Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Turco E et al. | The in vitro effect of gossypol and its interaction with salts on conidial germination and viability of Fusarium oxysporum sp. vasinfectum isolates. | 2007 | J. Appl. Microbiol. | pmid:18045422 |
Royer RE et al. | Inhibition of human immunodeficiency virus type I replication by derivatives of gossypol. | 1991 | Pharmacol. Res. | pmid:1805194 |
Murohara T et al. | Age related attenuation of the endothelium dependent relaxation to noradrenaline in isolated pig coronary arteries. | 1991 | Cardiovasc. Res. | pmid:1806231 |
Loberg RD et al. | In vivo evaluation of AT-101 (R-(-)-gossypol acetic acid) in androgen-independent growth of VCaP prostate cancer cells in combination with surgical castration. | 2007 | Neoplasia | pmid:18084610 |
Sagach VF and Kindybaliuk AM | [The role of the endothelium in the development of functional hyperemia of the skeletal muscles]. | 1991 | Biull Eksp Biol Med | pmid:1810472 |
HOFFPAUIR CL and GUTHRIE JD | The use of aminized and phosphorylated cotton fabrics as ion exchange materials in the preparation of oil seed proteins. | 1949 | J. Biol. Chem. | pmid:18112104 |
Akinola OB et al. | Spermatoprotective activity of the leaf extract of Psidium guajava Linn. | 2007 | Niger Postgrad Med J | pmid:18163132 |
Przybylski P et al. | EI MS and ESI MS studies of the bisesquiterpene from cotton seeds: Gossypol and its Aza-derivatives. | 2008 | J Mass Spectrom | pmid:18200654 |
Kitada S et al. | Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048). | 2008 | Blood | pmid:18202226 |
Brozic P et al. | Inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. | 2008 | Curr. Med. Chem. | pmid:18220769 |
Woolley RJ | Contraception--a look forward, Part II: Mifepristone and gossypol. | 1991 Mar-Apr | J Am Board Fam Pract | pmid:1823560 |
Tang G et al. | Acylpyrogallols as inhibitors of antiapoptotic Bcl-2 proteins. | 2008 | J. Med. Chem. | pmid:18237106 |
RodrÃguez-EnrÃquez S et al. | Energy metabolism transition in multi-cellular human tumor spheroids. | 2008 | J. Cell. Physiol. | pmid:18264981 |
Arnold AA et al. | Preclinical studies of Apogossypolone: a new nonpeptidic pan small-molecule inhibitor of Bcl-2, Bcl-XL and Mcl-1 proteins in Follicular Small Cleaved Cell Lymphoma model. | 2008 | Mol. Cancer | pmid:18275607 |
Sprogøe K et al. | Combining HPLC-PDA-MS-SPE-NMR with circular dichroism for complete natural product characterization in crude extracts: levorotatory gossypol in Thespesia danis. | 2008 | J. Nat. Prod. | pmid:18290629 |
Paoluzzi L et al. | Targeting Bcl-2 family members with the BH3 mimetic AT-101 markedly enhances the therapeutic effects of chemotherapeutic agents in in vitro and in vivo models of B-cell lymphoma. | 2008 | Blood | pmid:18292288 |
Zha SW et al. | [Male antifertility drugs and cell apoptosis]. | 2008 | Zhonghua Nan Ke Xue | pmid:18297819 |
Moon DO et al. | Gossypol suppresses NF-kappaB activity and NF-kappaB-related gene expression in human leukemia U937 cells. | 2008 | Cancer Lett. | pmid:18314260 |
Mazumder B et al. | Effect of chlorpromazine and gossypol on Ca(2+)-ATPase activity in the microsomal membranes of rat testes. | 1991 | Indian J. Biochem. Biophys. | pmid:1831790 |
Przybylski P et al. | CP/MAS spectroscopy in the determination of the tautomeric forms of gossypol, its Schiff bases and hydrazones in the solid state. | 2008 | Magn Reson Chem | pmid:18338327 |