Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Qiu J et al. | Different pathways of cell killing by gossypol enantiomers. | 2002 | Exp. Biol. Med. (Maywood) | pmid:12037129 |
Lee KJ and Dabrowski K | High-performance liquid chromatographic determination of gossypol and gossypolone enantiomers in fish tissues using simultaneous electrochemical and ultraviolet detectors. | 2002 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:12361745 |
Cheng JS et al. | Gossypol, a component in cottonseed, induced increases in cytosolic Ca2+ levels in Chang liver cells. | 2002 | Toxicon | pmid:12076637 |
Liu S et al. | The (-)-enantiomer of gossypol possesses higher anticancer potency than racemic gossypol in human breast cancer. | 2002 Jan-Feb | Anticancer Res. | pmid:12017312 |
Galegov GA et al. | [The effect of Kagocel on herpes virus reproduction]. | 2002 Jul-Aug | Vopr. Virusol. | pmid:12271726 |
Romualdo GS et al. | Postweaning exposure to gossypol results in epididymis-specific effects throughout puberty and adulthood in rats. | 2002 Mar-Apr | J. Androl. | pmid:11868815 |
Jiang J et al. | Effects of gossypol on O2 consumption and CO2 production in human prostate cancer cells. | 2002 May-Jun | Anticancer Res. | pmid:12168828 |
NarovlianskiÄ AN et al. | [Effect of interferon inductors on infection induced by hepatitis C virus and activity of mRNA cytokines in cell cultures SW-13 and MT-4]. | 2002 Nov-Dec | Vopr. Virusol. | pmid:12508677 |
Zhang M et al. | Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells. | 2003 | Biochem. Pharmacol. | pmid:12818369 |
Dowd MK | Preparation of enantiomeric gossypol by crystallization. | 2003 | Chirality | pmid:12774287 |
Yurtcu E et al. | Apoptotic effect of gossypol on human lymphocytes. | 2003 | Cell Biol. Int. | pmid:12972286 |
Wang YH et al. | 8-Hydroxy-(+)-delta-cadinene is a precursor to hemigossypol in Gossypium hirsutum. | 2003 | Phytochemistry | pmid:12946420 |
Kitada S et al. | Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins. | 2003 | J. Med. Chem. | pmid:13678404 |
Santos JE et al. | Type of cottonseed and level of gossypol in diets of lactating dairy cows: plasma gossypol, health, and reproductive performance. | 2003 | J. Dairy Sci. | pmid:12703626 |
Dao VT et al. | New thioderivatives of gossypol and gossypolone, as prodrugs of cytotoxic agents. | 2003 | Bioorg. Med. Chem. | pmid:12670651 |
Keller PA et al. | Novel pharmacophore-based methods reveal gossypol as a reverse transcriptase inhibitor. | 2003 | J. Mol. Graph. Model. | pmid:12543135 |
Bai JP et al. | Effects of demethylzeylasteral and celastrol on spermatogenic cell Ca2+ channels and progesterone-induced sperm acrosome reaction. | 2003 | Eur. J. Pharmacol. | pmid:12600689 |
Prieto JG et al. | Increasing dietary levels of cracked pima cottonseed increase plasma gossypol but do not influence productive performance of lactating Holstein cows. | 2003 | J. Dairy Sci. | pmid:12613869 |
Shi YL et al. | Ion-channels in human sperm membrane and contraceptive mechanisms of male antifertility compounds derived from Chinese traditional medicine. | 2003 | Acta Pharmacol. Sin. | pmid:12511225 |
Freedman TB et al. | Determination of the absolute configuration and solution conformation of gossypol by vibrational circular dichroism. | 2003 | Chirality | pmid:12520512 |
Dowd MK and Stevens ED | The gossypol-cyclododecanone (1/2) inclusion complex. | 2003 | Acta Crystallogr C | pmid:12855869 |
Jo C et al. | Irradiation effects on embryotoxicity and oxidative properties of gossypol dissolved in methanol. | 2003 | Food Chem. Toxicol. | pmid:12909266 |
Räsänen TL et al. | Gossypol activates pancreatic polyamine catabolism in normal rats and induces acute pancreatitis in transgenic rats over-expressing spermidine/spermine N1-acetyltransferase. | 2003 | Scand. J. Gastroenterol. | pmid:12889567 |
Kawanishi K et al. | Aldose reductase inhibitors from the nature. | 2003 | Curr. Med. Chem. | pmid:12871134 |
Kovacic P | Mechanism of drug and toxic actions of gossypol: focus on reactive oxygen species and electron transfer. | 2003 | Curr. Med. Chem. | pmid:14529461 |
Cheng JS et al. | Effect of gossypol on intracellular Ca2+ regulation in human hepatoma cells. | 2003 | Chin J Physiol | pmid:14672280 |
Aneja R et al. | Modulatory influence of tin-protoporphyrin on gossypol-induced alterations of heme oxygenase activity in male Wistar rats. | 2003 Jul-Sep | Eur J Drug Metab Pharmacokinet | pmid:14527098 |
Sabirova FM and Madaminov AA | [Anti-inflammatory activity of the novel water soluble gossipol derivative mebavine]. | 2003 Nov-Dec | Eksp Klin Farmakol | pmid:14743712 |
Carrière Y et al. | Effects of gossypol on fitness costs associated with resistance to Bt cotton in pink bollworm. | 2004 | J. Econ. Entomol. | pmid:15568363 |
Oliver CL et al. | In vitro effects of the BH3 mimetic, (-)-gossypol, on head and neck squamous cell carcinoma cells. | 2004 | Clin. Cancer Res. | pmid:15570010 |
Wang X et al. | Development of monoclonal antibody-based enzyme-linked immunosorbent assay for gossypol analysis in cottonseed meals. | 2004 | J. Agric. Food Chem. | pmid:15612757 |
Mandal AB et al. | Comparison of broiler chicken performance when fed diets containing meals of Bollgard II hybrid cotton containing Cry-X gene (Cry1Ac and Cry2ab gene), parental line or commercial cotton. | 2004 | Br. Poult. Sci. | pmid:15623220 |
Chang JS et al. | Upregulation of Fas/Fas ligand-mediated apoptosis by gossypol in an immortalized human alveolar lung cancer cell line. | 2004 | Clin. Exp. Pharmacol. Physiol. | pmid:15554914 |
Bork S et al. | Identification of Babesia bovis L-lactate dehydrogenase as a potential chemotherapeutical target against bovine babesiosis. | 2004 | Mol. Biochem. Parasitol. | pmid:15478796 |
Susman E | Cottonseed-oil byproduct as anticancer radiation sensitiser. | 2004 | Lancet Oncol. | pmid:15536689 |
Hamilton KA et al. | Bollgard II cotton: compositional analysis and feeding studies of cottonseed from insect-protected cotton (Gossypium hirsutum L.) producing the Cry1Ac and Cry2Ab2 proteins. | 2004 | J. Agric. Food Chem. | pmid:15537305 |
Han J et al. | [Determination of anti-nutrients in genetically modified crops]. | 2004 | Wei Sheng Yan Jiu | pmid:15727185 |
Cui X et al. | [Determination of free gossypol in meat by reversed-phased high performance liquid chromatography]. | 2004 | Se Pu | pmid:15706952 |
Yildirim-Aksoy M et al. | In vitro inhibitory effect of gossypol from gossypol-acetic acid, and (+)- and (-)-isomers of gossypol on the growth of Edwardsiella ictaluri. | 2004 | J. Appl. Microbiol. | pmid:15186445 |
Garcia-Abiado MA et al. | Effect of diets containing gossypol on blood parameters and spleen structure in tilapia, Oreochromis sp., reared in a recirculating system. | 2004 | J. Fish Dis. | pmid:15189376 |
Du L et al. | Effect of cotton cultivar on development and reproduction of Aphis gossypii (Homoptera: Aphididae) and its predator Propylaea japonica (Coleoptera: Coccinellidae). | 2004 | J. Econ. Entomol. | pmid:15384338 |
Tripathi AK et al. | An alpha-proteobacterial type malate dehydrogenase may complement LDH function in Plasmodium falciparum. Cloning and biochemical characterization of the enzyme. | 2004 | Eur. J. Biochem. | pmid:15317584 |
Cass QB et al. | Determination of gossypol enantiomer ratio in cotton plants by chiral higher-performance liquid chromatography. | 2004 | J. Agric. Food Chem. | pmid:15366827 |
Meyer R et al. | Identification and quantification of gossypol in cotton by using packed micro-tips columns in combination with HPLC. | 2004 | Anal Bioanal Chem | pmid:15372136 |
Yang ZJ et al. | Combined administration of low-dose gossypol acetic acid with desogestrel/mini-dose ethinylestradiol/testosterone undecanoate as an oral contraceptive for men. | 2004 | Contraception | pmid:15325889 |
Mena H et al. | The effects of varying gossypol intake from whole cottonseed and cottonseed meal on lactation and blood parameters in lactating dairy cows. | 2004 | J. Dairy Sci. | pmid:15328274 |
Cai Y et al. | An optimized gossypol high-performance liquid chromatography assay and its application in evaluation of different gland genotypes of cotton. | 2004 | J. Biosci. | pmid:15286405 |
Abe F et al. | Trypanocidal constituents in plants 3. Leaves of Garcinia intermedia and heartwood of Calophyllum brasiliense. | 2004 | Biol. Pharm. Bull. | pmid:14709920 |
Cui GH et al. | A combined regimen of gossypol plus methyltestosterone and ethinylestradiol as a contraceptive induces germ cell apoptosis and expression of its related genes in rats. | 2004 | Contraception | pmid:15451339 |
Xu YH et al. | Characterization of GaWRKY1, a cotton transcription factor that regulates the sesquiterpene synthase gene (+)-delta-cadinene synthase-A. | 2004 | Plant Physiol. | pmid:15133151 |