Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Mol. Cancer Ther. (4)
- Proc. Natl. Acad. Sci. U.S.A. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (2)
- Others (13)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| REISER R and FU HC | The mechanism of gossypol detoxification by ruminant animals. | 1962 | J. Nutr. | pmid:14491326 |
| Aneja R et al. | Modulatory influence of tin-protoporphyrin on gossypol-induced alterations of heme oxygenase activity in male Wistar rats. | 2003 Jul-Sep | Eur J Drug Metab Pharmacokinet | pmid:14527098 |
| Kovacic P | Mechanism of drug and toxic actions of gossypol: focus on reactive oxygen species and electron transfer. | 2003 | Curr. Med. Chem. | pmid:14529461 |
| Sheriff DS | Effect of gossypol on tissue levels of glutathione and thiobarbituric acid reactive products in rats. | 1992 | Indian J. Exp. Biol. | pmid:1459652 |
| Cheng JS et al. | Effect of gossypol on intracellular Ca2+ regulation in human hepatoma cells. | 2003 | Chin J Physiol | pmid:14672280 |
| Abe F et al. | Trypanocidal constituents in plants 3. Leaves of Garcinia intermedia and heartwood of Calophyllum brasiliense. | 2004 | Biol. Pharm. Bull. | pmid:14709920 |
| Sabirova FM and Madaminov AA | [Anti-inflammatory activity of the novel water soluble gossipol derivative mebavine]. | 2003 Nov-Dec | Eksp Klin Farmakol | pmid:14743712 |
| MARX MH | Note of depression of spontaneous running activity by the appetite depressant gossypol in rats. | 1950 | J Comp Physiol Psychol | pmid:14784530 |
| PARHAM AP et al. | The influence of solvent extracted and hydraulic processed cottonseed meals upon performance and level of plasma carotene, vitamin A, and fat in the blood of wintering beef cows. | 1950 | J. Anim. Sci. | pmid:14794574 |
| GALLUP WD et al. | Comparative effect on vitamin A metabolism in sheep of urea, soybean oil meal and cottonseed meal as sources of protein. | 1951 | J. Anim. Sci. | pmid:14814051 |
| AMBROSE AM and ROBBINS DJ | Studies on the chronic oral toxicity of cottonseed meal and cottonseed pigment glands. | 1951 | J. Nutr. | pmid:14851050 |
| HARMS WS and HOLLEY KT | Hypoprothrombinemia induced by gossypol. | 1951 | Proc. Soc. Exp. Biol. Med. | pmid:14854026 |
| COTTONSEED meal. | 1951 | Nutr. Rev. | pmid:14863810 | |
| Wang X and Plhak LC | Monoclonal antibodies for the analysis of gossypol in cottonseed products. | 2004 | J. Agric. Food Chem. | pmid:14969520 |
| Ergun MA et al. | Apoptosis and nitric oxide release induced by thalidomide, gossypol and dexamethasone in cultured human chronic myelogenous leukemic K-562 cells. | 2004 | Cell Biol. Int. | pmid:14984751 |
| Przybylski P et al. | Schiff base of gossypol with 3,6,9-trioxa-decylamine complexes with monovalent cations studied by mass spectrometry, (1)H-NMR, FTIR, and PM5 semiempirical methods. | 2004 | Biopolymers | pmid:14991665 |
| Jiang J et al. | The inhibitory effects of gossypol on human prostate cancer cells-PC3 are associated with transforming growth factor beta1 (TGFbeta1) signal transduction pathway. | 2004 Jan-Feb | Anticancer Res. | pmid:15015581 |
| Aneja R et al. | Effect of gossypol in association with chromium protoporphyrin on heme metabolic enzymes. | 2004 | Artif Cells Blood Substit Immobil Biotechnol | pmid:15027808 |
| Hassan ME et al. | Reversibility of the reproductive toxicity of gossypol in peripubertal bulls. | 2004 | Theriogenology | pmid:15037004 |
| Fombad RB and Bryant MJ | An evaluation of the use of cottonseed cake in the diet of growing pigs. | 2004 | Trop Anim Health Prod | pmid:15080544 |