Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Mol. Cancer Ther. (4)
- Proc. Natl. Acad. Sci. U.S.A. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (2)
- Others (13)
| Disease | Cross reference | Weighted score | Related literature |
|---|
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chen QQ | [Relationship between gossypol concentration and testicular damage]. | 1988 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:2968182 |
| Cheng JX | [Effect of gossypol (+/-, +, -) on Leydig cells of the rat in vitro]. | 1988 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:2970318 |
| Tang MY | [Electron microscopic observation of the effect of gossypol on atypical hyperplasia of the endometrium]. | 1988 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:2970320 |
| Ye WS | [Clastogenicity of gossypol as a male contraceptive in sperm head anomalies in mice]. | 1988 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:2970321 |
| Xue S | [A beam of dawn light of study on gossypol as a safe, effective, and reversible male antifertility contraceptive--evaluation of the studies by using low dose gossypol combined with steroid hormone for male contraception]. | 2000 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:12903461 |
| Wang L et al. | [Combined use of steroid hormone and low dose gossypol for antifertility and its mechanism in rats]. | 2000 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:12903462 |
| Cao J et al. | [Effect of low dose gossypol treatment on male sperm nuclear basic protein]. | 2000 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:12903463 |
| Li FY et al. | [The antiandrogen effect of gossypol and its influence on androgen receptor]. | 1985 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:3158419 |
| Wu F et al. | [Comparative study on the effect of gossypol and T7 on human spermatozoa ATPase activity]. | 1998 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:11367690 |
| Li XX et al. | [Spermicidal effects in vitro of gossypol acetic acid-povidone coprecipitate]. | 1986 | Zhongguo Yao Li Xue Bao | pmid:2954422 |
| Pathak HK et al. | Gossypol, ouabain and vanadate on the isolated perfused rat kidney and Na, K-ATPase. | 1984 | Zhongguo Yao Li Xue Bao | pmid:6326465 |
| Zhuang LZ et al. | Comparison of sensitivities of rat spermatozoa, Sertoli and Leydig cells to gossypol acetic acid in vitro by the LD50. | 1986 | Zhongguo Yao Li Xue Bao | pmid:2955650 |
| Wang WH et al. | [Antifertility actions of gossypol derivatives and analogues]. | 1990 | Zhongguo Yao Li Xue Bao | pmid:2088004 |
| Wang RL et al. | [Effect of gossypol acetic acid on the induction of sister chromatid exchange of spermatogonial cell in mice]. | 1984 | Zhongguo Yao Li Xue Bao | pmid:6240903 |
| Wang RL et al. | [Effect of gossypol acetic acid on induction of sister chromatid exchange of spermatogonial cell in mice]. | 1984 | Zhongguo Yao Li Xue Bao | pmid:6242220 |
| Gu ZP et al. | Morphological changes in the testes and epididymides of rats after gossypol. | 1983 | Zhongguo Yao Li Xue Bao | pmid:6223497 |
| Xu Y et al. | [Antagonism of antifertility effect of gossypol by aspirin]. | 1983 | Zhongguo Yao Li Xue Bao | pmid:6225300 |
| Qian SZ et al. | Antispermatogenic activity of gossypol in rats on low-potassium diet. | 1983 | Zhongguo Yao Li Xue Bao | pmid:6228118 |
| Dou SJ and Fu YF | [Effects of gossypol acetic acid on heart mitochondrial membranes ATPase]. | 1988 | Zhongguo Yao Li Xue Bao | pmid:2975138 |
| Shu HD et al. | [Effects of gossypol acetate on neuromuscular transmission (author's transl)]. | 1982 | Zhongguo Yao Li Xue Bao | pmid:6283787 |