Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Mol. Cancer Ther. (4)
- Proc. Natl. Acad. Sci. U.S.A. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (2)
- Others (13)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Schteingart DE et al. | Expression of anti-apoptosis genes determines the response of adrenal cancer to apoptosis-inducing chemotherapy. | 2010 | Anticancer Res. | pmid:21187456 |
| Cengiz E et al. | Overcoming drug resistance in hormone- and drug-refractory prostate cancer cell line, PC-3 by docetaxel and gossypol combination. | 2010 | Mol. Biol. Rep. | pmid:19288219 |
| Fulda S | Modulation of apoptosis by natural products for cancer therapy. | 2010 | Planta Med. | pmid:20486070 |
| Ionov M et al. | The interaction of PVP complexes of gossypol and its derivatives with an artificial membrane lipid matrix. | 2010 | Cell. Mol. Biol. Lett. | pmid:19936629 |
| Blevins S et al. | Effects of silymarin on gossypol toxicosis in divergent lines of chickens. | 2010 | Poult. Sci. | pmid:20709972 |
| Yan F et al. | A novel water-soluble gossypol derivative increases chemotherapeutic sensitivity and promotes growth inhibition in colon cancer. | 2010 | J. Med. Chem. | pmid:20684596 |
| Wu G et al. | Responses of three successive generations of beet armyworm, Spodoptera exigua, fed exclusively on different levels of gossypol in cotton leaves. | 2010 | J. Insect Sci. | pmid:21067414 |
| Wei J et al. | Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. | 2010 | J. Med. Chem. | pmid:21033669 |
| ZHU Y et al. | Involvement of Bcl-2, Src, and ERα in gossypol-mediated growth inhibition and apoptosis in human uterine leiomyoma and myometrial cells. | 2010 | Acta Pharmacol. Sin. | pmid:21102482 |
| Zhan WH et al. | [Studies on the killing effect of gamma ray irradiated peripheral blood mononuclear cells combined with (-)-gossypol on human prostate cancer LNCaP cells]. | 2010 | Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi | pmid:21319440 |
| Sung B et al. | Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL. | 2010 | J. Biol. Chem. | pmid:20837473 |
| Chang Q et al. | Effects of combined administration of low-dose gossypol with steroid hormones on the mitotic phase of spermatogenesis of rat. | 2010 | J Exp Zool A Ecol Genet Physiol | pmid:20839281 |
| Uzunoglu S et al. | Comparison of XTT and Alamar blue assays in the assessment of the viability of various human cancer cell lines by AT-101 (-/- gossypol). | 2010 | Toxicol. Mech. Methods | pmid:20843265 |
| Przybylski P et al. | The influence of protonation on molecular structure and physico-chemical properties of gossypol Schiff bases. | 2010 | Org. Biomol. Chem. | pmid:20959900 |
| Vizirianakis IS et al. | Toward the development of innovative bifunctional agents to induce differentiation and to promote apoptosis in leukemia: clinical candidates and perspectives. | 2010 | J. Med. Chem. | pmid:20925433 |
| Heist RS et al. | Phase I/II study of AT-101 with topotecan in relapsed and refractory small cell lung cancer. | 2010 | J Thorac Oncol | pmid:20808253 |
| Moretti L et al. | AT-101, a pan-Bcl-2 inhibitor, leads to radiosensitization of non-small cell lung cancer. | 2010 | J Thorac Oncol | pmid:20354451 |
| Priyadarshi A et al. | Structural insights into mouse anti-apoptotic Bcl-xl reveal affinity for Beclin 1 and gossypol. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20206602 |
| Reddish JM et al. | (-)-Gossypol containing hen sera and a myosin (-)-gossypol conjugate reduces the proliferation of MCF-7 cells. | 2010 | Anticancer Res. | pmid:20332451 |
| Banerjee S et al. | Preclinical studies of apogossypolone, a novel pan inhibitor of bcl-2 and mcl-1, synergistically potentiates cytotoxic effect of gemcitabine in pancreatic cancer cells. | 2010 | Pancreas | pmid:19823097 |
| Goldsmith KC et al. | BH3 response profiles from neuroblastoma mitochondria predict activity of small molecule Bcl-2 family antagonists. | 2010 | Cell Death Differ. | pmid:19893570 |
| Volate SR et al. | Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells. | 2010 | Mol. Cancer Ther. | pmid:20124455 |
| Barelier S et al. | Fragment-based deconstruction of Bcl-xL inhibitors. | 2010 | J. Med. Chem. | pmid:20192224 |
| Le A et al. | Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20133848 |
| Zhang XQ et al. | Inhibition of proliferation of prostate cancer cell line, PC-3, in vitro and in vivo using (-)-gossypol. | 2010 | Asian J. Androl. | pmid:20081872 |
| Liu YX | Temperature control of spermatogenesis and prospect of male contraception. | 2010 | Front Biosci (Schol Ed) | pmid:20036980 |
| El-Sharaky AS et al. | Spermatotoxicity, biochemical changes and histological alteration induced by gossypol in testicular and hepatic tissues of male rats. | 2010 | Food Chem. Toxicol. | pmid:20832445 |
| Wang H et al. | Inhibition of calcineurin by quercetin in vitro and in Jurkat cells. | 2010 | J. Biochem. | pmid:19880376 |
| Anuja MN et al. | Spermatotoxicity of a protein isolated from the root of Achyranthes aspera: a comparative study with gossypol. | 2010 | Contraception | pmid:20851234 |
| Li G et al. | [Effect of testosterone on the expression of CMTM family of the male spermatogenesis suppression rats]. | 2010 | Yao Xue Xue Bao | pmid:21351585 |
| Karaca B et al. | Enhancement of taxane-induced cytotoxicity and apoptosis by gossypol in human breast cancer cell line MCF-7. | 2009 Jul-Sep | J BUON | pmid:19810142 |
| Pankajakshy A and Madambath I | Spermatotoxic effects of Cananga odorata (Lam): a comparison with gossypol. | 2009 | Fertil. Steril. | pmid:18692834 |
| Wei J et al. | Synthesis and evaluation of Apogossypol atropisomers as potential Bcl-xL antagonists. | 2009 | Cancer Lett. | pmid:18782651 |
| Azmi AS and Mohammad RM | Non-peptidic small molecule inhibitors against Bcl-2 for cancer therapy. | 2009 | J. Cell. Physiol. | pmid:18767026 |
| Kang MH and Reynolds CP | Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy. | 2009 | Clin. Cancer Res. | pmid:19228717 |
| Lin J et al. | [Effect of apogossypolone on induction apoptosis in multiple myeloma cells and its mechanisms]. | 2009 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:19236755 |
| Przybylski P et al. | Complexes of heterocyclic aza-derivatives of phytoalexin from cotton plant-gossypol with alkali metal cations and perchlorate anion studied by ESI mass spectrometric method in the positive and negative modes. | 2009 | J Mass Spectrom | pmid:19189269 |
| Kilic A et al. | Efficacy of signal pathway inhibitors alone and in combination with Cisplatin varies between human non-small cell lung cancer lines. | 2009 | J. Surg. Res. | pmid:19084241 |
| Chen BB et al. | The (+)- and (-)-gossypols potently inhibit human and rat 11beta-hydroxysteroid dehydrogenase type 2. | 2009 | J. Steroid Biochem. Mol. Biol. | pmid:19150652 |
| Stipanovic RD et al. | Total and percent atropisomers of gossypol and gossypol-6-methyl ether in seeds from pima cottons and accessions of Gossypium barbadense L. | 2009 | J. Agric. Food Chem. | pmid:19113939 |
| Zhang L et al. | Chiral gossypol derivatives: evaluation of their anticancer activity and molecular modeling. | 2009 | Eur J Med Chem | pmid:19447525 |
| Sun J et al. | Apogossypolone inhibits cell growth by inducing cell cycle arrest in U937 cells. | 2009 | Oncol. Rep. | pmid:19513523 |
| Jiang J et al. | Gossypol inhibits the growth of MAT-LyLu prostate cancer cells by modulation of TGFbeta/Akt signaling. | 2009 | Int. J. Mol. Med. | pmid:19513537 |
| Przybylski P et al. | Synthesis, crystal structures and antibacterial activity studies of aza-derivatives of phytoalexin from cotton plant--gossypol. | 2009 | Eur J Med Chem | pmid:19577825 |
| Wei J et al. | Apogossypol derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. | 2009 | J. Med. Chem. | pmid:19555126 |
| Lestini BJ et al. | Mcl1 downregulation sensitizes neuroblastoma to cytotoxic chemotherapy and small molecule Bcl2-family antagonists. | 2009 | Cancer Biol. Ther. | pmid:19556859 |
| Ionov M et al. | The immobilization of gossypol derivative on N-polyvinylpyrrolidone increases its water solubility and modifies membrane-active properties. | 2009 | J. Med. Chem. | pmid:19603832 |
| Anilkumar KJ et al. | Synergistic interactions between Cry1Ac and natural cotton defenses limit survival of Cry1Ac-resistant Helicoverpa zea (Lepidoptera: Noctuidae) on Bt cotton. | 2009 | J. Chem. Ecol. | pmid:19588197 |
| Huang YW et al. | (-)-Gossypol reduces invasiveness in metastatic prostate cancer cells. | 2009 | Anticancer Res. | pmid:19528479 |
| Roychoudhury S et al. | In vitro gossypol induced spermatozoa motility alterations in rabbits. | 2009 | J Environ Sci Health B | pmid:20183084 |