Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
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| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
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What genes are associated with Gossypol?
Related references are published most in these journals:
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wu Y et al. | Changes in membrane properties during energy depletion-induced cell injury studied with fluorescence microscopy. | 1996 | Biophys. J. | pmid:8804592 |
| Akingbemi BT et al. | Infection with Trypanosoma brucei potentiates the antifertility effect of gossypol, especially in the protein-malnourished male rat. | 1996 | Int. J. Androl. | pmid:8876268 |
| Zhang Y et al. | Estrogen and progestin cytosol receptor concentrations in patients with endometriosis and their changes after gossypol therapy. | 1996 | Chin. Med. J. | pmid:9275362 |
| Ye WS et al. | [The antifertility effect of gossypol plus testosterone and estrogen]. | 1996 | Yao Xue Xue Bao | pmid:9208651 |
| Achudume AC and Eno TL | Characterization of ion interference in gossypol consumption. | 1996 | Adv Contracept | pmid:8910664 |
| Hervé JC et al. | Contraceptive gossypol blocks cell-to-cell communication in human and rat cells. | 1996 | Eur. J. Pharmacol. | pmid:8911921 |
| Shidaifat F et al. | Inhibition of human prostate cancer cells growth by gossypol is associated with stimulation of transforming growth factor-beta. | 1996 | Cancer Lett. | pmid:8913264 |
| Szücs G et al. | Characterization of volume-activated chloride currents in endothelial cells from bovine pulmonary artery. | 1996 | J. Membr. Biol. | pmid:8801351 |
| Guan MZ and Wang NG | [Effect of (+), (-) and (+/-) gossypol on early pregnancy in rats]. | 1996 | Yao Xue Xue Bao | pmid:8762457 |
| Ohmura H | [Suppressive effect of Gossypol, Gossypolone and serum from Gossypol treated rats on steroidogenesis in cultured porcine granulosa cells]. | 1996 | Nippon Ika Daigaku Zasshi | pmid:8707919 |
| Graier WF et al. | High D-glucose-induced changes in endothelial Ca2+/EDRF signaling are due to generation of superoxide anions. | 1996 | Diabetes | pmid:8826976 |
| Royer RE et al. | Comparison of the antiviral activities of 3'-azido-3'-deoxythymidine (AZT) and gossylic iminolactone (GIL) against clinical isolates of HIV-1. | 1995 | Pharmacol. Res. | pmid:7540302 |
| Velez de la Calle JF and Bujan L | [Male contraception]. | 1995 | Contracept Fertil Sex | pmid:7613573 |
| Gawai KR et al. | Changes in the activity of metabolic and non-metabolic liver enzymes in rats following co-administration of gossypol with phenobarbital. | 1995 | Pharmacol. Toxicol. | pmid:7617561 |
| Akingbemi BT et al. | The effects of protein malnutrition and experimental infection with Trypanosoma brucei on gossypol treatment in the rat: haematological and serum biochemical changes. | 1995 | J. Comp. Pathol. | pmid:7593758 |
| Gilbert NE et al. | Antiproliferative activity of gossypol and gossypolone on human breast cancer cells. | 1995 | Life Sci. | pmid:7596222 |
| Willard ST et al. | Effects of free gossypol in the diet of pregnant and postpartum Brahman cows on calf development and cow performance. | 1995 | J. Anim. Sci. | pmid:7601784 |
| Royer RE et al. | Synthesis and anti-HIV activity of 1,1'-dideoxygossypol and related compounds. | 1995 | J. Med. Chem. | pmid:7608907 |
| Teng CS | Biological activity in the repopulating rat spermatocyte after the withdrawal of gossypol treatment. V. Inhibition and recovery of microtubular dynein. | 1995 | Contraception | pmid:7628207 |
| Javed MH and Waqar MA | Protective effect of histidine by inhibition of gossypol on rat's liver LDH-5. | 1995 | Biochem. Soc. Trans. | pmid:8654811 |
| Yuan YY et al. | Inhibition of rabbit sperm acrosomal enzymes by gossypol. | 1995 | Mol. Reprod. Dev. | pmid:7766416 |
| Sakano T et al. | An experimental study of gastric mucosal blood flow in endotoxemia of the rat, with special reference to the vagus nerve and EDRF. | 1995 | J. Gastroenterol. | pmid:7719420 |
| Zelski RZ et al. | Gossypol toxicity in preruminant calves. | 1995 | Aust. Vet. J. | pmid:8599575 |
| Nwoha PU | The blood constituents of gossypol-treated, protein-malnourished Wistar rats. | 1995 | Contraception | pmid:8605784 |
| Nwoha PU and Aire TA | The effects of gossypol and chloroquine interaction on serum electrolytes of protein-malnourished rats. | 1995 | Contraception | pmid:8605785 |
| Nwoha PU and Aire TA | Reduced level of serum cholesterol in low protein-fed Wistar rats administered gossypol and chloroquine. | 1995 | Contraception | pmid:8605786 |
| Cusack PM and Perry V | The effect of feeding whole cottonseed on the fertility of bulls. | 1995 | Aust. Vet. J. | pmid:8825312 |
| González-Garza MT et al. | Orally administered gossypol has no effect on eight hamster erythrocytic enzymes. | 1995 | Contraception | pmid:8749602 |
| Teng CS | Gossypol-induced apoptotic DNA fragmentation correlates with inhibited protein kinase C activity in spermatocytes. | 1995 | Contraception | pmid:8749604 |
| Fan LP et al. | [Emergency treatment and care of hypokalemia paralysis due to gossypol poisoning]. | 1995 | Zhonghua Hu Li Za Zhi | pmid:8716068 |
| Liang XS et al. | Developing gossypol derivatives with enhanced antitumor activity. | 1995 | Invest New Drugs | pmid:8729944 |
| Teng CS et al. | Biological activity in the repopulating rat spermatocyte after the withdrawal of gossypol treatment. VI. Alteration in nuclear factors for interaction with histone gene promoter. | 1995 | Contraception | pmid:8536450 |
| Ivanov AA et al. | [Immunopharmacological analysis of secondary postradiation immunodeficiency]. | 1994 Jul-Oct | Radiats Biol Radioecol | pmid:7951873 |
| Lebedev VG et al. | [Effect of kagocel on the postradiation recovery of the hematopoiesis and immune status in mice exposed to ionizing radiation in sublethal dosage]. | 1994 Jul-Oct | Radiats Biol Radioecol | pmid:7951886 |
| Zakhidov ST et al. | [The modifying cytogenetic effects of gossypol and its derivatives]. | 1994 Jul-Aug | Izv. Akad. Nauk. Ser. Biol. | pmid:7987209 |
| Yu ZH and Chan HC | Gossypol and hypokalemia: a critical review. | 1994 | Adv Contracept Deliv Syst | pmid:12289957 |
| Matlin SA | Prospects for pharmacological male contraception. | 1994 | Drugs | pmid:7533693 |
| Bourinbaiar AS and Lee-Huang S | Comparative in vitro study of contraceptive agents with anti-HIV activity: gramicidin, nonoxynol-9, and gossypol. | 1994 | Contraception | pmid:7511493 |
| Jarvis WD et al. | Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C. | 1994 | Cancer Res. | pmid:7511048 |
| Huang HF and Wang M | [Effects of gossypol acetate, danazol, progesterone and GnRH-A on estrogen and progesterone receptors of human endometrial cells]. | 1994 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:8000225 |
| Tuhácková Z | Staurosporine and gossypol are inhibitors of the function of peptide elongation factor 1 alpha from rabbit reticulocytes. | 1994 | Biochem. Mol. Biol. Int. | pmid:8032322 |
| Zhang YW et al. | [Estrogen and progesterone cytosol receptor concentrations in patients with endometriosis and their changes after gossypol therapy]. | 1994 | Zhonghua Fu Chan Ke Za Zhi | pmid:8082445 |
| Chase CC et al. | Growth and reproductive development in Brahman bulls fed diets containing gossypol. | 1994 | J. Anim. Sci. | pmid:8157529 |
| East NE et al. | Apparent gossypol-induced toxicosis in adult dairy goats. | 1994 | J. Am. Vet. Med. Assoc. | pmid:8163423 |
| Lin YC et al. | Inhibition of in vitro fertilization and early embryonic development in hamsters by gossypol. | 1994 | Life Sci. | pmid:8090055 |
| Bansode FW | Genotoxic effects of gossypol acetate on the ovary of Rhinopoma kinneari wroughton (Microchiroptera: Mammalia). | 1994 | Contraception | pmid:8070265 |
| Benhaim P et al. | Induction of neutrophil Mac-1 integrin expression and superoxide production by the medicinal plant extract gossypol. | 1994 | Inflammation | pmid:7843790 |
| Cowart CL et al. | The effects of cyclic adenosine monophosphate, forskolin, and theophylline on motility parameters in gossypol-treated human sperm. | 1994 | Fertil. Steril. | pmid:8174733 |
| Penrith ML et al. | Gossypol intoxication in pigs. | 1994 | J S Afr Vet Assoc | pmid:7602565 |
| Akingbemi BT and Aire TA | Haematological and serum biochemical changes in the rat due to protein malnutrition and gossypol-ethanol interactions. | 1994 | J. Comp. Pathol. | pmid:7884058 |