Gossypol

Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.

Cross Reference

Introduction

To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Gossypol?

Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Gossypol

MeSH term MeSH ID Detail
Edema D004487 152 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Testicular Diseases D013733 15 associated lipids
Lymphoma, Large B-Cell, Diffuse D016403 13 associated lipids
Melanoma D008545 69 associated lipids
Weight Gain D015430 101 associated lipids
Abnormalities, Drug-Induced D000014 10 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Leukemia P388 D007941 43 associated lipids
Per page 10 20 50 100 | Total 52

PubChem Associated disorders and diseases

What pathways are associated with Gossypol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Gossypol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Gossypol?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Gossypol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Gossypol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Gossypol?

Xenograft Model

Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).

Transgenic Model

Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Gossypol

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Per page 10 20 50 100 | Total 1511
Authors Title Published Journal PubMed Link
Swan MA et al. Electron microscopic observations on the effect of gossypol on rat cauda epididymis. 1990 Z Mikrosk Anat Forsch pmid:2220026
Zheng DK et al. [Studies on the resolution of racemic gossypol. II. By chiral alpha-methylphenethylamine and alpha-methylbenzylamine]. 1990 Yao Xue Xue Bao pmid:2284966
Si YK et al. [Studies on the resolution of racemic gossypol. III. Study on the chemical and physical properties of the amino condensates of gossypol]. 1990 Yao Xue Xue Bao pmid:2284967
Zheng DK et al. [Studies on the resolution of racemic gossypol. IV. Use of threo (-) or (+)-1-(p-nitrophenyl)-1,3-dihydroxypropylamine-2 as the resolving agent]. 1990 Yao Xue Xue Bao pmid:2284968
Deng HL et al. [The subcellular distribution and covalent binding of 3H-(+) and 3H-(-) gossypol in the main tissues of rats]. 1989 Yao Xue Xue Bao pmid:2618689
Wu GP et al. [Synthesis and antifertility actions of gossypol derivatives and phenol aldehydes]. 1989 Yao Xue Xue Bao pmid:2618691
Wang MZ et al. [Determination of gossypol with high performance liquid chromatography]. 1985 Yao Xue Xue Bao pmid:3834747
Guo ZM et al. [Synthesis of mono-aldehyde gossypol and its analogues]. 1987 Yao Xue Xue Bao pmid:3450164
Zhou RH and Lin XD [Isolation of (-)-gossypol from natural plant]. 1987 Yao Xue Xue Bao pmid:3450165
Xu Y et al. [The effect of combined use of gossypol and tripterygium wilfordii on the fertility of male rats]. 1987 Yao Xue Xue Bao pmid:3452960
Wu DF et al. [Determination of (+)- and (-)-gossypol in human plasma using high performance liquid chromatography with pre-column chemical derivatization]. 1988 Yao Xue Xue Bao pmid:3256191
Wang WH et al. [Influence of salicylaldehyde and its analogs on the antispermatogenic effect of gossypol]. 1985 Yao Xue Xue Bao pmid:4083027
Qian SZ et al. [The potassium-depleting effect of gossypol on isolated rabbit heart and it's possible mechanism (author's transl)]. 1979 Yao Xue Xue Bao pmid:506710
Lei HP [Review and prospect of gossypol research (author's transl)]. 1982 Yao Xue Xue Bao pmid:7090820
Ye YX et al. [The effect of gossypol on the incorporation of H3-thymidine in the liver, testis and small intestine of experimental animals (author's transl)]. 1981 Yao Xue Xue Bao pmid:7246187
Ma XN et al. [Effect of gossypol acetic acid on testosterone, LH and FSH levels of male rats]. 1983 Yao Xue Xue Bao pmid:6433647
Zhang ZR et al. [High performance liquid chromatography of gossypol]. 1984 Yao Xue Xue Bao pmid:6544029
Wang NG et al. [Effect of gossypol acetic acid on early pregnancy in rats]. 1984 Yao Xue Xue Bao pmid:6544547
Wang NG et al. [Effects of (-) and (+) gossypol on the fertility of male rats]. 1984 Yao Xue Xue Bao pmid:6544566
Li G et al. [Effect of testosterone on the expression of CMTM family of the male spermatogenesis suppression rats]. 2010 Yao Xue Xue Bao pmid:21351585