Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Hernández-Cerón J et al. | Timing of inhibitory actions of gossypol on cultured bovine embryos. | 2005 | J. Dairy Sci. | pmid:15738226 |
Shen YL et al. | Study on structure and characterization of inclusion complex of gossypol/beta cyclodextrin. | 2005 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:15741097 |
Weissenmayer B et al. | The calcineurin inhibitor gossypol impairs growth, cell signalling and development in Dictyostelium discoideum. | 2005 | FEMS Microbiol. Lett. | pmid:15621416 |
Wang J et al. | Reversal of a full-length mutant huntingtin neuronal cell phenotype by chemical inhibitors of polyglutamine-mediated aggregation. | 2005 | BMC Neurosci | pmid:15649316 |
Lopez LM et al. | Nonhormonal drugs for contraception in men: a systematic review. | 2005 | Obstet Gynecol Surv | pmid:16250923 |
Dodou K et al. | Investigations on gossypol: past and present developments. | 2005 | Expert Opin Investig Drugs | pmid:16255680 |
Mohammad RM et al. | Nonpeptidic small-molecule inhibitor of Bcl-2 and Bcl-XL, (-)-Gossypol, enhances biological effect of genistein against BxPC-3 human pancreatic cancer cell line. | 2005 | Pancreas | pmid:16258364 |
Stipanovic RD et al. | Occurrence of (+)- and (-)-gossypol in wild species of cotton and in Gossypium hirsutum Var. marie-galante (Watt) Hutchinson. | 2005 | J. Agric. Food Chem. | pmid:16076104 |
Bauer JA et al. | Reversal of cisplatin resistance with a BH3 mimetic, (-)-gossypol, in head and neck cancer cells: role of wild-type p53 and Bcl-xL. | 2005 | Mol. Cancer Ther. | pmid:16020667 |
Mohammad RM et al. | Preclinical studies of a nonpeptidic small-molecule inhibitor of Bcl-2 and Bcl-X(L) [(-)-gossypol] against diffuse large cell lymphoma. | 2005 | Mol. Cancer Ther. | pmid:15657349 |
Oliver CL et al. | (-)-Gossypol acts directly on the mitochondria to overcome Bcl-2- and Bcl-X(L)-mediated apoptosis resistance. | 2005 | Mol. Cancer Ther. | pmid:15657350 |
Xu L et al. | (-)-Gossypol enhances response to radiation therapy and results in tumor regression of human prostate cancer. | 2005 | Mol. Cancer Ther. | pmid:15713891 |
That QT et al. | Schiff bases of gossypol: an NMR and DFT study. | 2005 | Magn Reson Chem | pmid:15678567 |
Ergun U et al. | Protective effect of ginkgo biloba against gossypol-induced apoptosis in human lymphocytes. | 2005 | Cell Biol. Int. | pmid:15949956 |
Uzal FA et al. | Gossypol toxicosis in a dog consequent to ingestion of cottonseed bedding. | 2005 | J. Vet. Diagn. Invest. | pmid:16475530 |
Lordelo MM et al. | Relative toxicity of gossypol enantiomers in broilers. | 2005 | Poult. Sci. | pmid:16206558 |
Sabirova FM et al. | [Immunomodulating effect of the novel water-soluble gossypol derivative Mebavin in adjuvant arthritis]. | 2004 Mar-Apr | Eksp Klin Farmakol | pmid:15188763 |
Jiang J et al. | The inhibitory effects of gossypol on human prostate cancer cells-PC3 are associated with transforming growth factor beta1 (TGFbeta1) signal transduction pathway. | 2004 Jan-Feb | Anticancer Res. | pmid:15015581 |
Cui X et al. | [Determination of free gossypol in meat by reversed-phased high performance liquid chromatography]. | 2004 | Se Pu | pmid:15706952 |
Yildirim-Aksoy M et al. | In vitro inhibitory effect of gossypol from gossypol-acetic acid, and (+)- and (-)-isomers of gossypol on the growth of Edwardsiella ictaluri. | 2004 | J. Appl. Microbiol. | pmid:15186445 |