| MeSH term | MeSH ID | Detail |
|---|---|---|
| Edema | D004487 | 152 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Testicular Diseases | D013733 | 15 associated lipids |
| Lymphoma, Large B-Cell, Diffuse | D016403 | 13 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Abnormalities, Drug-Induced | D000014 | 10 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Leukemia P388 | D007941 | 43 associated lipids |
Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Mol. Cancer Ther. (4)
- Proc. Natl. Acad. Sci. U.S.A. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (2)
- Others (13)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Anderson MA et al. | BH3 mimetic therapy: an emerging and promising approach to treating chronic lymphocytic leukemia. | 2013 | Leuk. Lymphoma | pmid:23339446 |
| Mellon JE et al. | Inhibitory effects of gossypol-related compounds on growth of Aspergillus flavus. | 2011 | Lett. Appl. Microbiol. | pmid:21291481 |
| Mellon JE et al. | Growth inhibitory effects of gossypol and related compounds on fungal cotton root pathogens. | 2014 | Lett. Appl. Microbiol. | pmid:24713043 |
| Susman E | Cottonseed-oil byproduct as anticancer radiation sensitiser. | 2004 | Lancet Oncol. | pmid:15536689 |
| Gossypol prospects. | 1984 | Lancet | pmid:6144835 | |
| Soufir JC et al. | Epididymal effects of gossypol. | 1984 | Lancet | pmid:6145995 |
| Pösö H et al. | Gossypol, a powerful inhibitor of human spermatozoal metabolism. | 1980 | Lancet | pmid:6103251 |
| Deng S et al. | Gossypol acetic acid induces apoptosis in RAW264.7 cells via a caspase-dependent mitochondrial signaling pathway. | 2013 | J. Vet. Sci. | pmid:23820203 |
| Uzal FA et al. | Gossypol toxicosis in a dog consequent to ingestion of cottonseed bedding. | 2005 | J. Vet. Diagn. Invest. | pmid:16475530 |
| Dale GL and Friese P | Bax activators potentiate coated-platelet formation. | 2006 | J. Thromb. Haemost. | pmid:16970802 |
| Yeow WS et al. | Gossypol, a phytochemical with BH3-mimetic property, sensitizes cultured thoracic cancer cells to Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand. | 2006 | J. Thorac. Cardiovasc. Surg. | pmid:17140955 |
| Kilic A et al. | Efficacy of signal pathway inhibitors alone and in combination with Cisplatin varies between human non-small cell lung cancer lines. | 2009 | J. Surg. Res. | pmid:19084241 |
| Druez D et al. | Effect of gossypol on the morphology, motility and metabolism of a flagellated protist, Dunaliella bioculata. | 1989 | J. Submicrosc. Cytol. Pathol. | pmid:2752364 |
| Gu Y et al. | Gossypolone suppresses progesterone synthesis in bovine luteal cells. | 1991 | J. Steroid Biochem. Mol. Biol. | pmid:2064986 |
| Sang GW et al. | Inhibitory effects of gossypol on corticosteroid 11-beta-hydroxysteroid dehydrogenase from guinea pig kidney: a possible mechanism for causing hypokalemia. | 1991 | J. Steroid Biochem. Mol. Biol. | pmid:1888675 |
| Cuéllar A et al. | Cholesterol side-chain cleavage and 11 beta-hydroxylation are inhibited by gossypol in adrenal cortex mitochondria. | 1990 | J. Steroid Biochem. Mol. Biol. | pmid:2278843 |
| Chen BB et al. | The (+)- and (-)-gossypols potently inhibit human and rat 11beta-hydroxysteroid dehydrogenase type 2. | 2009 | J. Steroid Biochem. Mol. Biol. | pmid:19150652 |
| Hu GX et al. | The (+)- and (-)-gossypols potently inhibit both 3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase 3 in human and rat testes. | 2009 | J. Steroid Biochem. Mol. Biol. | pmid:19429456 |
| Pearce S et al. | Site of gossypol inhibition of steroidogenesis in purified mouse Leydig cells. | 1986 | J. Steroid Biochem. | pmid:3025516 |
| Damaty SM and Hudson BJ | Preparation of low-gossypol cottonseed flour. | 1975 | J. Sci. Food Agric. | pmid:1172995 |
| Yang X et al. | Identification and proteomic analysis of a novel gossypol-degrading fungal strain. | 2012 | J. Sci. Food Agric. | pmid:22002592 |
| Den Boer PJ and Grootegoed JA | Differential effects of (+)- and (-)-gossypol enantiomers on LDH-C4 activity of hamster spermatogenic epithelium in vitro. | 1988 | J. Reprod. Fertil. | pmid:3411560 |
| Yang YQ and Wu XY | Antifertility mechanisms of gossypol acetic acid in female rats. | 1987 | J. Reprod. Fertil. | pmid:3656277 |
| Soufir JC et al. | Gossypol-induced modifications in the microenvironment of rat epididymal spermatozoa. | 1989 | J. Reprod. Fertil. | pmid:2760873 |
| Hunt S and Mittwoch U | Effects of gossypol on sperm counts in two inbred strains of mice. | 1984 | J. Reprod. Fertil. | pmid:6694149 |
| Stephens DT et al. | Mechanism of inhibition by gossypol of glycolysis and motility of monkey spermatozoa in vitro. | 1983 | J. Reprod. Fertil. | pmid:6631812 |
| Morris ID et al. | Inhibition of testicular LDH-X from laboratory animals and man by gossypol and its isomers. | 1986 | J. Reprod. Fertil. | pmid:3735252 |
| Wang JM et al. | Differential binding of (+) and (-) gossypol to plasma protein and their entry into rat testis. | 1992 | J. Reprod. Fertil. | pmid:1625243 |
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| Den Boer PJ and Grootegoed JA | Mechanism of action of (-)gossypol on ATP production in isolated hamster spermatids. | 1988 | J. Reprod. Fertil. | pmid:3411559 |
| Wichmann K et al. | Effect of gossypol on the motility and metabolism of human spermatozoa. | 1983 | J. Reprod. Fertil. | pmid:6411909 |
| Wong YC and Tam CC | A structural and cytochemical study of the effects of gossypol on the epithelial cells of the guinea-pig seminal vesicle. | 1988 | J. Reprod. Fertil. | pmid:3199385 |
| Wang JM et al. | Effect of gossypol on testicular blood flow and testosterone production in rats. | 1984 | J. Reprod. Fertil. | pmid:6726673 |
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| Neild TO et al. | Vasodilatation of arterioles by acetylcholine released from single neurones in the guinea-pig submucosal plexus. | 1990 | J. Physiol. (Lond.) | pmid:2324984 |
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| Haspel HC et al. | Cytocidal effect of gossypol on cultured murine erythroleukemia cells is prevented by serum protein. | 1984 | J. Pharmacol. Exp. Ther. | pmid:6584595 |
| Förstermann U et al. | Inhibitors of acyl-coenzyme A:lysolecithin acyltransferase activate the production of endothelium-derived vascular relaxing factor. | 1986 | J. Pharmacol. Exp. Ther. | pmid:3487639 |
| Förstermann U et al. | Endothelium-derived relaxing factor is likely to modulate the tone of resistance arteries in rabbit hindlimb in vivo. | 1987 | J. Pharmacol. Exp. Ther. | pmid:2447263 |
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| Le TT et al. | Evidence for a trianion intermediate in the metalation of 4-hydroxy-6,7-dimethoxy-8-methyl-2-naphthoic acid. Methodology and application to racemic 5,5'-didesisopropyl-5,5'-dialkylapogossypol derivatives. | 2011 | J. Org. Chem. | pmid:21174400 |
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| Kornegay ET et al. | Fungal-treated cottonseed meal for swine. | 1972 | J. Nutr. | pmid:4678034 |
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