Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Lin YL et al. | Synergistic combination of small molecule inhibitor and RNA interference against antiapoptotic Bcl-2 protein in head and neck cancer cells. | 2013 | Mol. Pharm. | pmid:23734725 |
El-Nassan HB | Advances in the discovery of kinesin spindle protein (Eg5) inhibitors as antitumor agents. | 2013 | Eur J Med Chem | pmid:23434636 |
Liu Z et al. | Protective effect of gossypol on lipopolysaccharide-induced acute lung injury in mice. | 2013 | Inflamm. Res. | pmid:23435932 |
Pridgeon JW et al. | Attempt to develop live attenuated bacterial vaccines by selecting resistance to gossypol, proflavine hemisulfate, novobiocin, or ciprofloxacin. | 2013 | Vaccine | pmid:23499519 |
Hamdy R et al. | Synthesis and evaluation of 3-(benzylthio)-5-(1H-indol-3-yl)-1,2,4-triazol-4-amines as Bcl-2 inhibitory anticancer agents. | 2013 | Bioorg. Med. Chem. Lett. | pmid:23474389 |
Yuan Y et al. | Gossypol and an HMT G9a inhibitor act in synergy to induce cell death in pancreatic cancer cells. | 2013 | Cell Death Dis | pmid:23807219 |
Deng S et al. | Gossypol acetic acid induces apoptosis in RAW264.7 cells via a caspase-dependent mitochondrial signaling pathway. | 2013 | J. Vet. Sci. | pmid:23820203 |
Zhan YH et al. | Growth inhibition and apoptosis induction of human umbilical vein endothelial cells by apogossypolone. | 2013 | Asian Pac. J. Cancer Prev. | pmid:23679275 |
Mellon JE et al. | Effects of temperature and medium composition on inhibitory activities of gossypol-related compounds against aflatoxigenic fungi. | 2013 | J. Appl. Microbiol. | pmid:23594138 |
Kapoor S | Attenuating effect of gossypol on tumor growth in systemic malignancies. | 2013 | Cell Biochem. Biophys. | pmid:23743711 |
Lin J et al. | Induction of apoptosis and antitumor effects of a small molecule inhibitor of Bcl-2 and Bcl-xl, gossypol acetate, in multiple myeloma in vitro and in vivo. | 2013 | Oncol. Rep. | pmid:23708869 |
Zhou M et al. | Metabolic engineering of gossypol in cotton. | 2013 | Appl. Microbiol. Biotechnol. | pmid:23775273 |
Song B et al. | Gossypol suppresses mouse T lymphocytes via inhibition of NFκB, NFAT and AP-1 pathways. | 2013 | Immunopharmacol Immunotoxicol | pmid:23981004 |
Billard C | BH3 mimetics: status of the field and new developments. | 2013 | Mol. Cancer Ther. | pmid:23974697 |
Jiao X et al. | Comparative transcriptomic analysis of developing cotton cotyledons and embryo axis. | 2013 | PLoS ONE | pmid:23977137 |
Semon B | Dietary intake of cottonseed toxins is hypothesized to be a partial cause of Alzheimer's disorder. | 2012 | Med. Hypotheses | pmid:22136946 |
Ilkevych NS et al. | Vibrational spectra, structure and antioxidant activity of gossypol imine derivatives. | 2012 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:22078080 |
Sonpavde G et al. | Randomized phase II trial of docetaxel plus prednisone in combination with placebo or AT-101, an oral small molecule Bcl-2 family antagonist, as first-line therapy for metastatic castration-resistant prostate cancer. | 2012 | Ann. Oncol. | pmid:22112969 |
Pond GR et al. | Evaluating the value of number of cycles of docetaxel and prednisone in men with metastatic castration-resistant prostate cancer. | 2012 | Eur. Urol. | pmid:21715086 |
Azab B et al. | Enhanced delivery of mda-7/IL-24 using a serotype chimeric adenovirus (Ad.5/3) in combination with the Apogossypol derivative BI-97C1 (Sabutoclax) improves therapeutic efficacy in low CAR colorectal cancer cells. | 2012 | J. Cell. Physiol. | pmid:21780116 |
Imai A et al. | Metronomic dosing of BH3 mimetic small molecule yields robust antiangiogenic and antitumor effects. | 2012 | Cancer Res. | pmid:22158856 |
Rathore KS et al. | Ultra-low gossypol cottonseed: generational stability of the seed-specific, RNAi-mediated phenotype and resumption of terpenoid profile following seed germination. | 2012 | Plant Biotechnol. J. | pmid:21902797 |
Mazumder S et al. | Mcl-1 Phosphorylation defines ABT-737 resistance that can be overcome by increased NOXA expression in leukemic B cells. | 2012 | Cancer Res. | pmid:22525702 |
El-Mokadem MY et al. | Alleviation of reproductive toxicity of gossypol using selenium supplementation in rams. | 2012 | J. Anim. Sci. | pmid:22585803 |
Cheng W et al. | [Effects of gossypol acetate on apoptosis in primary cultured cells from patients with lymphoid leukemia and its synergy with dexamethasone]. | 2012 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:22541072 |
Zhang YS et al. | Gossypol exhibits a strong influence towards UDP-glucuronosyltransferase (UGT) 1A1, 1A9 and 2B7-mediated metabolism of xenobiotics and endogenous substances. | 2012 | Molecules | pmid:22543504 |
Özdoğan M et al. | Effect of gossypol on blood serum parameters and small intestinal morphology of male broilers. | 2012 | J Anim Physiol Anim Nutr (Berl) | pmid:21261752 |
Wang AP et al. | Effects of different sources and levels of dietary gossypol on gossypol residues in plasma and milk of lactating cows. | 2012 | J. Dairy Sci. | pmid:22916918 |
Schuler MA | Insect P450s: mounted for battle in their war against toxins. | 2012 | Mol. Ecol. | pmid:22924794 |
Yang J et al. | Synthesis and antiviral activities of novel gossypol derivatives. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22226654 |
Jiang J et al. | Gossypol inhibits growth, invasiveness, and angiogenesis in human prostate cancer cells by modulating NF-κB/AP-1 dependent- and independent-signaling. | 2012 | Clin. Exp. Metastasis | pmid:22167622 |
Chien CC et al. | The role of COX-2/PGE2 in gossypol-induced apoptosis of colorectal carcinoma cells. | 2012 | J. Cell. Physiol. | pmid:22170686 |
Masood A et al. | Downregulation of BCL2 by AT-101 enhances the antileukaemic effect of lenalidomide both by an immune dependant and independent manner. | 2012 | Br. J. Haematol. | pmid:22171982 |
Lian J et al. | Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation. | 2012 | Mol. Cancer Ther. | pmid:22188816 |
Li HQ et al. | Structure-based design of rhodanine-based acylsulfonamide derivatives as antagonists of the anti-apoptotic Bcl-2 protein. | 2012 | Bioorg. Med. Chem. | pmid:22739087 |
Ignatova M et al. | Quaternized chitosan-coated nanofibrous materials containing gossypol: preparation by electrospinning, characterization and antiproliferative activity towards HeLa cells. | 2012 | Int J Pharm | pmid:22728261 |
Sun P et al. | Action of db-cAMP on the bystander effect and chemosensitivity through connexin 43 and Bcl-2-mediated pathways in medulloblastoma cells. | 2012 | Oncol. Rep. | pmid:22766741 |
Lin H et al. | A validated HPLC assay for the determination of R-(-)-gossypol in human plasma and its application in clinical pharmacokinetic studies. | 2012 | J Pharm Biomed Anal | pmid:22483642 |
Billard C | Development of Noxa-like BH3 mimetics for apoptosis-based therapeutic strategy in chronic lymphocytic leukemia. | 2012 | Mol. Cancer Res. | pmid:22466256 |
An T et al. | Amino acid derivatives of the (-) enantiomer of gossypol are effective fusion inhibitors of human immunodeficiency virus type 1. | 2012 | Antiviral Res. | pmid:22426469 |
Tao XY et al. | Gossypol-enhanced P450 gene pool contributes to cotton bollworm tolerance to a pyrethroid insecticide. | 2012 | Mol. Ecol. | pmid:22515600 |
Wagner TA et al. | Hemigossypol, a constituent in developing glanded cottonseed (Gossypium hirsutum). | 2012 | J. Agric. Food Chem. | pmid:22369216 |
Kisim A et al. | Pretreatment with AT-101 enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis of breast cancer cells by inducing death receptors 4 and 5 protein levels. | 2012 | J. Cancer Res. Clin. Oncol. | pmid:22411600 |
Bodur C and Basaga H | Bcl-2 inhibitors: emerging drugs in cancer therapy. | 2012 | Curr. Med. Chem. | pmid:22414090 |
Hsiao WT et al. | Involvement of Smac, p53, and caspase pathways in induction of apoptosis by gossypol in human retinoblastoma cells. | 2012 | Mol. Vis. | pmid:22876131 |
Wong FY et al. | Combination therapy with gossypol reveals synergism against gemcitabine resistance in cancer cells with high BCL-2 expression. | 2012 | PLoS ONE | pmid:23226540 |
Sarwar Gilani G et al. | Impact of antinutritional factors in food proteins on the digestibility of protein and the bioavailability of amino acids and on protein quality. | 2012 | Br. J. Nutr. | pmid:23107545 |
Vshivkov S et al. | Capillary electrophoresis to quantitate gossypol enantiomers in cotton flower petals and seed. | 2012 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:23122406 |
Zbidah M et al. | Gossypol-induced suicidal erythrocyte death. | 2012 | Toxicology | pmid:23041711 |
Hu W et al. | Proapoptotic protein Smac mediates apoptosis in cisplatin-resistant ovarian cancer cells when treated with the anti-tumor agent AT101. | 2012 | J. Biol. Chem. | pmid:22052903 |