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Spermatotoxic effects of Cananga odorata (Lam): a comparison with gossypol. |
2009 |
Fertil. Steril. |
pmid:18692834
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Wei J et al. |
Synthesis and evaluation of Apogossypol atropisomers as potential Bcl-xL antagonists. |
2009 |
Cancer Lett. |
pmid:18782651
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Przybylski P et al. |
Antifungal activity of alkyl and heterocyclic aza-derivatives of gossypol as well as their complexes with NaClO4 against Fusarium oxysporum f. sp. lupini. |
2009 |
Bioorg. Med. Chem. Lett. |
pmid:19264482
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Balakrishnan K et al. |
AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance. |
2009 |
Blood |
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An open-label, multicenter, phase I/II study of single-agent AT-101 in men with castrate-resistant prostate cancer. |
2009 |
Clin. Cancer Res. |
pmid:19366825
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2009 |
Mol. Cancer Ther. |
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Xu WB et al. |
The immunosuppressive effect of gossypol in mice is mediated by inhibition of lymphocyte proliferation and by induction of cell apoptosis. |
2009 |
Acta Pharmacol. Sin. |
pmid:19363517
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Zhan Y et al. |
Design and synthesis of a gossypol derivative with improved antitumor activities. |
2009 |
Arch. Pharm. (Weinheim) |
pmid:19340835
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Efficient production of gossypol from hairy root cultures of cotton (Gossypium hirsutum L.). |
2009 |
Curr Pharm Biotechnol |
pmid:19751178
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Targeting apoptosis in the hormone- and drug-resistant prostate cancer cell line, DU-145, by gossypol/zoledronic acid combination. |
2009 |
Cell Biol. Int. |
pmid:19716895
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Das SG et al. |
Structure-activity relationship and molecular mechanisms of ethyl 2-amino-4-(2-ethoxy-2-oxoethyl)-6-phenyl-4h-chromene-3-carboxylate (sha 14-1) and its analogues. |
2009 |
J. Med. Chem. |
pmid:19743858
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Hu ZY et al. |
ApoG2 induces cell cycle arrest of nasopharyngeal carcinoma cells by suppressing the c-Myc signaling pathway. |
2009 |
J Transl Med |
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Kilic A et al. |
Efficacy of signal pathway inhibitors alone and in combination with Cisplatin varies between human non-small cell lung cancer lines. |
2009 |
J. Surg. Res. |
pmid:19084241
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Chen BB et al. |
The (+)- and (-)-gossypols potently inhibit human and rat 11beta-hydroxysteroid dehydrogenase type 2. |
2009 |
J. Steroid Biochem. Mol. Biol. |
pmid:19150652
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Stipanovic RD et al. |
Total and percent atropisomers of gossypol and gossypol-6-methyl ether in seeds from pima cottons and accessions of Gossypium barbadense L. |
2009 |
J. Agric. Food Chem. |
pmid:19113939
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Zhang L et al. |
Chiral gossypol derivatives: evaluation of their anticancer activity and molecular modeling. |
2009 |
Eur J Med Chem |
pmid:19447525
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Yurekli B et al. |
Can gossypol be a hope for transsexual patients (male to female) before sex reassignment surgery? Just for adjusting the body to mind. |
2009 |
Med. Hypotheses |
pmid:19647947
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El-Sharaky AS et al. |
Mutual anti-oxidative effect of gossypol acetic acid and gossypol-iron complex on hepatic lipid peroxidation in male rats. |
2009 |
Food Chem. Toxicol. |
pmid:19665044
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Hu GX et al. |
The (+)- and (-)-gossypols potently inhibit both 3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase 3 in human and rat testes. |
2009 |
J. Steroid Biochem. Mol. Biol. |
pmid:19429456
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Barba-Barajas M et al. |
Gossypol induced apoptosis of polymorphonuclear leukocytes and monocytes: involvement of mitochondrial pathway and reactive oxygen species. |
2009 |
Immunopharmacol Immunotoxicol |
pmid:19235535
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Basini G et al. |
Gossypol, a polyphenolic aldehyde from cotton plant, interferes with swine granulosa cell function. |
2009 |
Domest. Anim. Endocrinol. |
pmid:19342192
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2009 |
Adv. Food Nutr. Res. |
pmid:19878861
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Atmaca H et al. |
Combined gossypol and zoledronic acid treatment results in synergistic induction of cell death and regulates angiogenic molecules in ovarian cancer cells. |
2009 |
Eur. Cytokine Netw. |
pmid:19825521
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Zerp SF et al. |
AT-101, a small molecule inhibitor of anti-apoptotic Bcl-2 family members, activates the SAPK/JNK pathway and enhances radiation-induced apoptosis. |
2009 |
Radiat Oncol |
pmid:19852810
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Varol U et al. |
The effect of racemic gossypol and at-101 on angiogenic profile of ovcar-3 cells: a preliminary molecular framework for gossypol enantiomers. |
2009 |
Exp. Oncol. |
pmid:20010531
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Wu G et al. |
Temporal allocation of metabolic tolerance in the body of beet armyworm in response to three gossypol-cotton cultivars. |
2009 |
Sci. China, C, Life Sci. |
pmid:20016971
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Wang WQ et al. |
[Apoptosis of multiple myeloma cells induced by gossypol acetic acid in vitro and its mechanism]. |
2009 |
Zhongguo Shi Yan Xue Ye Xue Za Zhi |
pmid:20030926
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Xu P et al. |
Mitogenic activity of zeranol in human breast cancer cells is enhanced by leptin and suppressed by gossypol. |
2009 |
Anticancer Res. |
pmid:20032412
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Cheng W et al. |
[Effect of gossypol acetate on proliferation and apoptosis in Raji lymphoblastoid cell line]. |
2009 |
Zhongguo Yi Xue Ke Xue Yuan Xue Bao |
pmid:19968063
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Pérez A et al. |
Endofacial competitive inhibition of the glucose transporter 1 activity by gossypol. |
2009 |
Am. J. Physiol., Cell Physiol. |
pmid:19386788
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Karaca B et al. |
Enhancement of taxane-induced cytotoxicity and apoptosis by gossypol in human breast cancer cell line MCF-7. |
2009 Jul-Sep |
J BUON |
pmid:19810142
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Fulda S |
Modulation of apoptosis by natural products for cancer therapy. |
2010 |
Planta Med. |
pmid:20486070
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The interaction of PVP complexes of gossypol and its derivatives with an artificial membrane lipid matrix. |
2010 |
Cell. Mol. Biol. Lett. |
pmid:19936629
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Effects of silymarin on gossypol toxicosis in divergent lines of chickens. |
2010 |
Poult. Sci. |
pmid:20709972
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Yan F et al. |
A novel water-soluble gossypol derivative increases chemotherapeutic sensitivity and promotes growth inhibition in colon cancer. |
2010 |
J. Med. Chem. |
pmid:20684596
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Responses of three successive generations of beet armyworm, Spodoptera exigua, fed exclusively on different levels of gossypol in cotton leaves. |
2010 |
J. Insect Sci. |
pmid:21067414
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Wei J et al. |
Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. |
2010 |
J. Med. Chem. |
pmid:21033669
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Involvement of Bcl-2, Src, and ERα in gossypol-mediated growth inhibition and apoptosis in human uterine leiomyoma and myometrial cells. |
2010 |
Acta Pharmacol. Sin. |
pmid:21102482
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Zhong S et al. |
Aromatase expression in leptin-pretreated human breast pre-adipocytes is enhanced by zeranol and suppressed by (-)-gossypol. |
2010 |
Anticancer Res. |
pmid:21187493
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Heist RS et al. |
Phase I/II study of AT-101 with topotecan in relapsed and refractory small cell lung cancer. |
2010 |
J Thorac Oncol |
pmid:20808253
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Moretti L et al. |
AT-101, a pan-Bcl-2 inhibitor, leads to radiosensitization of non-small cell lung cancer. |
2010 |
J Thorac Oncol |
pmid:20354451
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Sahin F et al. |
Gossypol exerts its cytotoxic effect on HL-60 leukemic cell line via decreasing activity of protein phosphatase 2A and interacting with human telomerase reverse transcriptase activity. |
2010 |
Hematology |
pmid:20557672
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D'Cruz SC et al. |
Effects of plants and plant products on the testis. |
2010 |
Asian J. Androl. |
pmid:20562897
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Gao P et al. |
The Bcl-2 homology domain 3 mimetic gossypol induces both Beclin 1-dependent and Beclin 1-independent cytoprotective autophagy in cancer cells. |
2010 |
J. Biol. Chem. |
pmid:20529838
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Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells. |
2010 |
Mol. Cancer Ther. |
pmid:20124455
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Barelier S et al. |
Fragment-based deconstruction of Bcl-xL inhibitors. |
2010 |
J. Med. Chem. |
pmid:20192224
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Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression. |
2010 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:20133848
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Zhang XQ et al. |
Inhibition of proliferation of prostate cancer cell line, PC-3, in vitro and in vivo using (-)-gossypol. |
2010 |
Asian J. Androl. |
pmid:20081872
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Liu YX |
Temperature control of spermatogenesis and prospect of male contraception. |
2010 |
Front Biosci (Schol Ed) |
pmid:20036980
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Wang H et al. |
Inhibition of calcineurin by quercetin in vitro and in Jurkat cells. |
2010 |
J. Biochem. |
pmid:19880376
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