Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Brocas C et al. | Deleterious actions of gossypol on bovine spermatozoa, oocytes, and embryos. | 1997 | Biol. Reprod. | pmid:9314596 |
Bernard JK and Calhoun MC | Response of lactating dairy cows to mechanically processed whole cottonseed. | 1997 | J. Dairy Sci. | pmid:9313148 |
Kalla NR et al. | alpha-Glucosidase activity in the rat epididymis under different physiological conditions. | 1997 | Int. J. Androl. | pmid:9292319 |
Zhang Y et al. | Estrogen and progestin cytosol receptor concentrations in patients with endometriosis and their changes after gossypol therapy. | 1996 | Chin. Med. J. | pmid:9275362 |
Akingbemi BT et al. | Chronic ethanol intake may delay the onset of gossypol-induced infertility in the male rat. | 1997 Jul-Aug | Andrologia | pmid:9263570 |
Akingbemi BT et al. | The influence of protein malnutrition on the antifertility action of gossypol in the Trypanosoma brucei-infected rat: some ultrastructural observations from the testis. | 1997 Jul-Aug | Reprod. Toxicol. | pmid:9241673 |
Blauwiekel R et al. | Effect of whole cottonseed, gossypol, and ruminally protected lysine supplementation on milk yield and composition. | 1997 | J. Dairy Sci. | pmid:9241597 |
Deoras DP et al. | Effect of gossypol on hepatic and serum gamma-glutamyltransferase activity in rats. | 1997 | Vet. Res. Commun. | pmid:9232775 |
Ligueros M et al. | Gossypol inhibition of mitosis, cyclin D1 and Rb protein in human mammary cancer cells and cyclin-D1 transfected human fibrosarcoma cells. | 1997 | Br. J. Cancer | pmid:9218727 |
Ye WS et al. | [The antifertility effect of gossypol plus testosterone and estrogen]. | 1996 | Yao Xue Xue Bao | pmid:9208651 |