism of action of gossypol as a male antifertility agent. | 1988 | Contraception | pmid:2836127 |
| Duo X et al. | Clinical safety of long-term administration of gossypol in 32 cases. | 1988 | Contraception | pmid:3370987 |
| van Ypersele de Strihou C et al. | Effects of gossypol on the kidney with special emphasis on potassium (K) excretion. | 1988 | Contraception | pmid:3370990 |
| Heywood R | The toxicology of gossypol acetic acid and (-)-gossypol. | 1988 | Contraception | pmid:3370991 |
| Wang RL et al. | Gossypol acetate-induced SCEs in spermatogonia and bone marrow cells of mice: dose-response relationships. | 1988 | Contraception | pmid:3370992 |
| Wu GP | [Gossypol and its related compounds as contraceptive drugs and drugs for gynecological diseases]. | 1988 | Shengzhi Yu Biyun | pmid:12282152 |
| Den Boer PJ and Grootegoed JA | Differential effects of (+)- and (-)-gossypol enantiomers on LDH-C4 activity of hamster spermatogenic epithelium in vitro. | 1988 | J. Reprod. Fertil. | pmid:3411560 |
| Kaur P et al. | Effect of gossypol on testes & epididymis of albino rats. | 1988 | Indian J. Med. Res. | pmid:3169891 |
| Jones LA | Gossypol toxicosis. | 1988 | Am. J. Vet. Res. | pmid:3178038 |
| Jones LA | Gossypol toxicosis. | 1988 | J. Am. Vet. Med. Assoc. | pmid:3182379 |
| Janero DR and Burghardt B | Protection of rat myocardial phospholipid against peroxidative injury through superoxide-(xanthine oxidase)-dependent, iron-promoted Fenton chemistry by the male contraceptive gossypol. | 1988 | Biochem. Pharmacol. | pmid:2840914 |
| Ueno H et al. | Interaction of gossypol with sperm macromolecules and enzymes. | 1988 | Contraception | pmid:2967157 |
| Liu GZ et al. | Effects of K salt or a potassium blocker on gossypol-related hypokalemia. | 1988 | Contraception | pmid:3370986 |
| Frick J et al. | Clinical microdose study of gossypol: effect on sperm motility and renal function. | 1988 | Contraception | pmid:3370988 |
| Drayer DE and Reidenberg MM | Gossypol and Na+, K+ ATPase from human erythrocytes. | 1988 | Contraception | pmid:2848657 |
| Xue SP et al. | Evaluation of the renal tubulo-toxic effect of gossypol by urinary protein analysis with SDS-polyacrylamide gel electrophoresis. | 1988 | Contraception | pmid:3370989 |
| Beaudoin AR | A developmental toxicity evaluation of gossypol. | 1988 | Contraception | pmid:3370993 |
| Benz C et al. | Selective toxicity of gossypol against epithelial tumors and its detection by magnetic resonance spectroscopy. | 1988 | Contraception | pmid:3370994 |
| Matlin SA et al. | Large-scale resolution of gossypol enantiomers for biological evaluation. | 1988 | Contraception | pmid:3370995 |
| Zhou RH and Lin XD | Isolation of (-)-gossypol from natural plant. | 1988 | Contraception | pmid:3370996 |
| Sonenberg M et al. | Anti-fertility and other actions of gossypol analogues. | 1988 | Contraception | pmid:3370997 |
| Stumpf WE et al. | Sites of action of gossypol studied by autoradiography and enzyme histochemistry. | 1988 | Contraception | pmid:3370998 |
| Fei RR and Teng CS | The effects of gossypol on nuclear protein in rat testes. I. Reduction in the content of basic proteins in the spermiogenic cells. | 1988 | Contraception | pmid:3370999 |
| Teng CS and Fei RR | The effects of gossypol on nuclear protein in rat testes. II. The synthesis of histones and testis-specific proteins after gossypol treatment. | 1988 | Contraception | pmid:3371000 |
| Hoffer AP et al. | Antifertility, spermicidal and ultrastructural effects of gossypol and derivatives administered orally and by intratesticular injections. | 1988 | Contraception | pmid:3371001 |
| Morgan S et al. | Clinical, clinicopathologic, pathologic, and toxicologic alterations associated with gossypol toxicosis in feeder lambs. | 1988 | Am. J. Vet. Res. | pmid:3377308 |
| Hudson LM et al. | Gossypol toxicosis in a herd of beef calves. | 1988 | J. Am. Vet. Med. Assoc. | pmid:3391858 |
| Reynolds JM and Tone JN | Subchronic oral administration of gossypol-acetic acid (GAA) alters the distribution and utilization of radioiron in male rats. | 1988 | Drug Chem Toxicol | pmid:3402348 |
| Baba Y | [Effect of HCG administration in the gossypol-treated male rats]. | 1988 | Hinyokika Kiyo | pmid:3135706 |
| Best RG and McKenzie WH | Variable sister-chromatid exchange response in human lymphocytes exposed in vitro to gossypol acetic acid. | 1988 | Mutat. Res. | pmid:3173390 |
| Dou SJ and Fu YF | [Effects of gossypol acetic acid on heart mitochondrial membranes ATPase]. | 1988 | Zhongguo Yao Li Xue Bao | pmid:2975138 |
| Den Boer PJ and Grootegoed JA | Mechanism of action of (-)gossypol on ATP production in isolated hamster spermatids. | 1988 | J. Reprod. Fertil. | pmid:3411559 |
| Liu DY et al. | Mutagenicity of gossypol analyzed by induction of meiotic micronuclei in vitro. | 1988 | Mutat. Res. | pmid:3380110 |
| Ye XQ | [Clinical and experimental study of gossypol in the treatment of dysfunctional menorrhagia, endometriosis and fibromyoma of the uterus]. | 1988 | Zhong Xi Yi Jie He Za Zhi | pmid:3191544 |
| Ohuchi K et al. | Inhibition by gossypol of tumor promoter-induced arachidonic acid metabolism in rat peritoneal macrophages. | 1988 | Biochim. Biophys. Acta | pmid:3136806 |
| Bender HS et al. | A histopathologic study of the effects of gossypol on the female rat. | 1988 | Contraception | pmid:3197423 |
| Dudel C and Förstermann U | Gossypol attenuates selectively the blood pressure lowering effect of endothelium-dependent vasodilators in the rabbit in vivo. | 1988 | Eur. J. Pharmacol. | pmid:2450761 |
| Bugeja V et al. | Primary mitochondrial activity of gossypol in yeast and mammalian cells. | 1988 | Biochem. Pharmacol. | pmid:2461202 |
| Wong YC and Tam CC | A structural and cytochemical study of the effects of gossypol on the epithelial cells of the guinea-pig seminal vesicle. | 1988 | J. Reprod. Fertil. | pmid:3199385 |
| Kainz V et al. | The effect of gossypol acetic acid on the different stages of the spermatogenic cycle in the rat. | 1988 | Int. J. Androl. | pmid:3215704 |
| Royer RE et al. | Binding of gossypol derivatives to human serum albumin. | 1988 | J Pharm Sci | pmid:3373428 |
| Reyes J and Benos DJ | Specificity of gossypol uncoupling: a comparative study of liver and spermatogenic cells. | 1988 | Am. J. Physiol. | pmid:3354655 |
| Wu YW et al. | [Ultrastructural studies on sodium and potassium ion active transport in the rat epididymis]. | 1988 | Shi Yan Sheng Wu Xue Bao | pmid:2849267 |
| Gonzalez-Garza MT and Said-Fernandez S | Entamoeba histolytica: potent in vitro antiamoebic effect of gossypol. | 1988 | Exp. Parasitol. | pmid:2899518 |
| Coutinho EM and Melo JF | Clinical experience with gossypol in non-Chinese men: a follow-up. | 1988 | Contraception | pmid:3286112 |
| BelokrinitskiÄ DV et al. | [Indices of the immune status of recurrent herpes patients being treated with a herpes polyvaccine]. | 1987 Mar-Apr | Vopr. Virusol. | pmid:3037800 |
| Su SY and Liu Y | Electron microscopic observation of gossypol effects on gastrocnemius muscles in laboratory animals. | 1987 | Proc Chin Acad Med Sci Peking Union Med Coll | pmid:2827153 |
| Beaujean V and Crabbé J | Gossypol interferes selectively with water and urea permeability of toad bladder. | 1987 | Pflugers Arch. | pmid:3114713 |
| Han ML et al. | Gossypol in the treatment of endometriosis and uterine myoma. | 1987 | Contrib Gynecol Obstet | pmid:3121251 |
| Sheriff DS et al. | Effect of gossypol on the activity of erythrocyte Na+-K+ ATPase activity in vitro. | 1987 | Clin. Chem. | pmid:3026686 |
| Baram N et al. | Inactivation of intestinal brush-border enzymes by gossypol. | 1987 | Agric. Biol. Chem. | pmid:12283503 |
| Ye YX et al. | Direct actions of gossypol on cardiac muscle. | 1987 | Eur. J. Pharmacol. | pmid:3036543 |
| Bassenge E et al. | Abluminal release and asymmetrical response of the rabbit arterial wall to endothelium-derived relaxing factor. | 1987 | Circ. Res. | pmid:3117407 |
| Tung DS et al. | Effect of long term gossypol treatment on human testicular structure. | 1987 | Adv Contracept Deliv Syst | pmid:12314752 |
| Xian SC et al. | Antifertility treating with long term gossypol. | 1987 | Adv Contracept Deliv Syst | pmid:12268655 |
| Russell DH et al. | Prolactin-dependent mitogenesis in Nb 2 node lymphoma cells: effects of immunosuppressive cyclopeptides. | 1987 | J. Immunol. | pmid:3097147 |
| Future prospects in male contraception. | 1987 | Netw Res Triangle Park N C | pmid:12269106 | |
| Hoffer AP et al. | Ultrastructural, fertility, and spermicidal studies with isomers and derivatives of gossypol in male hamsters. | 1987 | Biol. Reprod. | pmid:3689857 |
| Ye YX et al. | Cardiodepressant actions of the orally active male contraceptive, gossypol, in guinea-pig heart muscle. | 1987 | Eur. J. Pharmacol. | pmid:3691653 |
| Benz C et al. | Lactic dehydrogenase isozymes, 31P magnetic resonance spectroscopy, and in vitro antimitochondrial tumor toxicity with gossypol and rhodamine-123. | 1987 | J. Clin. Invest. | pmid:3805280 |
| Yang YQ and Wu XY | Antifertility mechanisms of gossypol acetic acid in female rats. | 1987 | J. Reprod. Fertil. | pmid:3656277 |
| Cooke E et al. | Diacylglycerol kinase inhibitor, R59022, potentiates neutrophil oxidase activation by Ca2+-dependent stimuli. Evidence for two separate but convergent pathways. | 1987 | Biochem. Pharmacol. | pmid:2823820 |
| Lin YC et al. | Effect of gossypol on spermatozoal lactate dehydrogenase-X (LDH-X) in male rats. | 1987 | Contraception | pmid:3447817 |
| Liu GZ et al. | Effect of K salt and K sparing agent in preventing gossypol-induced hypokalemia. | 1987 | Proc Chin Acad Med Sci Peking Union Med Coll | pmid:3423005 |
| Cheng JX et al. | Effect of gossypol(+/-, +, -) on Leydig cells of rat in vitro. | 1987 | Proc Chin Acad Med Sci Peking Union Med Coll | pmid:3423013 |
| Alheid U et al. | Endothelium-derived relaxing factor from cultured human endothelial cells inhibits aggregation of human platelets. | 1987 | Thromb. Res. | pmid:3499684 |
| Guo ZM et al. | [Synthesis of mono-aldehyde gossypol and its analogues]. | 1987 | Yao Xue Xue Bao | pmid:3450164 |
| Zhou RH and Lin XD | [Isolation of (-)-gossypol from natural plant]. | 1987 | Yao Xue Xue Bao | pmid:3450165 |
| Xu Y et al. | [The effect of combined use of gossypol and tripterygium wilfordii on the fertility of male rats]. | 1987 | Yao Xue Xue Bao | pmid:3452960 |
| Dhaliwal MK et al. | Cytogenetic analysis of a gossypol-induced murine myxosarcoma. | 1987 | J. Natl. Cancer Inst. | pmid:3473256 |
| Baccetti B et al. | Action of gossypol on rat germinal cells. II. The acrosome. | 1987 | Gamete Res | pmid:3506897 |
| Kim I et al. | Inhibition of lactate dehydrogenase-X by imino-derivatives of gossypol:structure activity relationship. | 1987 | Contraception | pmid:3608484 |
| Srivastava AK and Padmanaban G | Gossypol mediated DNA degradation. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3619941 |
| Sinha Hikim AP and Hoffer AP | Quantitative analysis of germ cells and Leydig cells in rat made infertile with gossypol. | 1987 | Contraception | pmid:3621939 |
| Zakhidov ST et al. | [Cytogenetic study of the effect of gossypol on mouse germ cells]. | 1987 | Genetika | pmid:3623090 |
| Lindberg MC et al. | Comparative anti-fertility effects of gossypol enantiomers in male hamsters. | 1987 | Int. J. Androl. | pmid:3654015 |
| Glander HJ | [Comments on reversible nonhormonal contraception in the male]. | 1987 | Hautarzt | pmid:3654202 |
| Buttar HS and Nayak BN | Cytogenetic effects of vaginally administered gossypol in murine bone marrow cells. | 1987 | Toxicol. Lett. | pmid:3660427 |
| Wang MZ | Analysis of gossypol by high performance liquid chromatography. | 1987 | J Ethnopharmacol | pmid:3626590 |
| Huang L et al. | Resolution of racemic gossypol. | 1987 | J Ethnopharmacol | pmid:3626591 |
| Wang NG et al. | Effect of (-)- and (+)-gossypol on fertility in male rats. | 1987 | J Ethnopharmacol | pmid:3626592 |
| Yao KQ et al. | Effect of (+/-)-, (+)- and (-)-gossypol on the lactate dehydrogenase-X activity of rat testis. | 1987 | J Ethnopharmacol | pmid:3626593 |
| Chen QQ et al. | Comparative study on the metabolism of optical gossypol in rats. | 1987 | J Ethnopharmacol | pmid:3626594 |
| Etindi RN and Rillema JA | Effect of kinase C inhibitor, gossypol, on the actions of prolactin in cultured mouse mammary tissues. | 1987 | Biochim. Biophys. Acta | pmid:2434140 |
| Liu GZ et al. | Clinical trial of gossypol as a male contraceptive drug. Part I. Efficacy study. | 1987 | Fertil. Steril. | pmid:3305087 |
| Liu GZ and Lyle KC | Clinical trial of gossypol as a male contraceptive drug. Part II. Hypokalemia study. | 1987 | Fertil. Steril. | pmid:3305088 |
| Yu YW | Probing into the mechanism of action, metabolism and toxicity of gossypol by studying its (+)- and (-)-stereoisomers. | 1987 | J Ethnopharmacol | pmid:3306161 |
| Liu GZ et al. | Experiences with gossypol as a male pill. | 1987 | Am. J. Obstet. Gynecol. | pmid:3314523 |
| Lei HP | Future research priorities of gossypol in the field of fertility regulation. | 1987 | Proc Chin Acad Med Sci Peking Union Med Coll | pmid:3321051 |
| Alheid U et al. | Selective inhibition by gossypol of endothelium-dependent relaxations augments relaxations to glyceryl trinitrate in rabbit coeliac artery. | 1987 | Br. J. Pharmacol. | pmid:2444300 |
| Förstermann U et al. | Endothelium-derived relaxing factor is likely to modulate the tone of resistance arteries in rabbit hindlimb in vivo. | 1987 | J. Pharmacol. Exp. Ther. | pmid:2447263 |
| Touvay C et al. | Gossypol: a potent inhibitor of PAF-acether- and leukotriene-induced contractions of guinea-pig lung parenchyma strips. | 1987 | J. Pharm. Pharmacol. | pmid:2886603 |
| Mülsch A et al. | Stimulation of soluble guanylate cyclase by endothelium-derived relaxing factor from cultured endothelial cells. | 1987 | Eur. J. Pharmacol. | pmid:2884122 |
| Pohl U et al. | Selective inhibition of endothelium-dependent dilation in resistance-sized vessels in vivo. | 1987 | Am. J. Physiol. | pmid:2887120 |
| Giridharan N et al. | Dose and time related changes in LDH-X activity, epididymal carnitine levels and fertility, in gossypol-treated male rats. | 1987 | Contraception | pmid:3568662 |
| YU TW | [Ultrastructural study of the testis in 22 persons based on the effect of gossypol]. | 1987 | Zhonghua Bing Li Xue Za Zhi | pmid:2957085 |
| Stephens DT et al. | Kinetic characterization of the inhibition of purified cynomolgus monkey lactate dehydrogenase isozymes by gossypol. | 1986 Nov-Dec | J. Androl. | pmid:3793617 |
| Sakhibov AD et al. | [Mechanism of Na,K-ATPase inhibition with gossypol and megasin]. | 1986 May-Jun | Vopr. Med. Khim. | pmid:3014735 |
| Ershov FI et al. | [A new interferon inducer active via peroral administration]. | 1986 May-Jun | Vopr. Virusol. | pmid:2429451 |