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Gossypol interferes with both type I and type II topoisomerase activities without generating strand breaks. |
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Cell Biochem. Biophys. |
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Clin Genitourin Cancer |
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2013 |
Plant Biotechnol. J. |
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2013 |
Acta Crystallogr C |
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2013 |
Eur J Med Chem |
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Zhong S et al. |
(-)-Gossypol-enriched cottonseed oil inhibits proliferation and adipogenesis of human breast pre-adipocytes. |
2013 |
Anticancer Res. |
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Sabutoclax (BI97C1) and BI112D1, putative inhibitors of MCL-1, induce mitochondrial fragmentation either upstream of or independent of apoptosis. |
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Neoplasia |
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[Influence of immunovac-VP-4 therapy on innate immunity effectors in patients with darier erythema annulare centrifugum]. |
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Zh. Mikrobiol. Epidemiol. Immunobiol. |
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Sequential treatment with AT-101 enhances cisplatin chemosensitivity in human non-small cell lung cancer cells through inhibition of apurinic/apyrimidinic endonuclease 1-activated IL-6/STAT3 signaling pathway. |
2014 |
Drug Des Devel Ther |
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Gossypol promotes degeneration of ovarian follicles in rats. |
2014 |
ScientificWorldJournal |
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2014 |
Urol. Clin. North Am. |
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AT-101 downregulates BCL2 and MCL1 and potentiates the cytotoxic effects of lenalidomide and dexamethasone in preclinical models of multiple myeloma and Waldenström macroglobulinaemia. |
2014 |
Br. J. Haematol. |
pmid:24236538
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Keshmiri-Neghab H and Goliaei B |
Therapeutic potential of gossypol: an overview. |
2014 |
Pharm Biol |
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Gossypol increases expression of the pro-apoptotic BH3-only protein NOXA through a novel mechanism involving phospholipase A2, cytoplasmic calcium, and endoplasmic reticulum stress. |
2014 |
J. Biol. Chem. |
pmid:24778183
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Effects of dietary gossypol concentration on growth performance, blood profiles, and hepatic histopathology in meat ducks. |
2014 |
Poult. Sci. |
pmid:24902707
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Targeting BCL2 for the treatment of lymphoid malignancies. |
2014 |
Semin. Hematol. |
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A phase I study of AT-101 with cisplatin and etoposide in patients with advanced solid tumors with an expanded cohort in extensive-stage small cell lung cancer. |
2014 |
Invest New Drugs |
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Autophagy inhibition enhances pan-Bcl-2 inhibitor AT-101-induced apoptosis in non-small cell lung cancer. |
2014 |
Neoplasma |
pmid:24299314
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Glucocorticoid sensitisation in Mixed Lineage Leukaemia-rearranged acute lymphoblastic leukaemia by the pan-BCL-2 family inhibitors gossypol and AT-101. |
2014 |
Eur. J. Cancer |
pmid:24703900
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