Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Gawande ND et al. | Molecular screening of insecticides with sigma glutathione S-transferases (GST) in cotton aphid Aphis gossypii using docking. | 2014 | Bioinformation | pmid:25512683 |
| Bhatia C et al. | Towards a systematic analysis of human short-chain dehydrogenases/reductases (SDR): Ligand identification and structure-activity relationships. | 2015 | Chem. Biol. Interact. | pmid:25526675 |
| Achilova GSh et al. | [Antiviral activity of derivatives of aldehydophenols, aldehydo- naphthols and sugar derivatives]. | 1989 May-Jun | Vopr. Virusol. | pmid:2552684 |
| Gadelha IC et al. | Gossypol promotes degeneration of ovarian follicles in rats. | 2014 | ScientificWorldJournal | pmid:25540815 |
| Ren T et al. | Sequential treatment with AT-101 enhances cisplatin chemosensitivity in human non-small cell lung cancer cells through inhibition of apurinic/apyrimidinic endonuclease 1-activated IL-6/STAT3 signaling pathway. | 2014 | Drug Des Devel Ther | pmid:25548514 |
| pmid:25565365 | ||||
| Ye YX et al. | Modification of the positive inotropic effects of catecholamines, cardiac glycosides and Ca2+ by the orally active male contraceptive, gossypol, in isolated guinea-pig heart. | 1989 | Life Sci. | pmid:2557505 |
| Gonzalez-Garza MT et al. | High susceptibility of five axenic Entamoeba histolytica strains to gossypol. | 1989 Jul-Aug | Trans. R. Soc. Trop. Med. Hyg. | pmid:2559507 |
| pmid:25664656 | ||||
| Zhan W et al. | Inhibitory activity of apogossypol in human prostate cancer in vitro and in vivo. | 2015 | Mol Med Rep | pmid:25672487 |
| pmid:25735889 | ||||
| pmid:25738577 | ||||
| pmid:25794893 | ||||
| Hanus J et al. | Gossypol Acetic Acid Prevents Oxidative Stress-Induced Retinal Pigment Epithelial Necrosis by Regulating the FoxO3/Sestrin2 Pathway. | 2015 | Mol. Cell. Biol. | pmid:25802279 |
| Kainz P et al. | Effect of gossypol on macromolecular synthesis in rat testis. An in vitro study. | 1985 | Contraception | pmid:2580663 |
| Zeng QF et al. | The response of meat ducks from 15 to 35 d of age to gossypol from cottonseed meal. | 2015 | Poult. Sci. | pmid:25834247 |
| Mani J et al. | Chemoresistance is associated with increased cytoprotective autophagy and diminished apoptosis in bladder cancer cells treated with the BH3 mimetic (-)-Gossypol (AT-101). | 2015 | BMC Cancer | pmid:25885284 |
| pmid:25904287 | ||||
| Sarkar S et al. | Therapy of prostate cancer using a novel cancer terminator virus and a small molecule BH-3 mimetic. | 2015 | Oncotarget | pmid:25926554 |
| Lan L et al. | Natural product (-)-gossypol inhibits colon cancer cell growth by targeting RNA-binding protein Musashi-1. | 2015 | Mol Oncol | pmid:25933687 |
| Strøm-Hansen T et al. | Interaction of gossypol with amino acids and peptides as a model of enzyme inhibition. | 1989 | Int. J. Pept. Protein Res. | pmid:2599770 |
| Maji S et al. | Mcl-1 is an important therapeutic target for oral squamous cell carcinomas. | 2015 | Oncotarget | pmid:26009874 |
| Quinn BA et al. | Pancreatic Cancer Combination Therapy Using a BH3 Mimetic and a Synthetic Tetracycline. | 2015 | Cancer Res. | pmid:26032425 |
| Pan R et al. | Inhibition of Mcl-1 with the pan-Bcl-2 family inhibitor (-)BI97D6 overcomes ABT-737 resistance in acute myeloid leukemia. | 2015 | Blood | pmid:26045609 |
| Wang Q et al. | Salt Stress Effects on Secondary Metabolites of Cotton in Relation to Gene Expression Responsible for Aphid Development. | 2015 | PLoS ONE | pmid:26061875 |
| He Z et al. | Chemical Composition of Defatted Cottonseed and Soy Meal Products. | 2015 | PLoS ONE | pmid:26079931 |
| pmid:26087752 | ||||
| Ren T et al. | Small-molecule BH3 mimetic and pan-Bcl-2 inhibitor AT-101 enhances the antitumor efficacy of cisplatin through inhibition of APE1 repair and redox activity in non-small-cell lung cancer. | 2015 | Drug Des Devel Ther | pmid:26089640 |
| Allamiiarova SA and Urazmetov KG | [The effect of batriden and dexasone on immune status indices in animals with experimental allergic contact dermatitis]. | 1989 | Vestn Dermatol Venerol | pmid:2609756 |
| Han SD et al. | [Study on quality of gossypol recrystalized from chloroform]. | 1989 | Yao Xue Xue Bao | pmid:2609986 |
| pmid:26113054 | ||||
| Obeidy A et al. | The effect of gossypol on serum lipoproteins of adult rats. | 1989 | Horm. Metab. Res. | pmid:2613178 |
| pmid:26185003 | ||||
| Deng HL et al. | [The subcellular distribution and covalent binding of 3H-(+) and 3H-(-) gossypol in the main tissues of rats]. | 1989 | Yao Xue Xue Bao | pmid:2618689 |
| Wu GP et al. | [Synthesis and antifertility actions of gossypol derivatives and phenol aldehydes]. | 1989 | Yao Xue Xue Bao | pmid:2618691 |
| Lin TS et al. | Selective inhibition of human immunodeficiency virus type 1 replication by the (-) but not the (+) enantiomer of gossypol. | 1989 | Antimicrob. Agents Chemother. | pmid:2619282 |
| pmid:26208739 | ||||
| Zerp SF et al. | Targeting anti-apoptotic Bcl-2 by AT-101 to increase radiation efficacy: data from in vitro and clinical pharmacokinetic studies in head and neck cancer. | 2015 | Radiat Oncol | pmid:26223311 |
| Santana AT et al. | Mechanisms involved in reproductive damage caused by gossypol in rats and protective effects of vitamin E. | 2015 | Biol. Res. | pmid:26227499 |
| Baoleri X et al. | Combination of L-gossypol and low-concentration doxorubicin induces apoptosis in human synovial sarcoma cells. | 2015 | Mol Med Rep | pmid:26238307 |
| Tomoda K et al. | Examination of Gossypol-Pluronic Micelles as Potential Radiosensitizers. | 2015 | AAPS J | pmid:26246329 |
| Judge JL et al. | Ionizing radiation induces myofibroblast differentiation via lactate dehydrogenase. | 2015 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:26254422 |
| pmid:26287003 | ||||
| Aletor VA | Effect of varying levels of oyster shell on serum constituents and erythrocyte indices in growing chicken fed gossypol-containing Nigerian cottonseed cake. | 1989 | Nahrung | pmid:2628756 |
| Shibatani M et al. | Accumulation of Isohemigossypolone and Its Related Compounds in the Inner Bark and Heartwood of Diseased Pachira aquatica. | 1999 | Biosci. Biotechnol. Biochem. | pmid:26300168 |
| pmid:26337022 | ||||
| pmid:26352605 | ||||
| Medeiros YS et al. | Gossypol affects the responsiveness of isolated rat myometrium and vas deferens. | 1989 | Braz. J. Med. Biol. Res. | pmid:2638200 |
| Kottmann RM et al. | Pharmacologic inhibition of lactate production prevents myofibroblast differentiation. | 2015 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:26408551 |
| Zhang SD et al. | Isochamaejasmin induces apoptosis in leukemia cells through inhibiting Bcl-2 family proteins. | 2015 | Chin J Nat Med | pmid:26412425 |