Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Jo C et al. | Irradiation effects on embryotoxicity and oxidative properties of gossypol dissolved in methanol. | 2003 | Food Chem. Toxicol. | pmid:12909266 |
Shaaban WF et al. | Reproductive toxicologic effects of gossypol on male rabbits: biochemical, enzymatic, and electrolytic properties of seminal plasma. | 2008 | Fertil. Steril. | pmid:17953964 |
Lin T et al. | Gossypol inhibits testicular steroidogenesis. | 1981 | Fertil. Steril. | pmid:7194804 |
Cameron SM et al. | Vaginal spermicidal activity of gossypol in the Macaca arctoides. | 1982 | Fertil. Steril. | pmid:7060775 |
Saksena SK and Salmonsen RA | Antifertility effects of gossypol in male hamsters. | 1982 | Fertil. Steril. | pmid:7075801 |
Coutinho EM et al. | Antispermatogenic action of gossypol in men. | 1984 | Fertil. Steril. | pmid:6468676 |
Pankajakshy A and Madambath I | Spermatotoxic effects of Cananga odorata (Lam): a comparison with gossypol. | 2009 | Fertil. Steril. | pmid:18692834 |
Ridley AJ and Blasco L | Testosterone and gossypol effects on human sperm motility. | 1981 | Fertil. Steril. | pmid:6273239 |
Liu GZ et al. | Clinical trial of gossypol as a male contraceptive drug. Part I. Efficacy study. | 1987 | Fertil. Steril. | pmid:3305087 |
Cowart CL et al. | The effects of cyclic adenosine monophosphate, forskolin, and theophylline on motility parameters in gossypol-treated human sperm. | 1994 | Fertil. Steril. | pmid:8174733 |
Liu GZ and Lyle KC | Clinical trial of gossypol as a male contraceptive drug. Part II. Hypokalemia study. | 1987 | Fertil. Steril. | pmid:3305088 |
Weissenmayer B et al. | The calcineurin inhibitor gossypol impairs growth, cell signalling and development in Dictyostelium discoideum. | 2005 | FEMS Microbiol. Lett. | pmid:15621416 |
VERMEL EM and KRUGLYAK SA | ANTITUMOR ACTIVITY OF GOSSYPOL IN EXPERIMENTS ON TRANSPLANTABLE TUMORS. | 1965 Jan-Feb | Fed Proc Transl Suppl | pmid:14275562 |
Junco M et al. | Substrate-dependent inhibition of protein kinase C by specific inhibitors. | 1990 | FEBS Lett. | pmid:2332048 |
Baker ME | Gossypol inhibits estrogen binding to rat alpha-fetoprotein. | 1984 | FEBS Lett. | pmid:6207049 |
Moon DO et al. | Gossypol suppresses telomerase activity in human leukemia cells via regulating hTERT. | 2008 | FEBS Lett. | pmid:18775705 |
Royer RE and Vander Jagt DL | Gossypol binds to a high-affinity binding site on human serum albumin. | 1983 | FEBS Lett. | pmid:6862017 |
Lei X et al. | Gossypol induces Bax/Bak-independent activation of apoptosis and cytochrome c release via a conformational change in Bcl-2. | 2006 | FASEB J. | pmid:16935937 |
Goriunova LV and Vichkanova SA | [Study of antiviral effect of gossypol on chick embryo model]. | 1969 Sep-Oct | Farmakol Toksikol | pmid:5364687 |
Dodou K et al. | Investigations on gossypol: past and present developments. | 2005 | Expert Opin Investig Drugs | pmid:16255680 |
Tone JN and Jensen DR | The accumulation pattern of ingested gossypol in selected organs of the rat. | 1976 | Experientia | pmid:1253913 |
Tone JN and Jensen DR | Effect of ingested gossypol on the growth performance of rats. | 1970 | Experientia | pmid:5478639 |
Abou-Donia MB et al. | Gossypol: antagonistic effect on toxicity of insecticides to Spodoptera littoralis. | 1974 | Experientia | pmid:4435119 |
Manmade A et al. | Gossypol. Synthesis and in vitro spermicidal activity of isomeric hemigossypol derivatives. | 1983 | Experientia | pmid:6641903 |
Eid JE et al. | Gossypol-induced death of African trypanosomes. | 1988 | Exp. Parasitol. | pmid:3366212 |
Rikihisa Y et al. | Taenia taeniaeformis: inactivation of metacestodes by gossypol in vitro. | 1990 | Exp. Parasitol. | pmid:2373186 |
Rikihisa Y and Lin YC | Taenia taeniaeformis: inhibition of metacestode development in the rat by gossypol. | 1986 | Exp. Parasitol. | pmid:3956677 |
Gonzalez-Garza MT and Said-Fernandez S | Entamoeba histolytica: potent in vitro antiamoebic effect of gossypol. | 1988 | Exp. Parasitol. | pmid:2899518 |
Konac E et al. | An in vitro study of cytotoxic effects of gossypol on human epidermoid larynx carcinoma cell line (HEp-2). | 2005 | Exp. Oncol. | pmid:15812364 |
Varol U et al. | The effect of racemic gossypol and at-101 on angiogenic profile of ovcar-3 cells: a preliminary molecular framework for gossypol enantiomers. | 2009 | Exp. Oncol. | pmid:20010531 |
Floridi A et al. | The effect of gossypol and Lonidamine on electron transport in Ehrlich ascites tumor mitochondria. | 1984 | Exp. Mol. Pathol. | pmid:6705894 |
Floridi A et al. | The effect of the association of Gossypol and Lonidamine on the energy metabolism of Ehrlich ascites tumor cells. | 1983 | Exp. Mol. Pathol. | pmid:6852206 |
Javed MH and Khan MA | Effect of amino acids on inhibition of lactate dehydrogenase-X by gossypol. | 1999 | Exp. Mol. Med. | pmid:10231019 |
Kline MP et al. | R-(-)-gossypol (AT-101) activates programmed cell death in multiple myeloma cells. | 2008 | Exp. Hematol. | pmid:18346839 |
Qiu J et al. | Different pathways of cell killing by gossypol enantiomers. | 2002 | Exp. Biol. Med. (Maywood) | pmid:12037129 |
Pond GR et al. | Evaluating the value of number of cycles of docetaxel and prednisone in men with metastatic castration-resistant prostate cancer. | 2012 | Eur. Urol. | pmid:21715086 |
Shen Y and Ye D | Re: Gregory R. Pond, Andrew J. Armstrong, Brian A. Wood, et al. Evaluating the value of number of cycles of docetaxel and prednisone in men with metastatic castration-resistant prostate cancer. Eur Urol 2012;61:363-9. | 2012 | Eur. Urol. | pmid:21824719 |
Bai JP et al. | Effects of demethylzeylasteral and celastrol on spermatogenic cell Ca2+ channels and progesterone-induced sperm acrosome reaction. | 2003 | Eur. J. Pharmacol. | pmid:12600689 |
Ye YX et al. | Direct actions of gossypol on cardiac muscle. | 1987 | Eur. J. Pharmacol. | pmid:3036543 |
Kuhn G et al. | Gossypol induces chloride secretion in rat proximal colon. | 2002 | Eur. J. Pharmacol. | pmid:12464365 |
Ye YX et al. | Cardiodepressant actions of the orally active male contraceptive, gossypol, in guinea-pig heart muscle. | 1987 | Eur. J. Pharmacol. | pmid:3691653 |
Carruthers NJ et al. | Gossypol inhibits calcineurin phosphatase activity at multiple sites. | 2007 | Eur. J. Pharmacol. | pmid:17141216 |
Alheid U et al. | Human endothelial cells inhibit platelet aggregation by separately stimulating platelet cyclic AMP and cyclic GMP. | 1989 | Eur. J. Pharmacol. | pmid:2546782 |
Hervé JC et al. | Contraceptive gossypol blocks cell-to-cell communication in human and rat cells. | 1996 | Eur. J. Pharmacol. | pmid:8911921 |
Gong YZ et al. | Cinnamyl-3,4-dihydroxy-alpha-cyanocinnamate and nordihydroguaiaretic acid inhibit human Kv1.5 currents independently of lipoxygenase. | 2008 | Eur. J. Pharmacol. | pmid:18930721 |
Dudel C and Förstermann U | Gossypol attenuates selectively the blood pressure lowering effect of endothelium-dependent vasodilators in the rabbit in vivo. | 1988 | Eur. J. Pharmacol. | pmid:2450761 |
Mülsch A et al. | Stimulation of soluble guanylate cyclase by endothelium-derived relaxing factor from cultured endothelial cells. | 1987 | Eur. J. Pharmacol. | pmid:2884122 |
Huang LH et al. | Gossypol inhibits phosphorylation of Bcl-2 in human leukemia HL-60 cells. | 2010 | Eur. J. Pharmacol. | pmid:20633548 |
Bai J and Shi Y | Inhibition of T-type Ca(2+) currents in mouse spermatogenic cells by gossypol, an antifertility compound. | 2002 | Eur. J. Pharmacol. | pmid:11959082 |
Spijkers-Hagelstein JA et al. | Glucocorticoid sensitisation in Mixed Lineage Leukaemia-rearranged acute lymphoblastic leukaemia by the pan-BCL-2 family inhibitors gossypol and AT-101. | 2014 | Eur. J. Cancer | pmid:24703900 |