MeSH term | MeSH ID | Detail |
---|---|---|
Chemical and Drug Induced Liver Injury | D056486 | 39 associated lipids |
Prostatic Neoplasms, Castration-Resistant | D064129 | 3 associated lipids |
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Zaidi R and Hadi SM | Strand scission in DNA by gossypol and Cu(II): role of Cu(I) and oxygen-free radicals. | 1992 | J. Biochem. Toxicol. | pmid:1293310 |
Jo C et al. | Irradiation effects on embryotoxicity and oxidative properties of gossypol dissolved in methanol. | 2003 | Food Chem. Toxicol. | pmid:12909266 |
Zaidi R and Hadi SM | Complexes involving gossypol, DNA and Cu(II). | 1992 | Biochem. Int. | pmid:1290468 |
Cao J et al. | [Effect of low dose gossypol treatment on male sperm nuclear basic protein]. | 2000 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:12903463 |
Wang L et al. | [Combined use of steroid hormone and low dose gossypol for antifertility and its mechanism in rats]. | 2000 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:12903462 |
Xue S | [A beam of dawn light of study on gossypol as a safe, effective, and reversible male antifertility contraceptive--evaluation of the studies by using low dose gossypol combined with steroid hormone for male contraception]. | 2000 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:12903461 |
Räsänen TL et al. | Gossypol activates pancreatic polyamine catabolism in normal rats and induces acute pancreatitis in transgenic rats over-expressing spermidine/spermine N1-acetyltransferase. | 2003 | Scand. J. Gastroenterol. | pmid:12889567 |
Kawanishi K et al. | Aldose reductase inhibitors from the nature. | 2003 | Curr. Med. Chem. | pmid:12871134 |
Dowd MK and Stevens ED | The gossypol-cyclododecanone (1/2) inclusion complex. | 2003 | Acta Crystallogr C | pmid:12855869 |
Tkachenko MN et al. | Involvement of endothelium in vasodilating effects of vintoperol. | 1992 | J. Cardiovasc. Pharmacol. | pmid:1282997 |
Sagach VF et al. | Functional hyperemia of skeletal muscle: role of endothelium. | 1992 | J. Cardiovasc. Pharmacol. | pmid:1282960 |
Zhang M et al. | Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells. | 2003 | Biochem. Pharmacol. | pmid:12818369 |
Cui GH et al. | [Determination of gossypol in cotton root bark by HPLC]. | 2002 | Zhongguo Zhong Yao Za Zhi | pmid:12774395 |
Dowd MK | Preparation of enantiomeric gossypol by crystallization. | 2003 | Chirality | pmid:12774287 |
Santos JE et al. | Type of cottonseed and level of gossypol in diets of lactating dairy cows: plasma gossypol, health, and reproductive performance. | 2003 | J. Dairy Sci. | pmid:12703626 |
Vershinina MY et al. | Regulation of cytokine mRNAs by interferon and interferon inducers. | 2002 | Russ. J. Immunol. | pmid:12687259 |
Dao VT et al. | New thioderivatives of gossypol and gossypolone, as prodrugs of cytotoxic agents. | 2003 | Bioorg. Med. Chem. | pmid:12670651 |
Prieto JG et al. | Increasing dietary levels of cracked pima cottonseed increase plasma gossypol but do not influence productive performance of lactating Holstein cows. | 2003 | J. Dairy Sci. | pmid:12613869 |
Bai JP et al. | Effects of demethylzeylasteral and celastrol on spermatogenic cell Ca2+ channels and progesterone-induced sperm acrosome reaction. | 2003 | Eur. J. Pharmacol. | pmid:12600689 |
Mego M | Telomerase inhibitors in anticancer therapy: gossypol as a potential telomerase inhibitor. | 2002 | Bratisl Lek Listy | pmid:12583508 |