MeSH term | MeSH ID | Detail |
---|---|---|
Adenocarcinoma | D000230 | 166 associated lipids |
Abnormalities, Drug-Induced | D000014 | 10 associated lipids |
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
To understand associated biological information of Gossypol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Gossypol is suspected in Severe Combined Immunodeficiency, Aortic Valve Insufficiency, PARKINSON DISEASE, LATE-ONSET, Infertility, CLEFT LIP, CONGENITAL HEALED, Pulmonary Fibrosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Gossypol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Gossypol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.' (Volate SR et al., 2010), Xenograft Model are used in the study 'Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.' (Lian J et al., 2012), Xenograft Model are used in the study 'Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.' (Meng Y et al., 2008), Xenograft Model are used in the study '(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.' (Pang X et al., 2011) and Xenograft Model are used in the study 'Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.' (Sung B et al., 2010).
Transgenic Model are used in the study 'Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).' (Kitada S et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Reyes J et al. | A bioenergetic model of gossypol action: effects of gossypol on adult rat spermatogenic cells. | 1988 | Am. J. Physiol. | pmid:3354654 |
Radermacher J et al. | Endothelium-derived relaxing factor influences renal vascular resistance. | 1990 | Am. J. Physiol. | pmid:2115741 |
SMITH HA | The pathology of gossypol poisoning. | 1957 Mar-Apr | Am. J. Pathol. | pmid:13402891 |
Robinson JM et al. | Gossypol-induced damage to mitochondria of transformed Sertoli cells. | 1986 | Am. J. Pathol. | pmid:3026188 |
Cheng KF et al. | Endometrial changes after administration of gossypol for menorrhagia. | 1980 | Am. J. Obstet. Gynecol. | pmid:7446637 |
Sheriff DS et al. | Gossypol and lipid peroxidation. | 1986 | Am. J. Obstet. Gynecol. | pmid:3740171 |
Zu PD et al. | Electron microscopic observations of the effects of gossypol on the human endometrium. | 1984 | Am. J. Obstet. Gynecol. | pmid:6465231 |
Wichmann K et al. | Inhibiting herpes simplex virus type 2 infection in human epithelial cells by gossypol, a potent spermicidal and contraceptive agent. | 1982 | Am. J. Obstet. Gynecol. | pmid:6277198 |
Liu GZ et al. | Experiences with gossypol as a male pill. | 1987 | Am. J. Obstet. Gynecol. | pmid:3314523 |
Tosukhowong P et al. | Environmental distal renal tubular acidosis in Thailand: an enigma. | 1999 | Am. J. Kidney Dis. | pmid:10352213 |
Graham GG et al. | Dietary protein quality in infants and children. II. Metabolic studies with cottonseed flour. | 1969 | Am. J. Clin. Nutr. | pmid:5819114 |
Wen W | China invents male birth control pill. | 1980 Spring-Summer | Am. J. Chin. Med. | pmid:7395797 |
Sein GM | The embryotoxic and immunodepressive effects of gossypol. | 1986 | Am. J. Chin. Med. | pmid:3799526 |
Lawrence SV | Gossypol: a potential male contraceptive? | 1981 | Am Pharm | pmid:7304423 |
Knych ET | Endothelium-dependent tolerance to ethanol-induced contraction of rat aorta: effect of inhibition of EDRF action and nitric oxide synthesis. | 1992 | Alcohol. Clin. Exp. Res. | pmid:1558303 |
Baram N et al. | Inactivation of intestinal brush-border enzymes by gossypol. | 1987 | Agric. Biol. Chem. | pmid:12283503 |
Adekunle AO et al. | Seminal plasma zinc level in users of gossypol. | 1999 Mar-Jun | Afr J Med Med Sci | pmid:12953977 |
Schmidt K et al. | EDRF-formation increases cGMP-levels in cultured endothelial cells. | 1990 | Adv. Second Messenger Phosphoprotein Res. | pmid:1976336 |
Fedeli E and Jacini G | Lipid composition of vegetable oils. | 1971 | Adv. Lipid Res. | pmid:4942102 |
Wang X et al. | Gossypol--a polyphenolic compound from cotton plant. | 2009 | Adv. Food Nutr. Res. | pmid:19878861 |