Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Mol. Cancer Ther. (4)
- Proc. Natl. Acad. Sci. U.S.A. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (2)
- Others (13)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kono H et al. | Gossypol effects on monoamine oxidase (MAO) activity in several organs of term rats. | 1991 | Tohoku J. Exp. Med. | pmid:2063399 |
| Zheng YH et al. | [Effect of gossypol acetic acid on hCG-stimulated progesterone production of dissociated rat luteal cells]. | 1991 | Yao Xue Xue Bao | pmid:1668561 |
| Manabe S et al. | Zone-specific hepatotoxicity of gossypol in perfused rat liver. | 1991 | Toxicon | pmid:1926180 |
| Messiha FS | Effect of gossypol on kinetics of mouse liver alcohol and aldehyde dehydrogenase. | 1991 | Gen. Pharmacol. | pmid:1936890 |
| Barak D et al. | Structural investigation of protein kinase C inhibitors. | 1991 | J Mol Struct | pmid:11538178 |
| Ikeda M | Inhibition kinetics of NAD-linked enzymes by gossypol acetic acid. | 1990 Sep-Oct | Andrologia | pmid:2073051 |
| Botsoglou NA and Kufidis DC | Determination of total gossypol in cottonseed and cottonseed meals by derivative UV spectrophotometry. | 1990 May-Jun | J Assoc Off Anal Chem | pmid:2376551 |
| Kalla NR and Sud S | Distribution of gossypol. | 1990 Mar-Apr | Acta Eur. Fertil. | pmid:2087941 |
| Kalla NR et al. | 65Zn incorporation in the male reproductive organs following gossypol treatment. | 1990 Mar-Apr | Acta Eur. Fertil. | pmid:2087942 |
| Kalla NR et al. | Effect of gossypol on rats maintained on protein deficient and low potassium diets. | 1990 Mar-Apr | Acta Eur. Fertil. | pmid:2087943 |
| Kalla NR et al. | Spermatogenic events in rat and mice following intratesticular administration of optical isomers of gossypol. | 1990 Mar-Apr | Acta Eur. Fertil. | pmid:2087944 |
| Vyas RK and Kalla NR | Effect of optical isomers of gossypol on mammalian spermatozoa: an in vitro study. | 1990 Mar-Apr | Acta Eur. Fertil. | pmid:2087945 |
| Frick J and Kalla NR | Clinical studies with gossypol. Current status. | 1990 Mar-Apr | Acta Eur. Fertil. | pmid:2087946 |
| Leal-Garza CH et al. | [Frequency of sister chromatid exchange in mice treated with gossypol]. | 1990 Jul-Sep | Arch Invest Med (Mex) | pmid:2131768 |
| Rovai LE et al. | Effect of gossypol on trypomastigotes and amastigotes of Trypanosoma cruzi. | 1990 Jul-Aug | J. Protozool. | pmid:2258832 |
| Vyas RK et al. | Early events in rat testis after gossypol administration. | 1990 Jan-Feb | Acta Eur. Fertil. | pmid:2150145 |
| Kalla NR et al. | Response of mice testis to gossypol acetic acid. | 1990 Jan-Feb | Acta Eur. Fertil. | pmid:2075791 |
| Kalla NR et al. | Effect of gossypol on domestic fowl, Gallus domesticus. | 1990 Jan-Feb | Acta Eur. Fertil. | pmid:2075792 |
| Vyas RK et al. | Recovery of normal testis function and sperm motility after cessation of gossypol treatment in hamster. | 1990 Jan-Feb | Acta Eur. Fertil. | pmid:2075793 |
| Kalla NR | Gossypol. | 1990 Jan-Feb | Acta Eur. Fertil. | pmid:2075794 |
| Kalla NR et al. | Response of hamster to the antifertility effect of gossypol. | 1990 Jan-Feb | Acta Eur. Fertil. | pmid:1706127 |
| Ranga A et al. | Effect of gossypol on the fertility of male rats. | 1990 Jan-Feb | Acta Eur. Fertil. | pmid:1706128 |
| Schmidt K et al. | EDRF-formation increases cGMP-levels in cultured endothelial cells. | 1990 | Adv. Second Messenger Phosphoprotein Res. | pmid:1976336 |
| Jaroszewski JW et al. | Action of gossypol and rhodamine 123 on wild type and multidrug-resistant MCF-7 human breast cancer cells: 31P nuclear magnetic resonance and toxicity studies. | 1990 | Cancer Res. | pmid:2208159 |
| Huang HF and Wang M | [Effects of gossypol acetate, progesterone, danazol and GnRH-A (gonadotropin release hormone-A) on the DNA-synthesis of human endometrial cell in vitro]. | 1990 | Zhong Xi Yi Jie He Za Zhi | pmid:2208435 |
| Swan MA et al. | Electron microscopic observations on the effect of gossypol on rat cauda epididymis. | 1990 | Z Mikrosk Anat Forsch | pmid:2220026 |
| Grando SA et al. | Clinical and laboratory evaluation of hemocarboadsorption in autoimmune bullous dermatoses. | 1990 | Int J Artif Organs | pmid:2189836 |
| Benz CC et al. | Biochemical correlates of the antitumor and antimitochondrial properties of gossypol enantiomers. | 1990 | Mol. Pharmacol. | pmid:2193225 |
| Junco M et al. | Substrate-dependent inhibition of protein kinase C by specific inhibitors. | 1990 | FEBS Lett. | pmid:2332048 |
| Gu Y et al. | Inhibitory effect of gossypol on human chorionic gonadotropin (hCG)-induced progesterone secretion in cultured bovine luteal cells. | 1990 | Life Sci. | pmid:2168511 |
| Hill MA et al. | Cyclooxygenase inhibition potentiates myogenic activity in skeletal muscle arterioles. | 1990 | Am. J. Physiol. | pmid:2105665 |
| Zhong CQ et al. | Study on sperm function in men long after cessation of gossypol treatment. | 1990 | Contraception | pmid:2113849 |
| Huang T et al. | Gossypol-induced alterations of aminophospholipid composition in human sperm. | 1990 | Proc Chin Acad Med Sci Peking Union Med Coll | pmid:2371261 |
| Rikihisa Y et al. | Taenia taeniaeformis: inactivation of metacestodes by gossypol in vitro. | 1990 | Exp. Parasitol. | pmid:2373186 |
| Zheng DK et al. | [Studies on the resolution of racemic gossypol. II. By chiral alpha-methylphenethylamine and alpha-methylbenzylamine]. | 1990 | Yao Xue Xue Bao | pmid:2284966 |
| Si YK et al. | [Studies on the resolution of racemic gossypol. III. Study on the chemical and physical properties of the amino condensates of gossypol]. | 1990 | Yao Xue Xue Bao | pmid:2284967 |
| Zheng DK et al. | [Studies on the resolution of racemic gossypol. IV. Use of threo (-) or (+)-1-(p-nitrophenyl)-1,3-dihydroxypropylamine-2 as the resolving agent]. | 1990 | Yao Xue Xue Bao | pmid:2284968 |
| Nair IN and Bhiwgade DA | Effect of gossypol on pituitary reproductive axis: ultrastructural and biochemical studies. | 1990 | Indian J. Exp. Biol. | pmid:2253964 |
| Lohiya NK et al. | Limitations in developing gossypol acetic acid as a male contraceptive. | 1990 | Contraception | pmid:2347196 |
| Chatterjee TK and Bhatnagar RK | Ca2(+)-dependent, ATP-induced conversion of the [3H]hemicholinium-3 binding sites from high- to low-affinity states in rat striatum: effect of protein kinase inhibitors on this affinity conversion and synaptosomal choline transport. | 1990 | J. Neurochem. | pmid:2324736 |
| Neild TO et al. | Vasodilatation of arterioles by acetylcholine released from single neurones in the guinea-pig submucosal plexus. | 1990 | J. Physiol. (Lond.) | pmid:2324984 |
| Warner TD | Simultaneous perfusion of rat isolated superior mesenteric arterial and venous beds: comparison of their vasoconstrictor and vasodilator responses to agonists. | 1990 | Br. J. Pharmacol. | pmid:2328405 |
| Wu DF and Reidenberg MM | Stereoselective interaction between gossypol and rat plasma. | 1990 | Contraception | pmid:2335102 |
| Lin YC et al. | Effect of gossypol on thyroid hormones in young female rats. | 1990 | Contraception | pmid:2335106 |
| Dézsi L et al. | Regulation of femoral vascular resistance by adenine nucleotides via endothelial and smooth muscle receptors. | 1990 | Acta Physiol Hung | pmid:2339604 |
| Aletor VA and Onibi OE | Use of oyster shell as calcium supplement. Part 1. Effect on the utilization of gossypol-containing cotton seed cake by the chicken. | 1990 | Nahrung | pmid:2388684 |
| Aletor VA and Aturamu OA | Use of oyster shell as calcium supplement. Part 2. An assessment of the responses of hepatic and serum enzymes, relative organ weights, and bone mineralization in the broiler chicken fed gossypol-containing cottonseed cake supplemented with oyster shell. | 1990 | Nahrung | pmid:2388685 |
| Kerr LA | Incidence and management of poisonings in livestock. | 1990 | Vet Hum Toxicol | pmid:2238452 |
| Gu ZP et al. | Relationship between hormone profiles and the restoration of spermatogenesis in men treated with gossypol. | 1990 | Int. J. Androl. | pmid:2117586 |
| Burton GA et al. | Cyclic GMP release and vasodilatation induced by EDRF and atrial natriuretic factor in the isolated perfused kidney of the rat. | 1990 | Br. J. Pharmacol. | pmid:2158376 |