MeSH term | MeSH ID | Detail |
---|---|---|
Chemical and Drug Induced Liver Injury | D056486 | 39 associated lipids |
Prostatic Neoplasms, Castration-Resistant | D064129 | 3 associated lipids |
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Balakrishnan K et al. | AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance. | 2009 | Blood | pmid:18836097 |
Liu G et al. | An open-label, multicenter, phase I/II study of single-agent AT-101 in men with castrate-resistant prostate cancer. | 2009 | Clin. Cancer Res. | pmid:19366825 |
Wei J et al. | Apogossypol derivatives as antagonists of antiapoptotic Bcl-2 family proteins. | 2009 | Mol. Cancer Ther. | pmid:19372563 |
Xu WB et al. | The immunosuppressive effect of gossypol in mice is mediated by inhibition of lymphocyte proliferation and by induction of cell apoptosis. | 2009 | Acta Pharmacol. Sin. | pmid:19363517 |
Zhan Y et al. | Design and synthesis of a gossypol derivative with improved antitumor activities. | 2009 | Arch. Pharm. (Weinheim) | pmid:19340835 |
Verma PC et al. | Efficient production of gossypol from hairy root cultures of cotton (Gossypium hirsutum L.). | 2009 | Curr Pharm Biotechnol | pmid:19751178 |
Yurekli B et al. | Can gossypol be a hope for transsexual patients (male to female) before sex reassignment surgery? Just for adjusting the body to mind. | 2009 | Med. Hypotheses | pmid:19647947 |
El-Sharaky AS et al. | Mutual anti-oxidative effect of gossypol acetic acid and gossypol-iron complex on hepatic lipid peroxidation in male rats. | 2009 | Food Chem. Toxicol. | pmid:19665044 |
Hu GX et al. | The (+)- and (-)-gossypols potently inhibit both 3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase 3 in human and rat testes. | 2009 | J. Steroid Biochem. Mol. Biol. | pmid:19429456 |
Barba-Barajas M et al. | Gossypol induced apoptosis of polymorphonuclear leukocytes and monocytes: involvement of mitochondrial pathway and reactive oxygen species. | 2009 | Immunopharmacol Immunotoxicol | pmid:19235535 |
Basini G et al. | Gossypol, a polyphenolic aldehyde from cotton plant, interferes with swine granulosa cell function. | 2009 | Domest. Anim. Endocrinol. | pmid:19342192 |
Wang X et al. | Gossypol--a polyphenolic compound from cotton plant. | 2009 | Adv. Food Nutr. Res. | pmid:19878861 |
Cheng W et al. | [Effect of gossypol acetate on proliferation and apoptosis in Raji lymphoblastoid cell line]. | 2009 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:19968063 |
Pérez A et al. | Endofacial competitive inhibition of the glucose transporter 1 activity by gossypol. | 2009 | Am. J. Physiol., Cell Physiol. | pmid:19386788 |
Zhai G et al. | A liposomal delivery vehicle for the anticancer agent gossypol. | 2008 Sep-Oct | Anticancer Res. | pmid:19035313 |
Macoska JA et al. | -(-)Gossypol promotes the apoptosis of bladder cancer cells in vitro. | 2008 Nov-Dec | Pharmacol. Res. | pmid:18840529 |
Sheweita SA et al. | N-Nitrosodimethylamine changes the expression of glutathione S-transferase in the liver of male mice: The role of antioxidants. | 2008 Nov-Dec | J. Biochem. Mol. Toxicol. | pmid:19111000 |
Ojha P et al. | Rat testicular germ cell type(s) targeted by anti-spermatogenic agents in vivo and their recovery on withdrawal of treatment--a flow cytometric study. | 2008 | Anim. Reprod. Sci. | pmid:17207942 |
Balakrishnan K et al. | Gossypol, a BH3 mimetic, induces apoptosis in chronic lymphocytic leukemia cells. | 2008 | Blood | pmid:18566329 |
Mi JX et al. | Synergistic antitumoral activity and induction of apoptosis by novel pan Bcl-2 proteins inhibitor apogossypolone with adriamycin in human hepatocellular carcinoma. | 2008 | Acta Pharmacol. Sin. | pmid:19026166 |