| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lung Neoplasms | D008175 | 171 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Gossypol?
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Mol. Cancer Ther. (4)
- Proc. Natl. Acad. Sci. U.S.A. (3)
- Am. J. Physiol. Lung Cell Mol. Physiol. (2)
- Others (13)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Gossypol
PubChem Associated disorders and diseases
What pathways are associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Gossypol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Gossypol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Gossypol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Gossypol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Gossypol?
Xenograft Model
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Gossypol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Srivastava A et al. | Studies on mechanism(s) of antifertility action of gossypol in rat and hamster. | 1989 | Contraception | pmid:2469550 |
| Rillema JA et al. | Studies on the possible role of protein kinase C in the prolactin regulation of cell replication in Nb2 node lymphoma cells. | 1989 | Proc. Soc. Exp. Biol. Med. | pmid:2813443 |
| Panigrahi S et al. | Effects of dietary cottonseed meal, with and without iron treatment, on laying hens. | 1989 | Br. Poult. Sci. | pmid:2819506 |
| Tanphaichitr N and Fitzgerald LM | Adverse effects of gossypol analogs on TM4 cell mitochondrial function. | 1989 | Contraception | pmid:2752754 |
| Soufir JC et al. | Gossypol-induced modifications in the microenvironment of rat epididymal spermatozoa. | 1989 | J. Reprod. Fertil. | pmid:2760873 |
| Mohan J et al. | Studies on antifertility effects of gossypol acetic acid in domestic cocks. | 1989 | J. Reprod. Fertil. | pmid:2536813 |
| Adlakha RC et al. | Modulation of 4'-(9-acridinylamino)methanesulfon-m-anisidide-induced, topoisomerase II-mediated DNA cleavage by gossypol. | 1989 | Cancer Res. | pmid:2539251 |
| Kanwar U et al. | Gossypol inhibition of Ca++ uptake and Ca++-ATPase in human ejaculated spermatozoal plasma membrane vesicles. | 1989 | Contraception | pmid:2541968 |
| Morgan SE | Gossypol as a toxicant in livestock. | 1989 | Vet. Clin. North Am. Food Anim. Pract. | pmid:2667706 |
| Wu D | An overview of the clinical pharmacology and therapeutic potential of gossypol as a male contraceptive agent and in gynaecological disease. | 1989 | Drugs | pmid:2680434 |
| Allamiiarova SA and Urazmetov KG | [The effect of batriden and dexasone on immune status indices in animals with experimental allergic contact dermatitis]. | 1989 | Vestn Dermatol Venerol | pmid:2609756 |
| Han SD et al. | [Study on quality of gossypol recrystalized from chloroform]. | 1989 | Yao Xue Xue Bao | pmid:2609986 |
| Tareeva IE et al. | [Treatment of chronic glomerulonephritis with cytostatics]. | 1989 | Ter. Arkh. | pmid:2799726 |
| Katoh N and Kimura K | Inhibition by gossypol of cyclic nucleotide-independent phosvitin kinase from pig testis. | 1989 | Nippon Juigaku Zasshi | pmid:2927017 |
| Nakamura M et al. | Metabolism of round spermatids in the rat: effect of gossypol on the glucose transport. | 1988 Sep-Oct | Andrologia | pmid:3207199 |
| Ershov FI et al. | [Interferonogenic activity of low-molecular compounds of plant origin]. | 1988 Nov-Dec | Vopr. Virusol. | pmid:2470203 |
| Wang JM et al. | The correlation between the gossypol contents in blood plasma, rete testis fluid, and cauda epididymal fluid following chronic treatment with gossypol in rats. | 1988 Nov-Dec | J. Androl. | pmid:3215825 |
| Zakhidov ST et al. | [Clastogenic action of gossypol on spermatogenic cells in rats studied by counting micronuclei]. | 1988 May-Jun | Izv Akad Nauk SSSR Biol | pmid:3411013 |
| Tazulakhova EB et al. | [Effect of low-molecular interferon inducers in experimental hepatitis in mice]. | 1988 Mar-Apr | Vopr. Virusol. | pmid:2457987 |
| Tanphaichitr N et al. | Differential effects of (+) and (-) gossypol enantiomers on mitochondrial function and proliferation of cultured TM4 cells. | 1988 Jul-Aug | J. Androl. | pmid:3182397 |
| Chen QQ | [Relationship between gossypol concentration and testicular damage]. | 1988 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:2968182 |
| Cheng JX | [Effect of gossypol (+/-, +, -) on Leydig cells of the rat in vitro]. | 1988 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:2970318 |
| Tang MY | [Electron microscopic observation of the effect of gossypol on atypical hyperplasia of the endometrium]. | 1988 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:2970320 |
| Ye WS | [Clastogenicity of gossypol as a male contraceptive in sperm head anomalies in mice]. | 1988 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:2970321 |
| Wang YF | [Observation on blood biochemical indices after gossypol treatment in gynecological cases]. | 1988 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:2972411 |
| Fu YF et al. | Effects of gossypol on the activity of rabbit kidney Na,K-ATPase and the functions of human erythrocyte membrane. | 1988 | Prog. Clin. Biol. Res. | pmid:2975784 |
| Fu YF et al. | Effects of gossypol on the activity of kidney (Na+ + K+)-ATPase and the functions of erythrocyte membrane. | 1988 | Contraception | pmid:2836126 |
| White IG et al. | Studies of the mechanism of action of gossypol as a male antifertility agent. | 1988 | Contraception | pmid:2836127 |
| Heywood R | The toxicology of gossypol acetic acid and (-)-gossypol. | 1988 | Contraception | pmid:3370991 |
| Wang RL et al. | Gossypol acetate-induced SCEs in spermatogonia and bone marrow cells of mice: dose-response relationships. | 1988 | Contraception | pmid:3370992 |
| Jones LA | Gossypol toxicosis. | 1988 | J. Am. Vet. Med. Assoc. | pmid:3182379 |
| Janero DR and Burghardt B | Protection of rat myocardial phospholipid against peroxidative injury through superoxide-(xanthine oxidase)-dependent, iron-promoted Fenton chemistry by the male contraceptive gossypol. | 1988 | Biochem. Pharmacol. | pmid:2840914 |
| Ueno H et al. | Interaction of gossypol with sperm macromolecules and enzymes. | 1988 | Contraception | pmid:2967157 |
| Xue SP et al. | Evaluation of the renal tubulo-toxic effect of gossypol by urinary protein analysis with SDS-polyacrylamide gel electrophoresis. | 1988 | Contraception | pmid:3370989 |
| Beaudoin AR | A developmental toxicity evaluation of gossypol. | 1988 | Contraception | pmid:3370993 |
| Benz C et al. | Selective toxicity of gossypol against epithelial tumors and its detection by magnetic resonance spectroscopy. | 1988 | Contraception | pmid:3370994 |
| Matlin SA et al. | Large-scale resolution of gossypol enantiomers for biological evaluation. | 1988 | Contraception | pmid:3370995 |
| Zhou RH and Lin XD | Isolation of (-)-gossypol from natural plant. | 1988 | Contraception | pmid:3370996 |
| Sonenberg M et al. | Anti-fertility and other actions of gossypol analogues. | 1988 | Contraception | pmid:3370997 |
| Stumpf WE et al. | Sites of action of gossypol studied by autoradiography and enzyme histochemistry. | 1988 | Contraception | pmid:3370998 |
| Fei RR and Teng CS | The effects of gossypol on nuclear protein in rat testes. I. Reduction in the content of basic proteins in the spermiogenic cells. | 1988 | Contraception | pmid:3370999 |
| Reynolds JM and Tone JN | Subchronic oral administration of gossypol-acetic acid (GAA) alters the distribution and utilization of radioiron in male rats. | 1988 | Drug Chem Toxicol | pmid:3402348 |
| Baba Y | [Effect of HCG administration in the gossypol-treated male rats]. | 1988 | Hinyokika Kiyo | pmid:3135706 |
| Best RG and McKenzie WH | Variable sister-chromatid exchange response in human lymphocytes exposed in vitro to gossypol acetic acid. | 1988 | Mutat. Res. | pmid:3173390 |
| Dou SJ and Fu YF | [Effects of gossypol acetic acid on heart mitochondrial membranes ATPase]. | 1988 | Zhongguo Yao Li Xue Bao | pmid:2975138 |
| Den Boer PJ and Grootegoed JA | Mechanism of action of (-)gossypol on ATP production in isolated hamster spermatids. | 1988 | J. Reprod. Fertil. | pmid:3411559 |
| Liu DY et al. | Mutagenicity of gossypol analyzed by induction of meiotic micronuclei in vitro. | 1988 | Mutat. Res. | pmid:3380110 |
| Ohuchi K et al. | Inhibition by gossypol of tumor promoter-induced arachidonic acid metabolism in rat peritoneal macrophages. | 1988 | Biochim. Biophys. Acta | pmid:3136806 |
| Royer RE et al. | Binding of gossypol derivatives to human serum albumin. | 1988 | J Pharm Sci | pmid:3373428 |
| Reyes J and Benos DJ | Specificity of gossypol uncoupling: a comparative study of liver and spermatogenic cells. | 1988 | Am. J. Physiol. | pmid:3354655 |