Gossypol

Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.

Cross Reference

Introduction

To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Gossypol?

Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Gossypol

MeSH term MeSH ID Detail
Lung Neoplasms D008175 171 associated lipids
Body Weight D001835 333 associated lipids
Per page 10 20 50 100 | Total 52

PubChem Associated disorders and diseases

What pathways are associated with Gossypol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Gossypol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Gossypol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Gossypol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Gossypol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Gossypol?

Xenograft Model

Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).

Transgenic Model

Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Gossypol

Download all related citations
Per page 10 20 50 100 | Total 1511
Authors Title Published Journal PubMed Link
Aitken RJ New techniques in contraception: gossypol, vaccines and GnRH analogues. 1983 Proc Annu Symp Eugen Soc pmid:6366784
Gerez de Burgos NM et al. Inhibition by gossypol of oxidoreductases from Trypanosoma cruzi. 1984 Biochem. Pharmacol. pmid:6370265
Qian SZ and Wang ZG Gossypol: a potential antifertility agent for males. 1984 Annu. Rev. Pharmacol. Toxicol. pmid:6375548
Huang TH [The effect of gossypol acetate on the function of rRNA gene and acrocentric chromosome association in human cells]. 1983 Zhonghua Yi Xue Za Zhi pmid:6407739
Wichmann K et al. Effect of gossypol on the motility and metabolism of human spermatozoa. 1983 J. Reprod. Fertil. pmid:6411909
Prasad MR and Diczfalusy E New contraceptives for men. What are the prospects? 1983 Int. J. Androl. pmid:6413430
Kennedy WP et al. Gossypol inhibition of acrosin and proacrosin, and oocyte penetration by human spermatozoa. 1983 Biol. Reprod. pmid:6416323
Weinbauer GF et al. The endocrine status of gossypol - treated male rats. 1983 Andrologia pmid:6421193
Ma XN et al. [Effect of gossypol acetic acid on testosterone, LH and FSH levels of male rats]. 1983 Yao Xue Xue Bao pmid:6433647
Hamasaki Y et al. [Rat basophilic leukemia-1 cell possesses 12-lipoxygenase and 5-lipoxygenase activities which are specifically inhibited by gossypol acetic acid]. 1984 Arerugi pmid:6442854
Han HL [Gossypol treatment for menopausal functional bleeding, myoma of uterus and endometriosis--preliminary report (author's transl)]. 1980 Zhongguo Yi Xue Ke Xue Yuan Xue Bao pmid:6451316
Kalla NR and Vasudev M Studies on the male antifertility agent-gossypol acetic acid. II. Effect of gossypol acetic acid on the motility and ATPase activity of human spermatozoa. 1981 Mar-Apr Andrologia pmid:6454365
El-Sebae AH et al. Gossypol as an inducer or inhibitor in Spodoptera littoralis larvae. 1981 J Environ Sci Health B pmid:6454717
Kalla NR et al. Studies on the male antifertility agent--gossypol acetic acid. III. Effect of gossypol acetic acid on rat testis. 1981 May-Jun Andrologia pmid:6455943
Liang DC et al. [Studies on distribution of 14C-gossypol in subcellular fractions of rat testes and site of gossypol action (author's transl)]. 1981 Zhongguo Yi Xue Ke Xue Yuan Xue Bao pmid:6459173
Bi XF et al. [Preliminary study on gossypol in causing hypokalemia (author's transl)]. 1981 Zhongguo Yi Xue Ke Xue Yuan Xue Bao pmid:6459178
Sang GW et al. [Chronic toxicity of gossypol and the relationship to its metabolic fate in dogs and monkeys (author's transl)]. 1980 Zhongguo Yao Li Xue Bao pmid:6461173
Shi QX et al. [Analysis on exfoliated cells in human semen after oral administrations of gossypol acetic acid (author's transl)]. 1981 Zhongguo Yao Li Xue Bao pmid:6462027
Wang NG et al. [Antisteroidal and antigonadotrophic effects of gossypol acetic acid in rats]. 1984 Yao Xue Xue Bao pmid:6464763
Zu PD et al. Electron microscopic observations of the effects of gossypol on the human endometrium. 1984 Am. J. Obstet. Gynecol. pmid:6465231