MeSH term | MeSH ID | Detail |
---|---|---|
Lung Neoplasms | D008175 | 171 associated lipids |
Body Weight | D001835 | 333 associated lipids |
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Tso WW and Lee CS | Gossypol uncoupling of respiratory chain and oxidative phosphorylation in ejaculated boar spermatozoa. | 1982 | Contraception | pmid:6889482 |
Tso WW and Lee CS | Cottonseed oil as a vaginal contraceptive. | 1982 | Arch. Androl. | pmid:6895984 |
Sotelo A et al. | Infertility in male rats induced by diets containing whole cottonseed flour. | 1982 | J. Nutr. | pmid:6897076 |
Gossypol as an oral contraceptive for men. | 1980 | J Med Soc N J | pmid:6928215 | |
Shandilya LN and Clarkson TB | Hypolipidemic effects of gossypol in cynomolgus monkeys (Macaca fascicularis). | 1982 | Lipids | pmid:6952061 |
Allamiiarova SA and Abidov MM | [Effect of the immunosuppressive agent batridene on contact allergic dermatitis induced by 2,4-dinitrochlorobenzene]. | 1982 | Vestn Dermatol Venerol | pmid:6979837 |
Majumdar SK et al. | Mutagenic evaluation of two male contraceptives: 5-thio-d-glucose and gossypol acetic acid. | 1982 Jan-Feb | J. Hered. | pmid:7040540 |
Jacobs HS | Contraception in the future. | 1981 | Proc Annu Symp Eugen Soc | pmid:7050975 |
Cameron SM et al. | Vaginal spermicidal activity of gossypol in the Macaca arctoides. | 1982 | Fertil. Steril. | pmid:7060775 |
Oko R and Hrudka F | Segmental aplasia of the mitochondrial sheath and sequelae induced by gossypol in rat spermatozoa. | 1982 | Biol. Reprod. | pmid:7066454 |
Saksena SK and Salmonsen RA | Antifertility effects of gossypol in male hamsters. | 1982 | Fertil. Steril. | pmid:7075801 |
Lei HP | [Review and prospect of gossypol research (author's transl)]. | 1982 | Yao Xue Xue Bao | pmid:7090820 |
Jiang DH and Xue H | [Monoanilinogossypol--the impurity possibly present in gossypol (author's transl)]. | 1982 | Yao Xue Xue Bao | pmid:7102321 |
Tso WW and Lee CS | Lactate dehydrogenase-X: an isozyme particularly sensitive to gossypol inhibition. | 1982 | Int. J. Androl. | pmid:7107034 |
Weinbauer GF et al. | Antifertility efficacy of gossypol acetic acid in male rats. | 1982 May-Jun | Andrologia | pmid:7114507 |
Hoffer AP | Ultrastructural studies of spermatozoa and the epithelial lining of the epididymis and vas deferens in rats treated with gossypol. | 1982 | Arch. Androl. | pmid:7114955 |
Shandilya L et al. | Effects of gossypol on reproductive and endocrine functions of male cynomolgus monkeys (Macaca fascicularis). | 1982 | Biol. Reprod. | pmid:7115850 |
Tso WW and Lee CS | Potassium leakage: not the cause of gossypol induced anti-motility in spermatozoa. | 1982 | Int. J. Androl. | pmid:7118270 |
Jensen DR et al. | Deposition pattern of the antifertility agent, gossypol, in selected organs of male rats. | 1982 | Toxicology | pmid:7135404 |
Zhou LF et al. | [Further observations on the effect of prolonged administration of gossypol acetic acid to rats]. | 1982 | Yao Xue Xue Bao | pmid:7136708 |